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PSOR CZAR CowBOY -- Psoriatical HIV Genetics ---->Wilson LiaO -->CpG HyPomethylation Or G(EE) becomes A! { segue Dopamine & Tyrosine} -- SEROTONIN JUNKIE -- JC Mathers - Folic Acid
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randall
May 15, 2012, 3:44:43 PM5/15/12
to
hi
Obama pull your head outa jPmorgans rectum...!
If jamie diamon did BAD then you (the gov [our GOV] you PRETEND to
RUN) DID 1000 times worse..ER ER ER.... LOL
STAT to stop spending TRILLIONS of BUCKs each YEAR....you've become
BUSH... obama BUSH III.... LOL
Duh... you deserve to be dog catcher in siberia or ER ER ER.
maybe in hawaii, for cocktails and luau's?
Will you and MOOOOOOchele take a 747 as a gift and simply LEAVE to
Luau time? LOL
Or we can find you two a stealth plane? Now that is a good idea...
Does mooooooooooooooooochele eat pork?
http://en.wikipedia.org/wiki/Kalua_pig
http://en.wikipedia.org/wiki/Luau
OTOH randall has BECOME czar of HEALTH by default on your PART...you
had your chance.
So?
Randall goes to WORK...as CZAR
Mama don't let your babies grow up to BE cowboys
or psoriatics for that matter.
But if you DO, then let them be psoriatic before a cowBOY.
That way their protected from HIV... LOL
And getting kicked in the head by some BULL, isn't any rodeo in my
BOOK.
Waylon Jennings & Willie Nelson - Mamas Don't Let Your Babies Grow Up
To Be Cowboys
http://www.youtube.com/watch?v=N_a4BU09GrU
<time: 3:30> <views: 1,241,345>
So why the GAY push, tar baby RANDALL?
Why NOT?
We have 7 going on 8 billion humans on this dirt ball hurtling through
SPACE
and feeding them isn't going to get any EASIER, unless we bounce in to
a new
planet full of tillable area and nice oceans chock a block full of
FISH.
DUH...
As to GAY folks.
Why don't we LET people of the SAME SEX form partnership unions with
ALL the benefits?
Or marry, i dare SAY?
And adopt not wanted KIDs? And if they don't adopt double their TAX,
say? LoL
If that isn't in their business interest, whose is it?
They suck up unWANTED kids and don't create excess humans like those
muslims.... on steroids to get to sex nirvanna... LOL
Oh bin laden please pass the viagra... LOL
Speaking of over SeXXXX'ed folks...>>>>>
Obama went FAR enough to pick up some money at clooney bird's
hollyweird roost, but NO WAY did he stand up for FREEDOM
or go out on a LIMB for GAY folk.
Heavens to betsy, they be extracting votes from po old dip wad oMAMA
in 2012.
How long ago did i say, hook me up to a GAY person so i could give
them excess TNF from my blood?
A long time ago...
If you can't help your brother or sister, who can YOU help?
Apparently my GENE's are being looked at for that and in the LONG run
that WILL HELP ME.
So why doesn't obama approach it that way?
Say let's HELP everyone. PERIOD... and we all get helped?
Wouldn't people like me who WILL NOT vote for obama go to him because
he's GOT a HEART full of LOVE for everyone?
Be a LEADER.
LOVE people and make it ALL people. Them you wIN.
I said make me your czar of health..
YOU Blew that JUAN... LOL
I already appointed ME... so you lose.
Like all the rich people are leaving town:
http://www.conservativedailynews.com/2010/03/are-wealthy-americans-leaving-the-country/
Hey it's like a sinking SHIP and their going to higher GROUND..
Thanks obama for forking up an entire country, you groucho
MArxxxist... LOL
Take some 5HTP (black pods from griffonia -- tree/africa) and relax
your not going to get voted back in..
check it out:
Subject: The Movie, 2016
An extremely important movie is coming this summer - - It is called
simply
"2016". The speaker here is Dinesh D'Souza,
college
president in New York and author of many New York Times best
sellers.� The
movie is from Gerald R. Molen, producer of Academy Award
winning Schindler's List, Jurrasic Park and Brave Heart. It explains
in plain
language who Barack Obama really is, what he stands for, and the
dangers
of him being reelected for another four years. Watch this short
informative video/preview of this movie which came out only yesterday
and share it with others.� The preview has already been seen by
over
18,000 people.� Within a very short time it will have been seen by
millions!� After you see the preview, listen to what Dinesh has to
say
about Obama.� Please take the time to hear this and pass it on.
http://www.youtube.com/v/Z6QOscKvUjU?version=3&feature=player_detailpage
AND i doubt you get anything but pity sex from
mooooooooooooooooooooooooooooooooochele.
She is NOT dumb... she knows those who voted for you.... ARE.
arf arf... BOW WOW...
-------------
OK so?
How psor people are NOW helping GAY people with HIV/AIDs..
http://www.ncbi.nlm.nih.gov/pubmed/22577363
PLoS Genet. 2012 Feb;8(2):e1002514. Epub 2012 Feb 16.
Psoriasis Patients Are Enriched for Genetic Variants That Protect
against HIV-1 Disease.
Chen H, Hayashi G, Lai OY, Dilthey A, Kuebler PJ, Wong TV, Martin MP,
Fernandez Vina MA, McVean G, Wabl M, Leslie KS, Maurer T, Martin JN,
Deeks SG, Carrington M, Bowcock AM, Nixon DF, Liao W.
Source
Department of Dermatology, University of California San Francisco, San
Francisco, California, United States of America.
Abstract
An important paradigm in evolutionary genetics is that of a delicate
balance between genetic variants that favorably boost host control of
infection but which may unfavorably increase susceptibility to
autoimmune disease. Here, we investigated whether patients with
psoriasis, a common immune-mediated disease of the skin, are enriched
for genetic variants that limit the ability of HIV-1 virus to
replicate after infection. We analyzed the HLA class I and class II
alleles of 1,727 Caucasian psoriasis cases and 3,581 controls and
found that psoriasis patients are significantly more likely than
controls to have gene variants that are protective against HIV-1
disease. This includes several HLA class I alleles associated with
HIV-1 control; amino acid residues at HLA-B positions 67, 70, and 97
that mediate HIV-1 peptide binding; and the deletion polymorphism
rs67384697 associated with high surface expression of HLA-C. We also
found that the compound genotype KIR3DS1 plus HLA-B Bw4-80I, which
respectively encode a natural killer cell activating receptor and its
putative ligand, significantly increased psoriasis susceptibility.
This compound genotype has also been associated with delay of
progression to AIDS. Together, our results suggest that genetic
variants that contribute to anti-viral immunity may predispose to the
development of psoriasis.
PMID: 22577363
This is odd. I ran Liao earlier and he had like 700 hits.
And now it says
1224 hits -Liao W[Author]
http://www.ncbi.nlm.nih.gov/pubmed?term=Liao%20W%5BAuthor%5D
And 16 of 700 or 1224 have keyword: psoria*
http://www.ncbi.nlm.nih.gov/pubmed?term=Liao%20W%5BAuthor%5D%20psoria*
Liao's second of 16 is with Katherine Jordan and Anne Bowcock no less
and the CARD14
80% of psoriasis due to carma2 gene.
#2 of 16:
http://www.ncbi.nlm.nih.gov/pubmed/22521419
Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of
NF-kappaB, in Psoriasis.
Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC,
Stuart PE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR,
Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V,
Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock
AM.
Am J Hum Genet. 2012 May 4;90(5):796-808. Epub 2012 Apr 19.
PMID: 22521419 <<<<-------
http://en.wikipedia.org/wiki/CARD14
Symbols CARD14; BIMP2; CARMA2
Caspase recruitment domain-containing protein 14, also known as CARD-
containing MAGUK protein 2 (Carma 2), is a protein that in humans is
encoded by the CARD14 gene.[1][2][3]
[...] Link to Psoriasis
The CARD14 gene was recently identified as the first gene directly
linked to the most common form of Psoriasis. It has been suggested
that a mutation in the gene plus an environmental trigger were enough
to elicit plaque psoriasis.[4][5]
<snip>
In this wikipedia card14 reference: Liao W, would be in #4, PMID:
22521419 <<<<-----
Liao's #3 of 16 --PMID: 22437317
was posted to the p ng March 23, of this year
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+22437317+&start=0&
And on that thread it says Liao W has 474 hits (not 1224 or over 700
as i surmised.. LOL)
See:
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Liao%20W%22%5BAuthor%5D
And W Liao still has 16 psoriasis hits and SOME with CpG of the blue
psoriatic *ISLANDER's*, Bowcock.
So read #3 and that thread:
goes here:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/dd6bb29ebb72a8a2/332737fa147ea75b?lnk=gst&q=PMID%3A+22437317++wilson+Liao#332737fa147ea75b
And i see i forgot his first NAME, Wilson in less then two months. LOL
And Wilson Liao has a psor DAY in SF by the bay.
So San Francisco and hiv and his #3 of 16 psoriasis hits, all make
total sense.
And Liao's #4, PMID: 22185198 was posted twice. A zinc finger
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+22185198+&start=0&
And Liao's #5 is CpG once again, PMID: 22071477 and as psoriasis is
HYPOmethylation according to
recent abstracts:
As #5 is also Bowcock and goes to their recent findings it's no
suprise:
http://www.ncbi.nlm.nih.gov/pubmed/22071477
A subset of methylated CpG sites differentiate psoriatic from normal
skin.
Roberson ED, Liu Y, Ryan C, Joyce CE, Duan S, Cao L, Martin A, Liao W,
Menter A, Bowcock AM.
J Invest Dermatol. 2012 Mar;132(3 Pt 1):583-92. doi: 10.1038/jid.
2011.348. Epub 2011 Nov 10.
PMID: 22071477
------
segue time:
Did Jordan & Bowcock et al (including Liao, Wilson) crack a Jeroboam
of Champagne (card14, carma2) or what?
OMG, I'm giving away the SECRETs of Autoimmune Cures! But didn't we
know ALL of this, more
or less already?
Today is OMG, OMG, omg!
Or hypo-methylation for you atheist autoimmune people....
Is hyPomethylation GOD saying SCREW YOU?
Do you believe anything? That is as good as some of the crap flying
over/under the radar these days......
Why...?
It's HyPo... don't you know?
We have 15 hits in the p ng: hypomethylation
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=hypomethylation&start=0&
Which means exactly what for YOU?
Nothing! LOL
Sorry, but if it meant anything you'd be ahead of me, btw. LOL
I said whey... SWEET! LoL
zzzzzzzzzzzzzzzzzzzzzzzzzz ok a short pause for those who might wet
their pants or
democorks who may fizzle their wizzle... uPon getting REAL TRUTH. lol
Study from China on alcohol and psoriasis.
First, i'd like to say.
Why don't they look at Inuit and carbs/alcohol, first?
It makes sense right?
They have never had carbs in their diet, out of SEASON till the last
100 years or so.
And that MEANs everything one NEEDS to know to UNDERSTAND this carb
gene thingy pooh.
So their.... or is it...this chinese abstract from some rookies, i'm
guessing.
http://www.ncbi.nlm.nih.gov/pubmed/22568495
J Dermatol. 2012 May 9. doi: 10.1111/j.1346-8138.2012.01577.x.
Alcohol consumption and psoriatic risk: A meta-analysis of case-
control studies.
Zhu KJ, Zhu CY, Fan YM.
Source
Department of Dermatology, Affiliated Hospital of Guangdong Medical
College, Zhanjiang, Guangdong, China.
Abstract
Psoriasis is one of the most common dermatological disorders. The
association between alcohol consumption and psoriasis has been
inconsistent among studies. To examine the magnitude of the risk of
developing psoriasis for drinking populations compared to those with
non-drinking, and to determine causes of the variation in odds ratios
(OR) between various case-control studies, we performed a
comprehensive published work search and a meta-analysis of case-
control studies considering prevalence. We did electronic searches on
Medline, and searched reports to identify case-control studies of
prevalent of psoriasis. We did meta-analyses of study-specific
incremental estimates to determine the risk of psoriasis associated
with drinking. The magnitude of the OR was analyzed by combining 15
case-control studies that matched defined criteria. The variance in OR
between studies was explored. The overall OR of psoriasis for drinking
persons compared to those with non-drinking was 1.531 (95% confidence
interval [CI] = 1.164-2.014, P = 0.002) and the association remains
statistically significant across a number of stratified analyses in
European descent subgroup (OR = 1.432, 95% CI = 1.085-1.889, P =
0.011) and also persists in sensitivity analyses performed to assess
the potential effect of varying psoriasis outcome definitions. Alcohol
consumption is associated with increased risk of psoriasis. These
epidemiological observations should inform the exploration of
biological mechanisms that link alcohol consumption with psoriasis.
PMID: 22568495
So getting to MY point: (if i had one..LOL)
2111 hits: carbohydrate brain neurotransmitter dopamine
http://www.ncbi.nlm.nih.gov/pubmed?term=carbohydrate%20brain%20neurotransmitter%20dopamine
http://www.livestrong.com/article/86350-foods-increase-dopamine-serotonin/
FOODS THAT INCREASE DOPAMINE & SEROTONIN
[...] The Tyrosine Connection
Low dopamine levels can cause depression, a loss of satisfaction,
addictions, cravings, compulsions, low sex drive, as well as an
inability to focus. Tyrosine is another important amino acid (a
building block of protein) found in dairy products, meats, poultry and
nuts. It encourages your brain to release dopamine and norepinephrine.
These neurotransmitters act as stimulating substances to the brain and
can help perk you up by making you feel more alert and sharpening your
thinking. In addition to meats and dairy products, other specific
tyrosine-rich foods that help increase dopamine levels are almonds,
avocados, bananas, lima beans, pumpkin seeds and sesame seeds.
<snip>
Alcohol and sugar can turn you in to a Serotonin Junky:
http://www.healthypeople.com/serotonin_junkie.htm
ARE YOU A SEROTONIN JUNKIE?
Do you crave carbohydrates all day long?
[...] Are you craving more sugars, starches or alcohol these days? It
may be a symptom of "Seasonal Affective Disorder" or "S.A.D.", which
kicks in around the Fall Season in areas where folks get less
sunlight. Or, perhaps you have been craving more carbohydrates since
you lost your job, got a promotion, got engaged or moved to a new
town. Whether the stress is a positive or a negative event, stress in
and of itself will be a trigger for the desire for carbohydrates in
order to raise serotonin. So, when you feel "bad" (anxious, nervous,
angry) it may be a symptom that you actually need more serotonin!
<snip>
No, no, i'm a doPamine junk head... and it's pointed... or to the
point and i live on a point? <G>
And adding serotonin takes us down to 1500 hits:
http://www.ncbi.nlm.nih.gov/pubmed?term=carbohydrate%20brain%20neurotransmitter%20serotonin
With dopamine down to 364 hits
http://www.ncbi.nlm.nih.gov/pubmed?term=carbohydrate%20brain%20neurotransmitter%20serotonin%20dopamine
And zero hits; with : feeling good... LOL
http://www.ncbi.nlm.nih.gov/pubmed?term=carbohydrate%20brain%20neurotransmitter%20serotonin%20dopamine%20feeling%20good
Obviously to subjective...
i guess XXX sex brain feel GOOD is out? LOL
-----------------ok feeling good and alcohol and carbs segue is sorta
over and OUT... burP!
And a LOT of those hypomethelations go with cancer.
WHY?
Maybe it's the first thing that comes up so it got studied 1st?
No, it must go deePer to reality i'm thinking or it's pointed towards.
So now we go and look at it:
13 of 15 : results for hypomethylation cancer - p ng:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=hypomethylation+cancer&start=0&
1441 hits: hypomethylation cancer - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20cancer
19 of 1441 have tyrosine:
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20cancer%20tyrosine
ZERO hits:
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20autoimmun*%20%20tyrosine
DroPPing the tyrosine.... is critical... So CritiCOW... MOOOOO
52 hits: hypomethylation autoimmun*- pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20autoimmun*%20
And three (3) hits: psoria* + hypomethylation - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20psoria*
#1 of three was posted yesterday:
http://www.ncbi.nlm.nih.gov/pubmed/22564738
The characteristics of genome-wide DNA methylation in naïve CD4+ T
cells of patients with psoriasis or atopic dermatitis.
Han J, Park SG, Bae JB, Choi J, Lyu JM, Park SH, Kim HS, Kim YJ, Kim
S, Kim TY.
Biochem Biophys Res Commun. 2012 Apr 30.
PMID: 22564738
#2 of 3
http://www.ncbi.nlm.nih.gov/pubmed/19072642
Epigenetics and dermatological disease.
Millington GW.
Pharmacogenomics. 2008 Dec;9(12):1835-50. Review.
PMID: 19072642
And PMID: 19072642 has been posted TWICE to the p ng: by me
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+19072642+&start=0&
#3 of 3
1996? huh?
http://www.ncbi.nlm.nih.gov/pubmed/8765212
DNA hypomethylation in inflammatory arthritis: reversal with
methotrexate.
Kim YI, Logan JW, Mason JB, Roubenoff R.
J Lab Clin Med. 1996 Aug;128(2):165-72.
PMID: 8765212
PMID: 8765212 was posted in the p ng:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+8765212&start=0&
by me... of course!
Sat, Sep 24 2005 11:26 am
Subject: Re: Folic acid supplements challenged - L-methylfolate
better?
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/b04ed000b0f93a10
OK so does folate help or hurt when it comes to hyPomethylation?
hence from 1996 (above:)
http://www.ncbi.nlm.nih.gov/pubmed/8765212
J Lab Clin Med. 1996 Aug;128(2):165-72.
DNA hypomethylation in inflammatory arthritis: reversal with
methotrexate.
Kim YI, Logan JW, Mason JB, Roubenoff R.
Source
University of Toronto, Ontario, Canada.
Abstract
This study investigated whether methotrexate, by interrupting the
methyl transfer function of folate, can induce genomic DNA
hypomethylation in patients with inflammatory arthritis. Consecutive
subjects with inflammatory arthritis (rheumatoid or psoriatic), who
were taking methotrexate (n = 7) or other medications (n = 6), and
control subjects, either healthy or with osteoarthritis and taking
nonsteroidal anti-inflammatory agents only (n = 9) were recruited. The
methylation status of genomic DNA from peripheral blood mononuclear
cells was determined. Plasma levels of folate, B12, and pyridoxal-5'-
phosphate (PLP), all of which are involved in biologic methylation,
were also examined. The extent of genomic DNA methylation was lowest
in subjects with inflammatory arthritis who were not taking
methotrexate, highest in subjects with inflammatory arthritis who were
taking methotrexate, and intermediate in control subjects (p < 0.05).
Plasma levels of folate and B12 were similar among the three groups.
The mean plasma PLP level in subjects with inflammatory arthritis was
33% lower than that in control subjects (p = 0.04). No significant
correlation between genomic DNA methylation and folate, B12, and PLP
levels was observed. These data do not support the hypothesis that
methotrexate induces genomic DNA hypomethylation. However, these data
indicate that inflammatory arthritis is associated with genomic DNA
hypomethylation that is reversed with methotrexate. Future studies
using a larger number of subjects are warranted to confirm these
findings.
PMID: 8765212
OK and what i said:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/806607ecac198693
and/or
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/806607ecac198693?&q=PMID%3A+8765212
And we do the logical...
search:
177 hits: hypomethylation + folate -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20folate
And find this Matther guy..
What's the mather's with this world? LOL
Is he like JC?
Could BE for you and ME? He's JC Mather's
And JC for you and me is an epigenetic event that slows psoriasis or
stops it...
So he is JC... you see?
See
http://www.ncbi.nlm.nih.gov/pubmed/15831897
Gut. 2005 May;54(5):579-81.
Reversal of DNA hypomethylation by folic acid supplements: possible
role in colorectal cancer prevention.
Mathers JC.
Source
Human Nutrition Research Centre, School of Clinical Medical Sciences,
University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK.
john.m...@ncl.ac.uk
Comment on
Gut. 2005 May;54(5):648-53.
http://www.ncbi.nlm.nih.gov/pubmed/15831910.1
PMID: 15831897
Free PMC Article
http://gut.bmj.com/content/54/5/579.full
or
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/15831897/?tool=pubmed
As i'm going to do all of JC Mather's in a minute we look at the
comment abstract:
http://www.ncbi.nlm.nih.gov/pubmed/15831910.1
Gut. 2005 May;54(5):648-53.
Effect of folic acid supplementation on genomic DNA methylation in
patients with colorectal adenoma.
Pufulete M, Al-Ghnaniem R, Khushal A, Appleby P, Harris N, Gout S,
Emery PW, Sanders TA.
Source
Nitritional Sciences Research Division, Department of Nutrition and
Dietetics, King's College London, Franklin Wilkins Building, 150
Stamford St, London SE1 9NH, UK. maria.p...@kcl.ac.uk
Abstract
BACKGROUND AND AIMS:
A low dietary folate intake can cause genomic DNA hypomethylation and
may increase the risk of colorectal neoplasia. The hypothesis that
folic acid supplementation increases DNA methylation in leucocytes and
colorectal mucosa was tested in 31 patients with histologically
confirmed colorectal adenoma using a randomised, double blind, placebo
controlled, parallel design.
METHODS:
Subjects were randomised to receive either 400 microg/day folic acid
supplement (n = 15) or placebo (n = 16) for 10 weeks. Genomic DNA
methylation, serum and erythrocyte folate, and plasma homocysteine
concentrations were measured at baseline and post intervention.
RESULTS:
Folic acid supplementation increased serum and erythrocyte folate
concentrations by 81% (95% confidence interval (CI) 57-104%; p<0.001 v
placebo) and 57% (95% CI 40-74%; p<0.001 v placebo), respectively, and
decreased plasma homocysteine concentration by 12% (95% CI 4-20%; p =
0.01 v placebo). Folic acid supplementation resulted in increases in
DNA methylation of 31% (95% CI 16-47%; p = 0.05 v placebo) in
leucocytes and 25% (95% CI 11-39%; p = 0.09 v placebo) in colonic
mucosa.
CONCLUSIONS:
These results suggest that DNA hypomethylation can be reversed by
physiological intakes of folic acid.
Comment in
Gut. 2005 May;54(5):579-81.
See above: PMID: 15831897
PMID: 15831910
Free PMC Article
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/15831910/?tool=pubmed
Back to JC for psor heads everywhere?
But don't most of know to take folic acid or eat greens?
I doubt it....so... jc me now please..
OK
Here he is:
174 hits - Mathers JC[Author]
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D
33 of 174 have keyword: methylation
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20methylation
11 have folic
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20folic
16 have folate:
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20folate
11 of those 16 have: methylation
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20folate%20methylation
8 of 11, of the folic's have methylation
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20folic%20methylation
2 of 174 JC's have hypomethylation:
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20%20hypomethylation
One to stop colon cancer and the other is
http://www.ncbi.nlm.nih.gov/pubmed/18195486
J Physiol Pharmacol. 2007 Dec;58(4):757-66.
Beta-carotene and arachidonic acid induced DNA methylation and the
regulation of pro-chemotactic activity of endothelial cells and its
progenitors.
Kiec-Wilk B, Polus A, Mikolajczyk M, Mathers JC.
Source
Department of Clinical Biochemistry, Jagiellonian University, Krakow,
Poland. mbb...@cyf-kr.edu.pl
Abstract
DNA methylation is one of the important mechanisms regulating gene
expression. Since beta-carotene (BC) was shown to have pro-chemotactic
activity and stimulates expression of pro-angiogenic genes, this study
was undertaken to define the possible changes in DNA methylation in
endothelial cell and its progenitors in the presence of BC. The
culture medium for human umbilical vein endothelial cells (HUVEC) and
endothelial progenitor cells (EPC) was supplemented with BC (1 - 10
microM) with the presence of arachidonic acid (AA) (3 microM). Global
DNA methylation tended to be lower in both endothelial cell lines,
after incubation with BC and AA. HUVEC incubated with AA demonstrated
the lowest DNA methylation. The decrease of DNA methylation in EPC,
induced by BC, was concentration-dependent. The microarray study
revealed, that the angiogenesis and homing-related genes were mostly
influenced by BC and AA in investigated cells. Our results indicate
that BC and AA-induced DNA hypomethylation in EPC and HUVEC, might be
a mechanism which may alter gene expression in endothelial cells what
in certain conditions may be connected with the suggested pro-
malignant effect of this compounds.
PMID: 18195486
Free full text
http://www.jpp.krakow.pl/journal/archive/12_07/pdf/757_12_07_article.pdf
Wow... this is making me THINK... LOL
randall... are you in the SAME boat? Stuck with a brain..is a pain?
Stat to obamacare?
Obama pull your head outa jPmorgans rectum...!
If jamie diamon did BAD then you (the gov [our GOV] you PRETEND to
RUN) DID 1000 times worse..ER ER ER.... LOL
STAT to stop spending TRILLIONS of BUCKs each YEAR....you've become
BUSH... obama BUSH III.... LOL
Duh... you deserve to be dog catcher in siberia or ER ER ER.
maybe in hawaii, for cocktails and luau's?
Will you and MOOOOOOchele take a 747 as a gift and simply LEAVE to
Luau time? LOL
Or we can find you two a stealth plane? Now that is a good idea...
Does mooooooooooooooooochele eat pork?
http://en.wikipedia.org/wiki/Kalua_pig
http://en.wikipedia.org/wiki/Luau
OTOH randall has BECOME czar of HEALTH by default on your PART...you
had your chance.
So?
Randall goes to WORK...as CZAR
Mama don't let your babies grow up to BE cowboys
or psoriatics for that matter.
But if you DO, then let them be psoriatic before a cowBOY.
That way their protected from HIV... LOL
And getting kicked in the head by some BULL, isn't any rodeo in my
BOOK.
Waylon Jennings & Willie Nelson - Mamas Don't Let Your Babies Grow Up
To Be Cowboys
http://www.youtube.com/watch?v=N_a4BU09GrU
<time: 3:30> <views: 1,241,345>
So why the GAY push, tar baby RANDALL?
Why NOT?
We have 7 going on 8 billion humans on this dirt ball hurtling through
SPACE
and feeding them isn't going to get any EASIER, unless we bounce in to
a new
planet full of tillable area and nice oceans chock a block full of
FISH.
DUH...
As to GAY folks.
Why don't we LET people of the SAME SEX form partnership unions with
ALL the benefits?
Or marry, i dare SAY?
And adopt not wanted KIDs? And if they don't adopt double their TAX,
say? LoL
If that isn't in their business interest, whose is it?
They suck up unWANTED kids and don't create excess humans like those
muslims.... on steroids to get to sex nirvanna... LOL
Oh bin laden please pass the viagra... LOL
Speaking of over SeXXXX'ed folks...>>>>>
Obama went FAR enough to pick up some money at clooney bird's
hollyweird roost, but NO WAY did he stand up for FREEDOM
or go out on a LIMB for GAY folk.
Heavens to betsy, they be extracting votes from po old dip wad oMAMA
in 2012.
How long ago did i say, hook me up to a GAY person so i could give
them excess TNF from my blood?
A long time ago...
If you can't help your brother or sister, who can YOU help?
Apparently my GENE's are being looked at for that and in the LONG run
that WILL HELP ME.
So why doesn't obama approach it that way?
Say let's HELP everyone. PERIOD... and we all get helped?
Wouldn't people like me who WILL NOT vote for obama go to him because
he's GOT a HEART full of LOVE for everyone?
Be a LEADER.
LOVE people and make it ALL people. Them you wIN.
I said make me your czar of health..
YOU Blew that JUAN... LOL
I already appointed ME... so you lose.
Like all the rich people are leaving town:
http://www.conservativedailynews.com/2010/03/are-wealthy-americans-leaving-the-country/
Hey it's like a sinking SHIP and their going to higher GROUND..
Thanks obama for forking up an entire country, you groucho
MArxxxist... LOL
Take some 5HTP (black pods from griffonia -- tree/africa) and relax
your not going to get voted back in..
check it out:
Subject: The Movie, 2016
An extremely important movie is coming this summer - - It is called
simply
"2016". The speaker here is Dinesh D'Souza,
college
president in New York and author of many New York Times best
sellers.� The
movie is from Gerald R. Molen, producer of Academy Award
winning Schindler's List, Jurrasic Park and Brave Heart. It explains
in plain
language who Barack Obama really is, what he stands for, and the
dangers
of him being reelected for another four years. Watch this short
informative video/preview of this movie which came out only yesterday
and share it with others.� The preview has already been seen by
over
18,000 people.� Within a very short time it will have been seen by
millions!� After you see the preview, listen to what Dinesh has to
say
about Obama.� Please take the time to hear this and pass it on.
http://www.youtube.com/v/Z6QOscKvUjU?version=3&feature=player_detailpage
AND i doubt you get anything but pity sex from
mooooooooooooooooooooooooooooooooochele.
She is NOT dumb... she knows those who voted for you.... ARE.
arf arf... BOW WOW...
-------------
OK so?
How psor people are NOW helping GAY people with HIV/AIDs..
http://www.ncbi.nlm.nih.gov/pubmed/22577363
PLoS Genet. 2012 Feb;8(2):e1002514. Epub 2012 Feb 16.
Psoriasis Patients Are Enriched for Genetic Variants That Protect
against HIV-1 Disease.
Chen H, Hayashi G, Lai OY, Dilthey A, Kuebler PJ, Wong TV, Martin MP,
Fernandez Vina MA, McVean G, Wabl M, Leslie KS, Maurer T, Martin JN,
Deeks SG, Carrington M, Bowcock AM, Nixon DF, Liao W.
Source
Department of Dermatology, University of California San Francisco, San
Francisco, California, United States of America.
Abstract
An important paradigm in evolutionary genetics is that of a delicate
balance between genetic variants that favorably boost host control of
infection but which may unfavorably increase susceptibility to
autoimmune disease. Here, we investigated whether patients with
psoriasis, a common immune-mediated disease of the skin, are enriched
for genetic variants that limit the ability of HIV-1 virus to
replicate after infection. We analyzed the HLA class I and class II
alleles of 1,727 Caucasian psoriasis cases and 3,581 controls and
found that psoriasis patients are significantly more likely than
controls to have gene variants that are protective against HIV-1
disease. This includes several HLA class I alleles associated with
HIV-1 control; amino acid residues at HLA-B positions 67, 70, and 97
that mediate HIV-1 peptide binding; and the deletion polymorphism
rs67384697 associated with high surface expression of HLA-C. We also
found that the compound genotype KIR3DS1 plus HLA-B Bw4-80I, which
respectively encode a natural killer cell activating receptor and its
putative ligand, significantly increased psoriasis susceptibility.
This compound genotype has also been associated with delay of
progression to AIDS. Together, our results suggest that genetic
variants that contribute to anti-viral immunity may predispose to the
development of psoriasis.
PMID: 22577363
This is odd. I ran Liao earlier and he had like 700 hits.
And now it says
1224 hits -Liao W[Author]
http://www.ncbi.nlm.nih.gov/pubmed?term=Liao%20W%5BAuthor%5D
And 16 of 700 or 1224 have keyword: psoria*
http://www.ncbi.nlm.nih.gov/pubmed?term=Liao%20W%5BAuthor%5D%20psoria*
Liao's second of 16 is with Katherine Jordan and Anne Bowcock no less
and the CARD14
80% of psoriasis due to carma2 gene.
#2 of 16:
http://www.ncbi.nlm.nih.gov/pubmed/22521419
Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of
NF-kappaB, in Psoriasis.
Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC,
Stuart PE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR,
Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V,
Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock
AM.
Am J Hum Genet. 2012 May 4;90(5):796-808. Epub 2012 Apr 19.
PMID: 22521419 <<<<-------
http://en.wikipedia.org/wiki/CARD14
Symbols CARD14; BIMP2; CARMA2
Caspase recruitment domain-containing protein 14, also known as CARD-
containing MAGUK protein 2 (Carma 2), is a protein that in humans is
encoded by the CARD14 gene.[1][2][3]
[...] Link to Psoriasis
The CARD14 gene was recently identified as the first gene directly
linked to the most common form of Psoriasis. It has been suggested
that a mutation in the gene plus an environmental trigger were enough
to elicit plaque psoriasis.[4][5]
<snip>
In this wikipedia card14 reference: Liao W, would be in #4, PMID:
22521419 <<<<-----
Liao's #3 of 16 --PMID: 22437317
was posted to the p ng March 23, of this year
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+22437317+&start=0&
And on that thread it says Liao W has 474 hits (not 1224 or over 700
as i surmised.. LOL)
See:
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Liao%20W%22%5BAuthor%5D
And W Liao still has 16 psoriasis hits and SOME with CpG of the blue
psoriatic *ISLANDER's*, Bowcock.
So read #3 and that thread:
goes here:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/dd6bb29ebb72a8a2/332737fa147ea75b?lnk=gst&q=PMID%3A+22437317++wilson+Liao#332737fa147ea75b
And i see i forgot his first NAME, Wilson in less then two months. LOL
And Wilson Liao has a psor DAY in SF by the bay.
So San Francisco and hiv and his #3 of 16 psoriasis hits, all make
total sense.
And Liao's #4, PMID: 22185198 was posted twice. A zinc finger
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+22185198+&start=0&
And Liao's #5 is CpG once again, PMID: 22071477 and as psoriasis is
HYPOmethylation according to
recent abstracts:
As #5 is also Bowcock and goes to their recent findings it's no
suprise:
http://www.ncbi.nlm.nih.gov/pubmed/22071477
A subset of methylated CpG sites differentiate psoriatic from normal
skin.
Roberson ED, Liu Y, Ryan C, Joyce CE, Duan S, Cao L, Martin A, Liao W,
Menter A, Bowcock AM.
J Invest Dermatol. 2012 Mar;132(3 Pt 1):583-92. doi: 10.1038/jid.
2011.348. Epub 2011 Nov 10.
PMID: 22071477
------
segue time:
Did Jordan & Bowcock et al (including Liao, Wilson) crack a Jeroboam
of Champagne (card14, carma2) or what?
OMG, I'm giving away the SECRETs of Autoimmune Cures! But didn't we
know ALL of this, more
or less already?
Today is OMG, OMG, omg!
Or hypo-methylation for you atheist autoimmune people....
Is hyPomethylation GOD saying SCREW YOU?
Do you believe anything? That is as good as some of the crap flying
over/under the radar these days......
Why...?
It's HyPo... don't you know?
We have 15 hits in the p ng: hypomethylation
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=hypomethylation&start=0&
Which means exactly what for YOU?
Nothing! LOL
Sorry, but if it meant anything you'd be ahead of me, btw. LOL
I said whey... SWEET! LoL
zzzzzzzzzzzzzzzzzzzzzzzzzz ok a short pause for those who might wet
their pants or
democorks who may fizzle their wizzle... uPon getting REAL TRUTH. lol
Study from China on alcohol and psoriasis.
First, i'd like to say.
Why don't they look at Inuit and carbs/alcohol, first?
It makes sense right?
They have never had carbs in their diet, out of SEASON till the last
100 years or so.
And that MEANs everything one NEEDS to know to UNDERSTAND this carb
gene thingy pooh.
So their.... or is it...this chinese abstract from some rookies, i'm
guessing.
http://www.ncbi.nlm.nih.gov/pubmed/22568495
J Dermatol. 2012 May 9. doi: 10.1111/j.1346-8138.2012.01577.x.
Alcohol consumption and psoriatic risk: A meta-analysis of case-
control studies.
Zhu KJ, Zhu CY, Fan YM.
Source
Department of Dermatology, Affiliated Hospital of Guangdong Medical
College, Zhanjiang, Guangdong, China.
Abstract
Psoriasis is one of the most common dermatological disorders. The
association between alcohol consumption and psoriasis has been
inconsistent among studies. To examine the magnitude of the risk of
developing psoriasis for drinking populations compared to those with
non-drinking, and to determine causes of the variation in odds ratios
(OR) between various case-control studies, we performed a
comprehensive published work search and a meta-analysis of case-
control studies considering prevalence. We did electronic searches on
Medline, and searched reports to identify case-control studies of
prevalent of psoriasis. We did meta-analyses of study-specific
incremental estimates to determine the risk of psoriasis associated
with drinking. The magnitude of the OR was analyzed by combining 15
case-control studies that matched defined criteria. The variance in OR
between studies was explored. The overall OR of psoriasis for drinking
persons compared to those with non-drinking was 1.531 (95% confidence
interval [CI] = 1.164-2.014, P = 0.002) and the association remains
statistically significant across a number of stratified analyses in
European descent subgroup (OR = 1.432, 95% CI = 1.085-1.889, P =
0.011) and also persists in sensitivity analyses performed to assess
the potential effect of varying psoriasis outcome definitions. Alcohol
consumption is associated with increased risk of psoriasis. These
epidemiological observations should inform the exploration of
biological mechanisms that link alcohol consumption with psoriasis.
PMID: 22568495
So getting to MY point: (if i had one..LOL)
2111 hits: carbohydrate brain neurotransmitter dopamine
http://www.ncbi.nlm.nih.gov/pubmed?term=carbohydrate%20brain%20neurotransmitter%20dopamine
http://www.livestrong.com/article/86350-foods-increase-dopamine-serotonin/
FOODS THAT INCREASE DOPAMINE & SEROTONIN
[...] The Tyrosine Connection
Low dopamine levels can cause depression, a loss of satisfaction,
addictions, cravings, compulsions, low sex drive, as well as an
inability to focus. Tyrosine is another important amino acid (a
building block of protein) found in dairy products, meats, poultry and
nuts. It encourages your brain to release dopamine and norepinephrine.
These neurotransmitters act as stimulating substances to the brain and
can help perk you up by making you feel more alert and sharpening your
thinking. In addition to meats and dairy products, other specific
tyrosine-rich foods that help increase dopamine levels are almonds,
avocados, bananas, lima beans, pumpkin seeds and sesame seeds.
<snip>
Alcohol and sugar can turn you in to a Serotonin Junky:
http://www.healthypeople.com/serotonin_junkie.htm
ARE YOU A SEROTONIN JUNKIE?
Do you crave carbohydrates all day long?
[...] Are you craving more sugars, starches or alcohol these days? It
may be a symptom of "Seasonal Affective Disorder" or "S.A.D.", which
kicks in around the Fall Season in areas where folks get less
sunlight. Or, perhaps you have been craving more carbohydrates since
you lost your job, got a promotion, got engaged or moved to a new
town. Whether the stress is a positive or a negative event, stress in
and of itself will be a trigger for the desire for carbohydrates in
order to raise serotonin. So, when you feel "bad" (anxious, nervous,
angry) it may be a symptom that you actually need more serotonin!
<snip>
No, no, i'm a doPamine junk head... and it's pointed... or to the
point and i live on a point? <G>
And adding serotonin takes us down to 1500 hits:
http://www.ncbi.nlm.nih.gov/pubmed?term=carbohydrate%20brain%20neurotransmitter%20serotonin
With dopamine down to 364 hits
http://www.ncbi.nlm.nih.gov/pubmed?term=carbohydrate%20brain%20neurotransmitter%20serotonin%20dopamine
And zero hits; with : feeling good... LOL
http://www.ncbi.nlm.nih.gov/pubmed?term=carbohydrate%20brain%20neurotransmitter%20serotonin%20dopamine%20feeling%20good
Obviously to subjective...
i guess XXX sex brain feel GOOD is out? LOL
-----------------ok feeling good and alcohol and carbs segue is sorta
over and OUT... burP!
And a LOT of those hypomethelations go with cancer.
WHY?
Maybe it's the first thing that comes up so it got studied 1st?
No, it must go deePer to reality i'm thinking or it's pointed towards.
So now we go and look at it:
13 of 15 : results for hypomethylation cancer - p ng:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=hypomethylation+cancer&start=0&
1441 hits: hypomethylation cancer - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20cancer
19 of 1441 have tyrosine:
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20cancer%20tyrosine
ZERO hits:
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20autoimmun*%20%20tyrosine
DroPPing the tyrosine.... is critical... So CritiCOW... MOOOOO
52 hits: hypomethylation autoimmun*- pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20autoimmun*%20
And three (3) hits: psoria* + hypomethylation - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20psoria*
#1 of three was posted yesterday:
http://www.ncbi.nlm.nih.gov/pubmed/22564738
The characteristics of genome-wide DNA methylation in naïve CD4+ T
cells of patients with psoriasis or atopic dermatitis.
Han J, Park SG, Bae JB, Choi J, Lyu JM, Park SH, Kim HS, Kim YJ, Kim
S, Kim TY.
Biochem Biophys Res Commun. 2012 Apr 30.
PMID: 22564738
#2 of 3
http://www.ncbi.nlm.nih.gov/pubmed/19072642
Epigenetics and dermatological disease.
Millington GW.
Pharmacogenomics. 2008 Dec;9(12):1835-50. Review.
PMID: 19072642
And PMID: 19072642 has been posted TWICE to the p ng: by me
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+19072642+&start=0&
#3 of 3
1996? huh?
http://www.ncbi.nlm.nih.gov/pubmed/8765212
DNA hypomethylation in inflammatory arthritis: reversal with
methotrexate.
Kim YI, Logan JW, Mason JB, Roubenoff R.
J Lab Clin Med. 1996 Aug;128(2):165-72.
PMID: 8765212
PMID: 8765212 was posted in the p ng:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+8765212&start=0&
by me... of course!
Sat, Sep 24 2005 11:26 am
Subject: Re: Folic acid supplements challenged - L-methylfolate
better?
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/b04ed000b0f93a10
OK so does folate help or hurt when it comes to hyPomethylation?
hence from 1996 (above:)
http://www.ncbi.nlm.nih.gov/pubmed/8765212
J Lab Clin Med. 1996 Aug;128(2):165-72.
DNA hypomethylation in inflammatory arthritis: reversal with
methotrexate.
Kim YI, Logan JW, Mason JB, Roubenoff R.
Source
University of Toronto, Ontario, Canada.
Abstract
This study investigated whether methotrexate, by interrupting the
methyl transfer function of folate, can induce genomic DNA
hypomethylation in patients with inflammatory arthritis. Consecutive
subjects with inflammatory arthritis (rheumatoid or psoriatic), who
were taking methotrexate (n = 7) or other medications (n = 6), and
control subjects, either healthy or with osteoarthritis and taking
nonsteroidal anti-inflammatory agents only (n = 9) were recruited. The
methylation status of genomic DNA from peripheral blood mononuclear
cells was determined. Plasma levels of folate, B12, and pyridoxal-5'-
phosphate (PLP), all of which are involved in biologic methylation,
were also examined. The extent of genomic DNA methylation was lowest
in subjects with inflammatory arthritis who were not taking
methotrexate, highest in subjects with inflammatory arthritis who were
taking methotrexate, and intermediate in control subjects (p < 0.05).
Plasma levels of folate and B12 were similar among the three groups.
The mean plasma PLP level in subjects with inflammatory arthritis was
33% lower than that in control subjects (p = 0.04). No significant
correlation between genomic DNA methylation and folate, B12, and PLP
levels was observed. These data do not support the hypothesis that
methotrexate induces genomic DNA hypomethylation. However, these data
indicate that inflammatory arthritis is associated with genomic DNA
hypomethylation that is reversed with methotrexate. Future studies
using a larger number of subjects are warranted to confirm these
findings.
PMID: 8765212
OK and what i said:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/806607ecac198693
and/or
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/806607ecac198693?&q=PMID%3A+8765212
And we do the logical...
search:
177 hits: hypomethylation + folate -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20folate
And find this Matther guy..
What's the mather's with this world? LOL
Is he like JC?
Could BE for you and ME? He's JC Mather's
And JC for you and me is an epigenetic event that slows psoriasis or
stops it...
So he is JC... you see?
See
http://www.ncbi.nlm.nih.gov/pubmed/15831897
Gut. 2005 May;54(5):579-81.
Reversal of DNA hypomethylation by folic acid supplements: possible
role in colorectal cancer prevention.
Mathers JC.
Source
Human Nutrition Research Centre, School of Clinical Medical Sciences,
University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK.
john.m...@ncl.ac.uk
Comment on
Gut. 2005 May;54(5):648-53.
http://www.ncbi.nlm.nih.gov/pubmed/15831910.1
PMID: 15831897
Free PMC Article
http://gut.bmj.com/content/54/5/579.full
or
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/15831897/?tool=pubmed
As i'm going to do all of JC Mather's in a minute we look at the
comment abstract:
http://www.ncbi.nlm.nih.gov/pubmed/15831910.1
Gut. 2005 May;54(5):648-53.
Effect of folic acid supplementation on genomic DNA methylation in
patients with colorectal adenoma.
Pufulete M, Al-Ghnaniem R, Khushal A, Appleby P, Harris N, Gout S,
Emery PW, Sanders TA.
Source
Nitritional Sciences Research Division, Department of Nutrition and
Dietetics, King's College London, Franklin Wilkins Building, 150
Stamford St, London SE1 9NH, UK. maria.p...@kcl.ac.uk
Abstract
BACKGROUND AND AIMS:
A low dietary folate intake can cause genomic DNA hypomethylation and
may increase the risk of colorectal neoplasia. The hypothesis that
folic acid supplementation increases DNA methylation in leucocytes and
colorectal mucosa was tested in 31 patients with histologically
confirmed colorectal adenoma using a randomised, double blind, placebo
controlled, parallel design.
METHODS:
Subjects were randomised to receive either 400 microg/day folic acid
supplement (n = 15) or placebo (n = 16) for 10 weeks. Genomic DNA
methylation, serum and erythrocyte folate, and plasma homocysteine
concentrations were measured at baseline and post intervention.
RESULTS:
Folic acid supplementation increased serum and erythrocyte folate
concentrations by 81% (95% confidence interval (CI) 57-104%; p<0.001 v
placebo) and 57% (95% CI 40-74%; p<0.001 v placebo), respectively, and
decreased plasma homocysteine concentration by 12% (95% CI 4-20%; p =
0.01 v placebo). Folic acid supplementation resulted in increases in
DNA methylation of 31% (95% CI 16-47%; p = 0.05 v placebo) in
leucocytes and 25% (95% CI 11-39%; p = 0.09 v placebo) in colonic
mucosa.
CONCLUSIONS:
These results suggest that DNA hypomethylation can be reversed by
physiological intakes of folic acid.
Comment in
Gut. 2005 May;54(5):579-81.
See above: PMID: 15831897
PMID: 15831910
Free PMC Article
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/15831910/?tool=pubmed
Back to JC for psor heads everywhere?
But don't most of know to take folic acid or eat greens?
I doubt it....so... jc me now please..
OK
Here he is:
174 hits - Mathers JC[Author]
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D
33 of 174 have keyword: methylation
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20methylation
11 have folic
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20folic
16 have folate:
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20folate
11 of those 16 have: methylation
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20folate%20methylation
8 of 11, of the folic's have methylation
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20folic%20methylation
2 of 174 JC's have hypomethylation:
http://www.ncbi.nlm.nih.gov/pubmed?term=Mathers%20JC%5BAuthor%5D%20%20hypomethylation
One to stop colon cancer and the other is
http://www.ncbi.nlm.nih.gov/pubmed/18195486
J Physiol Pharmacol. 2007 Dec;58(4):757-66.
Beta-carotene and arachidonic acid induced DNA methylation and the
regulation of pro-chemotactic activity of endothelial cells and its
progenitors.
Kiec-Wilk B, Polus A, Mikolajczyk M, Mathers JC.
Source
Department of Clinical Biochemistry, Jagiellonian University, Krakow,
Poland. mbb...@cyf-kr.edu.pl
Abstract
DNA methylation is one of the important mechanisms regulating gene
expression. Since beta-carotene (BC) was shown to have pro-chemotactic
activity and stimulates expression of pro-angiogenic genes, this study
was undertaken to define the possible changes in DNA methylation in
endothelial cell and its progenitors in the presence of BC. The
culture medium for human umbilical vein endothelial cells (HUVEC) and
endothelial progenitor cells (EPC) was supplemented with BC (1 - 10
microM) with the presence of arachidonic acid (AA) (3 microM). Global
DNA methylation tended to be lower in both endothelial cell lines,
after incubation with BC and AA. HUVEC incubated with AA demonstrated
the lowest DNA methylation. The decrease of DNA methylation in EPC,
induced by BC, was concentration-dependent. The microarray study
revealed, that the angiogenesis and homing-related genes were mostly
influenced by BC and AA in investigated cells. Our results indicate
that BC and AA-induced DNA hypomethylation in EPC and HUVEC, might be
a mechanism which may alter gene expression in endothelial cells what
in certain conditions may be connected with the suggested pro-
malignant effect of this compounds.
PMID: 18195486
Free full text
http://www.jpp.krakow.pl/journal/archive/12_07/pdf/757_12_07_article.pdf
Wow... this is making me THINK... LOL
randall... are you in the SAME boat? Stuck with a brain..is a pain?
Stat to obamacare?
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