Use of stromal fat to repair inflammatory lesions in Crohn's/IBD and MS

[Kofi]

J Transl Med. 2009 Apr 24;7:29.
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Non-expanded adipose stromal vascular fraction cell therapy for multiple
sclerosis.
Riordan NH, Ichim TE, Min WP, Wang H, Solano F, Lara F, Alfaro M,
Rodriguez JP, Harman RJ, Patel AN, Murphy MP, Lee RR, Minev B.
Medistem Inc, San Diego, CA, USA.

The stromal vascular fraction (SVF) of adipose tissue is known to
contain mesenchymal stem cells (MSC), T regulatory cells, endothelial
precursor cells, preadipocytes, as well as anti-inflammatory M2
macrophages. Safety of autologous adipose tissue implantation is
supported by extensive use of this procedure in cosmetic surgery, as
well as by ongoing studies using in vitro expanded adipose derived MSC.
Equine and canine studies demonstrating anti-inflammatory and
regenerative effects of non-expanded SVF cells have yielded promising
results. Although non-expanded SVF cells have been used successfully in
accelerating healing of Crohn's fistulas, to our knowledge clinical use
of these cells for systemic immune modulation has not been reported. In
this communication we discuss the rationale for use of autologous SVF in
treatment of multiple sclerosis and describe our experiences with three
patients. Based on this rationale and initial experiences, we propose
controlled trials of autologous SVF in various inflammatory conditions.
Publication Types:
* Review

PMID: 19393041