IS THIS the CURE? --> L. Plantarum controls SFB (segmented filamentous bacteria) & HIGH Levels of Th17
randall
Is this the CURE for ALL autoimmune conditions RULED by excess TH17?
What?
For psor?
YES....
*****SFB in the ileum of immunocompromised mice, which was abolished
upon administration of L. plantarum, an effect not described to date.
PMID: 18081591*******
[The abstract and LINK for study is below]
How did I get this?
Gut Hunches for over 30 FREAKING YEARs! :)
This THREAD one was posted late on Friday, two days ago:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/70a38e5660b9bc17
Fri, Oct 16 2009 10:28 pm
Subject: Th17 & Gut Psor Musings -- ID3 & GammaDelta T cells --PLUS
more...
And this is what was posted::
http://www.eurekalert.org/pub_releases/2009-10/nlmc-ubh101409.php
Unusual bacteria help balance the immune system in mice
Discovery lays groundwork for better understanding of protective human
microbes in the gut
Medical researchers have long suspected that obscure bacteria living
within the intestinal tract may help keep the human immune system in
balance. An international collaboration co-led by scientists at NYU
Langone Medical Center has now identified a bizarre-looking microbial
species that can single-handedly spur the production of specialized
immune cells in mice.
This remarkable activation of the immune response could point to a
similar phenomenon in humans, helping researchers understand how gut-
dwelling bacteria protect us from pathogenic bacteria, such as
virulent strains of E. coli. The study, published in the Oct. 30,
2009, issue of Cell, also supports the idea that specific bacteria may
act like neighborhood watchdogs at key locations within the small
intestine, where they sense the local microbial community and sound
the alarm if something seems amiss.
In mice, at least, the newly identified neighborhood watchdog looks
like something out of Disney's "The Shaggy D.A." Distinguished by long
hair-like filaments, "These bacteria are the most astounding things
I've ever seen," says Dan Littman, MD, PhD, the Helen L. and Martin S.
Kimmel Professor of Molecular Immunology and a Howard Hughes Medical
Institute Investigator.
Co-led by Dr. Littman's lab, the collaboration with researchers in
Japan, California, and Massachusetts zeroed in on a little-known
microbe named segmented filamentous bacterium, or SFB. In mice raised
under germ-free conditions, the scientists found that adding SFB was
sufficient to trigger the appearance of specialized T helper cells
known as Th17 cells. These immune specialists, in turn, can send
signals that tell epithelial cells lining the small intestine to
increase their output of molecules targeting selected microbes.
For the study's mice, the infection-fighting response was enough to
ward off the pathogen Citrobacter rodentium, considered a good model
for the type of disease-causing E. coli found in contaminated foods
like spinach or ground beef. Without SFB to protect them, mice
infected with Citrobacter rodentium became ill before recovering.
In the same way, commensal microbes—beneficial bacteria—could decrease
our susceptibility to various pathogenic invaders. "So you can
immediately see some practical application of this, if one can mimic
the presence of these commensal bacteria to strengthen resistance to
pathogenic microbes," Dr. Littman says.
Thanks to rapid progress in the field of genomics, he expects the
entire DNA sequence of the SFB species to be completed within a few
months. Armed with the sequence, researchers could focus on specific
proteins. "For example, can we identify a protein that, when we inject
it into an epithelial cell, sets off in motion the whole pathway to
make Th17 cells?" he says. "By knowing how to do this, you may be able
to give people a peptide or a compound that induces Th17 cells by
mimicking the bacterial product, and in that way either protect or
ameliorate the effect of the infection."
Too much Th17 cell activation, however, can lead to harmful
inflammation, Dr. Littman says. Excessive induction by specific
microbes in the gut, then, could contribute to autoimmune diseases
such as rheumatoid arthritis, psoriasis, Crohn's disease, and possibly
even multiple sclerosis.
-----
Segmented Filamentous Bacterium
http://www.eurekalert.org/multimedia/pub/17464.php?from=146686
Caption: A little-known bacterial species called segmented filamentous
bacterium, or SFB, can activate the production of specialized immune
cells in mice. This scanning electron microscope image of an SFB
colony shows a mass of long hair-like filaments created when the
bacteria stay attached to each other after they divide.
###
Same article with a science daily sPin: [posted on friday]
http://www.sciencedaily.com/releases/2009/10/091015123544.htm
===============
SFB -- 72 hits on pubmed:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=segmented+filamentous+bacteria&log$=activity
Are we going to heaven soon?
Yes...
Being 100% CLEAR of PSOR is and will be heaven on earth. LOL
Thank GOD... i'm almost DONE with all of this skin CRAP...
But more so then JUST that is the ramifications for ALL disease
including
cancer...
Gut stuff is UPstream of most disease conditions one whey or another,
i'd
suspect.
These French Folks nailed it on OCT 16, 2009 as WELL
www.ncbi.nlm.nih.gov/pubmed/19833089
The key role of segmented filamentous bacteria in the coordinated
maturation of gut helper T cell responses.
__Gaboriau-Routhiau V__**, Rakotobe S, Lécuyer E, Mulder I, Lan A,
Bridonneau C, Rochet V, Pisi A, De Paepe M, Brandi G, Eberl G, Snel J,
Kelly D, Cerf-Bensussan N.
INRA, U910, Unité Ecologie et Physiologie du Système Digestif, Domaine
de Vilvert, 78350 Jouy-en-Josas, France; INSERM, U793, Université
Paris Descartes, 156 rue de Vaugirard, 75730 Paris Cedex 15, France.
Microbiota-induced cytokine responses participate in gut homeostasis,
but the cytokine balance at steady-state and the role of individual
bacterial species in setting the balance remain elusive. Herein,
systematic analysis of gnotobiotic mice indicated that colonization by
a whole mouse microbiota orchestrated a broad spectrum of
proinflammatory T helper 1 (Th1), Th17, and regulatory T cell
responses whereas most tested complex microbiota and individual
bacteria failed to efficiently stimulate intestinal T cell responses.
This function appeared the prerogative of a restricted number of
bacteria, the prototype of which is the segmented filamentous
bacterium, a nonculturable Clostridia-related species, which could
largely recapitulate the coordinated maturation of T cell responses
induced by the whole mouse microbiota. This bacterium, already known
as a potent inducer of mucosal IgA, likely plays a unique role in the
postnatal maturation of gut immune functions. Changes in the infant
flora may thus influence the development of host immune responses.
PMID: 19833089
-------
www.ncbi.nlm.nih.gov/pubmed/19833084
Gut immune balance is as easy as s-f-B.
Mazmanian SK.
Division of Biology, California Institute of Technology, Pasadena, CA
91125, USA.
Microbes appear to modulate homeostatic plasticity of T helper and T
regulatory cells. In this issue of Immunity, ___Gaboriau-Routhiau__**
et al. (2009) now reveal that segmented filamentous bacteria uniquely
coordinate the intestinal T cell profile. The potential implications
of this process to various immune functions are discussed.
PMID: 19833084
=================
www.ncbi.nlm.nih.gov/pubmed/19327545
Intestinal Bifidobacterium association in germ-free T cell receptor
transgenic mice down-regulates dietary antigen-specific immune
responses of the small intestine but enhances those of the large
intestine.
Tsuda M, Hosono A, Yanagibashi T, Hachimura S, Hirayama K, Umesaki Y,
Itoh K, Takahashi K, Kaminogawa S.
Department of Food Science and Technology, College of Bioresource
Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa
252-8510, Japan.
Bifidobacterium is a dominant bacterial species among commensals in
the human intestine and is thought to have probiotic immunomodulatory
effects. In this study, we investigated the effect of the association
with Bifidobacterium pseudocatenulatum JCM 7041 (Bp) on dietary
ovalbumin (OVA)-specific immune responses using germ-free OVA-specific
T cell receptor transgenic mice (OVA23-3 mice). We established germ-
free OVA23-3 mice, and then associated with Bp (BIF group) or without
(CONT group) and additionally associated with ____segmented
filamentous bacteria____ (SFB) and clostridia in both groups. BIF and
CONT mice were fed an egg-white diet containing OVA for 1 week.
Cytokine production in response to OVA by cells of Peyer's patches
(PPs) and lamina propria (LP) from the small and large intestine was
measured. Interferon (IFN)-gamma and interleukin (IL)-6 production by
PP cells from BIF group mice was lower than that of the CONT group.
The proportion of PP cells expressing CD4+CD62L(low), an activated/
memory T cell phenotype, was higher in BIF group mice than the CONT
group. Furthermore, LP cells from the small intestine in Bp-associated
mice showed a tendency to produce slightly lower IFN-gamma and IL-6,
while the cells from large intestine produced markedly higher IFN-
gamma, IL-5 and IL-6 than those in the CONT group. The pattern of
cytokine production by PP in BIF animals was similar to those isolated
from conventional mice. These results suggest that intestinal
association with Bp might down-regulate excessive immune responses to
dietary antigens of the small intestine but enhance those of the large
intestine.
PMID: 19327545
And now we have proof of good gut flora...
www.ncbi.nlm.nih.gov/pubmed/18081591
A strain of Lactobacillus plantarum affects segmented filamentous
bacteria in the intestine of immunosuppressed mice.
Fuentes S, Egert M, Jimenez-Valera M, Monteoliva-Sanchez M, Ruiz-Bravo
A, Smidt H.
Department of Microbiology, School of Pharmacy, University of Granada,
Granada, Spain. susana....@wur.nl
Segmented filamentous bacteria (SFB) are present in the
gastrointestinal tract of mice from weaning until the maturation of
the immune system. Probiotic bacteria also have an effect on host
immunity. To study the relationships established between these
bacteria, samples from a mouse model fed with Lactobacillus plantarum
under different immunological conditions were analysed. SFB
populations were measured by a newly designed group-specific
quantitative PCR assay. __________________The results confirmed the
presence of the probiotic in the intestine and an expansion of SFB in
the ileum of immunocompromised mice, which was abolished upon
administration of L. plantarum, an effect not described to
date._______________*** see above
PMID: 18081591
L. Plantarum 1076 hits on pubmed:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=L.+plantarum&log$=activity
Surely this 5th on the list for IL-12 production and immune properties
is critical.
www.ncbi.nlm.nih.gov/pubmed/19740347
Have led to the above far reaching immunomodulatory ramifications.
www.ncbi.nlm.nih.gov/pubmed/19756155
Comparison of the immunomodulatory properties of three probiotic
strains of Lactobacilli using complex culture systems: prediction for
in vivo efficacy.
Mileti E, Matteoli G, Iliev ID, Rescigno M.
Department of Experimental Oncology, European Institute of Oncology,
Milan, Italy.
BACKGROUND: While the use of probiotics to treat or prevent
inflammatory bowel disease (IBD) has been proposed, to this point the
clinical benefits have been limited. In this report we analyzed the
immunological activity of three strains of Lactobacillus to predict
their in vivo efficacy in protecting against experimental colitis.
METHODOLOGY/PRINCIPAL FINDINGS: We compared the immunological
properties of Lactobacillus plantarum NCIMB8826, L. rhamnosus GG
(LGG), L. paracasei B21060 and pathogenic Salmonella typhimurium
(SL1344). We studied the stimulatory effects of these different
strains upon dendritic cells (DCs) either directly by co-culture or
indirectly via conditioning of an epithelial intermediary.
Furthermore, we characterized the effects of these strains in vivo
using a Dextran sulphate sodium (DSS) model of colitis. We found that
the three strains exhibited different abilities to induce inflammatory
cytokine production by DCs with L. plantarum being the most effective
followed by LGG and L. paracasei. L. paracasei minimally induced the
release of cytokines, while it also inhibited the potential of DCs to
both produce inflammatory cytokines (IL-12 and TNF-alpha) and to drive
Th1 T cells in response to Salmonella. This effect on DCs was found
under both direct and indirect stimulatory conditions - i.e. mediated
by epithelial cells - and was dependent upon an as yet unidentified
soluble mediator. When tested in vivo, L. plantarum and LGG
exacerbated the development of DSS-induced colitis and caused the
death of treated mice, while, conversely L. paracasei was protective.
CONCLUSIONS: We describe a new property of probiotics to either
directly or indirectly inhibit DC activation by inflammatory bacteria.
Moreover, some immunostimulatory probiotics not only failed to protect
against colitis, they actually amplified the disease progression. In
conclusion, caution must be exercised when choosing a probiotic strain
to treat IBD.
PMID: 19756155
OH WELL... We WiLL be WELL soon.
I'm SO JAZZED UP i'm watching NEW ORLEANs and Drew Brees
and NOT mad at him for leaving US.. Drew hit the 100 TDs passing
mark..
randall.... WELL this is ALL SWELL....