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Re: L-arginine for treatment of interstitial cystitis
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kimberly...@gmail.com
Nov 17, 2015, 6:52:50 PM11/17/15
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On Sunday, May 9, 1999 at 12:00:00 AM UTC-7, Anonymous wrote:
> J Urol 1999 Feb;161(2):558-65
>
> A randomized double-blind trial of oral L-arginine for treatment
> of interstitial cystitis.
>
> Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE Jr
>
> Department of Surgery, Yale University School of Medicine, New
> Haven, Connecticut 06520-8041, USA.
>
> PURPOSE: Nitric oxide synthase activity is decreased in the
> urine of patients with interstitial cystitis compared to the
> urine of controls. In a preliminary trial oral L-arginine, the
> substrate for nitric oxide synthase, increased urinary nitric
> oxide synthase activity and improved interstitial cystitis
> symptoms. This randomized, double-blind, placebo controlled
> study further investigates the efficacy of L-arginine treatment
> for interstitial cystitis. MATERIALS AND METHODS: A total of 53
> interstitial cystitis patients were assigned to receive daily
> 1,500 mg. L-arginine or placebo orally for 3 months.
> Interstitial cystitis symptoms were assessed by interviews at 2
> weeks, and 1, 2 and 3 months. RESULTS: The trial was completed
> by 21 of 27 patients in the L-arginine group and 25 of 26 in the
> placebo group. Using per protocol analysis 29% (6 of 21
> patients) in the L-arginine group and 8% (2 of 25) in the
> placebo group were clinically improved by the end of the trial
> (p = 0.07). A Likert scale showed greater global improvement in
> the L-arginine group (48%, 10 of 21) compared to the placebo
> group (24%, 6 of 25) at 3 months (p = 0.05) with a decrease in
> pain intensity (p = 0.04), and tendency toward improvement in
> urgency (p = 0.06) and frequency of pain (p = 0.09). Using an
> intention to treat approach to analysis there were no
> differences between groups. CONCLUSIONS: Oral L-arginine (1,500
> mg. daily) may decrease pain and urgency in a subset of
> interstitial cystitis patients.
>
> Publication Types:
>
> Clinical trial Randomized controlled trial
>
> PMID: 9915448, UI: 99112654
What does this actually mean? My mom purchased this for me to take but I am afraid to take anything new. Chronic pain from ic and pelvic pain is severe.
> J Urol 1999 Feb;161(2):558-65
>
> A randomized double-blind trial of oral L-arginine for treatment
> of interstitial cystitis.
>
> Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE Jr
>
> Department of Surgery, Yale University School of Medicine, New
> Haven, Connecticut 06520-8041, USA.
>
> PURPOSE: Nitric oxide synthase activity is decreased in the
> urine of patients with interstitial cystitis compared to the
> urine of controls. In a preliminary trial oral L-arginine, the
> substrate for nitric oxide synthase, increased urinary nitric
> oxide synthase activity and improved interstitial cystitis
> symptoms. This randomized, double-blind, placebo controlled
> study further investigates the efficacy of L-arginine treatment
> for interstitial cystitis. MATERIALS AND METHODS: A total of 53
> interstitial cystitis patients were assigned to receive daily
> 1,500 mg. L-arginine or placebo orally for 3 months.
> Interstitial cystitis symptoms were assessed by interviews at 2
> weeks, and 1, 2 and 3 months. RESULTS: The trial was completed
> by 21 of 27 patients in the L-arginine group and 25 of 26 in the
> placebo group. Using per protocol analysis 29% (6 of 21
> patients) in the L-arginine group and 8% (2 of 25) in the
> placebo group were clinically improved by the end of the trial
> (p = 0.07). A Likert scale showed greater global improvement in
> the L-arginine group (48%, 10 of 21) compared to the placebo
> group (24%, 6 of 25) at 3 months (p = 0.05) with a decrease in
> pain intensity (p = 0.04), and tendency toward improvement in
> urgency (p = 0.06) and frequency of pain (p = 0.09). Using an
> intention to treat approach to analysis there were no
> differences between groups. CONCLUSIONS: Oral L-arginine (1,500
> mg. daily) may decrease pain and urgency in a subset of
> interstitial cystitis patients.
>
> Publication Types:
>
> Clinical trial Randomized controlled trial
>
> PMID: 9915448, UI: 99112654
What does this actually mean? My mom purchased this for me to take but I am afraid to take anything new. Chronic pain from ic and pelvic pain is severe.
ellie kavanagh
Mar 28, 2016, 11:42:00 AM3/28/16
to
anyone have any have any tips to calm down the pain befor I can get into the doctors
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