gastrointestinal ischemic injury
doe
I thought some might find this interesting.
Vet Clin North Am Equine Pract. 2003 Dec; 19(3): 715-27. Related Articles,
Links
Treatment of gastrointestinal ischemic injury.
Blikslager AT.
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina
State University, Raleigh 27606, USA. Anthony_B...@ncsu.edu
Ischemic injury is one of the most important causes of mortality in equine
veterinary medicine. Although treatment of reperfusion injury has been
attempted in a number of experimental trials to reduce the level of injury
subsequent to an ischemic episode, this research has not resulted in the
development of useful clinical treatments. Nevertheless, recent studies
assessing intraluminal application of solutions containing antioxidants,
nutrients, and vasodilators are promising. Furthermore, focusing on improving
mucosal recovery after an ischemic event may provide an alternative method of
reducing mortality. Potential treatments include administration of basement
membrane components like hyaluronic acid, gut-specific nutrients like
glutamine, and early return to feeding to stimulate endogenous repair
mechanisms. Finally, recent studies evaluating NSAIDs have revealed the
potential of flunixin meglumine to retard the mucosal repair process,
indicating the need for judicious use of this drug.
PMID: 14740765 [PubMed - in process]
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Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
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DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Deb Schuback
tract-wise.
Debs
Billy Goat Gruff III
Mike
Drop PANTS before emailing.
--------------------------------------------------------------------------
An education teaches you that you don't know everything.
Intelligence means you know where to find the information you are lacking.
mgbio
Jeff2
one of my favorite jokes that I made up. Anyway, I forgot exactly what it
means. My dictionary only has ischemia - something to do with the blood
vessels.
Would you mind paraphrasing this a bit. I think I understand most of it but
certainly not all.
Thanks,
Jeff
"doe" <ironj...@aol.comdoe> wrote in message
news:20040128105636...@mb-m16.aol.com...
Gray...@webtv.net
cells to die be it in the heart or the intestine or the brain (or
anywhere else). In any event it is always serious.
Gray...@webtv.net
paula
Does this all mean there is a possibility that one's Crohn's can be caused by
this and in that case treatment is different then when caused by unknown
factors?
Jeff2
news:20040128105636...@mb-m16.aol.com...
/ IBD
> I thought some might find this interesting.
>
Are you saying that ischemic injury is recognized as one of the causes of
IBS/IBD in humans?
Just wanted to clarify, and if so, can you point to cooborating information.
Thanks,
Jeff
Deb Schuback
Debs
Deb Schuback
Debs
Jeff2
I thought some might find this interesting.
"Deb Schuback" <schu...@helix.mgh.harvard.edu> wrote in message news:401ADAFB...@helix.mgh.harvard.edu...
doe
>From: Deb Schuback schu...@helix.mgh.harvard.edu
>Date: 1/30/2004 3:30 PM Mountain Standard Time
>Message-id: <401ADAFB...@helix.mgh.harvard.edu>
>
>
>--------------080105080805080005060609
>Content-Type: text/plain; charset=us-ascii; format=flowed
>Content-Transfer-Encoding: 7bit
>
>I think in horses they can pretty easily get their intestines twisted
>leading to an ischemic injury because the blood supply to part of the
>intestine gets cut off. That's all that this paper is about. It has
>NOTHING to do with IBD or IBS.
>Debs
>
>Jeff2 wrote:
>
So just to .. clarify ..
YOU .. say .. "ischemic injury is NOT recognized as one of the causes of
IBS/IBD in humans?"
Is that .. right .. ?
Deb Schuback
Debs
doe
>Message-id: <401BE9A9...@helix.mgh.harvard.edu>
>
>
>--------------090501000809060406030107
>Content-Type: text/plain; charset=us-ascii; format=flowed
>Content-Transfer-Encoding: 7bit
>
>If it is it's rare.
>Debs
>
>doe wrote:
>
>>>Subject: Re: gastrointestinal ischemic injury
>>>From: Deb Schuback schu...@helix.mgh.harvard.edu
>>>Date: 1/30/2004 3:30 PM Mountain Standard Time
>>>Message-id: <401ADAFB...@helix.mgh.harvard.edu>
>>>
>>>
>>>--------------080105080805080005060609
>>>Content-Type: text/plain; charset=us-ascii; format=flowed
>>>Content-Transfer-Encoding: 7bit
>>>
>>>I think in horses they can pretty easily get their intestines twisted
>>>leading to an ischemic injury because the blood supply to part of the
>>>intestine gets cut off. That's all that this paper is about. It has
>>>NOTHING to do with IBD or IBS.
>>>Debs
>>>
>>>Jeff2 wrote:
>>>
>>>
>>>
>>
>>So just to .. clarify ..
>>
>>YOU .. say .. "ischemic injury is NOT recognized as one of the causes of
>>IBS/IBD in humans?"
>>
>>Is that .. right .. ?
>
>Debs
>
This isn't the original story I pulled the news from but it also speaks to the
finding.
http://www.newswise.com/articles/view/28790/
Jeff2
to IBS/IBD either pro or con. I have no opinion one way or the other. You
made the statement that it was recognized and I was interested to know more
and if you had any studies that could back up that claim. This is not a
challenge or anything, I'm just trying to learn more. Like I said, from all
the sources I've checked I've yet to see anything mentioned about this.
Personally I would find it very interesting if it is, and I already have a
number of thoughts about how that could relate to loss of cellular integrity
which may then allow for a bacterial infection, but I will hold off on
making any such assumptions until I get some supporting evidence to convince
me that this does play a role in IBS/IBS.
Contrary to what some people think I don't just make up ideas without what I
feel is cooborating evidence.
tx
Jeff
"doe" <ironj...@aol.comdoe> wrote in message
news:20040131123811...@mb-m03.aol.com...
tom hennessy
> No, that's is not my question. I have never heard of this as being related
> to IBS/IBD either pro or con. I have no opinion one way or the other. You
> made the statement that it was recognized and I was interested to know more
> and if you had any studies that could back up that claim. This is not a
> challenge or anything, I'm just trying to learn more. Like I said, from all
> the sources I've checked I've yet to see anything mentioned about this.
> Personally I would find it very interesting if it is, and I already have a
> number of thoughts about how that could relate to loss of cellular integrity
> which may then allow for a bacterial infection, but I will hold off on
> making any such assumptions until I get some supporting evidence to convince
> me that this does play a role in IBS/IBS.
>
> Contrary to what some people think I don't just make up ideas without what I
> feel is cooborating evidence.
>
> tx
> Jeff
I cannot find the article.
I attempted to upload the article last week and for some reason I
could not post.
I did not save the stupid article and now I cannot find it ..
Bummer ..
I have been trying to find it again but cannot..
Again .. bummmer ..
It spoke to the very fact ichemia should now be recognized as a cause
of IBS.
I will keep my eyes and ears open and hopefully will run into it
again.
I noticed it because .. if you will remember .. I attempted to discuss
the fact that blood thinners were being used with some efficacy in IBS
and I had wondered out loud whether the blood was too thick and the
blood couldn't force it's way through the tiny blood vessels which
nourish the gut .. ?
It said it did ..
Who loves ya.
Tom
Billy Goat Gruff III
So Tom how goes it, I am sorry I never emailed you. I was just going
to say howdy and what not.
Mike
On 1 Feb 2004 10:28:41 -0800, ironj...@aol.com (tom hennessy)
wrote:
Drop PANTS before emailing.
doe
>Date: 1/30/2004 2:48 PM Mountain Standard Time
>Message-id: <AiASb.185869$I06.2043672@attbi_s01>
Ischemic colitis
Definition:
Ischemic colitis involves an area of inflammation (irritation and swelling with
presence of extra immune cells) caused by interference with the blood flow to
the large intestine.
Alternative Names:
Acute interstitial ischemia
Causes, incidence, and risk factors:
Interference with blood flow to the colon is the cause of ischemic colitis. The
disorder mainly affects people over 50, many of whom have a history of
peripheral vascular disease. Other risk factors include previous aortic surgery
with inadvertent damage to the artery supplying the colon; history of stroke,
low blood pressure, congestive heart failure, or diabetes; and abdominal
radiation exposure.
Who loves ya.
Tom
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doe
>Date: 1/31/2004 3:42 PM Mountain Standard Time
>Message-id: <jbWSb.151240$sv6.839665@attbi_s52>
>
>Contrary to what some people think I don't just make up ideas without what I
>feel is cooborating evidence.
Ditto ..
ULCERATION OF THE ILEUM IN CROHN’S DISEASE: CORRELATION WITH VASCULAR
ANATOMY.
Anthony A; Dhillon AP; Pounder RE; Wakefield AJ; University Department of
Histopathology, Royal Free Hospital, School of Medicine, London, UK. J Clin
Pathol, 1997 Dec, 50:12, 1013-7
BACKGROUND: Ileal ulcers in Crohn’s disease tend to lie along the same side
of the bowel wall as the mesenteric attachment; the mesenteric and
antimesenteric borders are supplied by short and long arteries, respectively.
AIM: To examine the localisation of ileal Crohn’s ulcers and to test the
hypothesis that predilection of Crohn’s ulcers for the ileal mesenteric
margin is explained by the existence of end arteries that supply the mesenteric
margin. METHODS: The localisation of ulcers in the bowel wall was examined in
eight resection specimens of Crohn’s disease of the terminal ileum. The
vascular anatomy of normal terminal ileum (n = 8) and proximal jejunum (n = 8)
postmortem specimens was studied; isolated long and short vessels were ligated
before perfusion in four of these specimens. RESULTS: All eight specimens of
Crohn’s disease of the terminal ileum showed longitudinal ulceration along
the mesenteric margin. In the postmortem study, the submucosal vascular plexus
derived from ileal, but not jejunal short vessels, comprised end arteries with
little or no communication with the submucosal plexus arising from long
vessels. Prior ligation of ileal, but not jejunal, short vessels resulted in a
filling defect of the submucosal plexus along the mesenteric margin in three of
the four specimens. Ligation of ileal and jejunal long vessels did not affect
carbon ink perfusion of the bowel wall. CONCLUSIONS: In the human terminal
ileum, the short vessels supplying the mesenteric margin are end arteries, and
their pathological occlusion might cause ischaemia of this region. These
findings support a vascular hypothesis for Crohn’s disease and may explain,
in part, both the ileal and mesenteric distribution of Crohn’s disease
ulcers.
DETECTION OF SIGNIFICANT DISORDERS OF INTESTINAL MICROCIRCULATION IN VARIOUS
MODELS OF COLITIS
Kruschewski M; Rohweder J; Foitzik T; Hotz H; Buhr HJ, Abt. fÂur Allgemein-,
GefÂass- und Thoraxchirurgie, UniversitÂatsklinikum Benjamin Franklin, Freie
UniversitÂat Berlin. Langenbecks Arch Chir Suppl Kongressbd, 1997, 114:, 435-7
The role of changes in the capillary bed of the colon for the ethiopathology
and the course of chronic inflammatory bowel diseases is unknown. The results
of morphological and physiological studies are contradictory. The present study
systematically examines the microcirculation of the colonic mucosa in two
different experimental models of inflammatory bowel disease by means of
intravital microscopy. Significant impairment of the capillary blood flow in
the colonic mucosa in acute as well as in chronic inflammatory stage of the
disease was found. The findings suggest that impairment of the capillary blood
flow is an important factor in the course of chronic inflammatory bowel
disease. The influence of drugs on impaired colonic microcirculation in
inflammatory bowel diseases and subsequent changes in pathomorphology and the
course of the disease will be examined in further studies.
ANGIO-ARCHITECTURE OF THE COLON IN CROHN DISEASE AND ULCERATIVE COLITIS. LIGHT
MICROSCOPY AND SCANNING ELECTRON MICROSCOPY STUDIES WITH REFERENCE TO THE
MORPHOLOGY OF THE HEALTHY LARGE INTESTINE
Kruschewski M; Busch C; Dörner A; Lierse W, Chirurgische Abteilung, Klinikum
Niederberg, Velbert. Langenbecks Arch Chir, 1995, 380:5, 253-9
The etiology and the pathogenesis of the chronic inflammatory bowel diseases
known as Crohn’s disease and ulcerative colitis have not been defined.
Therefore, in this study the main emphasis was placed on description of the
pathologic anatomy. Disturbed blood supply and vascular disorders have been
discussed as etiopathogenetic factors. The results in the literature are
frequently contradictory. For this reason, the vascular system of the colon in
Crohn’s disease and ulcerative colitis was systematically examined by means
of various morphological methods in this study. Microvascular corrosion casting
and translucent specimens were taken from operative specimens taken from 12
patients with Crohn’s disease and 8 with ulcerative colitis. For comparison,
tumor-free parts of 6 colon cancer specimens were examined. The evaluation was
done by scanning electron- and/or stereoscopic microscopy. In the presence of
chronic inflammatory bowel disease dilatation of the submucosal veins, caliber
differences in the tunica muscularis and rarefaction of the penetrating blood
vessels were found. In summary, an impairment of the blood flow in the tunica
muscularis can be postulated. For the first time, the resulting venous stasis
has been described, in contrast to the previously described disturbed arterial
blood supply.
SURGERY IN CROHN'S DISEASE: WHEN, WHERE AND WHY THE RECURRENCES?
Del Gaudio A, Bragaglia RB, Boschi L, Del Gaudio GA, Fuzzi N, Department of
Surgery,
University of Bologna, School of Medicine, S.Orsola-Malpighi Hospital, Italy.
Hepatogastroenterology 1998 Jul-Aug;45(22):978-84
One frustrating feature in the surgical management of Crohn’s disease is the
high recurrence rate
which may lead to reoperation. It is common opinion that relapses occur
haphazardly both in time
and in site, and the causes remain unknown. When does a recurrence really arise
after surgery? Is
the site of recurrence determined by definite causes? Is there a relapsing
factor? Between 1965 and
1995, 177 patients underwent surgery for Crohn’s disease. The procedures
performed in 145
cases were those popular at the time, while a recent series of 20 selected
patients was managed following a new approach based on epiploonplasty. This
strategy stems from the strong conviction that Crohn’s disease is not a
primary bowel disease but the result of stasis
and superimposed infection due to a primary hemolymphatic disorder of the
mesentery. The five-year recurrence rate was 62% in patients operated on
according to standard procedures, while no recurrences were reported in the
epiploonplasty group. Among 12
remaining patients with recurrent disease, two cases are reported in detail
because they provide
evidence in favor of the hemolymphatic theory. This study also maintains that
recurrences, viewed
with the hemolymphatic disorder in mind, occur immediately after surgery, while
the superimposed
intestinal inflammatory process and stricturing events may appear clinically at
different time intervals
during follow-up. The site of recurrences usually corresponds to the mesenteric
region subjected to
compression. Altered mesenteric microcirculation appears to be the true essence
of the
disease
Jeff2
"tom hennessy" <ironj...@aol.com> wrote in message
news:aaed2aa8.04020...@posting.google.com...
Jeff2
flow possibly. So the inflammation comes first rather than being caused by
the lack of blood - just a thought.
Chinese Medicine has lots of things to say about blood flow, coagulated
blood and what they call stuck blood. I recently started taking a Chi Gung
class and a lot of the exercises just deal with circulating blood and
energy - very interesting approach to health, they don't concentrate on
building muscle mass at all really.
tx
Jeff
"doe" <ironj...@aol.comdoe> wrote in message
news:20040202141526...@mb-m01.aol.com...
paula
Well, a whole lots of words which doesn't mean anything to me. All I can see is
that blood flow might possibly be playing a part in getting Crohn's.
Actually I was hoping to figure out what the effect could be on the digestive
tract when one goes about 8 hours a day with an oxygen level of under 65%; i.e.
the body is basically deprived of oxygen for prolonged periods of time. I know
it effects many area's of the body. Oh well, maybe one day we will find out.
ironjustice
Bloodletting / phlebotomy, increases blood flow, by hemodilution.
“Serial phlebotomy works to reduce blood viscosity by hemodilution"
"higher total Hb, resulting in higher viscosity"
“Serial phlebotomy works to reduce blood viscosity by hemodilution, as the plasma is restored by hydration more rapidly than are the red blood cells. The study co-authors wrote that the subsequent reduction in viscosity leads to an increase in the delivery of oxygen to the body’s tissues by two physiologic mechanisms: (1) increased cardiac output and (2) reduced oxygen shunting that occurs normally between arterioles and venules. In the first mechanism, decreased viscosity reduces the flow resistance at the peripheral vessels, thus leading to greater oxygen delivery. In the second mechanism, the difference in oxygen concentration between the arterioles and venules leads to shunting, where oxygen is extracted from arterial blood to the veins. By reducing the viscosity, flow increases and the transit time to the capillaries is reduced, thereby limiting the amount of oxygen that is extracted from the arterioles. According to the authors, "an evaluation of blood viscosity by clinical means is a useful, inexpensive outpatient clinical tool,” and “the best-known mechanism for correcting [abnormal viscosity] is repeated (but not excessively frequent) phlebotomy in small amounts.”“
"SOURCE: T. Dorman, et al. Benefits of reducing whole blood viscosity for patients with angina and dementia symptoms. Alternative Therapies, (2008) 14 (4), 48-51”
Who loves ya.
Tom
Jesus Was A Vegetarian!
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk