Iron In Rosacea

[ironjustice]

The role of oxidative stress and iron in pathophysiology of rosacea.
Tisma VS, Poljak-Blazi M
Lijec Vjesn 2011 Jul-Aug; 133(7-8):288-91.

Rosacea is a common skin disease of unknown etiology.
The aim of the present paper is to explain the role of oxidative
stress triggered by UV light and iron metabolism in the
pathophysiology of rosacea.
It was recently described that the number of ferritin positive cells
was significantly higher in skin samples of rosacea patients compared
to controls of healthy skin samples.
The presence of ferritin was significantly higher in patients with the
severe stage of disease.
In addition, serum peroxide levels were significantly higher and serum
total antioxidative potential levels were significantly lower in
rosacea patients than in healthy controls.
These results support the role of oxidative stress and affected
metabolism of iron in etiology of rosacea.
The higher presence of ferritin in skin cells of rosacea patients
explains the exacerbation of symptoms by exposure to UV light, that
releases ferritin free iron, which is fundamental in the generation of
oxidative stress.

Lijec̆nic̆ki vjesnik [Lijec Vjesn]

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Rosacea associated with polycythemia vera: Skin lesions improved with
phlebotomy
Suhr, Ki-Beom; Yoon, Ji-Seong; Lee, Jeung-Hoon; Park, Jang-Kyu 1994
Annals of Dermatology 6(1): 98-101

We report a case of rosacea in a 65 year old female with a 14 year
history of polycythemia vera. The patient suffered from several
constitutional symptoms and signs suggestive of polycythemia vera.
Six
years prior to our initial examination, erythematous lesions were
first noted on the center of the face. These lesions exhibited
periodic improvement and exacerbation without specific treatment.
Histopathologic examination of the facial lesions showed nodular
infiltration of lymphocytes and histiocytes and dilation of blood
vessels. On the basis of laboratory examination, the patient was
diagnosed as polycythemia vera. The patient has received
metronidazole, tetracycline, and topical steroids to control rosacea-
like facial lesions. The treatment results were not significant.
However, phlebotomy markedly improved the skin lesion. To our
knowledge, there are no reports describing the clinical course of
rosacea lesions following the treatment with phlebotomy.


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