Fwd: help

[Tin Chi Nguyen]

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From: "Tin Chi Nguyen" <ex6...@wayne.edu>
To: "Roberta Spinelli" <spinelli...@gmail.com>
Sent: Tuesday, March 12, 2013 11:38:35 AM
Subject: Re: help

Hi,

1/ the equation e=rSp is the short form of the matrix equation described some lines above. e is the observation vector, r is the dummy expression abundance, S is the splicing matrix, p is the proportion vector.
2/ Adding sigma to the splicing vector helps to shrink the proportion of the corresponding transcript. You can look at Figure 3 B, by adding sigma to the 1st and 3th column, we shrink the proportions of the 1st and 3rd transcripts.

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From: "Roberta Spinelli" <spinelli...@gmail.com>
To: "Tin Chi Nguyen" <ex6...@wayne.edu>
Sent: Tuesday, March 12, 2013 11:27:42 AM
Subject: help

Dear Tin,

please can you explain me the mean of equantion (1) or rSp?
please, can you explain me what means 1+sigma in the modified splicing matrix where the sigma is equal to r and sigma(k) = r(k).

Why did you add r to 1 if e(i)=0? Or r is 0 or -1?

Grazie,
Roberta