IL-31 limits gut inflammation
Kofi
J Immunol. 2009 May 15;182(10):6088-94.
IL-31-IL-31R interactions limit the magnitude of Th2 cytokine-dependent
immunity and inflammation following intestinal helminth infection.
Perrigoue JG, Zaph C, Guild K, Du Y, Artis D.
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA
19104, USA.
IL-31 is a recently identified cytokine made predominantly by CD4(+) Th2
cells and its receptor, IL-31R, is expressed by a number of cell types
including monocytes, epithelial cells, and T cells. Originally
identified as a potential mediator of inflammation in the skin, we
recently reported a novel function for endogenous IL-31R interactions in
limiting type 2 inflammation in the lung. However, whether IL-31-IL-31R
interactions regulate immunity or inflammation at other mucosal sites,
such as the gut, is unknown. In this study, we report a regulatory role
for IL-31-IL-31R interactions in the intestine following infection with
the gastrointestinal helminth Trichuris muris, immunity to which is
critically dependent on CD4(+) Th2 cells that produce IL-4 and IL-13.
IL-31Ralpha was constitutively expressed in the colon and exposure to
Trichuris induced the expression of IL-31 in CD4(+) T cells. In response
to Trichuris infection, IL-31Ralpha(-/-) mice exhibited increased Th2
cytokine responses in the mesenteric lymph nodes and elevated serum IgE
and IgG1 levels compared with wild type mice. IL-31Ralpha(-/-) mice also
displayed enhanced goblet cell hyperplasia and a marked increase in
secretion of goblet cell-derived resistin-like molecule beta into the
intestinal lumen. Consistent with their exacerbated type 2 inflammatory
responses, IL-31Ralpha(-/-) mice exhibited accelerated expulsion of
Trichuris with significantly decreased worm burdens compared with their
wild type counterparts early following infection. Collectively, these
data provide the first evidence of a function for IL-31-IL-31R
interactions in limiting the magnitude of type 2 inflammatory responses
within the intestine.
Publication Types:
* Research Support, N.I.H., Extramural
* Research Support, Non-U.S. Gov't
PMID: 19414760
Jim Godamnski
Not overdone. Keeps it at a level where most people can dig it. JimG
"Kofi" <ko...@anon.un> wrote in message
news:kofi-C2C71E.2...@news.east.earthlink.net...
Gary R. Schmidt
[SNIP]
My first thought was "What does a Russian aircraft have to do with
inflammation?"
(For those who came in late - "IL" == Ilyushin.)
Cheers,
Gary B-)
Ernie
> Great post, Kofi.
>
> Not overdone. Keeps it at a level where most people can dig it. JimG
>
>
> - Show quoted text -
asshole farrel didn't understand a word of it. Ernie