Oxycodone information: dosages and strength
CrazyComposer
oxycodone. The only difference is the preparation. Oxycodone is a synthetic
form of morphine which is very well metabolized by the body in the treatment
of mild to severe chronic pain (for the treatment of both malignant and
non-malignant pain).
It is difficult to give an exact comparison strength between oxycodone and
morphine that will mean something to someone who is not in chronic pain ...
however, the various forms of oxycodone are important to differentiate. The
two main forms are the immediate release and the sustained release
(Oxycontin). With the Sustained release form of Oxycontin there is a dosing
titration schedule that I have that gives a comparison between morphine and
oxycontin at the following strength:
30 mg morphine/day => dosage of Oxycontin: 10 mg every 12 hours (2.5 mg)
60 mg morphine/day => dosage of Oxycontin: 20 mg q12h (5 mg)
120 mg morphine/day => dosage of Oxycontin: 30 mg q12h (5 mg)
150 mg morphine/day => dosage of Oxycontin: 40 mg q12h (10 mg)
200 mg morphine/day => dosage of Oxycontin: 50 mg q12h (10 mg)
320 mg morphine/day => dosage of Oxycontin: 80 mg q12h (15 mg)
400 mg morphine/day => dosage of Oxycontin: 100 mg q12h (20 mg)
So, the rough equivalence of the relationship is 4 mg of morphine to a
SUSTAINED release mg of Oxycontin. For breakthrough pain oxycodone is used,
shown in brackets at the end of the dosage line above. This can be used
every six hours, but generally if breakthrough medication is needed too much
at the end of a dose on a sustained release medication it is an indication
that the dosage should be increased. There is no ceiling dose for oxycontin
and it can be titrated at 24 hour intervals.
I hope this helps.
Amsel
--
*`~~`**`~~`**`~~`**`~~`**`~~`**`~~`**`~~`**`~~`**`~~`**`~~`*
CrazyC...@home.com
Amsel
The ingeniously CrazyComposer
They say that genius and insanity are closely related. . . .
So, who are "they" anyway?
*`~~`**`~~`**`~~`**`~~`**`~~`**`~~`**`~~`**`~~`**`~~`**`~~`*
Brian
news:sIeI6.57857$HF.12...@news4.rdc1.on.home.com...
> The active ingredient in oxycodone is the same as that in hydrocodone:
> oxycodone. The only difference is the preparation. Oxycodone is a
synthetic
> form of morphine which is very well metabolized by the body in the
treatment
> of mild to severe chronic pain (for the treatment of both malignant and
> non-malignant pain).
>
Uh, Hydrocodone and Oxycodone are two different chemicals. Niether of which
are "synthetic morphine." Synthetic morphine is.... well it's morphine.
Hydro and Oxy are both semi-synthetic opioids, which means they are
synthisized from opium products (Oxy being synthizised from Thebane IIRC).
They, like all opioids possesing "morphine like" properties are classed as
morphine-like.
CrazyComposer
Hydrocodone: the attachment of the hydroxyl group allows the use of
hydrocodone to be used in different ways, but the strength and effectiveness
is the same.
Orally administered oxycodone in a dose of 4.88 mg produces analgesia
comparable to 30 mg of oral codeine.
Chemistry and Stability from AHFS DIT
Chemistry
Oxycodone is a synthetic phenanthrene-derivative opiate agonist. The drug
differs structurally from hydrocodone only in the attachment of a hydroxyl
group to carbon 14 on the phenanthrene nucleus. Oxycodone occurs as long
rods or as tautomeric, strongly refringent scales and is insoluble in water
and soluble in alcohol. Oxycodone is commercially available as the
hydrochloride salt or in combination preparations as the hydrochloride and
the terephthalate salts; both salts are freely soluble in water and slightly
soluble in alcohol. Oxycodone hydrochloride oral solution has a pH of 1.4-4.
Stability
Oxycodone hydrochloride preparations should be stored in tight containers
and generally should be protected from light and stored at 15-30蚓.
Pharmacokinetics from AHFS DIT
Following oral administration of conventional preparations of oxycodone, the
analgesic effect occurs within 10-15 minutes, reaches its maximum in 30-60
minutes, and persists for 3-6 hours. Oxycodone is detoxified by the liver
and kidney and is excreted primarily in the urine.
The relative oral bioavailability of extended-release tablets of oxycodone
hydrochloride compared with conventional oral preparations is 100%. The
extended-release tablets are formulated to provide controlled delivery of
oxycodone over 12 hours. In healthy individuals, the absorption half-life is
0.4 hours for conventional preparations versus 2 apparent absorption
half-lives of 0.6 and 6.9 hours (corresponding to initial and prolonged
release) for extended-release tablets. Release of the drug from the
extended-release tablets is pH independent. With multiple dosing,
steady-state plasma concentrations usually are achieved within 24-36 hours
in healthy individuals. The apparent elimination half-life following oral
administration of extended-release or conventional preparations is 4.5 or
3.2 hours, respectively.
Dosages, more ...
The following doses administered IM or subcutaneously provide analgesia
comparable to that produced by 10 mg of morphine sulfate by those routes:
Comparative Opiate Agonist Dosage with Parenteral Administration
codeine phosphate 120 -130 mg
concentrated opium alkaloids hydrochlorides 20 mg
diacetylmorphine hydrochloride (heroin) 3-5.5 mg
fentanyl citrate 200 痢 (patch)
hydromorphone hydrochloride 1.3-2 mg
levorphanol tartrate 2-2.3 mg
meperidine hydrochloride 75-100 mg (demerol)
methadone hydrochloride 8-10 mg
oxymorphone hydrochloride 1-1.5 mg (semi-synthetic opiate)
Orally administered oxycodone in a dose of 4.88 mg produces analgesia
comparable to 30 mg of oral codeine.
Brian
> Please note the comment about the chemical similarity of Oxycodone and
> Hydrocodone: the attachment of the hydroxyl group allows the use of
> hydrocodone to be used in different ways, but the strength and
effectiveness
> is the same.
>
Ok, but the similarity of chemical structure does not make them "the same
active ingredient." And, as with all drugs in actual use, the effects of a
single drug will differ widely in a given group of people.
Brian
news:5633ftg2begbcohtc...@4ax.com...
> On Thu, 3 May 2001 09:24:12 -0700, "Brian" <ripro...@yahoo.com>
> informed me of this:
>
> <Uh, Hydrocodone and Oxycodone are two different chemicals. Niether
> of which
> <are "synthetic morphine." Synthetic morphine is.... well it's
> morphine.
> <Hydro and Oxy are both semi-synthetic opioids, which means they are
> <synthisized from opium products (Oxy being synthizised from Thebane
> IIRC).
> <They, like all opioids possesing "morphine like" properties are
> classed as
> <morphine-like.
>
> synthesized into morphine in the brain. Perhaps synthesized is not the
> right word, how about converted. From what I have read and what the
> doctor has told me, the end result is morphine once it reaches the
> brain.
>
> And I am not well educated on the subject so I could be completely
> wrong.
No, oxycodone and hydrocodone exert their effects directly. That is to say
they are not metabolized into morphine the way codeine is.
ETF
> in hydrocodone: oxycodone."
Hydrocodone is oxycodone?
There is no "active ingredient" "in" oxycodone. Oxycodone is the name of
a molecule. Hydrocodone is the name of a (different) molecule.
In case you're interested:
Structure of hydrocodone: http://opioids.com/hydrocodone/structure.html
Structure of oxycodone: http://opioids.com/oxycodone/structure.html
... though it doesn't sound like this info will mean much to you.
> I hope this helps.
It definitely helped my mood! They say that laughter's the best medicine
(though I'm not too sure about that).
--
ETF
----------------
Sublimity depends upon unintelligibility.
CrazyComposer <crazyc...@home.com> wrote in message
news:sIeI6.57857$HF.12...@news4.rdc1.on.home.com...
ETF
> synthesized into morphine in the brain.
If that is really what he was meaning to say, then his comments have even
less to do with reality than I originally thought they did (if that's
even possible).
> Perhaps synthesized is not the right word, how about converted?
"Converted" is not the right word, either. How about "metabolized?"
> From what I have read and what the doctor has told me, the
> end result is morphine once it reaches the brain.
Your doctor has misled you. The end result of heroin and codeine
metabolism *is* morphine. But the end result of oxycodone metabolism is
noroxycodone and oxymorphone, although the unchanged parent drug carries
most of the activity.
The end result of hydrocodone metabolism isn't morphine, either. But one
of its end results is hydromorphone (Dilaudid).
HTH.
Chem-R-Us
like that! How would you like it if people made fun of your stupidity
(assuming you had some)...
Hydro-, Oxy-, whatever! They're -codones, DAMMIT!!
Chem-R-Us
ETF
> Oxycodone and Hydrocodone
Oh, come on. At *least* don't start backpedaling. There *was* no such
"comment about the chemical similarity" in the original message. Rather,
you said:
> The active ingredient in oxycodone is the same as that in
> hydrocodone: oxycodone.
... which is plainly false (to the extent that it means anything at all,
of course), and then you said:
> The only difference is the preparation.
In pharmaceutical sciences, "preparation" is generally taken to mean
"formulation," not chemical structure.
Nice try, though, and you win the Home ADH Game as a consolation prize!
Next contestant?
Chem-R-Us
ETF wrote:
>
> > Please note the comment about the chemical similarity of
> > Oxycodone and Hydrocodone
>
> Oh, come on. At *least* don't start backpedaling.
He wouldn't know what chemical similarity was if it jumped right up and
bit him on the ass.
> There *was* no such
> "comment about the chemical similarity" in the original message. Rather,
> you said:
>
> > The active ingredient in oxycodone is the same as that in
> > hydrocodone: oxycodone.
Codone, dammit. Codone.
They're both 'codones'. Not to be confused with condoms...
> ... which is plainly false (to the extent that it means anything at all,
> of course), and then you said:
>
> > The only difference is the preparation.
>
> In pharmaceutical sciences, "preparation" is generally taken to mean
> "formulation," not chemical structure.
I thought a "preparation" was something you stuck up your ass. Like
Preparation H and suchlike.
> Nice try, though, and you win the Home ADH Game as a consolation prize!
>
> Next contestant?
Hey! I noticed you're ignoring the "They're both -codones DAMMIT!!"
retort. Met your match, huh?
Chem-R-Us
Brian
news:3AF1E8D2...@yahoo.com...
> You should be ashamed of yourself, laughing at the chemically challenged
> like that! How would you like it if people made fun of your stupidity
> (assuming you had some)...
>
> Hydro-, Oxy-, whatever! They're -codones, DAMMIT!!
>
> Chem-R-Us
>
Yeah! Sodium cyanide, sodium chloride... same thing, just sprinkle it on
that popcorn.
reese
there something i can buy that really works? or just drink sixteen gallons
of water before i piss?
on a good note i have a private bathroom with noone watching so i could
spike it with anything that is good. i just can't use anyone else's piss
becausee i've already done it to many times help help
headcase
You should be asking on alt.drugs. Most head shops sell a variety of drug
test cheat kits. I've never tried them but my brother did and he still
tested positive for pot.
headcase
bobwhelan
"Novashøk" <nova...@hotmailX.com> wrote in message
news:novashok-76F6DB...@news.fu-berlin.de...
> In article <RnKI6.408$Sf3....@newsfeed.slurp.net>,
> web page (obviously) but the drug-testing section seems to give general
> information on how the different tests work, which countermeasures work
> and which ones don't, and other useful information on drug testing in
> general.
>
> NS
Ah...just give up and go to Mexico and live happy in the sun....