I found it didn't matter, but I liked to have a routine, so I would take my first dose with my morning coffee, and then my 2nd dose an hr(ish) before my evening work out. After taking it for about 2 weeks, I began getting the pre workout boost. It was actually really unique, even to steroid effects. It gave me an anxious but highly focused feeling, and it dramaaaatically improved mind-muscle connection. To this day, I have never found another compound that does this. Rad is unique in this way. I have added it to full on cycles just because of this.