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Peter Paul and MARY -- Shaft! - Obama as Putney Swope --Fats Domino - HyPomethylation -Vitamin B12 - Folic Acid - Retinoic Acid - D3 - Zinc - Don Sipler & JXR Stern -Doctor Doctor ->Palmer - YKW --
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randall
May 26, 2012, 10:30:18 PM5/26/12
to
hi
Just thinking about
Fri, Apr 6 2012 9:29 am
Subject: Dr. Federica Sallusto & Dr. Christina Zielinski --
Biomedicine and PSOR (and MORE) Disease Causation via Fungus (Candida
vs Staph and Th2 critters) Foxp3- Tregs & IL10 vs Th17 & Th1 Skew in
YOU
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/cdc3bdf35aaff2d0
Brought back to LIFE in my MIND by vejetarian Bohgosity BumaskiL.
Or BB for short....
or for snort?
OK... today and the last week... i produced about two dozen posts.
But never found time to post any of them...
But...
why , why? why? --- nancy kerigan...
Wow... i'm having a DRD4 7R moment... i'm gonna puff the Dragon and
hammer about truth... and love...between...brothers and sisters..
and if i HAD my WHEY...
But, but...
If i had a hammer?
I'd be a unionist?
I'd hammer on your head... all over this marxist LAND..
I'd hammer about the love between my mother and my brother....and
comrades...
all over this ham...
... whoops?
We can only eat an apple and be fruitarians... LOL
In the GARDEN of eden?
With JC who BB said is and was a vejetarian iirc!
http://en.wikipedia.org/wiki/Fruitarianism
Where is the sickle? i'm gonna bake BREAD and kill a goat
to make a nice ;pita bread souvlaki... yummmmmmoh!
http://en.wikipedia.org/wiki/Souvlaki
I'd hammer some FREEDUMBS... i'd hammer some nails... LOL
And some freudian slips?
Like Bill with his chicks..
BILL CLINTON
SURROUNDED BY
PORN STARS
http://www.tmz.com/2012/05/23/bill-clinton-porn-stars/
<snip>
And no sickle cell anemia on this trip..
Shut your mouth!
Peter, Paul & Mary - If I Had A Hammer
http://www.youtube.com/watch?v=lUKB3PxG-0E
Danger warning a dream or scheme... i'd hammer their heads with gov
triPe... LOL
Bell... ring it ...DANGER... wARNING..
Love between the brothers and sister all over this HAM...
I'd hammer those none ham eaters...
I'm gonna make them eat pork..and smoke DOPE...
LOL
and take jet planes... and crash them in to ham land eaters..
Justice... freedom...--> love.. between those ham luau types.
But if i had my WAY... what you'd say?
Peter Paul & Mary - If I Had My Way
http://www.youtube.com/watch?v=TY-699M7j3g
I'd hit those jerks in the head with the jaw bone of a democrat ass?
LOL
What? Hey Samson did it....
But...
I would use Biden's butt bone?
OK... why?
I don't know... he said osama double tap'd master of disaster obama
has a BIg STICK..
Stick.. bone... what the heck..
So quick.. hit someone.. this is a wicked WORLD..
hate is great... and the buck don't suck... yet...
Good thing i'm not having my WAY... in this wicked word.
Run those planes in to twin towers?
ok... and toss in the pentagon and white house?
yikes.. double tap... those nit wits..
PETER, PAUL & MARY Leaving On A Jet Plane
http://www.youtube.com/watch?v=_BRaJ-xgDf0&feature=related
Yikes.... leaving for 72 virgins... no more viagra? What will
ben laden do in pair of dice now?
Watch porn? LOL
==================
Wow... i'm really really glad that DRD4 7R (one allele) in my case is
OvER.
Sheesh... that peter, paul and mary crap... is pure clap trap... shut
your mouth?
Oh...
Good one.
he's a bad mother ... obama... LOL
Shaft theme lyrics
http://www.youtube.com/watch?v=GdZQu0yyrM0
Who's the black private dick
That's a sex machine to all the chicks?
SHAFT!
Ya damn right!
Who is the man that would risk his neck
For his brother man?
SHAFT!
Can you dig it?
Who's the cat that won't cop out
When there's danger all about?
SHAFT!
Right On!
They say this cat Shaft is a bad mother
SHUT YOUR MOUTH!
I'm talkin' 'bout Shaft.
THEN WE CAN DIG IT!
He's a complicated man
But no one understands him but his woman
JOHN SHAFT!
=============
Wow.. this is almost as good as putney swope
for moooooooooooochele and barack obama double
tapped the din laden... war machine..
shut you mouth!
Shaft!
But obama is putney for sure:
SONG FROM PUTNEY SWOPE by The Bully Boys Band
http://www.youtube.com/watch?v=p_vEZXWBGHE&feature=related
i guess the truth is hard to double tap... lol
putney swope part 1
http://www.youtube.com/watch?v=4MGSfGr9qFs
Whoops they GOT me... LOL
-------------
Was there something wrong with his mucka mucka gland?
Well?
I wouldn't shake his ham hock.... LOL
Will he wear obama's wedding ring now?
Tap, tap.. never coming back?
Never let him Glow... leaving on a double tap PLANE to a higher
exxxxiztence?
Oh BABE... i hate to let you GLOW!
Unless it's in japan under
2011 Tōhoku earthquake and tsunami
http://en.wikipedia.org/wiki/2011_T%C5%8Dhoku_earthquake_and_tsunami
Life is GOOD... till you droP off and hatch another ... nevermind.
Did osama smoke crack or just use it?
Did obama smoke magic dragooooon?
Yes.. so he did the double tap... on laden.. and died him..
And now osama bin laden is living in the SEA..
Frolicking with puff the magic dragooon
Peter, Paul and Mary -Puff The Magic Dragon
http://www.youtube.com/watch?v=Qu_rItLPTXc
And osama lives in the sEA...just being kewl...
No porn stars for him..
Only bill...
http://www.tmz.com/2012/05/23/bill-clinton-porn-stars/
They are sorta cute:
http://ll-media.tmz.com/2012/05/23/0523-bill-clinton-avn-stars-5.jpg
Bill Clinton just out-Clinton'd himself -- posing with two famous porn
stars in Monaco moments ago ... and one of them's a real up-and-comer.
Clinton's in a Monte Carlo casino right now for a special "Nights in
Monaco" gala event -- and several celebrities are in attendance ...
including Diane Kruger, Joshua Jackson ... and a BUNCH OF PORN STARS.
The two porn stars on Bill's arms are Tasha Reign (left) and Brooklyn
Lee -- AVN's "Best New Starlet" in porn.
Brooklyn -- who just posted the pic on her Twitter account -- also
just won the award for "Best Sex Scene" in "Mission Asspossible." As
for Tasha's film credits ... those include "Baby Got Boobs 8" and
"Farm Girls Gone Bad."
Our guess -- Bill did not have sexual relations with these women.
What it IS Bill ..
<sniP>
Will Mooooooooooooooooooochele let her man hang with Bill
when he's out of the white house?
I hope so...
Maybe they'll take me along?
I'll bring the little blue pills...
Fats Domino - Blueberry Hill (with lyrics)
http://www.youtube.com/watch?v=VdGF-G5p-00
===============
Hey.... shaft caused an epigenetic like metaphor with peter paul and
nit wit?
yep...
after shaft... those white honkies sounded... stupidly.
Your DAMN white!
Shaft...
Who is the man who'd risk .. can you dig it?
Those white albino black mean men are dodging ..
their tAX duty to keep you po... shaft men
in plantation shakles...
i hate the shakle of ...dem left wing plantations...
who does?
I don't know..
$1.5 trillion a year on the credit card for another four mo years
and ... it's shaft time..
shut your moth!
=======================ok back to toPiCOW skin... things
OK we NOW KNOW we have 10 times more methylation then normal people.
OK it's really four times as much... but i'm doing or pulling a double
tap here.
WE HAVE hyPomethylation:
3 hits: psoria* hypomethylation - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20hypomethylation
#1 of 3
http://www.ncbi.nlm.nih.gov/pubmed/22564738
The characteristics of genome-wide DNA methylation in naïve CD4+ T
cells of patients with psoriasis or atopic dermatitis.
Han J, Park SG, Bae JB, Choi J, Lyu JM, Park SH, Kim HS, Kim YJ, Kim
S, Kim TY.
Biochem Biophys Res Commun. 2012 Apr 30.
Abstract
Psoriasis and atopic dermatitis (AD) are skin diseases that are
characterized by polarized CD4+ T cell responses. During the
polarization of naïve CD4+ T cells, DNA methylation plays an important
role in the regulation of gene transcription. In this study, we
profiled the genome-wide DNA methylation status of naïve CD4+ T cells
in patients with psoriasis or AD and healthy controls using a ChIP-seq
method. Only psoriasis patient T cells, not those of AD patients,
showed distinct hypomethylation (>4-fold) compared to healthy control
T cells in twenty-six regions of the genome ranging in size from 10 to
70kb. These regions were mostly pericentromeric on 10 different
chromosomes and incidentally coincided with various strong epigenomic
signals, such as histone modifications and transcription factor
binding sites, that had been observed in the ENCODE project implying
the potential epigenetic regulation in psoriasis development. The gene-
centric analysis indicated that the promoter regions of 121 genes on
the X chromosome had dramatically elevated methylation levels in
psoriasis patient T-cells compared to those from healthy controls (>4-
fold). Moreover, immune-related genes on the X chromosome had higher
hypermethylation than other genes (P=0.046). No such patterns were
observed with AD patient T cells. These findings imply that
methylation changes in naïve CD4+ T cells may affect CD4+ T cell
polarization, especially in the pathogenesis of psoriasis.
PMID: 22564738
While PMID: 22564738 has been out a short time (less then a month)
i've posted twice and now thrice.
PMID: 22564738 - 2 hits - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+22564738&start=0&
#2 of 3:
http://www.ncbi.nlm.nih.gov/pubmed/19072642
Pharmacogenomics. 2008 Dec;9(12):1835-50.
Epigenetics and dermatological disease.
Millington GW.
Source
Dermatology Department, Norfolk & Norwich University Hospitals, NHS
Foundation Trust, Colney Lane, Norwich, NR4 7UZ, UK.
george.m...@nnuh.nhs.uk
Abstract
Epigenetics is the study of differences in phenotype, in the absence
of variation in the genetic code. Epigenetics is relevant in the
pathogenesis of many skin diseases. In the case of the common skin
cancers, aberrant methylation of tumor suppressor gene promoters is
associated with their transcriptional inactivation. Environmental
carcinogens such as ultraviolet radiation and arsenic may act through
epigenetic mechanisms. Hypomethylation is associated with activation
of systemic autoimmune diseases, such as systemic lupus erythematosus,
subacute cutaneous lupus erythematosus and scleroderma. This may be
through a mechanism of immunological cross-reactivity with
hypomethylated DNA from pathogenic bacteria. Epigenetic factors may
also be relevant in the pathogenesis of psoriasis and other
inflammatory skin diseases, as well as in the pathogenesis of the
disorders of genomic imprinting with cutaneous features.
PMID: 19072642
3 hits on this one (PMID: 19072642 ) previously - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+19072642+&start=0&
<snip>
So?
It's knocking back vitamin B-12 in the BRAIN, perhaPs?
57 hits: psoria* + vitamin B12 -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20vitamin%20B12
http://www.ncbi.nlm.nih.gov/pubmed/22607050
Nutr Metab (Lond). 2012 May 18;9(1):41.
Vitamin B12 deficiency in the brain leads to DNA hypomethylation in
the TCblR/CD320 knockout mouse.
Quadros E.
ABSTRACT: Vitamin B12 deficiency in the brain leads to DNA
hypomethylation in the TCblR/CD320 knockout mouse. Authors: Silvia
Fernandez-Roig1, Shao-Chiang Lai2, Michelle M Murphy1, Joan Fernandez-
Ballart1, Edward V Quadros2*. Institutional addresses: 1Area of
Preventive Medicine and Public Health, Faculty of Medicine and Health
Sciences, Universitat Rovira i Virgili (URV), IISPV, Reus, Spain and
CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03) Instituto
Carlos III. 2Departments of Medicine and Cell Biology, SUNY Downstate
Medical Center, Brooklyn, New York, USA. Email address for all
authors: silvia.f...@urv.cat ; shao-ch...@downstate.edu
michell...@urv.cat; joan.fernan...@urv.cat ;
edward....@downstate.edu. *Corresponding author: Prof. Edward V
Quadros, Department of Medicine, SUNY Downstate Medical Center,
Brooklyn, New York, USA.
Abstract
BACKGROUND:
DNA methylation is an epigenetic phenomenon that can modulate gene
function by up or downregulation of gene expression. Vitamin B12 and
folate pathways are involved in the production of S-
Adenosylmethionine, the universal methyl donor.
FINDINGS:
Brain vitamin B12 concentration and global DNA methylation was
determined in transcobalamin receptor (TCblR/CD320) knock out (KO)
(n=4) and control mice (n=4) at 20-24 weeks of age. Median [IQR] brain
vitamin B12 concentrations (pg/mg) in TCblR/CD320 KO mice compared
with control mice was 8.59 [0.52] vs 112.42 [33.12]; p<0.05. Global
DNA methylation levels in brain genomic DNA were lower in TCblR/CD320
KO compared with control mice (Median [IQR]: 0.31[0.16] % vs
0.55[0.15] %; p<0.05.).
CONCLUSIONS:
In TCblR/CD320 KO mice, brain vitamin B12 drops precipitously by as
much as 90% during a 20 week period. This decrease is associated with
a 40% decrease in global DNA methylation in the brain. Future research
will reveal whether the disruption in gene expression profiles due to
changes in DNA hypomethylation contribute to central nervous system
pathologies that are frequently seen in vitamin B12 deficiency.
PMID: 22607050
Free full text
http://www.nutritionandmetabolism.com/content/9/1/41
Wow... wow ,,,,, duh? Bow woW.. LoL
And 53 hits: vitamin B12 + hypomethylation - pubmed
hypomethylation vitamin B12
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20vitamin%20B12
Duh? Don't they KNOW about this in the P NG?
Gee...? Mister tar baby smells like? Aren't you guys stuPidly on the
p ng?
Yes.. but you might be suprised. LOL
OK... ready?
Ready for BLAST OFF?
Yes... yes...
10
9
8
7
666...
5
4
333333333333----->
2
1
The BIG BANG of B12... LoL
B12 - 1580 hits - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=b12&start=0&
126 of these 1,580 have : folic acid:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=b12+folic+acid+&start=0&
108 of these 126 have: zinc
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=b12+folic+acid+zinc&start=0&
A typical haPPy psoriatic person's comments on this formula:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/eb8f8088f56abc75/7454a8b8e3f02f33?lnk=gst&q=b12+folic+acid+zinc#7454a8b8e3f02f33
Don Sipler as mentioned in the last thread:
https://groups.google.com/groups/profile?enc_user=U4WlJRcAAABRJdZGpcqksFdBoeblm7qQHEKW9NLDJmh6NfYqOvKnPw
Don sipler and jR stern putting CoQ10 on the butts, toPically!
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/ac1414a2046183f/039ee2b826fec626?lnk=gst&q=#039ee2b826fec626
Don Sipler mentioned on the dAVEW psorsite:
http://www.psorsite.com/docs/coq10.html
[...] Finally, I need to mention Don Sipler’s Psoriasis Regimen.
Although this web site has actually been down for more than three
years now (the prior link is to the latest archived version), he
claimed to have gotten rid of most of his psoriasis with a combination
of several supplements, baths with oil, coal tar, and CoQ10.
If you read Sipler’s story, however, you’ll find out that his use of
CoQ10 came last, after he’d gotten rid of much of his psoriasis, and
after he began to get sunlight on his skin again. Most, if not all of
his progress probably came from the oily baths, coal tar, and sunlight
(all fairly mainstream), and the supplements he used were unlikely to
do anything for his psoriasis, including the CoQ10. Note that at the
end, he says whenever new spots of psoriasis show up, he gets rid of
the scale and slaps on more MG217, his supplement dosages apparently
not changing.
<snip>
But daveW didn't say the B12 and zinc and Folic acid did he?
let's look at what DON said:
Don Sipler on the way back machine:
http://web.archive.org/web/20000612212800/http://www.freeyellow.com/members3/bizexcel/page1.html
[...] Is this a cure for Psoriasis?
Cure, I can't go as far as that claim. From the more than fifty people
I've talked to via email who have tried this the majority have had
good results.
How does it work?
The regimen I describe increases Vitamin B12 and Folic Acid and CoQ10
in the blood. My theory, based on published research in other
diseases, is that this may eliminate a cause of Psoriasis. B12 and
CoQ10 deficiency may be caused by a disfunction in the digestive
system or a genetic predisposition. When this exists, it blocks the
absorption of B12/Folic Acid and CoQ10, important DNA building blocks
in areas of rapid proliferation of cells. When this happens our own
immune system attacks weakened cells causing inflamation that triggers
a never ending healing cycle of scaling.
[...] HERE IS WHAT I DID TO END MY PSORIASIS
I used a two phase approach.
#1 I took vitamin B12 1000mcg sublingual liquid (B Total brand can be
ordered at 1 800 700 0770 $11.95)or outside U.S. at http://www.worlddrugstore.com
and Folic Acid 800mcg (any good brand, at drug stores, $3.00 100
pills )once a day for six weeks. Or until large amounts of flaking
comes loose. I used oil in a bath to help it along once it started.
Avoid scratching or picking, remember, let the skin heal. In two to
three weeks the areas of the skin should be lighter in color, flatter
and less flaking. Continue the daily B/Folic.
#2 To speed the healing, I then used a coal tar preparation (Brand
MG217 Ointment at drug stores $8.95) on the areas of the skin once a
day every night, agressively brush off flakes so they do not block the
absorption of the lotion. It's smelly so I shower it off in the
morning before going to work. This is also good because it allows the
skin to breathe and continue healing between applications. In aprox.
1.5 weeks the lesions begin to fade. I reduced the B12 and Folic Acid
to every other day and on alternate days I take Zinc, vitamin A and D
tablets to strengthen the skin and promote healing and continued with
the coal tar ointment. In three weeks from beginning with the lotion
the redness and flaking was reduced in area 75%. In a total of 4
months from the beginning only tiny bumps were still there and light
pink or bluish scaring remained but continued to fade. At this point I
began getting outside in shorts to get some sun, which also speeds
healing. In six months I was 99.9% clear. Recently I have been taking
CoQ10 100mg capsule each day. CoQ10 or sometimes called Coenzyme Q10
or NADH is a yellowish powder usually in capsule form, it is
manufactured by many different companies and is available nearly
everywhere vitamins are sold. My few remaining small spots shrunk to
gone in two weeks without any use of the MG217. I would begin day one
with the B12/Folic Acid and the CoQ10 in the dosages I mentioned each
day
This is not magic, it takes work and developing a regular routine not
missing a day of treatment. Important I continue (two years later)
with a maintenance regimen of 100mg CoQ10 daily and checking my self
at least twice a week for any tiny beginnings of new red marks. When I
find any I agressively remove the scale and treat them with the MG217
ointment and they clear to normal skin rather quickly.
This is the basic process.
If you have any difficulty understanding any of this material or have
any further questions please don't hesitate to contact me. I will be
more than happy to answer your email as quickly and honestly as I can.
My Best Regards
Don Sipler---UPDATED 09/30/99
<snip>
For those not familiar with the wayback machine(s):
http://en.wikipedia.org/wiki/Wayback_Machine
----------
OK-- caveats on taking folic acid:
http://www.ncbi.nlm.nih.gov/pubmed/18326588
Is folic acid good for everyone?
[...] PMID: 18326588
If you ain't autoimmune and Th1 skewed you could get CANCER.
Want to risk that instead of a skin rash?
Yikes...
What do i do tar baby stuPidly Juan?
Right.... kemosabe...
Get my horse... trigger--->>>> ready!
ER ER ER.... shall we ride or fight?
Neither... we shall hit the NOON day Sunshine... and top off the d3
inside of us?
One hit of 53 (hypo's + B12) : hypomethylation vitamin B12 D3- pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20vitamin%20B12%20D3
http://www.ncbi.nlm.nih.gov/pubmed/16844314
Med Hypotheses. 2006;67(6):1448-54. Epub 2006 Jul 17.
Recursive causality in evolution: a model for epigenetic mechanisms in
cancer development.
Haslberger A, Varga F, Karlic H.
Source
Ludwig Boltzmann Institute for Leukemia Research and Hematology,
Hanusch Hospital, Heinrich Collinstrasse 30, and Vienna Ecology
Center, University of Vienna, Austria.
Abstract
Interactions between adaptative and selective processes are
illustrated in the model of recursive causality as defined in Rupert
Riedl's systems theory of evolution. One of the main features of this
theory also termed as theory of evolving complexity is the centrality
of the notion of 'recursive' or 'feedback' causality - 'the idea that
every biological effect in living systems, in some way, feeds back to
its own cause'. Our hypothesis is that "recursive" or "feedback"
causality provides a model for explaining the consequences of
interacting genetic and epigenetic mechanisms which are known to play
a key role in development of cancer. Epigenetics includes any process
that alters gene activity without changes of the DNA sequence. The
most important epigenetic mechanisms are DNA-methylation and chromatin
remodeling. Hypomethylation of so-called oncogenes and
hypermethylation of tumor suppressor genes appear to be critical
determinants of cancer. Folic acid, vitamin B12 and other nutrients
influence the function of enzymes that participate in various
methylation processes by affecting the supply of methyl groups into a
variety of molecules which may be directly or indirectly associated
with cancerogenesis. We present an example from our own studies by
showing that vitamin D3 has the potential to de-methylate the
osteocalcin-promoter in MG63 osteosarcoma cells. Consequently, a
stimulation of osteocalcin synthesis can be observed. The above
mentioned enzymes also play a role in development and differentiation
of cells and organisms and thus illustrate the close association
between evolutionary and developmental mechanisms. This enabled new
ways to understand the interaction between the genome and environment
and may improve biomedical concepts including environmental health
aspects where epigenetic and genetic modifications are closely
associated. Recent observations showed that methylated nucleotides in
the gene promoter may serve as a target for solar UV-induced mutations
of the p53 tumor suppressor gene. This illustrates the close
interaction of genetic and epigenetic mechanisms in cancerogenesis
resulting from changes in transcriptional regulation and its
contribution to a phenotype at the micro- or macroevolutionary level.
Above-mentioned interactions of genetic and epigenetic mechanisms in
oncogenesis defy explanation by plain linear causality, things like
the continuing adaptability of complex systems. They can be explained
by the concept of recursive causality and has introduced molecular
biology into the realm of cognition science and systems theory: based
on the notion of so-called feedback- or recursive causality a model
for epigenetic mechanisms with relevance for oncology and biomedicine
is provided.
PMID: 16844314
ONLY one hit for hypomethylation and D3... wow how stuPidly is
science?
Duh?
Sometimes they don't get it?
OK... let's do vitamin D and hypo..DNA.
Five hits: hypomethylation D vitamin - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20D%20vitamin
#1 of 5
http://www.ncbi.nlm.nih.gov/pubmed/22319250
Interdiscip Toxicol. 2011 Dec;4(4):167-72.
Epigenetic regulation of fetal bone development and placental transfer
of nutrients: progress for osteoporosis.
Bocheva G, Boyadjieva N.
Source
Department of Pharmacology and Toxicology, Medical Faculty, Medical
University, Sofia, Bulgaria.
Abstract
Osteoporosis is a common age-related disorder and causes acute and
long-term disability and economic cost. Many factors influence the
accumulation of bone minerals, including heredity, diet, physical
activity, gender, endocrine functions, and risk factors such as
alcohol, drug abuse, some pharmacological drugs or cigarette smoking.
The pathology of bone development during intrauterine life is a factor
for osteoporosis. Moreover, the placental transfer of nutrients plays
an important role in the building of bones of fetuses. The importance
of maternal calcium intake and vitamin D status are highlighted in
this review. Various environmental factors including nutrition state
or maternal stress may affect the epigenetic state of a number of
genes during fetal development of bones. Histone modifications as
histone hypomethylation, histone hypermethylation, hypoacetylation,
etc. are involved in chromatin remodeling, known to contribute to the
epigenetic landscape of chromosomes, and play roles in both fetal bone
development and osteoporosis. This review will give an overview of
epigenetic modulation of bone development and placental transfer of
nutrients. In addition, the data from animal and human studies support
the role of epigenetic modulation of calcium and vitamin D in the
pathogenesis of osteoporosis. We review the evidence suggesting that
various genes are involved in regulation of osteoclast formation and
differentiation by osteoblasts and stem cells. Epigenetic changes in
growth factors as well as cytokines play a rol in fetal bone
development. On balance, the data suggest that there is a link between
epigenetic changes in placental transfer of nutrients, including
calcium and vitamin D, abnormal intrauterine bone development and
pathogenesis of osteoporosis.
PMID: 22319250
Free PMC Article
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22319250/?tool=pubmed
#2 of 5
http://www.ncbi.nlm.nih.gov/pubmed/20447390
Eur J Pharmacol. 2010 Jul 25;638(1-3):47-53. Epub 2010 May 3.
Hypomethylation and induction of retinoic acid receptor beta 2 by
concurrent action of adenosine analogues and natural compounds in
breast cancer cells.
Stefanska B, Rudnicka K, Bednarek A, Fabianowska-Majewska K.
Source
Department of Biomedical Chemistry, Medical University of Lodz, 6/8
Mazowiecka Street, 92-215 Lodz, Poland.
barbara....@mail.mcgill.ca
Abstract
DNA methylation is considered as a potential cause of aberrations in
regulation of gene expression during carcinogenesis. Therefore,
changes in DNA methylation patterns may be targets for
chemoprevention. In the present study, we investigated effects of all-
trans retinoic acid (ATRA), vitamin D(3), and resveratrol alone and in
combination with adenosine analogues: 2-chloro-2'-deoxyadenosine
(2CdA) and 9-beta-D-arabinosyl-2-fluoroadenine (F-ara-A), on
methylation and expression of retinoic acid receptor beta 2 (RAR beta
2) in MCF-7 and MDA-MB-231 breast cancer cell lines. Alterations in
methylation and expression levels after treatment of cells with the
tested compounds were evaluated by methylation-sensitive restriction
analysis (MSRA) and real-time PCR, respectively. RAR beta 2 promoter
in the tested fragment was partially methylated in MCF-7 cells and non-
methylated in MDA-MB-231 cells. In MCF-7 cells, all compounds, except
for resveratrol, inhibited promoter methylation and increased
expression of RAR beta 2. All natural compounds improved the action of
2CdA and F-ara-A on RAR beta 2 methylation and/or expression.
Combination of ATRA or vitamin D(3) with 2CdA was the most effective.
In MDA-MB-231 cells, only 2CdA, F-ara-A, and ATRA induced RAR beta 2
expression without any notable effects in combined treatment. Our
results demonstrate that both natural compounds and adenosine
analogues are able to reduce promoter methylation and/or induce
expression of RAR beta 2 in non-invasive MCF-7 cells. Furthermore, the
natural compounds improve effects of adenosine analogues, however only
at early non-invasive stages of carcinogenesis.
PMID: 20447390
OMG... is the retinoic acid the limiting factor to staying CLEAR?
Could exPlain why it stops working and the reboundus profundus?
Arf arf>>>> is this a REAL rectal cranial obama moment or what?
Hey.. hey! he hasn't had it yet... LOL
Doctor doctor give him the SHAFT...?
OK..
Robert Palmer- Doctor Doctor Give Me the News (I got a bad case of
http://www.youtube.com/watch?v=jQdaSpEeBvQ
[...] Whooaaaaa
The hot summer night fell like a net
I've got to find my baby yet
I need you to soothe my head
Turn my blue heart to red
Doctor, doctor, give me the news
I've got a bad case of lovin' you
No pill's gonna cure my ill
I've got a bad case of lovin' you
A pretty face don't make no pretty heart
I learned that, buddy, from the start
You think I'm cute, a little bit shy
Momma, I ain't that kind of guy
Doctor, doctor, give me the news
I got a bad case of lovin' you
No pill's gonna cure my ill
I got a bad case of lovin' you
Whooaaa
I know you like it, you like it on top
Tell me, momma, are you gonna stop?
You had me down, 21 to zip
Smile of Judas on your lip
Shake my fist, knock on wood
I've got it bad, and I've got it good
Doctor, doctor, gimme the news
I got a bad case of lovin' you
No pill's gonna cure my ill
I got a bad case of lovin' you
<snip>
This is all for YOU know WHO....?
Who?
Is he a whoman?
But he doesn't get... the intron exon A -- G
Thingy Bob..
Or what hypoxic and toxic are A ok or GEE whiz...
put cheese on it?
And miss muffet sat on her ass eating curds/whey.
Why?
so she would grow up and be strong?
And have more little citizens?
So the brits would rule the world...
until that indian gadhi gee dude came along
And did the movie so people who don't weed, could see it..
Gandhi (film)
http://en.wikipedia.org/wiki/Gandhi_(film)
[...] the film ending with a scene of Gandhi's ashes being scattered
on the holy Ganga.[14] As this happens, we hear Gandhi in another
voiceover:[15]
“ When I despair, I remember that all through history the way of truth
and love has always won. There have been tyrants, and murderers, and
for a time they can seem invincible, but in the end they always fall.
Think of it. Always.
<snip>
It's only a white guy ripping off the poor indian guy one more TIME?
LOL
http://en.wikipedia.org/wiki/Richard_Attenborough,_Baron_Attenborough
Bad , Richard Attenborough! BAD...
=================
23 hits: hypomethylation retinoic - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20retinoic
Wow... wow... pow wow?
Time?
#1 of 23
http://www.ncbi.nlm.nih.gov/pubmed/21843507
Biochem Biophys Res Commun. 2011 Sep 2;412(3):500-5. Epub 2011 Aug 6.
All-trans retinoic acid induces cellular senescence by up-regulating
levels of p16 and p21 via promoter hypomethylation.
Lim JS, Park SH, Jang KL.
Source
Department of Microbiology, College of Natural Sciences, Pusan
National University, Busan 609-735, Republic of Korea.
Abstract
All-trans retinoic acid (ATRA) induces cellular senescence via up-
regulation of p16 and p21; however, the action mechanism of ATRA is
unknown. Here, we show that ATRA induces promoter hypomethylation of
p16 and p21 via down-regulation of DNA methyltransferases 1, 3a, and
3b to facilitate binding of Ets1/2 to the p16 promoter and p53 to the
p21 promoter, resulting in up-regulation of their expression and
subsequent induction of cellular senescence in HepG2 cells. These
effects were mediated by retinoic acid receptor β₂ whose promoter was
also hypomethylated in the presence of ATRA. Therefore, ATRA can be
considered as an epi-drug in cancer therapy.
PMID: 21843507
Well... p53 and p16 are critical if your NOT going to develop CANCER.
This next pancan makes me think about ImMucin Vaccine to treat over
80% of ALL cancer's?
It makes the p53 or p16 tumor suppressor proteins work better and some
muc1 blockage or
something kewl and then your body stops the cancer... like the gene
would have done had
stinky mucus, mucins and/or muc1 should have DONE...had they not gone
wong?
So is the hypomethylation part of the the Th1 skew and keeping
psoriatics
clear without high levels of D3, vitamin A and what nots?
This is getting LESS clear now? LOL
But taking vitamin A with the D3 and B12 and some zinc and folic acid
and xyz... and eating your curds and whey... hey!
And then being like jeanne Calment and eating copious amounts of eVOO
Extra virgin olive oil and chocolate..( two pounds a week) and live to
122.
Sounds like a plan.
Will vejetarian Bohgosity BumaskiL comply?
Or will he maintain his freedumbs to eat an apple a day?
To keep the doctor a whey?
Hey.. i did a great post on BARNES fOUNDATION and albert barnes
the guy with a $26 billion art collection..
It's in Philly...NOW..
I'll try to post it soon.
randall... what a great great..... something or other... or udder?
Mooo..!
Just thinking about
Fri, Apr 6 2012 9:29 am
Subject: Dr. Federica Sallusto & Dr. Christina Zielinski --
Biomedicine and PSOR (and MORE) Disease Causation via Fungus (Candida
vs Staph and Th2 critters) Foxp3- Tregs & IL10 vs Th17 & Th1 Skew in
YOU
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/cdc3bdf35aaff2d0
Brought back to LIFE in my MIND by vejetarian Bohgosity BumaskiL.
Or BB for short....
or for snort?
OK... today and the last week... i produced about two dozen posts.
But never found time to post any of them...
But...
why , why? why? --- nancy kerigan...
Wow... i'm having a DRD4 7R moment... i'm gonna puff the Dragon and
hammer about truth... and love...between...brothers and sisters..
and if i HAD my WHEY...
But, but...
If i had a hammer?
I'd be a unionist?
I'd hammer on your head... all over this marxist LAND..
I'd hammer about the love between my mother and my brother....and
comrades...
all over this ham...
... whoops?
We can only eat an apple and be fruitarians... LOL
In the GARDEN of eden?
With JC who BB said is and was a vejetarian iirc!
http://en.wikipedia.org/wiki/Fruitarianism
Where is the sickle? i'm gonna bake BREAD and kill a goat
to make a nice ;pita bread souvlaki... yummmmmmoh!
http://en.wikipedia.org/wiki/Souvlaki
I'd hammer some FREEDUMBS... i'd hammer some nails... LOL
And some freudian slips?
Like Bill with his chicks..
BILL CLINTON
SURROUNDED BY
PORN STARS
http://www.tmz.com/2012/05/23/bill-clinton-porn-stars/
<snip>
And no sickle cell anemia on this trip..
Shut your mouth!
Peter, Paul & Mary - If I Had A Hammer
http://www.youtube.com/watch?v=lUKB3PxG-0E
Danger warning a dream or scheme... i'd hammer their heads with gov
triPe... LOL
Bell... ring it ...DANGER... wARNING..
Love between the brothers and sister all over this HAM...
I'd hammer those none ham eaters...
I'm gonna make them eat pork..and smoke DOPE...
LOL
and take jet planes... and crash them in to ham land eaters..
Justice... freedom...--> love.. between those ham luau types.
But if i had my WAY... what you'd say?
Peter Paul & Mary - If I Had My Way
http://www.youtube.com/watch?v=TY-699M7j3g
I'd hit those jerks in the head with the jaw bone of a democrat ass?
LOL
What? Hey Samson did it....
But...
I would use Biden's butt bone?
OK... why?
I don't know... he said osama double tap'd master of disaster obama
has a BIg STICK..
Stick.. bone... what the heck..
So quick.. hit someone.. this is a wicked WORLD..
hate is great... and the buck don't suck... yet...
Good thing i'm not having my WAY... in this wicked word.
Run those planes in to twin towers?
ok... and toss in the pentagon and white house?
yikes.. double tap... those nit wits..
PETER, PAUL & MARY Leaving On A Jet Plane
http://www.youtube.com/watch?v=_BRaJ-xgDf0&feature=related
Yikes.... leaving for 72 virgins... no more viagra? What will
ben laden do in pair of dice now?
Watch porn? LOL
==================
Wow... i'm really really glad that DRD4 7R (one allele) in my case is
OvER.
Sheesh... that peter, paul and mary crap... is pure clap trap... shut
your mouth?
Oh...
Good one.
he's a bad mother ... obama... LOL
Shaft theme lyrics
http://www.youtube.com/watch?v=GdZQu0yyrM0
Who's the black private dick
That's a sex machine to all the chicks?
SHAFT!
Ya damn right!
Who is the man that would risk his neck
For his brother man?
SHAFT!
Can you dig it?
Who's the cat that won't cop out
When there's danger all about?
SHAFT!
Right On!
They say this cat Shaft is a bad mother
SHUT YOUR MOUTH!
I'm talkin' 'bout Shaft.
THEN WE CAN DIG IT!
He's a complicated man
But no one understands him but his woman
JOHN SHAFT!
=============
Wow.. this is almost as good as putney swope
for moooooooooooochele and barack obama double
tapped the din laden... war machine..
shut you mouth!
Shaft!
But obama is putney for sure:
SONG FROM PUTNEY SWOPE by The Bully Boys Band
http://www.youtube.com/watch?v=p_vEZXWBGHE&feature=related
i guess the truth is hard to double tap... lol
putney swope part 1
http://www.youtube.com/watch?v=4MGSfGr9qFs
Whoops they GOT me... LOL
-------------
Was there something wrong with his mucka mucka gland?
Well?
I wouldn't shake his ham hock.... LOL
Will he wear obama's wedding ring now?
Tap, tap.. never coming back?
Never let him Glow... leaving on a double tap PLANE to a higher
exxxxiztence?
Oh BABE... i hate to let you GLOW!
Unless it's in japan under
2011 Tōhoku earthquake and tsunami
http://en.wikipedia.org/wiki/2011_T%C5%8Dhoku_earthquake_and_tsunami
Life is GOOD... till you droP off and hatch another ... nevermind.
Did osama smoke crack or just use it?
Did obama smoke magic dragooooon?
Yes.. so he did the double tap... on laden.. and died him..
And now osama bin laden is living in the SEA..
Frolicking with puff the magic dragooon
Peter, Paul and Mary -Puff The Magic Dragon
http://www.youtube.com/watch?v=Qu_rItLPTXc
And osama lives in the sEA...just being kewl...
No porn stars for him..
Only bill...
http://www.tmz.com/2012/05/23/bill-clinton-porn-stars/
They are sorta cute:
http://ll-media.tmz.com/2012/05/23/0523-bill-clinton-avn-stars-5.jpg
Bill Clinton just out-Clinton'd himself -- posing with two famous porn
stars in Monaco moments ago ... and one of them's a real up-and-comer.
Clinton's in a Monte Carlo casino right now for a special "Nights in
Monaco" gala event -- and several celebrities are in attendance ...
including Diane Kruger, Joshua Jackson ... and a BUNCH OF PORN STARS.
The two porn stars on Bill's arms are Tasha Reign (left) and Brooklyn
Lee -- AVN's "Best New Starlet" in porn.
Brooklyn -- who just posted the pic on her Twitter account -- also
just won the award for "Best Sex Scene" in "Mission Asspossible." As
for Tasha's film credits ... those include "Baby Got Boobs 8" and
"Farm Girls Gone Bad."
Our guess -- Bill did not have sexual relations with these women.
What it IS Bill ..
<sniP>
Will Mooooooooooooooooooochele let her man hang with Bill
when he's out of the white house?
I hope so...
Maybe they'll take me along?
I'll bring the little blue pills...
Fats Domino - Blueberry Hill (with lyrics)
http://www.youtube.com/watch?v=VdGF-G5p-00
===============
Hey.... shaft caused an epigenetic like metaphor with peter paul and
nit wit?
yep...
after shaft... those white honkies sounded... stupidly.
Your DAMN white!
Shaft...
Who is the man who'd risk .. can you dig it?
Those white albino black mean men are dodging ..
their tAX duty to keep you po... shaft men
in plantation shakles...
i hate the shakle of ...dem left wing plantations...
who does?
I don't know..
$1.5 trillion a year on the credit card for another four mo years
and ... it's shaft time..
shut your moth!
=======================ok back to toPiCOW skin... things
OK we NOW KNOW we have 10 times more methylation then normal people.
OK it's really four times as much... but i'm doing or pulling a double
tap here.
WE HAVE hyPomethylation:
3 hits: psoria* hypomethylation - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20hypomethylation
#1 of 3
http://www.ncbi.nlm.nih.gov/pubmed/22564738
The characteristics of genome-wide DNA methylation in naïve CD4+ T
cells of patients with psoriasis or atopic dermatitis.
Han J, Park SG, Bae JB, Choi J, Lyu JM, Park SH, Kim HS, Kim YJ, Kim
S, Kim TY.
Biochem Biophys Res Commun. 2012 Apr 30.
Abstract
Psoriasis and atopic dermatitis (AD) are skin diseases that are
characterized by polarized CD4+ T cell responses. During the
polarization of naïve CD4+ T cells, DNA methylation plays an important
role in the regulation of gene transcription. In this study, we
profiled the genome-wide DNA methylation status of naïve CD4+ T cells
in patients with psoriasis or AD and healthy controls using a ChIP-seq
method. Only psoriasis patient T cells, not those of AD patients,
showed distinct hypomethylation (>4-fold) compared to healthy control
T cells in twenty-six regions of the genome ranging in size from 10 to
70kb. These regions were mostly pericentromeric on 10 different
chromosomes and incidentally coincided with various strong epigenomic
signals, such as histone modifications and transcription factor
binding sites, that had been observed in the ENCODE project implying
the potential epigenetic regulation in psoriasis development. The gene-
centric analysis indicated that the promoter regions of 121 genes on
the X chromosome had dramatically elevated methylation levels in
psoriasis patient T-cells compared to those from healthy controls (>4-
fold). Moreover, immune-related genes on the X chromosome had higher
hypermethylation than other genes (P=0.046). No such patterns were
observed with AD patient T cells. These findings imply that
methylation changes in naïve CD4+ T cells may affect CD4+ T cell
polarization, especially in the pathogenesis of psoriasis.
PMID: 22564738
While PMID: 22564738 has been out a short time (less then a month)
i've posted twice and now thrice.
PMID: 22564738 - 2 hits - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+22564738&start=0&
#2 of 3:
http://www.ncbi.nlm.nih.gov/pubmed/19072642
Pharmacogenomics. 2008 Dec;9(12):1835-50.
Epigenetics and dermatological disease.
Millington GW.
Source
Dermatology Department, Norfolk & Norwich University Hospitals, NHS
Foundation Trust, Colney Lane, Norwich, NR4 7UZ, UK.
george.m...@nnuh.nhs.uk
Abstract
Epigenetics is the study of differences in phenotype, in the absence
of variation in the genetic code. Epigenetics is relevant in the
pathogenesis of many skin diseases. In the case of the common skin
cancers, aberrant methylation of tumor suppressor gene promoters is
associated with their transcriptional inactivation. Environmental
carcinogens such as ultraviolet radiation and arsenic may act through
epigenetic mechanisms. Hypomethylation is associated with activation
of systemic autoimmune diseases, such as systemic lupus erythematosus,
subacute cutaneous lupus erythematosus and scleroderma. This may be
through a mechanism of immunological cross-reactivity with
hypomethylated DNA from pathogenic bacteria. Epigenetic factors may
also be relevant in the pathogenesis of psoriasis and other
inflammatory skin diseases, as well as in the pathogenesis of the
disorders of genomic imprinting with cutaneous features.
PMID: 19072642
3 hits on this one (PMID: 19072642 ) previously - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=PMID%3A+19072642+&start=0&
<snip>
So?
It's knocking back vitamin B-12 in the BRAIN, perhaPs?
57 hits: psoria* + vitamin B12 -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20vitamin%20B12
http://www.ncbi.nlm.nih.gov/pubmed/22607050
Nutr Metab (Lond). 2012 May 18;9(1):41.
Vitamin B12 deficiency in the brain leads to DNA hypomethylation in
the TCblR/CD320 knockout mouse.
Quadros E.
ABSTRACT: Vitamin B12 deficiency in the brain leads to DNA
hypomethylation in the TCblR/CD320 knockout mouse. Authors: Silvia
Fernandez-Roig1, Shao-Chiang Lai2, Michelle M Murphy1, Joan Fernandez-
Ballart1, Edward V Quadros2*. Institutional addresses: 1Area of
Preventive Medicine and Public Health, Faculty of Medicine and Health
Sciences, Universitat Rovira i Virgili (URV), IISPV, Reus, Spain and
CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03) Instituto
Carlos III. 2Departments of Medicine and Cell Biology, SUNY Downstate
Medical Center, Brooklyn, New York, USA. Email address for all
authors: silvia.f...@urv.cat ; shao-ch...@downstate.edu
michell...@urv.cat; joan.fernan...@urv.cat ;
edward....@downstate.edu. *Corresponding author: Prof. Edward V
Quadros, Department of Medicine, SUNY Downstate Medical Center,
Brooklyn, New York, USA.
Abstract
BACKGROUND:
DNA methylation is an epigenetic phenomenon that can modulate gene
function by up or downregulation of gene expression. Vitamin B12 and
folate pathways are involved in the production of S-
Adenosylmethionine, the universal methyl donor.
FINDINGS:
Brain vitamin B12 concentration and global DNA methylation was
determined in transcobalamin receptor (TCblR/CD320) knock out (KO)
(n=4) and control mice (n=4) at 20-24 weeks of age. Median [IQR] brain
vitamin B12 concentrations (pg/mg) in TCblR/CD320 KO mice compared
with control mice was 8.59 [0.52] vs 112.42 [33.12]; p<0.05. Global
DNA methylation levels in brain genomic DNA were lower in TCblR/CD320
KO compared with control mice (Median [IQR]: 0.31[0.16] % vs
0.55[0.15] %; p<0.05.).
CONCLUSIONS:
In TCblR/CD320 KO mice, brain vitamin B12 drops precipitously by as
much as 90% during a 20 week period. This decrease is associated with
a 40% decrease in global DNA methylation in the brain. Future research
will reveal whether the disruption in gene expression profiles due to
changes in DNA hypomethylation contribute to central nervous system
pathologies that are frequently seen in vitamin B12 deficiency.
PMID: 22607050
Free full text
http://www.nutritionandmetabolism.com/content/9/1/41
Wow... wow ,,,,, duh? Bow woW.. LoL
And 53 hits: vitamin B12 + hypomethylation - pubmed
hypomethylation vitamin B12
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20vitamin%20B12
Duh? Don't they KNOW about this in the P NG?
Gee...? Mister tar baby smells like? Aren't you guys stuPidly on the
p ng?
Yes.. but you might be suprised. LOL
OK... ready?
Ready for BLAST OFF?
Yes... yes...
10
9
8
7
666...
5
4
333333333333----->
2
1
The BIG BANG of B12... LoL
B12 - 1580 hits - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=b12&start=0&
126 of these 1,580 have : folic acid:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=b12+folic+acid+&start=0&
108 of these 126 have: zinc
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=b12+folic+acid+zinc&start=0&
A typical haPPy psoriatic person's comments on this formula:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/eb8f8088f56abc75/7454a8b8e3f02f33?lnk=gst&q=b12+folic+acid+zinc#7454a8b8e3f02f33
Don Sipler as mentioned in the last thread:
https://groups.google.com/groups/profile?enc_user=U4WlJRcAAABRJdZGpcqksFdBoeblm7qQHEKW9NLDJmh6NfYqOvKnPw
Don sipler and jR stern putting CoQ10 on the butts, toPically!
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/ac1414a2046183f/039ee2b826fec626?lnk=gst&q=#039ee2b826fec626
Don Sipler mentioned on the dAVEW psorsite:
http://www.psorsite.com/docs/coq10.html
[...] Finally, I need to mention Don Sipler’s Psoriasis Regimen.
Although this web site has actually been down for more than three
years now (the prior link is to the latest archived version), he
claimed to have gotten rid of most of his psoriasis with a combination
of several supplements, baths with oil, coal tar, and CoQ10.
If you read Sipler’s story, however, you’ll find out that his use of
CoQ10 came last, after he’d gotten rid of much of his psoriasis, and
after he began to get sunlight on his skin again. Most, if not all of
his progress probably came from the oily baths, coal tar, and sunlight
(all fairly mainstream), and the supplements he used were unlikely to
do anything for his psoriasis, including the CoQ10. Note that at the
end, he says whenever new spots of psoriasis show up, he gets rid of
the scale and slaps on more MG217, his supplement dosages apparently
not changing.
<snip>
But daveW didn't say the B12 and zinc and Folic acid did he?
let's look at what DON said:
Don Sipler on the way back machine:
http://web.archive.org/web/20000612212800/http://www.freeyellow.com/members3/bizexcel/page1.html
[...] Is this a cure for Psoriasis?
Cure, I can't go as far as that claim. From the more than fifty people
I've talked to via email who have tried this the majority have had
good results.
How does it work?
The regimen I describe increases Vitamin B12 and Folic Acid and CoQ10
in the blood. My theory, based on published research in other
diseases, is that this may eliminate a cause of Psoriasis. B12 and
CoQ10 deficiency may be caused by a disfunction in the digestive
system or a genetic predisposition. When this exists, it blocks the
absorption of B12/Folic Acid and CoQ10, important DNA building blocks
in areas of rapid proliferation of cells. When this happens our own
immune system attacks weakened cells causing inflamation that triggers
a never ending healing cycle of scaling.
[...] HERE IS WHAT I DID TO END MY PSORIASIS
I used a two phase approach.
#1 I took vitamin B12 1000mcg sublingual liquid (B Total brand can be
ordered at 1 800 700 0770 $11.95)or outside U.S. at http://www.worlddrugstore.com
and Folic Acid 800mcg (any good brand, at drug stores, $3.00 100
pills )once a day for six weeks. Or until large amounts of flaking
comes loose. I used oil in a bath to help it along once it started.
Avoid scratching or picking, remember, let the skin heal. In two to
three weeks the areas of the skin should be lighter in color, flatter
and less flaking. Continue the daily B/Folic.
#2 To speed the healing, I then used a coal tar preparation (Brand
MG217 Ointment at drug stores $8.95) on the areas of the skin once a
day every night, agressively brush off flakes so they do not block the
absorption of the lotion. It's smelly so I shower it off in the
morning before going to work. This is also good because it allows the
skin to breathe and continue healing between applications. In aprox.
1.5 weeks the lesions begin to fade. I reduced the B12 and Folic Acid
to every other day and on alternate days I take Zinc, vitamin A and D
tablets to strengthen the skin and promote healing and continued with
the coal tar ointment. In three weeks from beginning with the lotion
the redness and flaking was reduced in area 75%. In a total of 4
months from the beginning only tiny bumps were still there and light
pink or bluish scaring remained but continued to fade. At this point I
began getting outside in shorts to get some sun, which also speeds
healing. In six months I was 99.9% clear. Recently I have been taking
CoQ10 100mg capsule each day. CoQ10 or sometimes called Coenzyme Q10
or NADH is a yellowish powder usually in capsule form, it is
manufactured by many different companies and is available nearly
everywhere vitamins are sold. My few remaining small spots shrunk to
gone in two weeks without any use of the MG217. I would begin day one
with the B12/Folic Acid and the CoQ10 in the dosages I mentioned each
day
This is not magic, it takes work and developing a regular routine not
missing a day of treatment. Important I continue (two years later)
with a maintenance regimen of 100mg CoQ10 daily and checking my self
at least twice a week for any tiny beginnings of new red marks. When I
find any I agressively remove the scale and treat them with the MG217
ointment and they clear to normal skin rather quickly.
This is the basic process.
If you have any difficulty understanding any of this material or have
any further questions please don't hesitate to contact me. I will be
more than happy to answer your email as quickly and honestly as I can.
My Best Regards
Don Sipler---UPDATED 09/30/99
<snip>
For those not familiar with the wayback machine(s):
http://en.wikipedia.org/wiki/Wayback_Machine
----------
OK-- caveats on taking folic acid:
http://www.ncbi.nlm.nih.gov/pubmed/18326588
Is folic acid good for everyone?
[...] PMID: 18326588
If you ain't autoimmune and Th1 skewed you could get CANCER.
Want to risk that instead of a skin rash?
Yikes...
What do i do tar baby stuPidly Juan?
Right.... kemosabe...
Get my horse... trigger--->>>> ready!
ER ER ER.... shall we ride or fight?
Neither... we shall hit the NOON day Sunshine... and top off the d3
inside of us?
One hit of 53 (hypo's + B12) : hypomethylation vitamin B12 D3- pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20vitamin%20B12%20D3
http://www.ncbi.nlm.nih.gov/pubmed/16844314
Med Hypotheses. 2006;67(6):1448-54. Epub 2006 Jul 17.
Recursive causality in evolution: a model for epigenetic mechanisms in
cancer development.
Haslberger A, Varga F, Karlic H.
Source
Ludwig Boltzmann Institute for Leukemia Research and Hematology,
Hanusch Hospital, Heinrich Collinstrasse 30, and Vienna Ecology
Center, University of Vienna, Austria.
Abstract
Interactions between adaptative and selective processes are
illustrated in the model of recursive causality as defined in Rupert
Riedl's systems theory of evolution. One of the main features of this
theory also termed as theory of evolving complexity is the centrality
of the notion of 'recursive' or 'feedback' causality - 'the idea that
every biological effect in living systems, in some way, feeds back to
its own cause'. Our hypothesis is that "recursive" or "feedback"
causality provides a model for explaining the consequences of
interacting genetic and epigenetic mechanisms which are known to play
a key role in development of cancer. Epigenetics includes any process
that alters gene activity without changes of the DNA sequence. The
most important epigenetic mechanisms are DNA-methylation and chromatin
remodeling. Hypomethylation of so-called oncogenes and
hypermethylation of tumor suppressor genes appear to be critical
determinants of cancer. Folic acid, vitamin B12 and other nutrients
influence the function of enzymes that participate in various
methylation processes by affecting the supply of methyl groups into a
variety of molecules which may be directly or indirectly associated
with cancerogenesis. We present an example from our own studies by
showing that vitamin D3 has the potential to de-methylate the
osteocalcin-promoter in MG63 osteosarcoma cells. Consequently, a
stimulation of osteocalcin synthesis can be observed. The above
mentioned enzymes also play a role in development and differentiation
of cells and organisms and thus illustrate the close association
between evolutionary and developmental mechanisms. This enabled new
ways to understand the interaction between the genome and environment
and may improve biomedical concepts including environmental health
aspects where epigenetic and genetic modifications are closely
associated. Recent observations showed that methylated nucleotides in
the gene promoter may serve as a target for solar UV-induced mutations
of the p53 tumor suppressor gene. This illustrates the close
interaction of genetic and epigenetic mechanisms in cancerogenesis
resulting from changes in transcriptional regulation and its
contribution to a phenotype at the micro- or macroevolutionary level.
Above-mentioned interactions of genetic and epigenetic mechanisms in
oncogenesis defy explanation by plain linear causality, things like
the continuing adaptability of complex systems. They can be explained
by the concept of recursive causality and has introduced molecular
biology into the realm of cognition science and systems theory: based
on the notion of so-called feedback- or recursive causality a model
for epigenetic mechanisms with relevance for oncology and biomedicine
is provided.
PMID: 16844314
ONLY one hit for hypomethylation and D3... wow how stuPidly is
science?
Duh?
Sometimes they don't get it?
OK... let's do vitamin D and hypo..DNA.
Five hits: hypomethylation D vitamin - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20D%20vitamin
#1 of 5
http://www.ncbi.nlm.nih.gov/pubmed/22319250
Interdiscip Toxicol. 2011 Dec;4(4):167-72.
Epigenetic regulation of fetal bone development and placental transfer
of nutrients: progress for osteoporosis.
Bocheva G, Boyadjieva N.
Source
Department of Pharmacology and Toxicology, Medical Faculty, Medical
University, Sofia, Bulgaria.
Abstract
Osteoporosis is a common age-related disorder and causes acute and
long-term disability and economic cost. Many factors influence the
accumulation of bone minerals, including heredity, diet, physical
activity, gender, endocrine functions, and risk factors such as
alcohol, drug abuse, some pharmacological drugs or cigarette smoking.
The pathology of bone development during intrauterine life is a factor
for osteoporosis. Moreover, the placental transfer of nutrients plays
an important role in the building of bones of fetuses. The importance
of maternal calcium intake and vitamin D status are highlighted in
this review. Various environmental factors including nutrition state
or maternal stress may affect the epigenetic state of a number of
genes during fetal development of bones. Histone modifications as
histone hypomethylation, histone hypermethylation, hypoacetylation,
etc. are involved in chromatin remodeling, known to contribute to the
epigenetic landscape of chromosomes, and play roles in both fetal bone
development and osteoporosis. This review will give an overview of
epigenetic modulation of bone development and placental transfer of
nutrients. In addition, the data from animal and human studies support
the role of epigenetic modulation of calcium and vitamin D in the
pathogenesis of osteoporosis. We review the evidence suggesting that
various genes are involved in regulation of osteoclast formation and
differentiation by osteoblasts and stem cells. Epigenetic changes in
growth factors as well as cytokines play a rol in fetal bone
development. On balance, the data suggest that there is a link between
epigenetic changes in placental transfer of nutrients, including
calcium and vitamin D, abnormal intrauterine bone development and
pathogenesis of osteoporosis.
PMID: 22319250
Free PMC Article
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22319250/?tool=pubmed
#2 of 5
http://www.ncbi.nlm.nih.gov/pubmed/20447390
Eur J Pharmacol. 2010 Jul 25;638(1-3):47-53. Epub 2010 May 3.
Hypomethylation and induction of retinoic acid receptor beta 2 by
concurrent action of adenosine analogues and natural compounds in
breast cancer cells.
Stefanska B, Rudnicka K, Bednarek A, Fabianowska-Majewska K.
Source
Department of Biomedical Chemistry, Medical University of Lodz, 6/8
Mazowiecka Street, 92-215 Lodz, Poland.
barbara....@mail.mcgill.ca
Abstract
DNA methylation is considered as a potential cause of aberrations in
regulation of gene expression during carcinogenesis. Therefore,
changes in DNA methylation patterns may be targets for
chemoprevention. In the present study, we investigated effects of all-
trans retinoic acid (ATRA), vitamin D(3), and resveratrol alone and in
combination with adenosine analogues: 2-chloro-2'-deoxyadenosine
(2CdA) and 9-beta-D-arabinosyl-2-fluoroadenine (F-ara-A), on
methylation and expression of retinoic acid receptor beta 2 (RAR beta
2) in MCF-7 and MDA-MB-231 breast cancer cell lines. Alterations in
methylation and expression levels after treatment of cells with the
tested compounds were evaluated by methylation-sensitive restriction
analysis (MSRA) and real-time PCR, respectively. RAR beta 2 promoter
in the tested fragment was partially methylated in MCF-7 cells and non-
methylated in MDA-MB-231 cells. In MCF-7 cells, all compounds, except
for resveratrol, inhibited promoter methylation and increased
expression of RAR beta 2. All natural compounds improved the action of
2CdA and F-ara-A on RAR beta 2 methylation and/or expression.
Combination of ATRA or vitamin D(3) with 2CdA was the most effective.
In MDA-MB-231 cells, only 2CdA, F-ara-A, and ATRA induced RAR beta 2
expression without any notable effects in combined treatment. Our
results demonstrate that both natural compounds and adenosine
analogues are able to reduce promoter methylation and/or induce
expression of RAR beta 2 in non-invasive MCF-7 cells. Furthermore, the
natural compounds improve effects of adenosine analogues, however only
at early non-invasive stages of carcinogenesis.
PMID: 20447390
OMG... is the retinoic acid the limiting factor to staying CLEAR?
Could exPlain why it stops working and the reboundus profundus?
Arf arf>>>> is this a REAL rectal cranial obama moment or what?
Hey.. hey! he hasn't had it yet... LOL
Doctor doctor give him the SHAFT...?
OK..
Robert Palmer- Doctor Doctor Give Me the News (I got a bad case of
http://www.youtube.com/watch?v=jQdaSpEeBvQ
[...] Whooaaaaa
The hot summer night fell like a net
I've got to find my baby yet
I need you to soothe my head
Turn my blue heart to red
Doctor, doctor, give me the news
I've got a bad case of lovin' you
No pill's gonna cure my ill
I've got a bad case of lovin' you
A pretty face don't make no pretty heart
I learned that, buddy, from the start
You think I'm cute, a little bit shy
Momma, I ain't that kind of guy
Doctor, doctor, give me the news
I got a bad case of lovin' you
No pill's gonna cure my ill
I got a bad case of lovin' you
Whooaaa
I know you like it, you like it on top
Tell me, momma, are you gonna stop?
You had me down, 21 to zip
Smile of Judas on your lip
Shake my fist, knock on wood
I've got it bad, and I've got it good
Doctor, doctor, gimme the news
I got a bad case of lovin' you
No pill's gonna cure my ill
I got a bad case of lovin' you
<snip>
This is all for YOU know WHO....?
Who?
Is he a whoman?
But he doesn't get... the intron exon A -- G
Thingy Bob..
Or what hypoxic and toxic are A ok or GEE whiz...
put cheese on it?
And miss muffet sat on her ass eating curds/whey.
Why?
so she would grow up and be strong?
And have more little citizens?
So the brits would rule the world...
until that indian gadhi gee dude came along
And did the movie so people who don't weed, could see it..
Gandhi (film)
http://en.wikipedia.org/wiki/Gandhi_(film)
[...] the film ending with a scene of Gandhi's ashes being scattered
on the holy Ganga.[14] As this happens, we hear Gandhi in another
voiceover:[15]
“ When I despair, I remember that all through history the way of truth
and love has always won. There have been tyrants, and murderers, and
for a time they can seem invincible, but in the end they always fall.
Think of it. Always.
<snip>
It's only a white guy ripping off the poor indian guy one more TIME?
LOL
http://en.wikipedia.org/wiki/Richard_Attenborough,_Baron_Attenborough
Bad , Richard Attenborough! BAD...
=================
23 hits: hypomethylation retinoic - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=hypomethylation%20retinoic
Wow... wow... pow wow?
Time?
#1 of 23
http://www.ncbi.nlm.nih.gov/pubmed/21843507
Biochem Biophys Res Commun. 2011 Sep 2;412(3):500-5. Epub 2011 Aug 6.
All-trans retinoic acid induces cellular senescence by up-regulating
levels of p16 and p21 via promoter hypomethylation.
Lim JS, Park SH, Jang KL.
Source
Department of Microbiology, College of Natural Sciences, Pusan
National University, Busan 609-735, Republic of Korea.
Abstract
All-trans retinoic acid (ATRA) induces cellular senescence via up-
regulation of p16 and p21; however, the action mechanism of ATRA is
unknown. Here, we show that ATRA induces promoter hypomethylation of
p16 and p21 via down-regulation of DNA methyltransferases 1, 3a, and
3b to facilitate binding of Ets1/2 to the p16 promoter and p53 to the
p21 promoter, resulting in up-regulation of their expression and
subsequent induction of cellular senescence in HepG2 cells. These
effects were mediated by retinoic acid receptor β₂ whose promoter was
also hypomethylated in the presence of ATRA. Therefore, ATRA can be
considered as an epi-drug in cancer therapy.
PMID: 21843507
Well... p53 and p16 are critical if your NOT going to develop CANCER.
This next pancan makes me think about ImMucin Vaccine to treat over
80% of ALL cancer's?
It makes the p53 or p16 tumor suppressor proteins work better and some
muc1 blockage or
something kewl and then your body stops the cancer... like the gene
would have done had
stinky mucus, mucins and/or muc1 should have DONE...had they not gone
wong?
So is the hypomethylation part of the the Th1 skew and keeping
psoriatics
clear without high levels of D3, vitamin A and what nots?
This is getting LESS clear now? LOL
But taking vitamin A with the D3 and B12 and some zinc and folic acid
and xyz... and eating your curds and whey... hey!
And then being like jeanne Calment and eating copious amounts of eVOO
Extra virgin olive oil and chocolate..( two pounds a week) and live to
122.
Sounds like a plan.
Will vejetarian Bohgosity BumaskiL comply?
Or will he maintain his freedumbs to eat an apple a day?
To keep the doctor a whey?
Hey.. i did a great post on BARNES fOUNDATION and albert barnes
the guy with a $26 billion art collection..
It's in Philly...NOW..
I'll try to post it soon.
randall... what a great great..... something or other... or udder?
Mooo..!
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