Choline Calms Asthma
ironjustice
stress in patients with asthma.
Immunobiology 2009 Nov 6.
Mehta AK, Singh BP, Arora N, Gaur SN
Asthma is a chronic immune inflammatory disease characterized by
variable airflow obstruction and increased bronchial hyperreactivity
(BHR).
Therapeutic interventions reduce airway inflammation and relieve
symptoms
but associated with potential side effects that limit their
usefulness.
The present study was undertaken to assess the effect of choline on
immune inflammation and BHR in asthma subjects.
The patients of asthma (n=76) were recruited and treated with choline
supplement (1500mg twice) or standard pharmacotherapy for 6 months
in two groups.
The patients were evaluated by clinical, immunologic and biochemical
parameters.
The treatment with choline showed significant reduction in symptom/
drug
score and improvement in PC(20) FEV1 compared to baseline or standard
pharmacotherapy (p<0.01).
Choline therapy significantly reduced IL-4, IL-5 and TNF-alpha level
as
compared to baseline or standard pharmacotherapy after 6 months
(p<0.01).
Blood eosinophil count and total IgE levels were reduced in both the
treatment
groups.
Cysteinyl leukotriene and leukotriene B4 were suppressed significantly
by
choline treatment (p<0.01).
This was accompanied by decreased 8-isoprostanes, a biomarker for
oxidative
stress after choline treatment (p<0.01).
Choline therapy modulates immune inflammation and suppresses
oxidative
stress in asthma patients.
It can be used as an adjunct therapy for asthma patients.
Immunobiology [Immunobiology]
----------------
Lecithin consumption raises serum-free-choline levels.
Lancet 1977 Jul 9;2(8028):68-9
Wurtman RJ, Hirsch MJ, Growdon JH.
Consumption of choline by rats sequentially increases
serum-choline, brain-choline, and brain-acetylcholine
concentrations.
In man consumption of choline increases in levels in the
serum and cerebrospinal fluid; its administration is an
effective way of treating tardive dyskinesia.
We found that oral lecithin is considerably more effective in
raising human serum-choline levels than an equivalent quantity
of choline chloride.
30 minutes after ingestion of choline chloride (2-3 g free base),
serum- choline levels rose by 86% and returned to normal values
within 4 hours; 1 hour after lecithin ingestion, these levels rose
by 265% and remained significantly raised for 12 hours.
Lecithin may therefore be the method of choice for accelerating
acetylcholine synthesis by increasing the availability of choline,
its precursor in the blood.
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