Nuttall and Gannon just published a new joke ...

[GysdeJongh]

Eight men studied for 5 weeks ??????

Quote :
"Whether such a diet in people with type 2 diabetes is useful is to be
determined"
Unquote

Ok, I agree with *That* conclusion !!!
Gys



<http://www.nutritionandmetabolism.com/content/9/1/43/abstract>

Nutr Metab (Lond). 2012 May 20;9(1):43.
Effect of a LoBAG30 diet on protein metabolism in men with type 2 diabetes.
Nuttall FQ, Gannon MC.

We previously reported that a weight-maintenance diet with a
carbohydrate:protein:fat ratio of 30:30:40%, ingested for 5 weeks, improved
blood glucose control in subjects with untreated type 2 diabetes. In this
study we also determined that insulin and insulin-like growth factor-I
(IGF-I) were increased. In this report we provide further information.
Specifically, 24-hour total and individual amino acid, glucagon and cortisol
data are provided. In addition, we determined whether these multiple
effectors resulted in a positive nitrogen balance and an increase in
fat-free mass. Insulin and IGF-I should stimulate protein accumulation. An
increase in amino acids, particularly branched chain amino acids should
facilitate this, whereas glucagon and cortisol could have adverse effects in
this regard. METHODS: Eight men with untreated type 2 diabetes were studied.
A randomized crossover design was used. Data were obtained before and after
5 weeks on a control diet (55% carbohydrate:15% protein:30% fat) and the 30%
carbohydrate:30% protein:40% fat diet. Nitrogen balance and body composition
were determined at the beginning and end of each dietary intervention.
RESULTS: As expected, the mean 24-hour total amino acid area response was
higher after ingesting the 30:30:40 diet. However, the increase was only
statistically significant for the branched chain amino acids, and
phenylalanine and tyrosine. The 24-hour cortisol profile was unchanged.
Glucagon was increased. Nitrogen balance was positive. Body weight was
stable. Body composition and computed tomography data indicate no change in
the fat-free mass had occurred. CONCLUSION: This high protein, low
carbohydrate diet induced a metabolic milieu which strongly favors a
positive protein balance, and a positive balance was present. However, an
increase in lean (protein) mass was not documented. Whether such a diet in
people with type 2 diabetes is useful in preventing or delaying the loss of
total lean body mass and/or sarcopenia associated with aging remains to be
determined.
PMID: 22607113

[randyf]

Authors conclusion:
It didn't result in what we were looking for, but it sure seemed like
it should have.

That is a (unintentional) joke.

But what I find interesting is the following:
This diet (Lo-Bag), researched by this group, has been shown to be
successful in lowering bg levels, but at the expense of raising IGF1
and the m-tor signal pathway. These markers indicate danger signals
regarding healthy aging.

A diet should be judged on more than bg levels.

Regards
Randy

[GysdeJongh]

and sad,
if you don't agree with the data, you choose the wrong carreer

> But what I find interesting is the following:
> This diet (Lo-Bag), researched by this group, has been shown to be
> successful in lowering bg levels, but at the expense of raising IGF1
> and the m-tor signal pathway. These markers indicate danger signals
> regarding healthy aging.
>
> A diet should be judged on more than bg levels.

nice summary of what we try to say here :)

Or

every complicated problem has a simple solution .....
that does not work

Gys