A cigarette metabolite accelerates vitamin D breakdown via the aryl hydrocarbon receptor
Kofi
helps to account for the adverse effects of smoking on other conditions
like Crohn's. In essence, smoking is chewing up your vitamin D stores.
Toxicol Sci. 2009 May;109(1):50-8. Epub 2009 Feb 25
�
The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin
D3 catabolism in macrophages.
Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M.
Division of Biochemistry, Department of Biomedical Sciences, Nihon
University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan.
Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon produced by
cigarette combustion, is implicated as a causative agent in
smoking-related cancer and atherosclerosis. 1,25-Dihydroxyvitamin D3
[1,25(OH)2D3], a potent ligand for the nuclear receptor vitamin D
receptor (VDR), has been shown to decrease the risk of osteoporosis,
some types of cancer and cardiovascular disease, suggesting an opposing
effect of vitamin D3 to cigarette smoking. In this study, we
investigated the effects of BaP on the vitamin D3 signaling pathway. BaP
effectively enhanced the 1,25(OH)2D3-dependent induction of cytochrome
P450 24A1 (CYP24A1) in human monocyte/macrophage-derived THP-1 cells and
breast cancer MCF-7 cells. BaP combination was less or not effective on
mRNA expression of CD14, arachidonate 5-lipoxygenase, and cathelicidin
antimicrobial peptide in THP-1 cells. BaP also increased the expression
of CYP24A1 induced by a non-vitamin D VDR ligand, lithocholic acid
acetate. Another aryl hydrocarbon receptor (AhR) ligand,
2,3,7,8-tetrachlorodibenzo-p-dioxin, enhanced CYP24A1 expression by
1,25(OH)2D3 in THP-1 cells. Treatment of cells with an AhR antagonist
and a protein synthesis inhibitor inhibited the enhancing effect of BaP
on CYP24A1 induction, indicating that the effects of BaP are mediated by
AhR activation and de novo protein synthesis. BaP pretreatment increased
1,25(OH)2D3-dependent recruitment of VDR and retinoid X receptor to the
CYP24A1 promoter. Analysis of 1,25(OH)2D3 metabolism showed that BaP
enhanced the hydroxylation of 1,25(OH)2D3 by CYP24A1 in THP-1 cells.
Thus, AhR activation by BaP stimulates vitamin D3 catabolism. Modulation
of vitamin D signaling by AhR may represent a mechanism underlying
cigarette smoking-related diseases.
Publication Types:
* Research Support, Non-U.S. Gov't
PMID: 19244278
Dr. DRErnie
news:kofi-EBB321.0...@news.west.earthlink.net...
Smoking gets more nutrients to the hairy one. Ernie
Ernie
> "Kofi" <k...@anon.un> wrote in message
>
> - Show quoted text -
Commander cocksucker asshole farrel babbles using my name due to her
insanity. Ernie
Live from the Engine Room
> "Dr. DRErnie" <Word69TI...@pluckery.com> wrote:
>> "Kofi" <k...@anon.un> wrote in message
>>
>>> helps to account for the adverse effects of smoking on other conditions
>>
>>> PMID: 19244278
>>
>> Smoking gets more nutrients to the hairy one. Ernie
>
> insanity. Ernie
This vile post was made by someone who is 67 years old...
Ernie
wrote:
> Ernie wrote:
> > "Dr. DRErnie" <Word69TI...@pluckery.com> wrote:
> >> "Kofi" <k...@anon.un> wrote in message
>
> >>> No doubt this accelerated breakdown of vitamin D by smoking metabolites
> >>> helps to account for the adverse effects of smoking on other conditions
>
> >>> PMID: 19244278
>
> >> Smoking gets more nutrients to the hairy one. Ernie
>
> > Commander cocksucker asshole farrel babbles using my name due to her
> > insanity. Ernie
>
>
> - Show quoted text -
What a co-incidence, my age is the same as commander cocksucker
asshole farrel's IQ score. My age will keep increasing. her IQ will
remain the same, or regress. Ernie
Live from the Engine Room
> asshole farrel's IQ score. My age will keep increasing. her IQ will
> remain the same, or regress. Ernie
Viler and viler. Ernest Primeau is a dirty old man.
Ernie
Commander cocksucker farrel is a stupid old pussy and asshole. Ernie
Live from the Engine Room
> Live from the Engine Room <davidp...@yahoo.com> wrote:
>> Ernie wrote:
>>> Live from the Engine Room <davidp...@yahoo.com> wrote:
>>>> Ernie wrote:
>>>>> Commander cocksucker asshole farrel babbles using my name due to her
>>>>> insanity. Ernie
>>
>>>> This vile post was made by someone who is 67 years old...
>>> What a co-incidence, my age is the same as commander cocksucker
>>> asshole farrel's IQ score. My age will keep increasing. her IQ will
>>> remain the same, or regress. Ernie
>>
>> Viler and viler. Ernest Primeau is a dirty old man.
>
> Commander cocksucker farrel is a stupid old pussy and asshole. Ernie
Another example of the old pervert Ernest Primeau making vile posts.
Ernie
>
> - Show quoted text -
That is funny coming from asshole farrel, who called named herself
commander cocksucker. Ernie
Live from the Engine Room
> Live from the Engine Room <davidp...@yahoo.com> wrote:
>> Ernie wrote:
>>> Live from the Engine Room <davidp...@yahoo.com> wrote:
>>>> Ernie wrote:
>>>>> Live from the Engine Room <davidp...@yahoo.com> wrote:
>>>>>> Ernie wrote:
>>>>>>> Commander cocksucker asshole farrel babbles using my name due to her
>>>>>>> insanity. Ernie
>>
>>>>>> This vile post was made by someone who is 67 years old...
>>>>> What a co-incidence, my age is the same as commander cocksucker
>>>>> asshole farrel's IQ score. My age will keep increasing. her IQ will
>>>>> remain the same, or regress. Ernie
>>>> Viler and viler. Ernest Primeau is a dirty old man.
>>> Commander cocksucker farrel is a stupid old pussy and asshole. Ernie
>>
>> Another example of the old pervert Ernest Primeau making vile posts.
>
> commander cocksucker. Ernie
The old pervert Ernie69 is suffering from X-rated hallucinations.
Ernie
>
> - Show quoted text -
Commander cocksucker asshole farrel calls others what she is due to
her disgust with herself. Ernie