Vitamin E Intake In Asthma

[ironjustice]

Natural-source d-α-tocopheryl acetate inhibits oxidant stress and
modulates atopic asthma in humans in vivo;
Hoskins A, Roberts JL, Milne G, Choi L, Dworski R;
Allergy (Mar 2012)

BACKGROUND:
Asthma is associated with oxidant stress and diminished antioxidant
defenses.
Yet, the mechanistic role of oxidant stress and antioxidant
supplementation in human asthmatics remains uncertain.
We determined the effect of high doses of the antioxidant natural-
source d-α-tocopheryl acetate for 16 weeks on allergen-induced airway
oxidant stress, inflammation, and bronchial responsiveness to
methacholine and allergen in atopic asthmatics in vivo.
METHODS:
Thirty-three mild atopic asthmatics underwent bronchoscopy with
baseline bronchoalveolar lavage and segmental allergen challenge.
The allergen-challenged airway was lavaged 24 h later.
At least 3 weeks later, patients underwent inhaled challenges with
methacholine and specific allergen.
Volunteers took 1500 IU of natural-source d-α-tocopheryl acetate daily
for at least 16 weeks.
At the end of the treatment, the two bronchoscopies and inhaled
methacholine and allergen challenges were repeated.
F(2) -isoprostanes, specific markers of oxidant stress, and selected
Th1 and Th2 cytokines were analyzed in the lavage fluid.
RESULTS:
Following supplementation of natural-source d-α-tocopheryl acetate,
plasma concentrations of α-tocopherol increased and γ-tocopherol
decreased.
Both baseline and allergen-induced F(2) -isoprostanes significantly
decreased, providing biochemical evidence for an antioxidant effect.
Natural-source d-α-tocopheryl acetate reduced allergen-provoked
concentrations of interleukin 3 and interleukin 4 and augmented levels
of interleukin 12 in bronchoalveolar lavage fluid.
Natural-source d-α-tocopheryl acetate improved airway responsiveness
to methacholine but did not alter airway reactivity to specific
allergen. CONCLUSIONS:
Inhibition of oxidant stress by natural-source d-α-tocopheryl acetate
modulates allergic inflammation and airway hyperresponsiveness in
human atopic asthmatics in vivo.
These results need to be confirmed by a randomized placebo-controlled
trial.

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