MAGNESIUM search
Bob Kemmler
In a Random Adult Population Sample. Lancet 1994 Aug 6;344(8919):357-62.
Low magnesium intake may be involved in the aetiology of asthma and
chronic obstructive airways disease.
Effect of Parenteral Magnesium Sulphate On Pulmonary Functions In
Bronchial Asthma. J. Asthma 1994;31(2):109-15.
They infused MgSO4 and found: It is concluded that modest improvement in
airways resistance and specific conductance and only small improvement
in maximal expiratory flow rates is consistent with a predominant effect
of MgSO4 on large airways in patients with bronchial asthma.
Clinical Studies With The Nova ISE for IMg2+. Scand. J. Clin. Lab Invest
Suppl 1994;217:53-67.
The Ca2+/Mg2+ ratio appears to be an important guide for signs of
vascoconstriction and/or spasm and possibly enhanced athergenesis.
Overall, the data point to important uses for ISE's for IMg2+ in the
diagnosis and treatment of disease states. (He studied asthma).
The Role Of Disorders In The Homeostasis Of Divalent Cations In The
Pathogenesis And Clinical Picture Of Bronchial Asthma. (Russian) Ter
Arkh 1994; 66(3):8-12.
Lack of Mg and excess of Ca in blood cells (seem to be)... responsible
for bronchial hyperreactivity.
Rapid Infusion Of Magnesium Sulphate Obviates Need For Intubation In
Status Asthmaticus. Am J Emerg Med 1994 Mar;12(2):164-6.
Rapid infusion of MgSO4 .... obviated the need for endotracheal
intubation and mechanical ventilation.
Magnesium Sulphate Potentiates Several Cardiovascular And Metabolic
Actions of Terbutaline. Chest 1994 Mar;105(3):701-5.
MgSO4 has been shown to be efficacious .... for the emergency treatment
of asthma.
Magnesium And Its Therapeutic Uses; A Review. Am J Med 1994 Jan;
96(1):63-76
Evidence investigating magnesium's use is presented, with a number of
studies suggesting it should be seriously considered in such conditions
as .... asthma.
Role of Magnesium In Regulation Of Lung Function. J Am Diet Assoc 1993
Jun;93(6):674-7
(Indicates patients should be monitored routinely for Mg deficiency).
Intravenous Magnesium For Acute Asthma. Ann Emerg Med 1993
Mar;22(3):617-9 (letter)
Hypomagnesemia Due to beta 2-agonist Use In Bronchial Asthma (letter). J
Assoc Physicians India 1992 May;40(5):346
There were many other studies and references to magnesium and asthma.
Many of the studies noted that drugs used in the treatment of asthma
caused loss of magnesium. A great many drugs, including alcohol, cause
rapid loss of magnesium. Common sense would suggest that instead of
waiting for an asthma attack before administering magnesium, oral
magnesium supplementation should be a part of treatment for asthma as a
preventive.
A Google search will bring up at least the complete abstracts, and
possibly the complete studies on most or all of the above.
Colin Campbell
<rcke...@nospam1st.net> wrote:
>There were many other studies and references to magnesium and asthma.
>Many of the studies noted that drugs used in the treatment of asthma
>caused loss of magnesium. A great many drugs, including alcohol, cause
>rapid loss of magnesium. Common sense would suggest that instead of
>waiting for an asthma attack before administering magnesium, oral
>magnesium supplementation should be a part of treatment for asthma as a
>preventive.
Common sense would make me wonder why you failed to provide the
results of the clinical trials where oral magnesium supplements were
tested as a treatment for asthma.
Cynicism would suggest that this is because that these studies
determined that it is of no benefit.
"They laughed at Galileo. They laughed at Newton
But they also laughed at Bozo the Clown."
Carl Sagan
Pat Kohli
yours?
Colin Campbell wrote:
> On Wed, 05 Sep 2001 19:21:36 GMT, "Bob Kemmler"
> <rcke...@nospam1st.net> wrote:
>
> >There were many other studies and references to magnesium and asthma.
> >Many of the studies noted that drugs used in the treatment of asthma
> >caused loss of magnesium. A great many drugs, including alcohol, cause
> >rapid loss of magnesium. Common sense would suggest that instead of
> >waiting for an asthma attack before administering magnesium, oral
> >magnesium supplementation should be a part of treatment for asthma as a
> >preventive.
>
> Common sense would make me wonder why you failed to provide the
> results of the clinical trials where oral magnesium supplements were
> tested as a treatment for asthma.
>
> Cynicism would suggest that this is because that these studies
> determined that it is of no benefit.
_My_ cynicism might question _who_ sponsored these studies that found Mg to
be of no benefit?
My anecdotal personal experience is that I take Mg.
I also take asthma medication at times. When I do go on asthma medication,
it seems most efficacious the first few days and less efficacious afterwards
- consistent with depletion of needed vitamins or minerals, regardless of
whether that/those vitamins/minerals might be MgSO4, vit. C, Se, etc.
I'm not hawking expensive vitamins; I'm not encouraging anyone to stop
taking Advair, or Flovent, etc.
I don't come here for cynicism; I have an abundance. I am looking for some
humor in accepting my situation, and maybe some helpful advice. Maybe some
titles of articles on Magnesium is something short of stimulating reading,
but it looked like something in a constructive direction.
Bob, no silver bullets. I got asthma last January, I take magnesium daily,
I still have asthma - it looks like a _chronic_ disease. Mg may reduce
symptoms, but it hasn't cured me, nor is it likely to do so.
- Pat
ko...@ameritel.net
Colin Campbell
<kohliCUT...@ameritel.net> wrote:
>> Common sense would make me wonder why you failed to provide the
>> results of the clinical trials where oral magnesium supplements were
>> tested as a treatment for asthma.
>>
>> Cynicism would suggest that this is because that these studies
>> determined that it is of no benefit.
>
>_My_ cynicism might question _who_ sponsored these studies that found Mg to
>be of no benefit?
Well, at least one of them was funded by the NIH. (In other words a
Federal research grant.)
BTW, can you identify _who_ paid for the studies those results you
posted?
My point was that you omitted relevant data.
>
>My anecdotal personal experience is that I take Mg.
As long as you admit that your personal results are no indication that
anybody else is likely to get similar results.
Please post the good and the bad. Selectively posting only one side
prevents people from making informed decisions regarding their health.
Bob Kemmler
histamine and adenosine monophosphate in asthmatic subjects
Clinical and Experimental Allergy (United Kingdom), 1997, 27/5 (546-551)
Background: Magnesium is a cation with smooth muscle relaxant and anti-
inflammatory effects and may therefore have a role in the therapy of
asthma. Several studies have investigated the effects of intravenous
magnesium in acute or stable asthma, but little is known about the
effects of inhaled magnesium. Objective: To measure the effects of a
single inhaled nebulized dose of 180 mg magnesium sulphate on airway
reactivity to a direct-acting bronchoconstrictor (histamine) and an
indirect-acting bronchoconstrictor (adenosine monophosphate (AMP)) in
asthmatic subjects. Methods: Two separate randomized, double blind,
placebo controlled crossover studies. each involving 10 asthmatic
subjects. In the histamine study, airway reactivity to histamine was
measured and lung function allowed to recover spontaneously over 50 min
before administering nebulized magnesium sulphate or saline placebo.
Airway reactivity to histamine was then measured at 5 and 50 min. In the
AMP study, a single measurement of airway reactivity was made 5 min
after magnesium or placebo. Results: In the histamine study, the
provocative dose required to reduce FEV1 by 20% (PD20FEV1) was
significantly lower after magnesium than after placebo, by a mean (95%
CI) of 1.02 (0.22- 1.82) doubling doses at 5 min (P=0.018), and 1.0
(0.3-1.7) doubling doses at 50 min (P = 0.01). In the AMP study,
PD20FEV1 was also significantly lower at 5 min after magnesium than
alter saline, by 0.64 (0.12-1.16) doubling doses (P = 0.023), though
this difference was not statistically significant.
Effect of inhaled magnesium sulfate on sodium metabisulfite-induced
Bronchoconstriction in asthma
Chest (USA), 1997, 111/4 (858-861)
Background: Inhaled magnesium (Mg) seemed to have a mild protective
(nonbronchodilator) effect against histamine and methacholine. Inhaled
sodium metabisulfite (MBS) causes bronchoconstriction in asthma through
indirect mechanisms that involve sensory, nerve stimulation, and it is
extensively used to study airway hyperresponsiveness. We designed this
double-blind, randomized, crossover, and placebo-controlled study to
test the effect of nebulized Mg sulfate against indirect challenge with
MBS. Methods: Ten asthmatic subjects (three male) aged 38.8 (3.29, SEM)
years came on three occasions to perform MBS challenges 5 min after
inhalation of either normal saline solution as placebo or Mg sulfate (4
mL; 286 mOsm). Doubling increasing concentrations of MBS were
administered by continuous nebulization at tidal breathing during 1 min
starting at 0.3 to 80 mg/mL until a 20% fall in FEV1 (PC20) from post
saline solution baseline value was achieved. PC20 values were
logarithmically transformed before analysis. Results: The mean baseline
FEV1 at control day was 2.52 (0.14) L and 88.46 (4.28) percentage
predicted, while the geometric mean MBS PC20 was 1.95 (1.38, geometric
SEM) mg/mL. After placebo, the geometric mean PC20 was 2.26 (1.26)
mg/mL. Inhaled Mg increased significantly the PC20 to 5.06 (1.52) mg/mL;
p<0.05. Mg diminished the bronchoconstrictor response to MBS by 1.3
doubling doses (p=0.08). Conclusions: Inhaled Mg attenuates MBS-induced
bronchoconstriction in these asthmatic subjects. This new feature of Mg,
even modest in magnitude, emphasizes the necessity of studying the
potential role of this cation in modulating airway response.
Physicochemical characterization of nedocromil bivalent metal salt
hydrates. 1. Nedocromil magnesium
Journal of Pharmaceutical Sciences (USA), 1996, 85/10 (1026-1034)
Nedocromil sodium is used in the treatment of reversible obstructive
airways diseases, such as asthma. The physicochemical, mechanical, and
biological characteristics of nedocromil sodium can be altered by its
conversion to other salt forms. In this study, three crystalline
hydrates, the pentahydrate, heptahydrate, and decahydrate, of a bivalent
metal salt, nedocromil magnesium (NM), were prepared. The relationships
between these hydrates were studied through their characterization by
differential scanning calorimetry (DSC), thermogravimetric analysis
(TGA), Karl Fischer titrimetry (KFT), hot stage microscopy (HSM),
ambient or variable temperature powder X- ray diffraction (PXRD),
Fourier-transform infrared (FTIR) spectroscopy, solid-state nuclear
magnetic resonance (SSNMR) spectroscopy, scanning electron microscopy
(SEM), water uptake at various relative humidities (RH), intrinsic
dissolution rate (IDR), and solubility measurements. The pentahydrate
showed two dehydration steps, corresponding to two binding states of
water, a more temperature-sensitive tetramer and a more stable monomer,
deduced from the crystal structure previously determined. The
heptahydrate and decahydrate each showed a dehydration step with a minor
change in slope at about 50 degreeC, which was analyzed by derivative
TGA and confirmed by DSC. HSM and variable temperature PXRD also
confirmed the thermal dehydration behavior of the NM hydrates. The
decahydrate underwent an apparently irreversible phase transformation to
the pentahydrate at 75 degreeC at an elevated water vapor pressure. The
PXRD, FTIR, and SSNMR of the decahydrate were similar to those of the
heptahydrate, suggesting that the three extra water molecules in the
decahydrate are loosely bound, but were significantly different from
those of the pentahydrate. The rank order of both IDR and solubility in
water at 25 degreeC was heptahydrate similar decahydrate pentahydrate,
corresponding to the rank order of free energy with respect to the
aqueous solution.
Frequently nebulized beta-agonists for asthma: effects on serum
electrolytes.
Ann Emerg Med (UNITED STATES) Nov 1992, 21 (11) p1337-42
STUDY OBJECTIVE: To determine the magnitude of the changes in serum
potassium, magnesium, and phosphate during the treatment of acute
bronchospasm with repeated doses of beta-adrenergic agonists. DESIGN:
Prospective study of a convenience sample of asthmatic patients.
SETTING: University teaching hospital emergency department. TYPE OF
PARTICIPANTS: Twenty-three patients met the inclusion criteria of age of
more than 16 years; a history of asthma or chronic obstructive pulmonary
disease; and an acute exacerbation. INTERVENTIONS: Baseline peak
expiratory flow rate and serum potassium, magnesium, and phosphate
levels were measured. Nebulized albuterol (2.5 mg) was administered
every 30 minutes until the patient was discharged from the ED. Before
each albuterol treatment, repeat serum levels of potassium, magnesium,
and phosphate were determined. MEASUREMENTS AND MAIN RESULTS: Baseline
peak expiratory flow rate averaged 188 +/- 119 L/min. Serum potassium
levels decreased significantly (P = .0001 by repeated-measures analysis
of variance) from 4.10 +/- 0.468 (baseline) to 3.55 +/- 0.580 mmol/L (90
minutes) and 3.45 +/- 0.683 mmol/L (180 minutes). Potassium decreased to
less than 3.0 mmol/L in 22% of patients at some point during the study.
Magnesium decreased from 1.64 +/- 0.133 mmol/L (baseline) to 1.48 +/-
0.184 mmol/L (90 minutes) and 1.40 +/- 0.219 mmol/L (180 minutes) (P =
.0001). Phosphate levels also decreased, from 3.74 +/- 1.029 (baseline)
to 2.84 +/- 0.957 mmol/L (90 minutes) and 2.55 +/- 0.715 mmol/L (180
minutes) (P = .0001). CONCLUSION: Aggressive administration of nebulized
albuterol during the emergency treatment of acute bronchospasm is
associated with statistically significant decreases in serum potassium,
magnesium, and phosphate. The mechanism and clinical significance of
these findings are unknown and warrant further study.
Folks, if you have gone no further than read these abstracts, I would
think you would come to the conclusion that as a minimum 5 or 600 mg
magnesium/day is appropriate -- after consulting with your MD, of
course.
"Colin Campbell" <col...@linkline.com> wrote in message
news:0tedpt8hc1b7c19lo...@4ax.com...
> On Wed, 05 Sep 2001 19:21:36 GMT, "Bob Kemmler"
> <rcke...@nospam1st.net> wrote:
>
>
> >There were many other studies and references to magnesium and asthma.
> >Many of the studies noted that drugs used in the treatment of asthma
> >caused loss of magnesium. A great many drugs, including alcohol,
cause
> >rapid loss of magnesium. Common sense would suggest that instead of
> >waiting for an asthma attack before administering magnesium, oral
> >magnesium supplementation should be a part of treatment for asthma as
a
> >preventive.
>
> Common sense would make me wonder why you failed to provide the
> results of the clinical trials where oral magnesium supplements were
> tested as a treatment for asthma.
>
> Cynicism would suggest that this is because that these studies
> determined that it is of no benefit.
I do not know much about cynicism,the posts were intended to enlighten/
remind the group that it may behoove them to maintain optimum magnesium
levels. It appears that the inhaled medications play havoc with Mn and
potassium levels. Any scientific proof to the contrary?.
Now I think I know what _cynicism_ means! Are you not the one who tried
to cite a 25 year old paper that suggested that vit. C caused kidney
stones? Sure it was! What a laugh! You had to know that study was thrown
in the trash can years ago, but none the less you tried to pass it off
on the group -- why, I wonder.
Randy
Bob Kemmler <rcke...@nospam1st.net> wrote in message
news:xqEl7.260$4C2.4989@news...
> I ...intended to enlighten/
> remind the group that it may behoove them to maintain optimum magnesium
> levels. It appears that the inhaled medications play havoc with Mn and
> potassium levels. Any scientific proof to the contrary?.
Mn is manganese if I remember correctly. Why don't you also remind us to
eat a banana everyday and to put on clean underwear every morning?
Colin Campbell
<rcke...@nospam1st.net> wrote:
>Studies of the effects of inhaled magnesium on airway reactivity to
>histamine and adenosine monophosphate in asthmatic subjects
>
>Clinical and Experimental Allergy (United Kingdom), 1997, 27/5 (546-551)
>
>alter saline, by 0.64 (0.12-1.16) doubling doses (P = 0.023), though
>this difference was not statistically significant.
So the people who performed the study were of the conclusion that
their results were not statistically significant. Kind of fails to
support your case.
>
>Effect of inhaled magnesium sulfate on sodium metabisulfite-induced
>Bronchoconstriction in asthma
>
>doubling doses (p=0.08). Conclusions: Inhaled Mg attenuates MBS-induced
>bronchoconstriction in these asthmatic subjects. This new feature of Mg,
>even modest in magnitude, emphasizes the necessity of studying the
>potential role of this cation in modulating airway response.
Notice that they are describing the effects as 'modest in magnitude?'
Interesting that you provided the same study that resulted in the
discontinuation of research into _inhaled_ magnesium as a
bronchodilator. (Note that this does not support the use of oral
magnesium in any way.)
>
>Physicochemical characterization of nedocromil bivalent metal salt
>hydrates. 1. Nedocromil magnesium
>
Did not seem to provide any real support for your position.
>minutes) (P = .0001). CONCLUSION: Aggressive administration of nebulized
>albuterol during the emergency treatment of acute bronchospasm is
>associated with statistically significant decreases in serum potassium,
>magnesium, and phosphate. The mechanism and clinical significance of
>these findings are unknown and warrant further study.
Something we already knew. And notice that this study refers to the
aggressive use of nebulized albuterol in an ER setting. (Which is
going to be something like 10 to 30 times the dosages from an
inhaler.)
>Folks, if you have gone no further than read these abstracts, I would
>think you would come to the conclusion that as a minimum 5 or 600 mg
>magnesium/day is appropriate -- after consulting with your MD, of
>course.
Hmmm, I read the abstracts and they seem not to support your case.
>I do not know much about cynicism,the posts were intended to enlighten/
>remind the group that it may behoove them to maintain optimum magnesium
>levels. It appears that the inhaled medications play havoc with Mn and
>potassium levels. Any scientific proof to the contrary?.
This conclusion is not supported by the citations you provided.
>
>Now I think I know what _cynicism_ means! Are you not the one who tried
>to cite a 25 year old paper that suggested that vit. C caused kidney
>stones? Sure it was! What a laugh! You had to know that study was thrown
>in the trash can years ago, but none the less you tried to pass it off
>on the group -- why, I wonder.
Did I? Can you provide the reference please?
galleyleo
----------
In article <93Kl7.222464$NK1.20...@bin3.nnrp.aus1.giganews.com>, "Randy"
<Some...@not.here> wrote:
My mother used to insist we put on clean underwear
every day. "You never know when you might get hit by a car."
Bob Kemmler
"Randy" <Some...@not.here> wrote in message
news:93Kl7.222464$NK1.20...@bin3.nnrp.aus1.giganews.com...
>
> Bob Kemmler <rcke...@nospam1st.net> wrote in message
> news:xqEl7.260$4C2.4989@news...
> > I ...intended to enlighten/
> > remind the group that it may behoove them to maintain optimum
magnesium
> > levels. It appears that the inhaled medications play havoc with Mn
and
> > potassium levels. Any scientific proof to the contrary?.
>
> Mn is manganese if I remember correctly. Why don't you also remind us
My mistake --- meant Mg rather than Mn.
Pythoness
galleyleo wrote:
>
>
> My mother used to insist we put on clean underwear
> every day. "You never know when you might get hit by a car."
Mine too. What always puzzled me was that she seemed to expect that
they'd be clean *after* I was hit by a car... :-\
zg
Denise F. Hayden
asthmatic. His response to all these articles is "so?". There are more
questions after the studies than answers. If he hasn't taken magnesium
supplements yet then it ain't worth it, folks.
Denise
Indianapolis
"Colin Campbell" <col...@linkline.com> wrote in message
news:rhtepto1abcfp6diq...@4ax.com...
Gemgirl888
>they'd be clean *after* I was hit by a car... :-\
>
>zg
>
LOL so would my mother.
Denise F. Hayden
I think dirty was okay but not holey.
Denise
Indianapolis
"Gemgirl888" <gemgi...@aol.com> wrote in message
news:20010906195416...@mb-mk.aol.com...
Pat Kohli
Colin Campbell wrote:
> On Wed, 05 Sep 2001 22:54:20 -0400, Pat Kohli
> <kohliCUT...@ameritel.net> wrote:
>
> >> Common sense would make me wonder why you failed to provide the
> >> results of the clinical trials where oral magnesium supplements were
> >> tested as a treatment for asthma.
> >>
> >> Cynicism would suggest that this is because that these studies
> >> determined that it is of no benefit.
> >
> >_My_ cynicism might question _who_ sponsored these studies that found Mg to
> >be of no benefit?
>
> Well, at least one of them was funded by the NIH. (In other words a
> Federal research grant.)
>
> BTW, can you identify _who_ paid for the studies those results you
> posted?
I didn't post the studies. If the Magnesium Institue of America wants us to
know that Magnesium is "the other white metal", I'm hip with that, though.
>
> My point was that you omitted relevant data.
There is _always_ a flip side of the coin.
>
>
> >
> >My anecdotal personal experience is that I take Mg.
>
> As long as you admit that your personal results are no indication that
> anybody else is likely to get similar results.
>
> Please post the good and the bad. Selectively posting only one side
> prevents people from making informed decisions regarding their health.
I was not aware that a gram or two a day of magnesium had adverse consequences.
If you are aware of spontaneous combustion etc., please post some links.
Pat Kohli
galleyleo wrote:
All these years!
My mom said, "wear clean underwear; there could be an accident". I thought the
'accident' would obliterate the cleanliness (or lack there of) of my
underwear. Now I realize she was not talking about _that_ kind of accident, I
guess.
Hmmmm, if I'm going to get hit by a car, maybe I should just stay home, in the
clean underwear, so they don't get blood and stuff on them.
- Pat
ko...@ameritel.net
Larry Preuss
<kohliCUT...@ameritel.net> wrote:
> I was not aware that a gram or two a day of magnesium had adverse consequences.
> If you are aware of spontaneous combustion etc., please post some links.
You might be interested in
http://www.mercola.com/2000/mar/12/magnesium_overdose.htm
http://www.vitaminsplus.com/vplus/magnesium.htm
Larry
Boyd Annas
Those are pretty wobbly sources. Any properly peer-reviewed studies(with
particular aim at asthma)?
Boyd
P.S. note 80% (100% for weight-loss) or more of the studies written up in
JAMA and the New England Journal of Medicine are written by those in the pay
of companies with a financial interest. This is why NO negative information
about studies is ever published.
--
----------------------------------------------------------------------
"The cure for boredom is curiosity. There is no cure for curiosity."
(Ellen Parr- author)
"Larry Preuss" <LPr...@provide.net> wrote in message
news:060920012156223439%LPr...@provide.net...
galleyleo
----------
In article <vZUl7.435$be6.2...@news1.iquest.net>, "Denise F. Hayden"
<dfha...@iquest.net> wrote:
> The issue with my mother wasn't clean....she didn't want them to look ratty!
> I think dirty was okay but not holey.
>
> Denise
> Indianapolis
What kind of a mother would rear her daughter to be dirty and unholy?
Larry Preuss
any argument about it, but someone asked for links and so I took a
look. I didn't spend any time at it but just asked Google, and didn't
sift, as I had no great interest in the topic.
Larry
In article <tpgl4i7...@corp.supernews.com>, Boyd Annas
Colin Campbell
<boyd...@tstonramp.com> wrote:
>Larry,
> Those are pretty wobbly sources. Any properly peer-reviewed studies(with
>particular aim at asthma)?
>Boyd
>P.S. note 80% (100% for weight-loss) or more of the studies written up in
>JAMA and the New England Journal of Medicine are written by those in the pay
>of companies with a financial interest. This is why NO negative information
>about studies is ever published.
Actually, the problem is a little different. 'Negative' findings in
any scientific subject are regarded as less publishable than positive
findings (people are interested in discoveries not in why a theory did
not work).
For the past several years there has been a movement to create an
archive of negative studies (mostly for the purpose of avoiding
duplicate research in something that was already found not to work).
BTW, the FDA requires that all studies on potential human medications
be published on peer reviewed medical journals, this will tend to
inflate the number of these studies that appear in the journals you
mention.