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Research: (mouse) Researchers show prebiotic can reduce severity of colitis
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zumone2002
May 3, 2012, 10:50:32 PM5/3/12
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http://news.msu.edu/story/researchers-show-prebiotic-can-reduce-severity-of-colitis/
Researchers show prebiotic can reduce severity of colitis
Published: May 03, 2012 E-mail Editor Jenifer Fenton
EAST LANSING, Mich. — Researchers at Michigan State University have
shown a prebiotic may help the body's own natural killer cells fight
bacterial infection and reduce inflammation, greatly decreasing the
risk of colon cancer.
Prebiotics are fiber supplements that serve as food for the trillions
of tiny bacteria living in the gut. When taken, they can stimulate the
growth of the "good" bacteria. The evolution of prebiotic supplements
(as well as probiotics, which are actual bacteria ingested into the
system) provide new therapeutic targets for researchers and
physicians.
In research published in the Journal of Nutrition, MSU's Jenifer
Fenton reports that mice given the prebiotic galacto-oligosaccharide,
or GOS, saw the severity of their colitis (one of the main forms of
inflammatory bowel disease) significantly reduced.
In fact, the mice fed GOS – a synthetic compound that is known to
stimulate beneficial bacteria and is found in foods such as biscuits
and infant formula – saw a 50 percent reduction in colitis.
Research has shown certain types of foods and fibers can reduce colon
cancer risk, said Fenton of the Department of Food Science and Human
Nutrition.
"There is something unique about certain types of fibers, such as GOS,
and how they alter cells and influence the immune system to change
disease risk, either for the good or bad," she said. "Our overall goal
is to identify either dietary patterns or diet components to reduce
inflammation and cancer risk.
"In this case, we used prebiotics to stimulate changes in bacteria in
the gut that may have a beneficial impact on the colon."
Fenton worked closely on the project with Elizabeth Gardner, also with
the Department of Food Science and Human Nutrition and who previously
has looked at the impact diet plays in fighting off the flu. In
applying some of the lessons learned in those studies to mice with
bacterially induced colitis, the researchers found mice given GOS had
significantly less inflammation and fewer abnormal cells, two
precursors for colon cancer.
It appeared, Fenton said, the positive results were linked to the
significant enhancement of the body's own natural killer cells, found
in the immune system and crucial in fighting off new infections in the
body.
"Our results suggest GOS may be effective in reducing colitis severity
by priming the innate immune system," she said.
The next step is to verify how that mechanism works; finding that link
could help researchers apply the lessons learned to other intestinal
ailments.
Fenton and Gardner’s work also supported by MSU AgBioResearch.
--
Luke
Researchers show prebiotic can reduce severity of colitis
Published: May 03, 2012 E-mail Editor Jenifer Fenton
EAST LANSING, Mich. — Researchers at Michigan State University have
shown a prebiotic may help the body's own natural killer cells fight
bacterial infection and reduce inflammation, greatly decreasing the
risk of colon cancer.
Prebiotics are fiber supplements that serve as food for the trillions
of tiny bacteria living in the gut. When taken, they can stimulate the
growth of the "good" bacteria. The evolution of prebiotic supplements
(as well as probiotics, which are actual bacteria ingested into the
system) provide new therapeutic targets for researchers and
physicians.
In research published in the Journal of Nutrition, MSU's Jenifer
Fenton reports that mice given the prebiotic galacto-oligosaccharide,
or GOS, saw the severity of their colitis (one of the main forms of
inflammatory bowel disease) significantly reduced.
In fact, the mice fed GOS – a synthetic compound that is known to
stimulate beneficial bacteria and is found in foods such as biscuits
and infant formula – saw a 50 percent reduction in colitis.
Research has shown certain types of foods and fibers can reduce colon
cancer risk, said Fenton of the Department of Food Science and Human
Nutrition.
"There is something unique about certain types of fibers, such as GOS,
and how they alter cells and influence the immune system to change
disease risk, either for the good or bad," she said. "Our overall goal
is to identify either dietary patterns or diet components to reduce
inflammation and cancer risk.
"In this case, we used prebiotics to stimulate changes in bacteria in
the gut that may have a beneficial impact on the colon."
Fenton worked closely on the project with Elizabeth Gardner, also with
the Department of Food Science and Human Nutrition and who previously
has looked at the impact diet plays in fighting off the flu. In
applying some of the lessons learned in those studies to mice with
bacterially induced colitis, the researchers found mice given GOS had
significantly less inflammation and fewer abnormal cells, two
precursors for colon cancer.
It appeared, Fenton said, the positive results were linked to the
significant enhancement of the body's own natural killer cells, found
in the immune system and crucial in fighting off new infections in the
body.
"Our results suggest GOS may be effective in reducing colitis severity
by priming the innate immune system," she said.
The next step is to verify how that mechanism works; finding that link
could help researchers apply the lessons learned to other intestinal
ailments.
Fenton and Gardner’s work also supported by MSU AgBioResearch.
--
Luke
Johnny
May 4, 2012, 7:16:59 AM5/4/12
to
It's true. For a long time I was using Prebiotin which works really well and fast, but doesn't appreciably stay in your body after you stop taking it unfortunately. It's also somewhat expensive to buy all the time. I started buying Stabilized Rice Bran and not only is it cheaper but it lasts longer. The downside is I can only get it through the mail and it has to be refrigerated right away or it spoils.
I also eat it naturally. Bananas, Cauliflower, Broccoli, Whole Grains (from Oats), you get the idea. Just a word of warning for people. I didn't realize this at first but powdered Inulin that you buy can actually feed your UC so beware.
I also eat it naturally. Bananas, Cauliflower, Broccoli, Whole Grains (from Oats), you get the idea. Just a word of warning for people. I didn't realize this at first but powdered Inulin that you buy can actually feed your UC so beware.
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