Leukemia / niacin / picolinic acid

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Apoptosis induced by Picolinic Acid-related Compounds in HL-60 Cells

Shin OGATA, Kazuko INOUE, Keiko IWATA, Katsuzumi OKUMURA, and Hiroshi
TAGUCHI†

Laboratory of Molecular and Cellular Biology, Department of Life
Science, Faculty of Bioresources,
Mie University, Tsu, Mie 514-8507, Japan

Received April 16, 2001; Accepted June 4, 2001
We have found that niacin-related compounds, particularly picolinic
acid, induced apoptosis in human leukemia cells. In this paper, we
investigated whether various picolinic acid-related compounds had
apoptosis-inducing activities or not. Particularly, fusaric acid,
picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine
also induced apoptosis in HL-60 cells. These results suggest that
pyridine substituted with various groups and the consequent change of
resonance structure may have an important role in the induction of
apoptosis.
Key words: niacin; picolinic acid; NAD; apoptosis; HL-60

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