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http://www.diabetesincontrol.com/remission-of-prediabetes-to-normal-glucose-tolerance-in-obese-adults/?xtor=-[Issue%20#870
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There are several important findings of this study, which previously
have not been reported. The HP diet resulted in 100% remission of
prediabetes to normal glucose tolerance while the HC diet resulted in
only 33% remission. To the best of our knowledge, this is the first
lifestyle intervention study where 100% remission of prediabetes was
obtained. Our results show that high efficacy can be achieved with
dietary modification if parameters are rigorously controlled and
monitored. The HP group had greater improvement in insulin sensitivity,
greater reduction in CVR factors, oxidative stress (ROS) and
inflammation than the HC diet group. The HP diet group’s percent lean
body mass (LM) increased while percent body FM was decreased; whereas,
the HC diet group lost both percent LM and FM. There was no physical
activity modification during the 6 months on the diets, and since all
subjects were minimally physically active, we were able to study the
direct effect of the HP versus HC diets. Diet meals were given to each
patient weekly at our CRC along with a survey of food consumption, which
resulted in a high level of compliance (>90%; ).
*Practice Pearls:*
* To the best of our knowledge, this is the first lifestyle
intervention study where 100% remission of prediabetes was obtained.
* This study demonstrates that strict adherence to dietary
intervention with the HP diet is possible and results in remission
of prediabetes to NGT.
* Increase in percent lean body mass and decrease in percent fat body
mass with weight loss is obtained on the HP diet, but there was a
decrease in percent lean body mass and percent fat body mass with
weight loss on the HC diet in IGT subjects.