Iron In PCOS and Hyperandrogenemia

[tom hennessy]

Body iron stores and glucose intolerance in premenopausal
women: role of hyperandrogenism, insulin resistance and
genomic variants related to inflammation, oxidative stress
and iron metabolism
Mª Ángeles Martínez-García, Ph.D., Manuel Luque-Ramírez, M.D., Ph.D.,
José L. San-Millán, Ph.D. and Héctor F. Escobar-Morreale, M.D., Ph.D.
Departments of Endocrinology and
Molecular Genetics, Hospital Universitario Ramón y Cajal &
Universidad de Alcalá, Madrid, and Centro de Investigaciones
Biomédicas en Red de Diabetes y Enfermedades Metabólicas
Asociadas CIBERDEM, Spain
hescob...@salud.madrid.org

ABSTRACT

Objective—
Increased serum ferritin levels and iron stores might be involved in
the development of abnormal glucose tolerance in women presenting with
obesity and or polycystic ovary syndrome (PCOS).
We aimed to study the determinants of serum ferritin levels in
premenopausal women among indexes of insulin resistance, adiposity,
hyperandrogenism and genotypes pertaining to inflammation, oxidative
stress and iron metabolism.

Research Design and Methods—
Two hundred fifty-seven premenopausal women, classified depending on
the presence or absence of PCOS, obesity and/or abnormal glucose
tolerance, were submitted to a complete metabolic evaluation, serum
ferritin, haptoglobin and C-reactive protein (CRP) measurements, and
genotyping for proinflammatory and prooxidant variants and mutations
in the HFE gene.

Results—
Serum ferritin concentrations were increased in women presenting with
PCOS and/or abnormal glucose tolerance, independently of obesity.
A stepwise multivariate linear regression analysis (R2 = 0.18, P <
0.0001) retained menstrual regularity (β = 0.14, P = 0.035), free
testosterone (β = 0.14, P = 0.052), insulin sensitivity index (β = – 0.12, P =
0.012),
His63Asp variant in HFE (β = 0.16, P = 0.008) and abnormal glucose
tolerance (β = 0.15, P = 0.015) as significant predictors of the
logarithm of ferritin levels, whereas neither CRP, haptoglobin, waist to hip
ratio nor variants in the TNF, TNFRSF1B, IL6, IL6ST, IL6R, PON-1 and HFE
Cys282Tyr mutation exerted any influence.

Conclusions—
Androgen excess (partly because of hyperandrogenemia and partly
because of menstrual dysfunction), insulin resistance, abnormal glucose
tolerance and HFE His63Asp variant correlate with ferritin levels in premenopausal women.

https://pubmed.ncbi.nlm.nih.gov/19401444/

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"Reduction of the body iron stores can improve hyperandrogenemia and insulin resistance"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716867

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