Meat Iron And Endometrial Cancer
ironjustice
population-based case-control study in Shanghai, China.
Nutr Cancer. 2010;62(1):40-50.
Kallianpur AR, Lee SA, Xu WH, Zheng W, Gao YT,
Cai H, Ruan ZX, Xiang YB, Shu XO.
Institute for Medicine and Public Health,
Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center,
Vanderbilt University, Nashville, Tennessee 37203-1738, USA.
asha.ka...@vanderbilt.edu
Dietary red meat and animal fat have been linked to endometrial
cancer (EC) risk, but the impact of bioavailable iron in
animal-derived foods has been less well studied.
Our objective was to investigate the effects of iron and fats on
the risk of EC in a large, population-based, case-control study.
The Shanghai Endometrial Cancer Study enrolled 1,204 EC cases
and 1,212 controls who completed in-person interviews, including
a food frequency questionnaire.
Animal-derived iron and fat intakes were calculated from dietary
intakes and food composition tables.
Logistic regression models were used to evaluate independent and
joint effects of iron and fat on EC risk.
Animal-derived iron intake was positively associated with EC risk
[adjusted OR = 1.9; 95% CI = 1.4-2.7, P(trend) < 0.01, highest vs.
lowest quartile], predominantly after menopause (OR = 2.2; 95%CI
= 1.4-3.4, P(trend) < 0.01) and in women with BMI >or= 25 kg/m(2)
(OR = 3.2; 95% CI = 1.4-7.5 in postmenopausal obese women, P(trend)
< 0.01).
Animal-derived fat was also associated with postmenopausal EC risk
(OR = 1.7; 95% CI = 1.2-2.5, P(trend) < 0.01).
Multiplicative interactions between animal-derived iron and BMI or
animal-derived fat intake were not observed.
Animal-derived iron intake is associated with increased risk of EC
after menopause and among obese women.
Avoidance of animal-derived (heme) iron may reduce the risk of EC
in these women.
PMID: 20043258
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