How does Buspar work?
jime...@my-deja.com
receptors" - but, if it works on serotonin, how is it different from the
SSRIs? Does anyone know? Also, does Buspar increase the quality of
sleep? My Doc said it helps regulate sleep patterns.
Being weaned off of Effexor and weaned up to Buspar. Perhaps I'll try
Wellbutrin next.
Jim
Sent via Deja.com http://www.deja.com/
Before you buy.
Shahlala50
I don't know the answer to the functionings of buspar but it has helped
my sleep which came as a real surprise to me. I'm using it to augment
zoloft and haven't had any luck with it other than the improvement in
sleeping. It's an antianxiety drug though so I'm not sure why you'd go
from effexor to buspar without another ad.
Elizabeth Shapere
overall amount of serotonin in the brain, so they cause (indirectly)
nonselective activation of all 14+ serotonin receptor subtypes.
My suggestion, if you're trying Buspar, would be to keep pushing the dose up
(to at least 90mg) until it works. Also, give it time, as it appears that it
may take longer to work than some other antidepressant/antianxiety drugs.
Given its site of action I'd imagine it would have some effect on sleep. As far
as I know it generally doesn't worsen sleep, at least, though it doesn't cause
daytime sedation either.
-elizabeth
Courageous
> overall amount of serotonin in the brain, so they cause (indirectly)
> nonselective activation of all 14+ serotonin receptor subtypes.
Misfortunately 5-HT3 is included in that, if I remember correctly.
Libido goes pfui.
C/
Courageous
With SSRIs, I mean.
C/
Elizabeth Shapere
>> Libido goes pfui.
>
>With SSRIs, I mean.
Did they decide that -3 was responsible for that one? If so, a bit of Remeron
ought to do away with it. (Or depending how kind your insurance is, you could
get some Kytril or Zofran.)
Buspar doesn't kill libido, or cause a lot of the other side effects that SSRIs
sometimes cause. Sometimes it's even used to counter the sexual side effect.
jime...@my-deja.com
Shahlala50 <shahl...@my-deja.com> wrote:
> Jim,
> I don't know the answer to the functionings of buspar but it has
helped
> my sleep which came as a real surprise to me.
That's a cause for hope in itself!
I'm using it to augment
> zoloft and haven't had any luck with it other than the improvement in
> sleeping. It's an antianxiety drug though so I'm not sure why you'd go
> from effexor to buspar without another ad.
Believe me, I'll be going to something different as soon as Effexor is
out of my system. Only one week into the weaning off of Effexor and I
physically feel 100% better - now if I was just able to eliminate the
depression, I'd be good to go.
Marcus Urban
> >> Libido goes pfui.
> >
> >With SSRIs, I mean.
From what research I've read, 5-HT3 has to do with nausea, and 5-HT2
is implicated for the sexual problems.
jime...@my-deja.com
> Misfortunately 5-HT3 is included in that, if I remember correctly.
> Libido goes pfui.
Since my depression and anxiety are a result of a touch of PTSD
following an abusive marriage and nasty, expensive divorce/custody
litigation, having my libido go pfui is a blessing, not a curse.
Courageous
> >receptors" - but, if it works on serotonin, how is it different from the
> >SSRIs? Does anyone know?
"CLINICAL PHARMACOLOGY
The mechanism of action of busprione is unknown. Buspirone differs
from typical benzodiazepine anxiolytics in that it does not exert
anticonvulsant or muscle relaxant effects. It also lacks the
prominent sedative effect that is assocatiated with more typical
anxiolytics. In vitro preclinical studies have shown that buspirone
has a high affinity for serotonin (5-HT1A) receptors."
In understanding SSRIs, you must understand that there are multiple
receptors for serotonin in the brain, and some SSRIs are broader
spectrum than others. BuSpar is highly selective on the 5-HT1A
receptor, as I understand it.
I'm not a clinical pharmacologist and don't play one on T.V.
Anyone who really knows their shit can feel free to correct me
or what not...
C/
jime...@my-deja.com
> In understanding SSRIs, you must understand that there are multiple
> receptors for serotonin in the brain, and some SSRIs are broader
> spectrum than others. BuSpar is highly selective on the 5-HT1A
> receptor, as I understand it.
So, let me see if I get this right. SSRIs inhibit the reuptake of the
existing serotonin, so that the existing serotonin is available to the
receptors for a longer period of time. SSRIs do not CREATE serotonin,
unlike 5-http or tryptophan, which DO create serotonin.
Buspar plugs into the the serotonin receptors, in effect fooling the
receptors into thinking that they're linked with serotonin. Since each
serotonin receptor does something different, Buspar just happens to
target those receptors which affect anxiety and sleep normalization.
Please correct me if I'm wrong.
dj...@my-deja.com
system, its primary effect is blocking the re-uptake @ the 1a sites,
but as a consequence of blocking these receptors, the production of
serotonin is slightly increased (more is secreated from the synaptic
vesicles) this accounts for its efficasy.
In article <7u7biu$hrr$1...@nnrp1.deja.com>,
Neuro...@aol.com
effects does it have?
Kathy
> buspar seems to have an affinity for certain receptors in the
serotonin
> system, its primary effect is blocking the re-uptake @ the 1a sites,
> but as a consequence of blocking these receptors, the production of
> serotonin is slightly increased (more is secreated from the synaptic
> vesicles) this accounts for its efficasy.
>
dj...@my-deja.com
far as ad's go. Most docs only find it effective for GAD, it's not
always used for this because most with GAD want immediate results
(benzos)
In article <7u7hv6$mvf$1...@nnrp1.deja.com>,