Elevated Iron In Myeloma

[ironjustice]

Elevation of Serum Ferritin is Associated with the Outcome
of Patients with Newly Diagnosed Multiple Myeloma.
Song MK, Chung JS, Seol YM, Shin HJ, Choi YJ, Cho GJ.
Korean J Intern Med. 2009 Dec;24(4):368-73. Epub 2009 Nov 27.
Department of Hematology-Oncology,
Pusan National University Hospital, Busan, Korea.

BACKGROUND/AIMS:
Serum ferritin is a marker of acute phase reactions and iron
storage.
In addition, hematologic malignancies are associated with
elevated serum ferritin levels.
Other studies have suggested that ferritin is a surrogate for
advanced disease and has an impact on relapse, because elevated
serum ferritin predicts overall survival (OS) and relapse-free
survival following autologous stem cell transplantation for
lymphomas.
METHODS:
We studied 89 consecutive patients with newly diagnosed multiple
myeloma to determine the value of serum ferritin in comparison
with known prognostic factors.
RESULTS:
The OS in the elevated serum ferritin group (>/=300 ng/mL) was
shorter than that in the normal serum ferritin group (<300 ng/mL,
p<0.001) after a median follow-up of 25 months.
In univariate analysis, elevated ferritin was correlated with
poor survival in the patients (relative risk [RR], 2.588; 95%
confidence interval [CI], 1.536 to 4.358; p<0.001).
Furthermore, multivariate analysis showed that elevated serum
ferritin was an independent predictor of mortality in patients
with multiple myeloma (RR, 2.594; 95% CI, 1.403 to 4.797; p=0.002).
CONCLUSIONS:
The serum ferritin can a prognostic parameter of survival as well
as disease activity in patients with multiple myeloma.

PMID: 19949737

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PMID: 11854986

Who loves ya.
Tom

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[fer...@paris.com]

"Elevation of Serum Ferritin is Associated with the Outcome
of Patients with Newly Diagnosed Multiple Myeloma."

The iron levels are a diagnostic tool, they are a result not a
cause. The article is about how this tool can be used.

More donkey and cart confusion.

The real question is why iron stores should increase with this disorder.

[Old Bill]

"ironjustice" <teamt...@hotmail.com> wrote in message
news:9a189e89-c526-4013...@s31g2000yqs.googlegroups.com...

| Elevation of Serum Ferritin is Associated with the Outcome
| of Patients with Newly Diagnosed Multiple Myeloma.
| Song MK, Chung JS, Seol YM, Shin HJ, Choi YJ, Cho GJ.
| Korean J Intern Med. 2009 Dec;24(4):368-73. Epub 2009 Nov 27.
| Department of Hematology-Oncology,
| Pusan National University Hospital, Busan, Korea.
|
| BACKGROUND/AIMS:
| Serum ferritin is a marker of acute phase reactions and iron
| storage.
| In addition, hematologic malignancies are associated with
| elevated serum ferritin levels.
|

| ------------
|
|
| Who loves ya.
| Tom
|
|

Thanks Tom.

Old Bill