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Ultra-clean homes could trigger childhood leukaemia, major review suggests

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Leroy N. Soetoro

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May 23, 2018, 5:15:13 PM5/23/18
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https://www.telegraph.co.uk/science/2018/05/21/ultra-clean-homes-could-
trigger-childhood-leukaemia-major-review/

Keeping children cocooned in ultra-clean homes away from other youngsters
could trigger childhood leukaemia, a landmark study suggests.

A major new analysis by Britain’s leading leukaemia expert has concluded a
deadly chain of events is set in motion when susceptible children are not
exposed to enough bugs to prime their immune system at an early age.

Without sufficient immunity, if vulnerable youngsters catch even a
relatively harmless virus like flu, the immune system malfunctions
creating far more infection-fighting white blood cells than needed,
causing leukaemia.

Professor Mel Greaves of The Institute of Cancer Research, London, said it
was a ‘paradox of progress in modern societies’ that advances in
cleanliness had caused such a devastating condition.

The study, which compiled 30 years of research into the cancer, raises the
prospect that Acute lymphoblastic leukaemia (ALL) could become a
preventable disease, which charities said was ‘enormously exciting.’

Simple steps such as allowing children to attend a day nursery so they
come into contact with germ-laden youngsters, breastfeeding, outdoor play
and not overly cleaning the house could all help boost immunity, the study
suggests.

Professor Mel Greaves, Director of the Centre for Evolution and Cancer at
The Institute of Cancer Research, London, said: “The research strongly
suggests that ALL has a clear biological cause, and is triggered by a
variety of infections in predisposed children whose immune systems have
not been properly primed.

“The most important implication is that most cases of childhood leukaemia
are likely to be preventable.

“It might be done in the same way that is currently under consideration
for autoimmune disease or allergies – perhaps with simple and safe
interventions to expose infants to a variety of common and harmless bugs."

The new research is the most comprehensive analysis ever carried out into
the illness, which is the most common type of childhood cancer, affecting
more than 600 children each year in Britain.

Acute lymphoblastic leukaemia is particularly prevalent in advanced,
affluent societies and is increasing in incidence at around one per cent
per year.

The study found that ALL is partially caused by a genetic mutation which
predisposes some youngsters to the disease. But only one per cent of
children born with this genetic change go on to develop cancer.

Prof Greaves concluded that the disease is triggered later in childhood
when youngsters are exposed to common infections, particularly youngsters
who experienced ‘clean’ childhoods in the first year of life, without much
interaction with other children.

He suggests that it might be preventable if a child's immune system is
properly ‘primed’ in the first year of life – potentially sparing children
the trauma and life-long consequences of chemotherapy.

The study also rules out possible environmental causes, such as ionising
radiation, electricity cables, electromagnetic waves or man-made
chemicals.

Dr Alasdair Rankin, Director of Research at the blood cancer charity
Bloodwise, which has funded Professor Greaves’ work for over 30 years,
said: “Decades of research by Professor Greaves have shown that the most
common type of childhood leukaemia is most probably caused by an abnormal
response to infection in children already at risk.

“Current treatments for childhood leukaemia are not always successful, and
even when they are, can have severe short and long-term side effects, so
research to find kinder treatments is very important.

“If we could stop this type of leukaemia from happening in the first place
it would be enormously exciting, but many more questions still need to be
answered in the research lab before we will know for sure whether that
could become a reality.”

Professor Paul Workman, Chief Executive of The Institute of Cancer
Research, London, added: “It’s exciting to think that, in future,
childhood leukaemia could become a preventable disease as a result of this
work.

“Preventing childhood leukaemia would have a huge impact on the lives of
children and their families in the UK and across the globe.”

The research was published in the journal Nature Reviews Cancer.


--
Donald J. Trump, 304 electoral votes to 227, defeated compulsive liar in
denial Hillary Rodham Clinton on December 19th, 2016. The clown car
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Congratulations President Trump. Thank you for cleaning up the disaster
of the Obama presidency.

Under Barack Obama's leadership, the United States of America became the
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#BeamMeUpScotty

unread,
May 23, 2018, 5:27:24 PM5/23/18
to
On 05/23/2018 05:15 PM, Leroy N. Soetoro wrote:
> https://www.telegraph.co.uk/science/2018/05/21/ultra-clean-homes-could-
> trigger-childhood-leukaemia-major-review/
>
> Keeping children cocooned in ultra-clean homes away from other youngsters
> could trigger childhood leukemia, a landmark study suggests.

Wouldn't kids with immune deficiency who are naturally kept in a clean
environment all develop leukemia? Triggered by their sterile bubble?
--
That's Karma
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