I'm hoping to hear some success stories, but I'll welcome any information
relevant to this question -- favorable or not.
I've been on Zoloft for about two weeks for depression, currently at 50 mg.
2x/day, combined with Wellbutrin 150 mg. 2x/day, but that's not enough time
to assess the effects. I have an appointment with my MD this Friday and I'm
trying to make my mind up before then whether to stay on Zoloft or get off.
Thanks!
I understand what you're saying. However, I'm not "new to AD meds" and I
didn't want to be on Zoloft to start with. I've been on Wellbutrin since
March 2003; initially 100 mg. BID which was raised to 150 mg. BID a year
later. I went to a new GP recently for a physical and I asked if she
would consider raising the Wellbutrin for me again because periods of
depression were returning. She replied that 150 mg. BID was the maximum
recommended dose and instead wrote me a prescription for Zoloft starting
at 25 mg. and a week later up to 50 mg.
I've since done some research online and have found that 150 mg. is not
the maximum dose for Wellbutrin, and that many people are prescribed
twice that. I was pleased with the Wellbutrin initially; I simply asked
for it to be increased. I didn't ask for an SSRI, though I did agree to
give it a try when my doctor presented it as my only option.
What I'm hoping she'll do is withdraw the Zoloft and increase the
Wellbutrin as I initially asked. If she won't, I'll ask her if she'll
recommend a psychiatrist for a second opinion (or I'll find my own.)
Truthfully, though I said that it's too early to assess the effects, I've
recently been having difficulty getting an erection, despite the fact
that I'm also taking Wellbutrin. Additionally, on Saturday night I took
10 mg. of Cialis and last night I took 50 mg. of Viagra, with a fairly
limp response (not totally flacid, but definitely not all there). Since
this isn't typical for me, I'm beginning to suspect that I'm not immune
to the negative sexual effects of Zoloft. It could have been a fluke or
maybe my stomach wasn't empty enough when I took the Viagra, but I doubt
that. I think it's the Zoloft. Wellbutrin has had no sexual effects
positive or negative on me. It's a good drug, as far as I'm concerned.
I am well aware that SSRIs have saved many lives from depression. I have
felt better since starting Zoloft; energized and motivated to take long
walks and also to write more than I have in ages; my mood has been less
dark and I think my behavior has been less irritable. However, if an
increase in Wellbutrin would work as well (which I have no reason to
doubt), and I now do not believe my GP was correct when she said 150 mg.
BID is the maximum dose, why risk chemical castration on Zoloft?
The reason for my question here is to get information that will either
give me hope and reasonable cause to believe that the Zoloft will not
make me impotent; or else to give up the little bit of hope that I have
now and push hard for an increase in W while dropping the Z.
Does that make sense?
"Peter V'ylliki" <vyl...@remove.mail.com> wrote in
news:Xns9554CB6A5...@216.196.97.131:
> If you get off Zoloft you'll be making a typical mistake of
> individuals new to AD meds. Generally it can take up to six weeks for
> the effects to make themselves known and as long or so for the side
> effects to subside.
>
> Why would you want to get off it if you know it's to early to access
> the effects? Why would you want to get off if your aware [you know
> are] that the side effects will subside. That makes no sense
> whatsoever. If it were six months or so I'd understand- it's only been
> two weeks.
> I've recently been having difficulty getting an erection, despite the
> fact that I'm also taking Wellbutrin. Additionally, on Saturday night
> I took 10 mg. of Cialis and last night I took 50 mg. of Viagra, with a
Correction: I meant to say that I took 10 mg. of Cialis on Friday night and
50 mg. of Viagra last night (Saturday).
I've been looking for documentation to to take with me with Friday
regarding the max dose of Wellbutrin and these are the best two that I've
come up with:
http://www.healthscout.com/rxdetail/68/8/7/main.html
http://www.mhsource.com/expert/exp1082503c.html
Can you point me to anything more authorative? What is the reference
guide that doctors use to look up optimal doses?
I will see a pdoc if I need to, but I'd rather not if my GP can do it.
Another factor here is that I've only seen her once. I'm no longer seeing
my former GP who initially prescribed the WB. My initial impression of
the new doctor is that she's a good listener and respectful of her
patients. I'm hoping to persuade her to reconsider, but I'd like to have
reliable backup in support of my assertion that she is incorrect.
Can you point me to someplace where a 450 mg. dose of WB is indicated?
Thanks for your replies.
"Peter V'ylliki" <vyl...@remove.mail.com> wrote in
news:Xns9554D517C...@216.196.97.131:
>
> Yes it does make sense. I've not personal experience with Zoloft. I
> have had experience with other SSRI's combined with Wellbutrin. I found
> that 300 mg of Wellbutrin was the answer for me augmenting the SSRIs.
>
> I'd insist on 300 mg [bring documentation if you need to on the max
> dosage which IIRC is 450 mg]. Your GP is absolutely wrong on that one.
> If you insist on getting off Zoloft and would like to try another SSRI
> Lexapro has been touted as having mild effects vis-a-vis other SSRIs.
>
> My personal opinion on SSRIs in general is the effects wear off after a
> few weeks and if augmented with 300 mg Wellbutrin disappear pretty much
> completely. Have you tried a pdoc for your AD meds? I think that's a
> good alternative as well. That's their specialty and they'll be better
> acquainted [if experienced] with other patients experiences. My .02.
Thanks.
deeps...@aol.comshitlist (BanAIPACNow) wrote in
news:20040829212853...@mb-m02.aol.com:
***
> If you are male and depressed, its also always a good idea to get your
> testosterone checked. Particularly if you have a low sex drive and are
> thirty or above or have any history of injury or surgery to the
> testicles. Low testosterone can be caused by prolonged clinical
> depression and vice versa, low testosterone can cause clinical
> depression.
***
I couldn't care less about my doctor's gender as long as s/he knows how to
doctor. At the risk of getting side-tracked in an OT discussion of sexual
politics, the vast majority of ob-gyn's are men, and likewise most GPs who
treat female patients are men, so why object to a woman who is licensed and
qualified, schooled, and experienced to practice medicine doing so in the
male realm? Is your reservation due to old-fashioned personal modesty, or
to a belief that physicians are incapable of treating members of the
opposite sex?
***
> The maximum dose for sustained release Wellbutrin (Wellbutrin SR) is
> 400 mg a day. Thats usually in two divided doses of 200 mg a day. For
> the original immediate release Wellbutrin, I believe the max dose is
> 450 mg, in three divided doses. For the new once a day Wellbutrin I
> dont know what the max dose is.
***
If the PDR is sufficient for what I ought to take with me to the doctor's
office, I suppose this excerpt covers it:
--QUOTE--
Dose: At doses of WELLBUTRIN SR up to a dose of 300 mg/day, the incidence
of seizure is approximately 0.1% (1/1,000) and increases to approximately
0.4% (4/1,000) at the maximum recommended dose of 400 mg/day.
Data for the immediate-release formulation of bupropion revealed a seizure
incidence of approximately 0.4% (i.e., 13 of 3,200 patients followed
prospectively) in patients treated at doses in a range of 300 to 450
mg/day. The 450-mg/day upper limit of this dose range is close to the
currently recommended maximum dose of 400 mg/day for WELLBUTRIN SR Tablets.
This seizure incidence (0.4%) may exceed that of other marketed
antidepressants and WELLBUTRIN SR Tablets up to 300 mg/day by as much as 4-
fold. This relative risk is only an approximate estimate because no direct
comparative studies have been conducted.
Additional data accumulated for the immediate-release formulation of
bupropion suggested that the estimated seizure incidence increases almost
tenfold between 450 and 600 mg/day, which is twice the usual adult dose and
one and one-half the maximum recommended daily dose (400 mg) of WELLBUTRIN
SR Tablets. This disproportionate increase in seizure incidence with dose
incrementation calls for caution in dosing.
Data for WELLBUTRIN SR Tablets revealed a seizure incidence of
approximately 0.1% (i.e., 3 of 3,100 patients followed prospectively) in
patients treated at doses in a range of 100 to 300 mg/day. It is not
possible to know if the lower seizure incidence observed in this study
involving the sustained-release formulation of bupropion resulted from the
different formulation or the lower dose used. However, as noted above, the
immediate-release and sustained-release formulations are bioequivalent with
regard to both rate and extent of absorption during steady state (the most
pertinent condition to estimating seizure incidence), since most observed
seizures occur under steady-state conditions.
Patient factors: Predisposing factors that may increase the risk of seizure
with bupropion use include history of head trauma or prior seizure, central
nervous system (CNS) tumor, the presence of severe hepatic cirrhosis, and
concomitant medications that lower seizure threshold.
Clinical situations: Circumstances associated with an increased seizure
risk include, among others, excessive use of alcohol or sedatives
(including benzodiazepines); addiction to opiates, cocaine, or stimulants;
use of over-the-counter stimulants and anorectics; and diabetes treated
with oral hypoglycemics or insulin.
Concomitant medications: Many medications (e.g., antipsychotics,
antidepressants, theophylline, systemic steroids) are known to lower
seizure threshold.
Recommendations for Reducing the Risk of Seizure: Retrospective analysis of
clinical experience gained during the development of bupropion suggests
that the risk of seizure may be minimized if
- the total daily dose of WELLBUTRIN SR Tablets does not exceed 400 mg,
- the daily dose is administered twice daily, and
- the rate of incrementation of dose is gradual.
- No single dose should exceed 200 mg to avoid high peak concentrations of
bupropion and/or its metabolites.
-- END QUOTE --
In a related vein, in 1978 I had surgery on my penis to correct a torn
(i.e. broken) corpus cavernosum, but I don't suspect this would come under
the category of surgery that would impact on hormones, although it's in the
same general area. The 1978 operation was successful in that my erections
and sexual capacity were normal until recently.
> I think this might help. The following is the Wellbutrin website and
> the pdf file is GlaxoSmithKline's [the maker] clinical trials, pharma
> and patient profile of Wellbutrin with the suggested 450 mg max
> dosage. Hope this helps.
>
> http://www.wellbutrin-xl.com/
>
> http://us.gsk.com/products/assets/us_wellbutrinXL.pdf
I'll take these along as well. Thanks.
> No problem, it was interesting reading for me. I read your quote from
> the PDR on Wellbutrin on another post, if the PDR says 400 mg then a
> GP will only go up to that dosage. Would a pdoc exceed that? I don't
> know, maybe Eric could answer that.
I don't know, and I don't know that I need to exceed 400 mg. Maybe, but
currently I'm on 300 mg. split between AM and PM, so with this
documentation I can't see any reason why she would decline to move it up by
another 50 mg. each dose. If she does decline, I'll get a second opinion --
probably from a pdoc.
Eric, if you know have a further answer to the above, I'd appreciate it,
especially if you can point me to something medically authorative that I
can print out and take with me.
Thanks again, to both of you.
> I've been on Zoloft for about two weeks for depression, currently at 50 mg.
> 2x/day, combined with Wellbutrin 150 mg. 2x/day, but that's not enough time
> to assess the effects. I have an appointment with my MD this Friday and I'm
> trying to make my mind up before then whether to stay on Zoloft or get off.
You'll doubtless hear this from other ppl, but two weeks is
not enough time (two years is way enough... ?two months)
I had to go to a urologist for some problems (and I am female) and I was
sent to a female urologist , and one of her specialities was male erectile
dysfunction. And she was not young, and she was from Yugoslavia (Serbia).
Perhaps when it was communist, they just made her be a urologist, but she
had alot of male patients who all seemed to really like her. Just FYI :-)
cogge
**get off**
Depends what you mean by get off, ya know!.
>
> Thanks!
Wow, the deal with taking Wellbutrin twice a day is news to me which I
learned from this thread. I have WellbutrinSR and my doc just said to take
300mg per day. Never mentioned taking the 150mg doses separatly for maximum
effect. Any idea what's the best way to do it? Is it fine to take one when I
get up and one before bed?
--
Personally, the only smoking I approve of comes from the barrel of a gun
Interesting. On the package of my Wellbutrin SR, it says the max is 300.
The fact that she brought up the subject of hormone testing, when my
previous two male GPs (including the one who started me on Zoloft) had
never mentioned it, says something by itself. There's no question in my
mind about her competence as a physician and her ability to treat me. As
more women continue to enter the medical profession in the U.S. I think
it's a factor male patients will just get used to.
"cogge'" <co...@yahoo.com> wrote in news:2pfnnsF...@uni-berlin.de:
I think the Zoloft must be getting to me. :-)
rabbit <rab...@mailinator.net> wrote in
news:Xns9555406AD669E...@24.168.128.78:
***
> previous two male GPs (including the one who started me on Zoloft) had
***
you
> might as well just switch over to full blown amphetamines like Ritalin.
That
> makes more sense.
>
^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
sounds like very bad advice that no Doctor would allow.
Zoloft can also be used for the type of depression called premenstrual
dysphoric disorder (PMDD). This recurring problem is marked by a
depressed mood, anxiety or tension, emotional instability, and anger or
irritability in the two weeks preceding menstruation. Other symptoms may
include loss of interest in activities, difficulty concentrating, lack
of energy, changes in appetite or sleep patterns, and feeling out of
control.
In addition,
Zoloft is used in the treatment of obsessive-compulsive
disorder--symptoms of which include unwanted thoughts that won't go away
and an irresistible urge to keep repeating certain actions, such as
hand-washing or counting. It is also prescribed for the treatment of
panic disorder (unexpected attacks of overwhelming anxiety, accompanied
by fear of their return), and for posttraumatic stress disorder
(re-experiencing a dangerous or life-threatening event through intrusive
thoughts, flashbacks, and intense psychological distress).
Zoloft is a member of the family of drugs called "selective serotonin
re-uptake inhibitors." Serotonin is one of the chemical messengers
believed to govern moods. Ordinarily, it is quickly reabsorbed after its
release at the junctures between nerves. Re-uptake inhibitors such as
Zoloft slow this process, thereby boosting the levels of serotonin
available in the brain.
Most important fact about this drug
Do not take Zoloft within 2 weeks of taking any drug classified as an
MAO inhibitor. Drugs in this category include the antidepressants
Marplan, Nardil, and Parnate. When serotonin boosters such as Zoloft are
combined with MAO inhibitors, serious and sometimes fatal reactions can
occur.
How should you take this medication?
Take Zoloft exactly as prescribed: once a day, in either the morning or
the evening.
Zoloft is available in capsule and oral concentrate forms. To prepare
Zoloft oral concentrate, use the dropper provided. Measure out the
amount of concentrate prescribed by your doctor and mix it with 4 ounces
of water, ginger ale, lemon/lime soda, lemonade, or orange juice. (Do
not mix the concentrate with any other type of beverage.) Drink the
mixture immediately; do not prepare it in advance for later use. At
times, a slight haze may appear after mixing, but this is normal.
Improvement with Zoloft may not be seen for several days to a few weeks.
You should expect to keep taking it for at least several months.
Zoloft may make your mouth dry. For temporary relief suck a hard candy,
chew gum, or melt bits of ice in your mouth.
--If you miss a dose...
Take the forgotten dose as soon as you remember. If several hours have
passed, skip the dose. Never try to "catch up" by doubling the dose.
--Storage instructions...
Store at room temperature.
What side effects may occur?
Side effects cannot be anticipated. If any
develop or change in intensity, inform your doctor as soon as possible.
Only your doctor can determine if it is safe for you to continue taking
Zoloft.
More common side effects may include:
Abdominal pain, agitation, anxiety, constipation, decreased sex drive,
diarrhea or loose stools, difficulty with ejaculation, dizziness, dry
mouth, fatigue, gas, headache, decreased appetite, increased sweating,
indigestion, insomnia, nausea, nervousness, pain, rash, sleepiness, sore
throat, tingling or pins and needles, tremor, vision problems, vomiting
Less common or rare side effects may include:
Acne, allergic reaction, altered taste, back pain, blindness, breast
development in males, breast pain or enlargement, breathing
difficulties, bruise-like marks on the skin, cataracts, changeable
emotions, chest pain, cold, clammy skin, conjunctivitis (pinkeye),
coughing, difficulty breathing, difficulty swallowing, double vision,
dry eyes, eye pain, fainting, feeling faint upon arising from a sitting
or lying position, feeling of illness, female and male sexual problems,
fever, fluid retention, flushing, frequent urination, hair loss, heart
attack, hemorrhoids, hiccups, high blood pressure, high pressure within
the eye (glaucoma), hearing problems, hot flushes, impotence, inability
to stay seated, increased appetite, increased salivation, increased sex
drive, inflamed nasal passages, inflammation of the penis, intolerance
to light, irregular heartbeat, itching, joint pains, kidney failure,
lack of coordination, lack of sensation, leg cramps, menstrual problems,
low blood pressure, migraine, movement problems, muscle cramps or
weakness, need to urinate during the night, nosebleed, pain upon
urination, prolonged erection, purplish spots on the skin, racing
heartbeat, rectal hemorrhage, respiratory infection/lung problems,
ringing in the ears, rolling eyes, sensitivity to light, sinus
inflammation, skin eruptions or inflammation, sleepwalking, sores on
tongue, speech problems, stomach and intestinal inflammation, swelling
of the face and throat, swollen wrists and ankles, thirst, throbbing
heartbeat, twitching, vaginal inflammation, hemorrhage or discharge,
yawning
Zoloft may also cause mental or emotional symptoms such as:
Abnormal dreams or thoughts, aggressiveness, exaggerated feeling of
well-being, depersonalization ("unreal" feeling), hallucinations,
impaired concentration, memory loss, paranoia, rapid mood shifts,
suicidal thoughts, tooth-grinding, worsened depression
Many people lose a pound or two of body weight while taking Zoloft. This
usually poses no problem but may be a concern if your depression has
already caused you to lose a great deal of weight.
In a few people, Zoloft may trigger the grandiose, inappropriate,
out-of-control behavior called mania or the similar, but less dramatic,
"hyper" state called hypomania.
Why should this drug not be prescribed?
Do not use this drug while taking an MAO inhibitor (see "Most important
fact about this drug"). Avoid Zoloft if it causes an allergic-type
reaction.
Special warnings about this medication
If you have a kidney or liver disorder, or are subject to seizures, take
Zoloft cautiously and under close medical supervision. Your doctor may
limit your dosage if you have one of these conditions.
Zoloft has not been found to impair the ability to drive or operate
machinery. Nevertheless, the manufacturer recommends caution until you
know how the drug affects you.
If you are sensitive to latex, use caution when handling the dropper
provided with the oral concentrate.
Possible food and drug interactions
when taking this medication
You should not drink alcoholic beverages while taking Zoloft. Use
over-the-counter remedies with caution. Although none is known to
interact with Zoloft, interactions remain a possibility.
If Zoloft is taken with certain other drugs, the effects of either could
be increased, decreased, or altered. It is especially important to check
with your doctor before combining Zoloft with the following:
Cimetidine (Tagamet)
Diazepam (Valium)
Digitoxin (Crystodigin)
Flecainide (Tambocor)
Lithium (Eskalith, Lithobid)
MAO inhibitor drugs such as the antidepressants Nardil and Parnate
Other serotonin-boosting drugs such as Paxil and Prozac
Other antidepressants such as Elavil and Serzone
Over-the-counter drugs such as cold remedies
Propafenone (Rythmol)
Sumatriptan (Imitrex)
Tolbutamide (Orinase)
Warfarin (Coumadin)
If you are using the oral concentrate form of Zoloft, do not take
disulfiram (Antabuse)
Special information
if you are pregnant or breastfeeding
The effects of Zoloft during pregnancy have not been adequately studied.
If you are pregnant or plan to become pregnant, inform your doctor
immediately. Zoloft should be taken during pregnancy only if it is
clearly needed. It is not known whether Zoloft appears in breast milk.
Caution is advised when using Zoloft during breastfeeding.
Recommended dosage
ADULTS
Depressive or Obsessive Compulsive Disorder
The usual starting dose is 50 milligrams once a day, taken either in the
morning or in the evening.
Your doctor may increase your dose depending upon your response. The
maximum dose is 200 milligrams in a day.
Premenstrual Dysphoric Disorder
Doses may be prescribed throughout the menstrual cycle or limited to the
2 weeks preceding menstruation. The starting dose is 50 milligrams a
day. If this proves insufficient, the doctor will increase the dose in
50-milligram steps at the start of each new menstrual cycle up to a
maximum of 100 milligrams per day in the 2-week regimen or 150
milligrams per day in the full-cycle regimen. (During the first 3 days
of the 2-week regimen, doses are always limited to 50 milligrams.)
Panic Disorder and Posttraumatic Stress Disorder
During the first week, the usual dose is 25 milligrams once a day. After
that, the dose increases to 50 milligrams once a day. Depending on your
response, your doctor may continue to increase your dose up to a maximum
of 200 milligrams a day.