[RITUPARNA CHAKRABORTY]

What is multuple and region in promoter type of DNMT3l

[CCG EPFL]

Promoters often have multiple initiation sites (TSSs). Promoters in EPD are assigned to three types: "single", "multiple", and "region", depending on the breadth of the initiation patterns.

The EPDnew home page at:

https://epd.expasy.org/epd/EPDnew_database.php

defines these types as follows:

Promoter type: three types of promoters are distinguished, reflecting the variety of transcription initiation patterns in Eukaryotes. They are based on the Dispersion Index (a statistic defined in Dreos et al., 2016 that is conceptually similar to a the standard deviation of the observed initiation sites around the annotated TSS) and are defined as follows:

• Single initiation site: dispersion index value between 0 and 3;
• Multiple initiation sites: dispersion index value between 3 and 10;
• Initiation region: dispersion index value > 10;

Philipp Bucher

PS: Note that the EPDnew home page can be accessed from the EPD home page at:

https://epd.expasy.org/epd/

by clicking on the the link "Access EPDnew" in the upper left corner.