Re: Transferrin Predicts Chemotherapy Prognosis

[Dr. Neil Novak]

On Apr 28, 6:40 pm, "John H. Gohde" <john.h.go...@gmail.com> wrote:
> On Apr 28, 8:41 pm, ironjustice <ironjust...@rock.com> wrote:
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> > "Survival rates of patients who had serum transferrin ≥190 mg/dL (MST,
> > 12.0 months) were significantly better than those of patients who had
> > serum transferrin<190 mg/dL"
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> > Serum transferrin as a predictor of prognosis for hepatic arterial
> > infusion chemotherapy in advanced hepatocellular carcinoma
> > Zaitsu J, Yamasaki T, Saeki I, Harima Y, Iwamoto T, Harima Y,
> > Matsumoto T, Urata Y, Hidaka I, Marumoto Y, Ishikawa T, Takami T,
> > Yamamoto N, Kaino S, Uchida K, Terai S, Sakaida I
> > Hepatology Research (Apr 2013)
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> > AIM: We recently reported that the iron chelator deferoxamine (DFO) is
> > efficacious in advanced hepatocellular carcinoma (HCC) patients. Iron
> > regulation may thus have an important impact in HCC therapy. Because
> > transferrin is a native chelator that regulates iron homeostasis, it
> > may act as an anti-cancer agent in a similar manner as DFO. The
> > objective of this study was to evaluate serum transferrin as a
> > prognostic predictor in advanced HCC patients undergoing hepatic
> > arterial infusion chemotherapy (HAIC).
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> > METHODS: We retrospectively studied 44 patients receiving HAIC and
> > analyzed various parameters for their possible use as prognostic
> > predictors.
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> > RESULTS: The 1-, 2-, and 3-year cumulative survival rates were 36.4%,
> > 18.2%, and 8.5%, respectively, and the median survival time (MST) was
> > 7.0 months. The survival rates of patients who had serum transferrin
> > ≥190 mg/dL (MST, 12.0 months) were significantly better than those of
> > patients who had serum transferrin<190 mg/dL (MST, 4.9 months).
> > Multivariate analysis identified serum transferrin ≥190 mg/dL [hazard
> > ratio (HR), 0.282; 95% confidence interval (CI), 0.132-0.603; P =
> > 0.001] and Child-Pugh score B (HR, 1.956; 95% CI, 1.034-3.700; P =
> > 0.039) as independent prognostic predictors. There was a significant
> > correlation between serum transferrin level and therapeutic effect
> > (P<0.001).
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> > CONCLUSIONS: Serum transferrin could be useful as a prognostic
> > predictor in advanced HCC patients before HAIC treatment.
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> > -----------------
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> > "A patient with an increased serum transferrin level often suffers
> > from iron deficiency anemia."
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> >http://en.wikipedia.org/wiki/Transferrin
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> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/634q5a
>
> > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> Whoopie Do

I say whoopdie frigging do, if you know what I mean

[John H. Gohde]

Perhaps, if you actually communicated that Whoop?

It is NOT up to moi. It is up to frigging YOU, to point out that
Whoop.

Just thought that YOU might want to know.