Choline In MS
ironjustice
The effectiveness of choline citrate infusions monitored
by lymphocyte transformation test (LTT) in multiple sclerosis.
A new approach to the diagnosis and treatment of the disease.
Muss C, Stejskal V, Titel E
Neuro Endocrinol Lett 2009 Aug 26; 30(3):331-334.
The efficacy of intravenous choline citrate infusions was
investigated in 34 patients with multiple sclerosis (MS) by
clinical evaluation and by monitoring of lymphocyte proliferation
in vitro against fragments of myelin basic protein (MOG-35-55,
MBP15-31, PLP 39-15) over a period of 12 weeks.
Patients have been diagnosed with MS at least one year before
entering the study and suffered from mild relapsing/remitting course
to long-term chronic progressive disease.
Twenty one patients exhibited positive lymphocyte proliferation to
myelin fragments prior to treatment and were therefore selected for
further studies.
Choline citrate was administered with a dosage of 1200mg/ 2x week
for a period of 3 months.
This treatment resulted in a significant decrease of lymphocyte
proliferation to neural fragments (MOG- 35-55, MBP15-31) in
lymphocyte
transformation test (LTT).
There was no significant SI change of PLP Peptide (PLP 39-15) LTT
found after treatment with choline citrate.
During the 3 mo observation period, patients remained stable and
no side-effects of the treatment were observed.
In addition, some patients reported long-lasting improvement (less
paresthesia and increase of muscle strength in lower extremities)
which
was demonstrated up to 3 years later.
In one spectacular case a commercial pilot was able to return to duty
again after treatment.
This pilot was allowed back in to his position as a commercial flying
cockpit member and is on duty for more than 4 yrs now.
Neuro endocrinology letters [Neuro Endocrinol Lett]
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ironjustice
commercial pilot <<
Hmmm .. altitude ..
Therefore erythrocytosis / polycythemia / thick blood ..
Sooo was the MS in the pilot just misdiagnosed erythrocytosis / thick
blood since MS .. IS more prevalent at ..
altitude .. ?
THAT is coincidence .. ?
"High altitude areas have the highest frequency of MS patients"
High altitude areas, both the northern and southern hemispheres, seem
to have the highest frequency of MS patients. There were 50 to 100
cases per 100,000 in the higher latitudes and only 5 to 10 cases per
100,000 in the tropics [Agranoff, et al. "Diet and the Geographical
Distribution of Multiple Sclerosis." Lancet. V.2. (1974) p.1061-1066.
