Hi,
It's maybe worth saying what Astrometry.net produces and what is missing. Astrometry.net starts by matching 3- or 4-star features in your image to a reference catalog of known stars. It then uses 10+ more stars to confirm that match. So normally we have 10-20 stars matched, sometimes many more. Starting with that, we can also compute polynomial distortion terms to give a more precise match between image stars and known stars.
This is all done image-by-image, and always matching images to reference catalogs. For some images (but not wide-field ones), they can be deeper than the reference catalogs, so aligning image-to-image could improve things. And doing simultaneous fitting (including assuming that some parts of the distortion are constant -- like Scamp done) could also improve overall results for a large image collection.
For wide-field images, I would say the bigger issue would be getting good distortions, since they tend to be larger for wide-field (especially consumer-grade) images.
cheers,
dustin