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OT: Placebo power behind many natural cures

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JRStern

unread,

Nov 10, 2009, 10:39:40 PM11/10/09

http://news.yahoo.com/s/ap/20091110/ap_on_he_me/med_unproven_remedies_placebo

Experts: Placebo power behind many natural cures

EDITOR'S NOTE: Ten years and $2.5 billion in research have found no
cures from alternative medicine.

...

Bullcrap. I know that most studies show placebo improvements, and
these are used as a base for comparing actual drug improvements.

BS, BS, BS. I want to suggest that most any "placebo effect" is
simply bad methodology.

Any control group will have some variations, I suppose, but that is a
separate issue.

Trying to find a *mechanism* for placebo effects, gripes me bigtime.
Yes, there probably are some mental effects and beta endorphins and
selective reporting and yada yada, but these should be controlled, not
counted and explained, because all they do is louse up the evaluation
of the ethical drug being tested.

Grrrrrrrrrrrrrrrrrrrrr.

Any study that can't find objective improvements from turmeric for
psoriasis, or for cardiac health from co-q10, for two examples, has
simply been run by chimps. And I don't doubt that a dozen different
bioflavanoids could show various health benefits, but would be
somewhat trickier. To say "no cures from alternative medicine" is
bullcrap. Of course, neither of the nutritionals I mentioned *cures*
anything, but has objective biochemical effects and clinical benefits,
definitely, obviously, blatantly.

randall

unread,

Nov 12, 2009, 1:55:39 AM11/12/09

On Nov 10, 7:39 pm, JRStern <JRSt...@foobar.invalid> wrote:
> http://news.yahoo.com/s/ap/20091110/ap_on_he_me/med_unproven_remedies...

JRS...

OK, i feel your rant. Let me help you with this TEST rant POST.

I'm doing a scientific study here and NOW, boys... <G>

-------

Commence: Test post for RANT trial:::

When dem dar derms told me diet had NOTHING to do with it.

I simply wondered how they could treat a disease with NO CAUSE?

What haPPened to their hiPPoPotomas oath?

First do NO harm, perchance?

Primum non nocere
http://en.wikipedia.org/wiki/Primum_non_nocere
Nonmaleficence, which derives from the maxim, is one of the principal
precepts that all medical students are taught in medical school and is
a fundamental principle for emergency medical services around the
world. Another way to state it is that "given an existing problem, it
may be better to do nothing than to do something that risks causing
more harm than good."
<sniP>

I figured a derm in or out of school simply didn't get it on either
count.

Unless they had empirical knowledge they could stay
in college till they turned blue with book knowledge and it
still wouldn't cut it with my bookie.

Oddly enough I knew i was right all along and they would finish the
race last.

Or those derms would make their bones doing plastic work for ugly
people.
That is their reason right? My NOSE is to obese so suck the fat out
of it. LOL

And when it comes to those really hard and tricky conditions paste
some goop on it?

How do you treat an inside out disease from the outside in,
with sun, tar, topicals and voodo?

You have to treat an inside out condition from the inside.

And I knew the gut was the battleground from a gut hunch.

Inside intuition you can call it....

So i went with it and it's been nearly 30 years now.

And they've caught up with me. <W>

The probiotical wizards of science are hitting homeruns left and
right.

Instead of wrong and right. LOL

Or left field foul balls....

This next abstract is from Krueger JG, who i thought would cure us by
now.

NO such luck. <G>

But does he SUCK?

Why does it seem like a sop for pharma?

But from a scientist whose suPPosedly looking for a CUrE?

http://en.wikipedia.org/wiki/Standard_operating_procedure

Did Krueger lose his whey?

DID krueger sell out to big pig pharma?

Same as that new worthless pile of skin we call the prez.

Another sop for everything he said he wasn't for?

And now he wants to tax you to spread YOUR wealth around.

What a clueless socialist idiot and those worthless dems said bush was
bad.

LOL... at least those idiots on the left are consistently stupid.

Here mister prezidential moron pay for psoriatics to use $20K a year
worth of
biologicals in your healthcare fiasco.

But whose the bigger morons if WE LET YOU TAX US TO PAY FOR YOUR
STUPIDLY?

Health cARE CRIMES and other Gov malfeasance or bio ILL LOGICALs?

www.ncbi.nlm.nih.gov/pubmed/19895991
Effective treatment of psoriasis with etanercept is linked to
suppression of IL-17 signaling, not immediate response TNF genes.

Zaba LC, Suárez-Fariñas M, Fuentes-Duculan J, Nograles KE, Guttman-
Yassky E, Cardinale I, Lowes MA, Krueger JG.

Laboratory for Investigative Dermatology, Rockefeller University, New
York, NY 10065, USA.

BACKGROUND: TNF inhibitors have revolutionized the treatment of
psoriasis vulgaris as well as psoriatic and rheumatoid arthritis and
Crohn disease. Despite our understanding that these agents block TNF,
their complex mechanism of action in disease resolution is still
unclear. OBJECTIVE: To analyze globally the genomic effects of TNF
inhibition in patients with psoriasis, and to compare genomic profiles
of patients who responded or did not respond to treatment. METHODS: In
a clinical trial using etanercept TNF inhibitor to treat psoriasis
vulgaris (n = 15), Affymetrix gene arrays were used to analyze gene
profiles in lesional skin at multiple time points during drug
treatment (baseline and weeks 1, 2, 4, and 12) compared with
nonlesional skin. Patients were stratified as responders (n = 11) or
nonresponders (n = 4) on the basis of histologic disease resolution.
Cluster analysis was used to define gene sets that were modulated with
similar magnitude and velocity over time. RESULTS: In responders, 4
clusters of downregulated genes and 3 clusters of upregulated genes
were identified. Genes downmodulated most rapidly reflected direct
inhibition of myeloid lineage immune genes. Upregulated genes included
the stable dendritic cell population genes CD1c and CD207 (langerin).
Comparison of responders and nonresponders revealed rapid
downmodulation of innate IL-1beta and IL-8 sepsis cascade cytokines in
both groups, but only responders downregulated IL-17 pathway genes to
baseline levels. CONCLUSION: Although both responders and
nonresponders to etanercept inactivated sepsis cascade cytokines,
response to etanercept is dependent on inactivation of myeloid
dendritic cell genes and inactivation of the T(H)17 immune response.

PMID: 19895991

Why does this bio nonsense seem inept?

Easy. In the first sentence when he says, " mechanism of action in
disease resolution is still unclear"
but very profitable to game your insurance companies coffers for their
GREED?

How do the Chinese see it?

Do they give everyone free health insurance?

I don't know, do you?

Do you know we're gonna be in a bIG PIG tax plantation thanks to
democrats?

Then you don't know anything.

They mortgaged our future and that of our children and grand children.

www.ncbi.nlm.nih.gov/pubmed/19894384
Distribution and development of the TCM syndromes in psoriasis
vulgaris.

Zhang GZ, Wang JS, Wang P, Jiang CY, Deng BX, Li P, Zhao YM, Liu WL,
Qu X, Chen WW, Zeng L, Zhou DM, Sun LY, Li RY.

Department of Dermatology and Venereology, Beijing TCM Hospital
Affiliated to the Capital Medical University, Beijing 100010, China.

OBJECTIVE: To study the distribution and development rules of the TCM
syndromes in psoriasis vulgaris. METHODS: Based on the clinical
epidemiologic mass survey, the study was carried out by means of a
status survey, multi-center and large-sample research. The data base
was set up by EPIINFO6.0. The SPSS was used to do the statistical
analyses in 2651 cases of psoriasis vulgaris to study the correlations
among the distribution and development of the TCM syndromes, the
stages of the disease, nationality, psoriasis history, family history,
smoking history, alcohol drinking history, and severity of the
disease. RESULTS: The TCM syndromes in psoriasis vulgaris mainly
include the blood-heat syndrome (53.8%), blood-dryness syndrome
(27.4%), and blood-stasis syndrome (18.1%). Other syndromes were
rarely seen, covering 0.6%. The concurrent syndromes mainly involve
dampness, heat, blood stasis and toxin. The distribution differences
of the main syndromes at different stages of the disease had
statistical significance (P < 0.01). The syndrome distribution is not
related with nationality and family history (P > 0.05), but it was
closely related with the psoriasis history, smoking history, alcohol
drinking history, and severity of the disease (P < 0.01). CONCLUSION:
At the initial stage, psoriasis vulgaris usually manifests itself as
the blood-heat syndrome, and later it may be improved or turn into the
blood-dryness or blood-stasis syndrome. Smoking, alcohol consumption,
and severity of the disease may play a role in the syndrome's
transformation.

PMID: 19894384

Wow... at least they KNOW that putting CRAP in to your body makes
psoriasis WORSE.

Amazing and totally puts to shame those derms who said diet doesn't
matter. LOL

So why do we let people smoke them selves to DEATH?

ARe they not FREE to kill them selves at their pace?

While the gov is addicted to the tax revenue?

A double addiction and totally stupid on both sides.

So let's tax responsible folks to pay for their prematurely and
untimely deaths?

Now that really makes sense. Punish those who do the right thing.

I believe this Walter Williams guy says the truth and i love him for
that:
http://www.hillsdale.edu/news/imprimis/archive/issue.asp?year=2009&month=09

But if you want to kill yourself with CIGs and pay your own way i'm OK
with dat:

COPD is fourth leading cause of death in America:
http://www.medicalnewstoday.com/articles/170298.php

-----------

Why not take the cancer stick out of their mouths and stick some LAB
in to them instead?

African sauerkraut or kimchee?

Hardly but high in LAB.

www.ncbi.nlm.nih.gov/pubmed/19895650
Genotypic diversity of lactic acid bacteria (LAB) isolated from
African traditional alkaline-fermented foods.

Ouoba LI, Nyanga-Koumou CA, Parkouda C, Sawadogo H, Kobawila SC,
Keleke S, Diawara B, Louembe D, Sutherland JP.

Microbiology Research Unit, School of Human Sciences, Faculty of Life
Sciences, London Metropolitan University, London, UK.

Abstract Aim: To identify and compare lactic acid bacteria (LAB)
isolated from alkaline fermentations of cassava (Manihot esculenta
Crantz) leaves, roselle (Hibiscus sabdariffa) and African locust bean
(Parkia biglobosa) seeds for production of, respectively, Ntoba Mbodi,
Bikalga and Soumbala. Methods and Results: A total of 121 LAB were
isolated, identified and compared by phenotyping and genotyping using
PCR amplification of 16S-23S rDNA intergenic transcribed spacer (ITS-
PCR), repetitive sequence-based PCR (rep-PCR) and DNA sequencing. The
results revealed a diversity of genera, species and subspecies of LAB
in African alkaline fermentations. The isolates were characterized as
nonmotile (in most cases) Gram-positive rods, cocci or coccobacilli,
catalase and oxidase negative. ITS-PCR allowed typing mainly at
species level, with differentiation of a few bacteria at subspecies
level. Rep-PCR permitted typing at subspecies level and revealed
significant genotypic differences between the same species of bacteria
from different raw materials. DNA sequencing combined with use of API
50CHL and API 20Strep systems allowed identification of bacteria as
Weissella confusa, Weissella cibaria, Lactobacillus plantarum,
Pediococcus pentosaceus, Enterococcus casseliflavus, Enterococcus
faecium, Enterococcus faecalis, Enterococcus avium and Enterococcus
hirae from Ntoba Mbodi; Ent. faecium, Ent. hirae and Pediococcus
acidilactici from Bikalga and Soumbala. Conclusion: LAB found in
African alkaline-fermented foods belong to a range of genera, species
and subspecies of bacteria and vary considerably according to raw
material. Significance and Impact of the Study: Our study confirms
that LAB survive in alkaline fermentations, a first crucial stage in
determining their significance and possible value as probiotic
bacteria.

PMID: 19895650

WOW, i want to get down with african LAB. Lacti loving bacteria are
way way cool...

And grow faster with sweet whey each DAY.

Since i hardly know my Enterococcus from my Lactobacilli what am i to
say?

But I really want to get to know Lactobacillus plantarum for
attenuation of SFB reasons. LOL

Then i suppose i won't have to know enterococci, will i?

==========

This next one knocks down PKC. Not like i haven't done PKC a few
times.

www.ncbi.nlm.nih.gov/pubmed/19889806
A Bifidobacterium Probiotic Strain and Its Soluble Factors Alleviate
Chloride Secretion by Human Intestinal Epithelial Cells.
Heuvelin E, Lebreton C, Bichara M, Cerf-Bensussan N, Heyman M.

INSERM U793, 75730 Paris, France.

Previous studies indicate that certain probiotic bacterial strains or
their soluble products can alleviate proinflammatory cytokine
secretion by intestinal epithelial cells (IEC), but their impact on
epithelial chloride (Cl(-)) secretion remains elusive. To further
decipher the mechanisms of the cross-talk between bacteria/soluble
factors and epithelial cells, we analyzed the capacity of the
probiotic strain Bifidobacterium breve C50 (Bb C50), its conditioned
medium, and other commensal Gram (+) bacteria to modulate epithelial Cl
(-) secretion. The effect of Bb C50 on carbachol- (CCh) or forskolin
(Fsk)-induced Cl(-) secretion was measured in an IEC line in Ussing
chambers. The mechanisms involved in the regulation of Cl(-) secretion
were assessed by measuring intracellular Ca(2+) concentration,
phosphatase activity, protein kinase (PK) C and PKA activation, and
cystic fibrosis transmembrane conductance regulator (CFTR) expression.
CCh- or Fsk-induced Cl(-) secretion [short-circuit current (Isc): 151
+/- 28 and 98 +/- 14 muA/cm(2), respectively] was inhibited dose-
dependently by Bb C50 (Isc 33 +/- 12 and 49 +/- 7 muA/cm(2) at
multiplicity of infection 100; P < 0.02). Fsk-induced Cl(-) secretion
was also inhibited by Lactobacillus rhamnosus 10893. No other
inhibitory effect was recorded with the other Gram (+) bacteria
tested. The inhibitory effect of Bb C50 on CCh-induced Cl(-) secretion
targeted a step downstream of epithelial Ca(2+) mobilization and was
associated with decreased PKC activity. Thus, Bb C50 and secreted
soluble factors, by inhibiting phosphorylation processes, may promote
intestinal homeostasis by controlling Cl(-) secretion.

PMID: 19889806

But if we're really worried about chloride secretion, how about taking
bicarb for a week?

Who was it a few months back that flared upon vinegar in his diet?

It was....

Hold on....

Thinking...

JR randy...

Junior me.

Now my brain unfroze long enough to tell him. Drink bicarbonate of
soda before bed .. LOL

---------

What the heck? Let's get back to LAB...

Only three hits for keywords: probiotic bacteria pkc
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=probiotic+bacteria+pkc&log$=activity

They look almost as good as the above pmid: 19889806

Oh really?

Yes really..

Get your zonulin junctions all tighten uP'd...

Tight junctions RULE.

www.ncbi.nlm.nih.gov/pubmed/18292183
Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier
disruption by a PKC- and MAP kinase-dependent mechanism.
Seth A, Yan F, Polk DB, Rao RK.

Dept. of Physiology, Univ. of Tennessee Health Science Center,
Memphis, TN 38163, USA.

Probiotics promote intestinal epithelial integrity and reduce
infection and diarrhea. We evaluated the effect of Lactobacillus
rhamnosus GG-produced soluble proteins (p40 and p75) on the hydrogen
peroxide-induced disruption of tight junctions and barrier function in
Caco-2 cell monolayers. Pretreatment of cell monolayers with p40 or
p75 attenuated the hydrogen peroxide-induced decrease in
transepithelial resistance and increase in inulin permeability in a
time- and dose-dependent manner. p40 and p75 also prevented hydrogen
peroxide-induced redistribution of occludin, ZO-1, E-cadherin, and
beta-catenin from the intercellular junctions and their dissociation
from the detergent-insoluble fractions. Both p40 and p75 induced a
rapid increase in the membrane translocation of PKCbetaI and
PKCepsilon. The attenuation of hydrogen peroxide-induced inulin
permeability and redistribution of tight junction proteins by p40 and
p75 was abrogated by Ro-32-0432, a PKC inhibitor. p40 and p75 also
rapidly increased the levels of phospho-ERK1/2 in the detergent-
insoluble fractions. U0126 (a MAP kinase inhibitor) attenuated the
p40- and p75-mediated reduction of hydrogen peroxide-induced tight
junction disruption and inulin permeability. These studies demonstrate
that probiotic-secretory proteins protect the intestinal epithelial
tight junctions and the barrier function from hydrogen peroxide-
induced insult by a PKC- and MAP kinase-dependent mechanism.

PMID: 18292183

And the last in that search:
www.ncbi.nlm.nih.gov/pubmed/17087734

=================

But what in the gut do i have to know before i go all ga ga on l.
plantarum?

LOOK at it?

OK...

What does this one mean?

www.ncbi.nlm.nih.gov/pubmed/19647100
Immunomodulatory effects of Lactobacillus plantarum on human colon
cancer cells.
Paolillo R, Romano Carratelli C, Sorrentino S, Mazzola N, Rizzo A.

Department of Experimental Medicine, Section of Microbiology and
Clinical Microbiology, Faculty of Medicine and Surgery-Second
University of Naples, Naples, Italy.

Probiotics, defined as live microbial food supplements which improve
the health of the host, have obtained increasing medical importance.
In the intestine they may prevent the overgrowth of pathogenic
bacteria, increase the resistance of the gut to invasion by pathogens
and ameliorate disease processes by inducting the secretion of soluble
factors such as cytokines and antimicrobial beta-peptides. One
important class of human antimicrobial peptides is the family of
defensins. Human beta-defensin 2 (HBD-2) is a major inducible peptide
which plays an important role in host defense and represents a link
between innate and adaptive immune responses. This linkage is in part
mediated through the recognition of conserved bacterial products or
bacteria by Toll-like receptors (TLRs). The aim of this study was to
investigate the effects of Lactobacillus plantarum on intestinal
epithelial cells. We found that Caco-2 cells exposed to L. plantarum
bacteria significantly induced HBD-2 mRNA expression and HBD-2
secretion in a dose- (16+/-1.4 pg/ml and 31.5+/-2.3 pg/ml at MOI 10
and 50, respectively) and time-dependent manner, but not HBD-3,
compared to controls; in addition, when LPS was added to cells for 48
h, the interleukin (IL)-23 secretion (850+/-5.4 pg/ml) and IL-23 mRNA
expression increased; while it was reduced when LPS was cocultured
with L. plantarum (330+/-4.2 pg/ml). The L. plantarum-induced increase
in HBD-2 expression is inhibited by anti-TLR-2 neutralizing
antibodies, in the same way the pre-treatment with the anti-TLR-2
antibody inhibited the production of IL-23 induced by LPS in Caco-2
cells. The results of our study help to achieve a better understanding
of how the intestinal epithelium participates in the innate immune
response to commensal bacteria and pathogens in the gut.

PMID: 19647100

WE must kill or stop the LPS evil doers?

Right on..

www.ncbi.nlm.nih.gov/pubmed/19589943
Probiotic Lactobacillus casei strain Shirota prevents indomethacin-
induced small intestinal injury: involvement of lactic acid.
Watanabe T, Nishio H, Tanigawa T, Yamagami H, Okazaki H, Watanabe K,
Tominaga K, Fujiwara Y, Oshitani N, Asahara T, Nomoto K, Higuchi K,
Takeuchi K, Arakawa T.

Dept. of Gastroenterology, Osaka City Univ. Graduate School of
Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
wata...@med.osaka-cu.ac.jp

Inflammatory responses triggered by activation of the
lipopolysaccharide (LPS)/Toll-like receptor (TLR) 4 signaling pathway
are a key mechanism in nonsteroidal anti-inflammatory drug-induced
enteropathy. The aim of this study was to investigate the probiotic
effect of Lactobacillus casei strain Shirota (LcS) on indomethacin-
induced small intestinal injury. Rats pretreated with viable LcS or
heat-killed LcS once or once daily for a week were administered
indomethacin by gavage to induce injury. Anti-inflammatory effects of
L-lactic acid (1-15 mM) were evaluated in vitro by use of THP-1 cells.
One-week treatment with viable LcS prevented indomethacin-induced
intestinal injury with increase in the concentration of lactic acid in
small intestinal content and inhibited increases in myeloperoxidase
activity and expression of mRNA for tumor necrosis factor-alpha (TNF-
alpha) while affecting neither TLR4 expression nor the number of gram-
negative bacteria in intestinal content, whereas neither heat-killed
LcS nor a single dose of viable LcS inhibited intestinal injury.
Prevention of this injury was also observed in rats given l-lactic
acid in drinking water. Both L-lactic acid and LcS culture supernatant
containing 10 mM lactic acid inhibited NF-kappaB activation and
increases in TNF-alpha mRNA expression and TNF-alpha protein secretion
in THP-1 cells treated with LPS. Western blot analyses showed that
both L-lactic acid and LcS culture supernatants suppressed
phosphorylation and degradation of I-kappaB-alpha induced by LPS
without affecting expression of TLR4. These findings suggest that LcS
exhibits a prophylactic effect on indomethacin-induced enteropathy by
suppressing the LPS/TLR4 signaling pathway and that this probiotic
effect of LcS may be mediated by L-lactic acid.

PMID: 19589943

What more does one have to say?

Try, actions speak louder then words...

Get your probiotic on and forget the antibiotics.

----------

Do you need one more?

What for?

I do...

www.ncbi.nlm.nih.gov/pubmed/19442172
The role of the gut microbiota in energy metabolism and metabolic
disease.
Cani PD, Delzenne NM.

Université catholique de Louvain, Louvain Drug Research Institute,
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology,
Brussels, Belgium. patric...@uclouvain.be

Obesity is now classically characterized by a cluster of several
metabolic disorders, and by a low grade inflammation. The evidence
that the gut microbiota composition can be different between healthy
and or obese and type 2 diabetic patients has led to the study of this
environmental factor as a key link between the pathophysiology of
metabolic diseases and the gut microbiota. Several mechanisms are
proposed linking events occurring in the colon and the regulation of
energy metabolism, such as i.e. the energy harvest from the diet, the
synthesis of gut peptides involved in energy homeostasis (GLP-1,
PYY...), and the regulation of fat storage. Moreover, the development
of obesity and metabolic disorders following a high-fat diet may be
associated to the innate immune system. Indeed, high-fat diet feeding
triggers the development of obesity, inflammation, insulin resistance,
type 2 diabetes and atherosclerosis by mechanisms dependent of the LPS
and/or the fatty acids activation of the CD14/TLR4 receptor complex.
Importantly, fat feeding is also associated with the development of
metabolic endotoxemia in human subjects and participates in the low-
grade inflammation, a mechanism associated with the development of
atherogenic markers. Finally, data obtained in experimental models and
human subjects are in favour of the fact that changing the gut
microbiota (with prebiotics and/or probiotics) may participate in the
control of the development of metabolic diseases associated with
obesity. Thus, it would be useful to find specific strategies for
modifying gut microbiota to impact on the occurrence of metabolic
diseases.

PMID: 19442172

OK, so JRSTERN had his rant and do did i....

But my alt medicine will cure me some day.

How about you?

randall... test post over....

zzznot

unread,

Nov 12, 2009, 10:56:55 AM11/12/09

"randall" <ranh...@aol.com> wrote in message
news:200b471f-6f6b-4f52...@a32g2000yqm.googlegroups.com...

> www.ncbi.nlm.nih.gov/pubmed/19895991
> Effective treatment of psoriasis with etanercept is linked to
> suppression of IL-17 signaling, not immediate response TNF genes.

Hey, that's hilarious!

So, is there really any difference between Enbrel and
the new Stelara?

randall

unread,

Nov 12, 2009, 12:23:06 PM11/12/09

On Nov 12, 7:56 am, "zzznot" <zzz...@invalid.net> wrote:
> "randall" <ranhu...@aol.com> wrote in message

That was a test post. :)

I'm not doing your homework on stella....

Hey stellla... do you need pella windows?

Marlon Brando ~ 'Hey Stella!'~ A Streetcar Named Desire
http://www.youtube.com/watch?v=S1A0p0F_iH8

Stella segue over.... did love it.

Do they have get the soap from last tango?

nOPE.... can't find it.

They have a love scene, but he doesn't say
Git the soap...

More like cut the sap. LOL
http://www.youtube.com/watch?v=gb6-Nq8VQ-8&feature=related

OK, back to serious stuff.
For flakes to unflake with.

Or to make J laugh?

No, no real testy stuff NOW....L. Plantarum...

So?

After i test L. Plantarum, i'll let you know if
you want to make a few hundred bucks shorting
big pharma STOCKs with high biological profiles. LOL

THOSE TNF boys are going DOWN.

You know, like what happened to buggy whips when
ford rolled out his horseless carriage.

But isn't this suPPose to be a placebo thread?

And why did J say, *Hey, that's hilarious!*?

We should be looking at the "psychoneuroimmunological component"
of psoriasis, shouldn't we?

The cure is nearly in our hands.

Why bother with TNF gizmoids?

I haven't and i'm nearly CLEAR now.

http://www.physorg.com/news177180535.html
Researchers Study Whether Psychosocial Interventions Ease Psoriasis

November 11, 2009 (PhysOrg.com) -- The National Center for
Complementary and Alternative Medicine has awarded University of
Rochester Medical Center researchers $2.5 million to investigate the
impact of psychological interventions on attacks of psoriasis and the
intensity of the disease.

Researchers will measure and track the biological markers of the
disease in the skin lesions that are the hallmark of psoriasis and
also in the blood of volunteers who have participated in programs
designed to improve daily living.

Psoriasis appears to have a strong psychoneuroimmunological component
to it, such that signals from the brain may exacerbate the disease,
and the disease itself may induce psychological distress, said Jan
Moynihan, Ph.D., director of the Rochester Center for Mind-Body
Research and principal investigator for the study.

“We want to determine whether increasing psychological well-being
results in measurable decreases in inflammation,” said Moynihan, a
professor of Psychiatry. “We want to see if positive changes in
psychological well-being affect actual psoriatic lesions and which
immune mechanisms are the targets.”

Researchers plan to recruit 200 Rochester-area residents with
psoriasis to take part in the study, which will test the effects of
two interventions, Mindfulness Based Stress Reduction and Living Well.

Psoriasis is a chronic inflammatory disease of the skin that affects
about 7.5 million people in the United States. The disease causes
silvery scales and red patches that are sites of inflammation and
excessive production of skin cells.

In many people with psoriasis, psychological or life stress precedes
flare-ups of the disease, according to Moynihan. Research also
suggests that stress is associated with increased production of many
of the proinflammatory proteins called cytokines that are involved in
psoriasis, including interleukin-6 and tumor necrosis factor-alpha.
Researchers will test skin lesions and blood for these cytokines and
other markers.

Participants in the study will take part in one of two interventions.
Mindfulness Based Stress Reduction, a program developed at the
University of Massachusetts Medical Center, uses meditation and yoga
to develop a calm, non-judgmental awareness and acceptance of the
present moment. Living Well is a didactic intervention that includes
seminars on relevant topics, including sleep, nutrition and the
importance of exercise. It will be led by a team of wellness educators
and researchers.

Psoriasis patients could benefit from these low-cost, adjunctive
psychological interventions that are intended to decrease
psychological distress, but which may also ameliorate the skin disease
and inflammatory processes by interrupting the connection between the
stress response and flare-ups of psoriasis.

“We have the opportunity to use new technology to look at the
molecular biology of this disease. We hope to elucidate new ways that
the brain can direct our immune responses,” Moynihan said.

==================

If you want to look at serious psychological well-being by treating my
"strong psychoneuroimmunological" feelings then figure out who the
HELL these morons are: *careandcureskin.blogspot.com*
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_thread/thread/1886af39dd736117?hl=en#

http://groups.google.com/groups/profile?hl=en&enc_user=buq0vhMAAADP4DgrbNFLpoN3J4AMthRqWMj6vob75xS36mXc24h6ww
Two posts?

A cursory look at them yields nada.

Not one hit on the web:
http://www.google.com/search?hl=en&qt_s=1&q=careandcureskin.blogspot.com&sa=N&tab=gw

And one MORON CORN PORN post to the groups besides the thread in this
group.
http://groups.google.com/group/best-health--beauty-offers-and-deals-/browse_thread/thread/30efaae7b16bb41b/d506d0a2cc61e1ff?hl=en&ie=UTF-8&q=careandcureskin.blogspot.com

Now if that doesn't flare your pyscho metrical skin flake levels
nothing will. LOL

But am i being victorian, a prude or heavens to betsy puritanical?
http://en.wikipedia.org/wiki/Puritan
http://en.wikipedia.org/wiki/Victorian_morality
http://en.wikipedia.org/wiki/Prude

Hey, hey.... don't get me wrong... i'm all for porn. LOL

I'm watching Bill GATES and Warren Buffett with Becky Quick right now
on CNBC.

BECKY has the HUGE interview today.

But ....let's face it

To socialists i'm watching porn....

Ugly disgusting capitalism that needs to be taxed to death.

WE need a real bIG depression to bring people back to morality?

http://en.wikipedia.org/wiki/Depression_(economics)
In economics, a depression is a sustained, long-term downturn in
economic activity in one or more economies. It is a more severe
downturn than a recession, which is seen as part of a normal business
cycle.

Considered a rare and extreme form of recession, a depression is
characterized by its length, and by abnormal increases in
unemployment, falls in the availability of credit, shrinking output
and investment, numerous bankruptcies, reduced amounts of trade and
commerce, as well as highly volatile relative currency value
fluctuations, mostly devaluations. Price deflation, financial crisis
and bank failures are also common elements of a depression.
<sniP>

This is what obama is doing isn't he?

He owns it now. LOL

Then he and that puke face rahm *the Lamb* of Emanuel and chicago
style pizza and business.... will do....

And centralize all the power under bamarama czar's.

OH?

Yes don't you KNOW?

Beauty is in the EYE of the BEholder.

So what does a psor flake person do?

Open your eyes and look at my skin in the game.

it's CLEAR....do i fear a depression? For you yes.
For me, i'm all for higher FDR style morality via the
democratic atheists.

Why shouldn't we give washington the power to
tax us at 50% levels so they can play power TRIP?

J, did you read the walter williams link? I love him.
http://www.hillsdale.edu/news/imprimis/archive/issue.asp?year=2009&month=09

But what is my skin secret?

And i haven't even used the kimchee cure yet. LOL

Btw... kimchee is loaded with L. Plantarum.

And L. plantarum will smack down sFB's...

No shirt?

WWE SmackDown vs. Raw 2009 ?

Yeah a real diversion from reality.

So?

Yes... you psor morons ... this is the korean skin
cure....

Now how do we hook those Lacti loving plantarum
in to our ileums?

How disgusting....

Open your eyes and ears... and cheer in the NEW
Millennium for zero PASi psor folk....

This is gonna be bigger then the salk vaccine.

Well?

For psor folks anyway. :)

randall.... wow is this another TEST post? Not sure- waiting for
results. ;~/

JRStern

unread,

Nov 12, 2009, 8:05:01 PM11/12/09

On Thu, 12 Nov 2009 09:23:06 -0800 (PST), randall <ranh...@aol.com>
wrote:

>http://www.physorg.com/news177180535.html
>Researchers Study Whether Psychosocial Interventions Ease Psoriasis
>
>November 11, 2009 (PhysOrg.com) -- The National Center for
>Complementary and Alternative Medicine has awarded University of
>Rochester Medical Center researchers $2.5 million to investigate the
>impact of psychological interventions on attacks of psoriasis and the
>intensity of the disease.
>
>Researchers will measure and track the biological markers of the
>disease in the skin lesions that are the hallmark of psoriasis and
>also in the blood of volunteers who have participated in programs
>designed to improve daily living.
>
>Psoriasis appears to have a strong psychoneuroimmunological component
>to it, such that signals from the brain may exacerbate the disease,
>and the disease itself may induce psychological distress, said Jan
>Moynihan, Ph.D., director of the Rochester Center for Mind-Body
>Research and principal investigator for the study.

Easy to test, remove brains from half the subjects, see how they do.

Bunch o'crap.

randall

unread,

Nov 12, 2009, 9:32:50 PM11/12/09

On Nov 12, 5:05 pm, JRStern <JRSt...@foobar.invalid> wrote:
> On Thu, 12 Nov 2009 09:23:06 -0800 (PST), randall <ranhu...@aol.com>

> J.- Hide quoted text -
>
> - Show quoted text -

JRs....

OK, so your saying that half the people in this country
should have psoriasis?

randall...

Message has been deleted

JRStern

unread,

Nov 14, 2009, 10:32:39 PM11/14/09

On Sat, 14 Nov 2009 14:32:48 -0500, Susan <su...@nothanks.org> wrote:

>x-no-archive: yes

>
>JRStern wrote:
>
>> Easy to test, remove brains from half the subjects, see how they do.
>>
>> Bunch o'crap.
>>
>

>It doesn't have to be crap if they measure CRH and ACTH.
>
>Psychological interventions may lower them, any kind of stress relief
>should.

Yes, sure.

And other signals from my brain cause me to take some turmeric, and
voila, improvement.

It's this "monsters from the id" stuff I don't like.

Message has been deleted

randall

unread,

Nov 15, 2009, 5:07:37 PM11/15/09

On Nov 15, 11:26 am, Susan <su...@nothanks.org> wrote:
> x-no-archive: yes
>

> ________________________________________
> Regular Article
> Stress-Induced Endocrine and Immunological Changes in Psoriasis Patients
> and Healthy Controls
> A Preliminary Study
> Gerhard Schmid-Otta, Roland Jacobsb, Burkard Jägera, Sabine Klagesa,
> Joana Wolfa, Thomas Werfelc, Alexander Kappc, Thomas Schürmeyere,
> Friedhelm Lamprechta, Reinhold E. Schmidtb, Manfred Schedlowskid
>
> Departments of
> a Psychosomatic Medicine,
> b Clinical Immunology,
> c Dermatology and
> d Clinical Psychiatry, Hannover Medical School, Hannover,
> e Department of Clinical Endocrinology and Metabolism, FFP, University
> of Trier, Germany
> Address of Corresponding Author
> Psychother Psychosom 1998;67:37-42 (DOI: 10.1159/000012257)
> ________________________________________
> Key Words
> • Stress
> • Psoriasis
> • Cortisol
> • Catecholamine
> • Lymphocytes
> • NK cells
> ________________________________________
> Abstract
>
> Background: Clinical observations suggest that psychological stress can
> induce exacerbation of psoriasis. It is hypothesized that these stress
> effects on the course and outcome of psoriasis are caused by
> neuroendocrine modulation of immune functions.
>
> Therefore we investigated the cardiovascular, endocrine and
> immunological response to a laboratory stressor in psoriasis patients
> and healthy controls. Methods: Untreated (n = 7) and PUVA-treated (n =
> 4) psoriatics and healthy controls (n = 7) were exposed to a brief
> laboratory stressor (public speaking and mental arithmetic). Heart rate
> and blood pressure, catecholamine, cortisol, and DHEA plasma
> concentration, as well as distribution of T and NK lymphocytes were
> analyzed before, immediately after and 1 h after stress exposure.
> Results: Heart rate and blood pressure increased in all three groups
> during stress exposure with the most pronounced changes in PUVA-treated
> patients.
>
> Psoriasis patients displayed higher adrenaline values but diminished
> cortisol and DHEA plasma concentrations compared to controls. NK cell
> numbers (CD16+, CD56+), but not T lymphocyte subsets, increased
> immediately after stress exposure in untreated patients and controls.
> This effect was significantly diminished in PUVA-treated patients.
>
> Conclusions: The data of this pilot study indicate an enhanced
> stress-induced autonomic response and diminished pituitary-adrenal
> activity in psoriasis patients. PUVA treatment seems to interfere with
> the cardiovascular and NK cell response to acute psychological stress.
> Future studies will analyze the stress-induced neuroimmunological
> mechanisms in psoriatics in more detail.

OK,

Disregard if you wish as i'm not saying anything.

Just keePing notes:

Thank you

==================

susan posted:
http://content.nejm.org/cgi/content/abstract/344/21/1594

Previous
Volume 344:1594-1602 May 24, 2001 Number 21
Next
Is the Placebo Powerless?— An Analysis of Clinical Trials Comparing
Placebo with No Treatment
Asbjorn Hrobjartsson, M.D., and Peter C. Gotzsche, M.D.

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Editorial

by Bailar, J. C.

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ravi

unread,

Nov 21, 2009, 12:18:35 PM11/21/09

On Nov 11, 8:39 am, JRStern <JRSt...@foobar.invalid> wrote:
> http://news.yahoo.com/s/ap/20091110/ap_on_he_me/med_unproven_remedies...
>

I am Ravi chandren from India,living in Tamil nadu.First,I am not a
Docter and I don't know proper English.But in 12 years research I
think that all types of Psoriasis ,all types of arthritis,some types
of Asthma,some types of kidney failier,vericose vein,migrine andheart
attack are linked with one separate virus or cells,and its over
productions or multipication inthe human body these diseases will
coming.
For example,this virus affects and over production in the skin,skin
will became hard and losses its elasticity(psoriasis)It affects bone
joints,the lubricating system failed or damaged,So the joints are
tight and pain(arthritis)It affects Lungs,Lungs will became hard and
losses its elasticity.So breathing problem and Lungs are shinkaged
(asthma)It affects skin and joints (psoriatic arthrtis).It affects
kidney,kidney shinkaged and could not work properly(kidney failier)It
affects all over the body, LUPUS will coming.It affects and
multipication in the,inside of the veins(vericose vein)I t rarely
affects and over production the main blood vessels hart attack.
Why I toled this ?
Be cause last 12 years back I was attacked with Asthma.So I taked many
types of treatments but not one help ,but only controled.So I
researched in many ways and read old herbal based books and cunsult
many Adhivasi Trible peoples and their treatment methodes in thick
forest areas.Because no hospital fesility in thick forest areas.Then
Last I discoverd one powerfull and divne power herbal and different
type of treatment.No intake medicince.My asthma would gone only 3
days.so I was gived this treatment many asthma patients.95 pations are
complete cured minimum 3 days.Then gived this treatment
arthritis,psoriasis,psoriatic arthritis,kidney failier ex
tra ....extra....
First alopathi docters are Laufed with me.Now many Docters taked this
treatment and all are says this was God's gift.
Why I tolled this?this is not advertisement.Any scientists or
researchers take this clues and try in yours research.More details
please contact kamal...@yahoo.co.in
My mobile no +919843127766
Sorry I don't know proper English.I know only Tamil,kannada and some
Telugu.

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