MaxQuant crashing

[Ameesha Paliwal]

Hi everyone, 

I'm pretty new to using MaxQuant and I'm having some trouble with a large dataset. I have ~150 raw files each around 4 gb. I'm doing IBAQ and LFQ and using version 2.2. I tried running all the files at once using 10 threads, but the computer crashed after a few days. I tried again using just a few files to try and troubleshoot the problem, but even with 5 files the computer crashed after 24 hours. Does anyone have any experience running large datasets? 

Thanks for your help in advance!