You may be eligible if you: - Are male, aged 18-55
- Are a cyclist who participates in endurance training at least 150 min/week for the past 6 months
- Have no known or suspected cardiopulmonary disease, metabolic disorders, Parkinson’s disease, multiple sclerosis, or other autonomic nervous system condition, not diagnosed or being treated for arthritis or any inflammatory condition (such as Lupus, gout, or Sjogren’s syndrome)
- Do not have orthostatic hypotension or low blood pressure
- Have never experienced a heat-related illness, such as heat exhaustion or heat stroke and do not have issues with cooling or sweating
- Do not smoke or quit more than a year ago
- Willing to provide blood and stool samples
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