PSOR aPeMAN Shoots Genetic DICE with Eienstein
randall
Does your bride or sweetheard call you an APE?
OK, so don't toss so much crap around. LOL
But are you?
And how come apes don't get psoriasis?
What's the C. Diff in this equation Eienstein?
Got a GUT hunch?
http://www.sciencedaily.com/releases/2009/12/091202153802.htm
Why Humans Outlive Apes: Human Genes Have Adapted to Inflammation, but
We Are More Susceptible to Diseases of Aging
ScienceDaily (Dec. 3, 2009) — In spite of their genetic similarity to
humans, chimpanzees and great apes have maximum lifespans that rarely
exceed 50 years. The difference, explains USC Davis School of
Gerontology Professor Caleb Finch, is that as humans evolved genes
that enabled them to better adjust to levels of infection and
inflammation and to the high cholesterol levels of their meat rich
diets.
In the December issue of Proceedings of the National Academy of
Sciences (Early Edition), Finch reveals that these evolutionary
genetic advantages, caused by slight differences in DNA sequencing and
improvements in diet, make humans uniquely susceptible to diseases of
aging such as cancer, heart disease and dementia when compared to
other primates.
Finch, the ARCO & William F. Kieschnick Professor in the Neurobiology
of Aging and a distinguished University Professor, argues that a major
contributor to longevity for humans is the genes that adapt to higher
exposure to inflammation.
"Over time, ingestion of red meat, particularly raw meat infected with
parasites in the era before cooking, stimulates chronic inflammation
that leads to some of the common diseases of aging," Finch said.
In addition to differences in diets between species of primates,
humans evolved unique variants in a cholesterol transporting gene,
apolipoprotein E, which also regulates inflammation and many aspects
of aging in the brain and arteries.
ApoE3 is unique to humans and may be what Finch calls "a meat-adaptive
gene" that has increased the human lifespan.
However, the minor allele, apoE4, when expressed in humans, can impair
neuronal development, as well as shorten human lifespan by about four
years and increase the risk of heart disease and Alzheimer disease by
several-fold. ApoE4 carriers have higher totals of blood cholesterol,
more oxidized blood lipids and early onset of coronary heart disease
and Alzheimer's disease.
"The chimpanzee apoE functions more like the "good" apoE3, which
contributes to low levels of heart disease and Alzheimer's," Finch
said. Correspondingly, chimpanzees in captivity have unusually low
levels of heart disease and Alzheimer-like changes during aging.
Finch hypothesizes that the expression of ApoE4 could be the result of
the antagonistic pleiotropy theory of aging, in which genes selected
to fight diseases in early life have adverse affects in later life.
"ApoeE may be a prototype for other genes that enabled the huge
changes in human lifespan, as well as brain size, despite our very
unape-like meat-rich diets," Finch said. "Drugs being developed to
alter activities of apoE4 may also enhance lifespan of apoE4
carriers."
Support was provided by the National Institute on Aging and the
Ellison Medical Foundation.
<sniP>
So diet and the Gi tract makes a big difference?
Surely TRAVIS the chimp who tore the face off the owners friend had a
gut
full of HUMAN vittles.
Maybe feeding TRAVIS the wrong diet made him go BONKERs?
Is the randall right on again?
Most likely. I'm a crapologist with my head in the Gi tract. LOL
Or is that UP the tract?
What monkey business am i talking about?
http://www.timeslive.co.za/news/world/article192542.ece
Charla Nash on Oprah:
http://gothamist.com/2009/11/11/oprah_amazed_at_spirit_resilience_o.php
Could the wrong diet make an ape or chimp or MAN do this to
a woman?
Charla Nash went from this
http://www.nypost.com/rw/nypost/2009/11/11/news/photos_stories/CharlaNash3122235--300x300.jpg
TO THIS
http://stupidcelebrities.net/wp-content/charla2.jpg
What lies in the soul is mediated by the GUT (micro flora et al)
perhaPs?
==============
Oh, oh.... will you live longer and stronger or weaker and sicker?
Live longer, silence the Rasgrf1 gene:
http://en.wikipedia.org/wiki/Ras-GRF1
Ras-GRF1 is a guanine nucleotide exchange factor. Its function is to
remove GDP from the signalling protein RAS, this increases the
activity of RAS. Since RAS is involved in signalling from IGF-1, which
controls growth, increased activity of Ras-GRF1 makes animals grow
larger.[1] Although it is sometimes known as CDC25, it should not be
confused with Cdc25. The fact that it is expressed in men, but
silenced in women has been linked to women's longer lifespans.[2
<sniP>
I'm not gonna let rasgrf1 control me, i'll commit suicide?
Only if i was the guy behind this guy. LOL
http://www.youtube.com/watch?v=nBnKh6B2cMw
So why live so long in the first place APE man?
Become a chick instead?
http://www.sciencedaily.com/releases/2009/12/091201192105.htm
Why Females Live Longer Than Males: Is It Due to the Father's Sperm?
<sniP>
What's in your sPerm? So psor DNA or chimP chumP genes?
And is this why women drug us in to civilization?
So they didn't have to go on the hunt and have to forage
while MAN brought home the bacon?
You women have come so far you DON'T need a man. LOL
http://www.youtube.com/watch?v=4X4MwbVf5OA
===========
LIVE LONGER STILL... cut out the methionine and balance amino acids
http://www.sciencedaily.com/releases/2009/12/091202131622.htm
Balancing Protein Intake, Not Cutting Calories, May Be Key to Long
Life
ScienceDaily (Dec. 2, 2009) — Getting the correct balance of proteins
in our diet may be more important for healthy ageing than reducing
calories, new research funded by the Wellcome Trust and Research into
Ageing suggests.
<sniP>
218 hits for methionine in our group:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?hl=en&q=methionine&start=0&scoring=d&hl=en&
Methionine gets placed incorrectly in proteins. Bad news. LOL
See this from the dec 1 thread:
http://news.biocompare.com/News/NewsStory/300994/NewsStory.html
Cells Defend Themselves From Viruses, Bacteria With Armor Of Protein
Errors
<sniP>
The whole thread:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/3066836556908147
So?
Just know it, makes you OWN it. LOL
It becomes so HARD when you KNOW more then is warranted.
Personal responsibility is anti itch and perfectly CLEAR.
From your gut to your skin and eliminating all the CRAP.
And i'm not the type to use low dose dirt bugs. LOL
Back to the gut then.
First a disease that may lend a clue from a recent abstract.
Three month old baby treated for kawasaki disease (KD) onsets with
psoriasis & cured with NASONEX:
www.ncbi.nlm.nih.gov/pubmed/19951646
Well it said. **The eruption resolved after one month of topical
momentasone furoate treatment.**
http://en.wikipedia.org/wiki/Mometasone_furoate
Mometasone furoate (also referred to as mometasone) is a
glucocorticoid steroid used to reduce inflammation in the nose and
other airways.[2]
It is used in the treatment of inflammatory skin disorders (such as
eczema and psoriasis), allergic rhinitis (such as hay fever), and
asthma[3] for patients unresponsive to less potent corticosteroids. In
terms of steroid strength, it is more potent than hydrocortisone, and
less potent than dexamethasone.
Schering-Plough markets the medication under the following brand
names; Elocon (Elocom, Elomet) as a cream or ointment for skin
conditions, Nasonex as a nasal spray for upper respiratory conditions
such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder
inhaler (DPI) for lower respiratory conditions.
It reduces inflammation by causing several effects:[4][5]
reversing the activation of inflammatory genes
activating the secretion of anti-inflammatory proteins
stabilising cell membranes
decreasing the influx of inflammatory cells
[...]
Nasonex is known in the U.S. for a series of television ads featuring
an animated bee which is voiced by the Spanish actor Antonio Banderas
<sniP>
KD in children does a psor warning apparently:
www.ncbi.nlm.nih.gov/pubmed/19950847
32 returns for :: KD + psoriasis [pubmed]
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=kawasaki+disease+psoriasis&log$=activity
===========
Eating Indian food is it good for L. Plantarun and vitamin B12
creation?
http://en.wikipedia.org/wiki/Kanjika
Kanjika (Indian functional food, also abbreviated as Kanji), is a dish
in which lactic fermentation is the terminal step in food processing;
it is suitable for vegans as it is prepared from raw material of plant
origin and devoid of dairy product.
Kanjika-satwa is a dried kanjika. Kanjika may prepared using barley or
millet in place of rice. Sometimes bamboo leaves are added along with
radish in the fermentation mixture. Fried lentil balls (Urid wada) are
also combined with Kanjika. This dish is known as Kanjiwada.
<sniP>
www.ncbi.nlm.nih.gov/pubmed/19953302
Probiotic lactic acid bacterium from kanjika as a potential source of
vitamin B(12): evidence from LC-MS, immunological and microbiological
techniques.
Madhu AN, Giribhattanavar P, Narayan MS, Prapulla SG.
Fermentation Technology and Bioengineering Department, Central Food
Technological Research Institute, Mysore, 570 020, India.
Vitamin B(12) was produced by probiotic Lactobacillus plantarum in
submerged fermentation (96 h) with successive anaerobic and aerobic
phases of 48 h each to give 13 ng vitamin B(12)/g dry biomass. Sodium
cyanide-mediated cell lysis, followed by benzyl alcohol/chloroform/
water extraction, improved the release of intracellular vitamin B(12)
for analysis. The presence of the K(+) adduct of cyanocobalamin (m/z
of 1394) was established using electron spray ionization-mass spectra;
growth of a mutant of Escherichia coli in the presence of
cyanocobalamin ascertained its bioavailability.
PMID: 19953302
This next plantarum with lacti loving bugs makes sense.
www.ncbi.nlm.nih.gov/pubmed/19949794
An In Vitro Study on Bacterial Growth Interactions and Intestinal
Epithelial Cell Adhesion Characteristics of Probiotic Combinations.
Moussavi M, Adams MC.
School of Environmental and Life Sciences, The University of
Newcastle, Callaghan, NSW, 2308, Australia,
Mahta.M...@newcastle.edu.au.
The aims of this study were to examine long-term growth interactions
of five probiotic strains (Lactobacillus casei 01, Lactobacillus
plantarum HA8, Lactobacillus rhamnosus GG, Lactobacillus reuteri ATCC
55730 and Bifidobacterium lactis Bb12) either alone or in combination
with Propionibacterium jensenii 702 in a co-culture system and to
determine their adhesion ability to human colon adenocarcinoma cell
line Caco-2. Growth patterns of probiotic Lactobacillus strains were
not considerably affected by the presence of P. jensenii 702, whereas
lactobacilli exerted a strong antagonistic action against P. jensenii
702. In the co-culture of Bif. lactis Bb12 and P. jensenii 702, a
significant synergistic influence on growth of both bacteria was
observed (P < 0.05). The results of adhesion assay showed that when
probiotic strains were tested in combination, there was evidence of an
associated effect on percentage adherence. However, in most cases
these differences were not statistically significant (P < 0.05).
Adhesion percentage of Lb. casei 01 and Lb. rhamnosus GG both
decreased significantly in the presence of P. jensenii 702 compared to
their adhesion levels when alone (P < 0.05). These results show that
the survival and percentage adhesion of some probiotic strains may be
influenced by the presence of other strains and this should be
considered when formulating in the probiotic products.
PMID: 19949794
Why are these gut bugs lacti loving?
http://en.wikipedia.org/wiki/Lactobacillus
Since a new series of lacti loving trials for psoriasis attenuation
are coming up
i'm excited.
Do we need probiotics?
http://timesofindia.indiatimes.com/life/health-fitness/diet/Do-we-need-probiotics/articleshow/5291791.cms
In order to create a new colon use the wit kit and 30 day diet.
======
In google news:
http://www.alternativehealthjournal.com/article/know_your_probiotics_benefits_of_lactobacillus_plantarum/3887
Know Your Probiotics: Benefits of Lactobacillus Plantarum
By Catherine Lewis, AHJ Editor -- Published: December 03, 2009
You’ve most likely been hearing the praises of probiotics lately, and
it’s no surprise why. Research on probiotics has suggested health
benefits ranging from digestive support to promoting healthy
cholesterol. But which strains of “good bacteria” should you be
incorporating into your daily regimen? In our probiotic series, we
take a look at four of the most beneficial strains of probiotics.
First up – Lactobacillus Plantarum.
Lactobacillus Plantarum is a part of the genus Lactobacillus in the
Lactobacillaceae family. It’s very common in many fermented foods, in
anaerobic plant matter as well as in your saliva. In fact, it may be
unknown to many, but saliva is where the species was first isolated.
Today the benefits of Lactobacillus Plantarum are still being widely
studied at the Lund University in Lund, Sweden by researcher and M.D.
S. Bengmark.
Lactobacillus Plantarum is one of the most beneficial bacteria in your
body and can live in your stomach for a long time. It continuously
fights disease and prevents entry of pathogenic microorganisms that
might otherwise cause disease, as well as prevent them from growing.
It also provides excellent benefits to the colon by preventing the
intestinal lining from being attacked by bacteria that might also
enter the blood stream, causing further damage and destruction of the
body.
Lactobacillus Plantarum is one of the largest genomes in the lactic
acid bacteria group and is such a versatile species that its benefits
to the human body are almost unending. You need this good bacterium in
your body for your entire life, regardless of age. It can provide
treatment for irritable bowel syndrome, decrease Crohn’s disease
symptoms, help heal colitis and act as one of the best probiotics for
aiding your intestines with digestion.
Lactobacillus Plantarum has an uncanny ability to quickly digest
protein and liquefy gelatin, making it very beneficial in not only
treating, but also preventing food allergies. It also performs the
functions of regulating immunity and stomach inflammation. Of even
more importance to the human body is its ability to absorb and
maintain important nutrients such as omega-3 fatty acids, vitamins and
anti-oxidants, making it vital for fighting infection and taking
control over the “bad” bacteria.
In many cases where patients are taking antibiotics for an infection
they develop a yeast infection, which contributes to good bacteria
becoming destroyed. This is not the case with there is an adequate
amount of Lactobacillus Plantarum in the body. They manage to continue
to do their job while allowing the antibiotic to do its work as well.
They continue to fight infection and provide the body with the
nutrients and preventative measure to fight bad bacteria.
Many doctors and surgeons rely on this popular and beneficial strain
both before and after performing a colonoscopy on patients. In fact,
many surgeons will not perform colonoscopies without ensuring a
treatment of this powerful probiotic pre- and post-operative. There
are many reasons for this decision but the major reason is its ability
to treat and prevent intestinal infection or inflammation and for the
many healthful benefits it provides to the colon.
The most important contribution Lactobacillus Plantarum provides to
the colon, stomach and entire intestinal tract is its constant
production of “good” or “friendly” bacteria, which overrule the bad
bacteria. While you can obtain this valuable dietary aid through
certain foods, supplements also offer an easy and inexpensive way to
ensure you’re getting enough of this essential probiotic. Visit the
Bacteral website for more information on supplementation with
probiotics.
<sniP>
I wonder what's up between Plantarum bugs and methionine?
15 hits on pubmed:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=methionine+plantarum&log$=activity
And only one on our group from Nov 29, 2009:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?hl=en&group=alt.support.skin-diseases.psoriasis&q=methionine+plantarum
As to the ape man diet we can't discount apes simply going ape:
http://www.youtube.com/watch?v=ZwaiMCsyXas
Evolution & or evil solutions in the hearts of MAN kind or UN and much
in you is still an ape
mister prezident.
Where is Marylin Monroe when you need her?
http://www.youtube.com/watch?v=k4SLSlSmW74
HaPPy Birthday to YOU...
========================
That was a nice segue... for me anyway...time for sweet whey?
Or eat some dirt antibiotic... we have tacrolimus, MTX, rapamycin and
a few dozen more.
Is that the hygience hyPothesis in action?
With the right dirt in your diet you avoid the genetic glitch?
I doubt it.
What's current in abstracts?
Here's a clue to those pathways.
www.ncbi.nlm.nih.gov/pubmed/19956430
Modulation of NFAT-5, an outlying member of the NFAT family, in human
keratinocytes and skin.
Al-Daraji WI, Afolayan J, Zelger BG, Abdellaoui A, Zelger B.
BACKGROUND: Cyclosporin A (CsA) and tacrolimus block T cell activation
by inhibiting the phosphatase calcineurin and preventing translocation
from the cytoplasm to the nucleus of the transcription factor Nuclear
Factor of Activated T cells (NFAT). NFAT compose a family of
transcription factors that are turned on during T cell activation.
AIMS: To study the expression of NFAT-5 mRNA and protein in normal
human keratinocytes and to investigate the cellular and subcellular
pattern of expression of NFAT-5 in normal human skin and psoriasis,
and analyze effects of different agonists and ultraviolet radiation on
NFAT-5 in normal human skin. METHODS: Tissue cultures, Reverse
Transcriptase-Polymerase Chain Reaction (RT-PCR), Western analysis,
immunostaining, confocal microscopy. RESULTS: Sequencing of RT-PCR
products confirmed the identity of the product that showed 100 %
homology with the predicted NFAT-5 sequence. anti-NFAT-5 mainly
detected a single band in cultured keratinocytes and dermal
fibroblasts using Western analysis. Immunohistochemistry showed that
epidermal keratinocytes and dermal fibroblasts in normal human and
psoriatic skin express NFAT-5. NFAT-5 showed predominantly nuclear
localization in epidermal keratinocytes and dermal fibroblasts within
five normal adult skin biopsies. Our data also suggest that UV
irradiation reduces NFAT-5 nuclear localization within the epidermis.
Unlike NFAT 1-4, NFAT-5/TonEBP was localized to both nucleus and
cytoplasm of cultured keratinocytes. Cyclosporin A induces nuclear
membrane translocation of NFAT-5 in cultured keratinocytes and
raffinose (a hypertonicity inducing agent) induces more nuclear
localization of NFAT-5 compared to untreated cells. In addition,
differentiation-promoting agonists that induce sustained rise in
intracellular calcium did not result in changes in NFAT-5 localization
in cultured keratinocytes. CONCLUSION: These studies provide the first
observation of expression of NFAT-5/TonEBP mRNA protein in cultured
keratinocytes and dermal fibroblasts and possible functional
regulation in cultured keratinocytes. CsA and raffinose effects on
NFAT-5/TonEBP in cultured keratinocytes suggest diverse intracellular
signaling pathways for NFAT-5/TonEBP in these cells, and that NFAT-5/
TonEBP might function to translate different extracellular stimuli
into appropriate functional responses.
PMID: 19956430
This is a rapa nui dirt product abstract:
Severe atopic dermatitis treated with everolimus.
Van Velsen SG, Haeck IM, Bruijnzeel-Koomen CA.
Department of Dermatology and Allergology, University Medical Centre
Utrecht, Utrecht, The Netherlands.
Background: Patients with severe atopic dermatitis (AD) often require
treatment with oral immunosuppressive drugs. Everolimus is a rapamycin-
derived macrolide with immunosuppressive and antiproliferative
effects. Everolimus demonstrated efficacy not only in the prophylaxis
of organ rejection in kidney transplant patients, but also in
decreasing disease activity in psoriasis patients. Objective: To
evaluate whether everolimus is an effective treatment in patients with
severe AD. Methods: Two patients with severe AD were treated with
everolimus in combination with low-dose cyclosporin A (CsA) or
prednisone. During treatment, a disease activity and safety laboratory
examination was performed. Results: Everolimus either in combination
with prednisone or with CsA did not result in improvement of disease
activity in two patients with severe AD. Conclusion: Everolimus does
not seem to be an effective treatment in these two AD patients, either
in combination with prednisone or with CsA.
PMID: 19954394
Oh well. This one is getting to long... the extra material will go in
the next one. :)
But did GOD have a Choice?
God does or does NOT play dice...
http://www.youtube.com/watch?v=bgoiLJZRmtM
Creationist Miss Garison explains evolution:
http://www.youtube.com/watch?v=8asQkegV_wk&feature=PlayList&p=B796ED6D62B82423&playnext=1&playnext_from=PL&index=48
Evolution Explained: South Park Exposes Stupidity Of Creationists
http://www.youtube.com/watch?v=rby5itnDloI
Does the lord belong on your throne? Will it nudge that ego aside?
What does big AL say?
Albert Einstein
"Any intelligent fool can make things bigger, more complex, and more
violent. It takes a touch of genius -- and a lot of courage -- to move
in the opposite direction."
"Imagination is more important than knowledge."
"Gravitation is not responsible for people falling in love."
"I want to know God's thoughts; the rest are details."
randall... An ignoRANT ape man in paradise... AH... CRAP--&-psor
ski..n.;~? LOL
;~?