Drugs and Baldness1/2
peter@.interramp.com
HOW TO STOP HAIR LOSS and REGROW HAIR (condensed)**
1995 Infonet communication Inc. (inquiry: in...@infonet.com)
by Mary Sheen, MD
Part 1 Introduction
Hair plays a significant role in our life. Another person's hair is one of the first characteristics we
notice upon meeting. Our own hair is one of the first and last things we attend to before a meeting
or a social engagement. Hair disorder, especially when severe, often profoundly affects the lives of
those afflicted. Severe hair loss evokes not only cosmetic concerns but may also evoke feelings of
vulnerability (nakedness), loss of self-esteem, alterations in self-image, and, perhaps, even self-
identity.
In 1992, researchers at Old Dominion University in Norfolk, Virginia, surveyed 145 men, and found
that 84 percent of the balding men were preoccupied with their loss. They described themselves
as filled with self-consciousness, helplessness, and envy of men with full heads of hair. Single men
and woman who had begun losing hair in their early twenties were more likely to suffer from
extremely low self-esteem.
While stressful, balding isn't the end of the world. Although the men reported glancing in the
mirror constantly and wearing hats even in warm weather, they manage to make it through their
daily lives without much problem. For some it even sparked self-improvement tactics like fiddling
with hair styles, working out more, and dressing better. Servey result is shown in the following
chart.
How deep does a bald man's anxiety runs?
Reported extent of hair los
experience low high
Notice bald/balding men 54% 82%
spend time looking in mirror at hair 54 69
Feel self-conscious 42 78
Look older than actual age 40 55
Worry that others will notice 39 56
worry about aging 37 46
Feel less attractive 31 51
Envy good-looking men 33 34
Try to improve hair style 63 66
Try to improve physique 41 36
dress nicer 26 45
Wear hats or caps 23 41
Seek reassurance about looks 23 39
Grow a beard or a mustache 18 36
Stereotypes associated with baldness are not flattering. A research back in 1971( reference) had
been conducted to investigate how one person was perceived by others can be influenced by
quantity of scalp hair (regular, balding, and bald) as well as color, length, and quality of scalp hair.
Pictures of the same person were presented to 60 judges. Differences in appearances of this
person (ie, experimental conditions of regular, balding, and bald) were manipulated through
modifications made by a commerical artist. The results revealed that the person with a regular
quantity of hair was rated as most handsome, virile, strong, active, and sharp. The person with a
balding head of hair was rated as least potent, weak, dull, and inactive, and the person with a bald
head of hair was rated as most unkind, bad, and ugly. Many other studies also show employment
discrimination based on a person's appearance (ref )
Motivation to avoid baldness is not confined to this century. In 1150 BC Egyptian men smear their
pates with fats from ibex, lions, crocodiles, serpents, geese, and hippopotamuses. In modern
society, this aversion is readily evident from the many available remedies such as creams,
hormones, vitamins, hairpieces, wigs, scalp reduction and hair transplants. A government report in
1983 reveals that over the past 9 years the FDA has overseen the investigation of ingrediets in
about 300,000 products claimed to help hair regrowth, none of them has any medical benefit, of
course.
The goal of this book is to provide comprehensive information on how to cope with baldness.
From this book, you will learn how to preserve what you've got, restore what you haven't, or live
happily with your follocular deficit.
Part 2 Get to Know Your Hair
The amount of hair and where it grows vary with different mammals. The entire body of the dog,
the sheep, the cow, and the horse is covered with a hairy coat. The whale and the hippopotamus
have only a few hairs. In humans, hair is not found on palms of the hands or the soles of the feet.
The coloration and pattern of coats in animals serve both as a camouflage for protection against
enemies and as an allurement to mates. Fine and transparent, human hair is a vestige of our
hairier animal forbears, that probably evolved from the scales of reptiles. The adult human body
averages five million hairs, of which 100,000 to 150,000 are on the scalp.
Hair is composed of keratin, the same protein that makes up nails and the outer layer of our skin.
The part seen rising out of the skin is called hair shaft or strand. Each strand consist of three
layers. The outermost protective layer (cuticle) is thin and colorless. The middle layer, or cortex , is
the thicknest. It provides strength, determines your hair color and whether your hair is straight or
curly.
Hair color is determined by melanin from your pigment cells. The more pigment granules there
are, and the more tightly packed, the darker the hair. Two kinds of melanin contribute to hair
color. Eumelanin colors hair brown to black, and an iron-rich pigment, pheomelanin colors it
yellow-blonde to red. Whether hair is mousy, brown, brunette or black depends on the type and
amount of melanin and how densely it's distributed within the hair. For example, deep-black
African hair contains closely packed melanin in the cortex, a few in the cuticle. Very dark
European hair, quite apart from having more melanin granules than lighter or blonde hair, has
more melanin per granule. When pigment-producing cells cease to function, the result is the
uncolored white or gray hair.
Scalp hair varies tremendously between races, between individuals of same race, and even within
an individual. Mongolians have straight hair simply because their scalp hair has the greatest
thickness and the roundest cross-section. In Caucasians the hair is more elliptical and slender; in
Negroes it is flattened, resulting in kinky curls. Mongolians, both male and female, have much less
public, axillary, facial, and body hair than Caucasians. In Caucasians, true blonds typically have
more hair (about 140,000 hair) than brunette (about 105,000) or redhead (about 90,000).
Below your skin is the hair root which is enclosed by a sack-like structure called the hair follicle.
Tiny blood vessels at the base of the follicle provide nourishment. A nearby gland secretes a
mixture of fats (called sebum) which keep the hair shiny and waterproof to some extent. Secretions
from some sweat glands also produce a characteristic odor. A dog can differentiate a human being
by the typical scent secreted by these glands. Two sets of glands discharge secretions through the
skin. while sebaceous, or oil, glands arise from the walls of hair follicles and produce an oil
called sebum that lubricates the skin and hair, Sweat glands, embedded in the subcutaneous
layer, are scattered over the body, particularly in the palms and soles. Sweat glands produce
moisture called perspiration that reaches the skin's surface through the pores and evaporates to
cool the body.
At the base of the follicle is the papilla, which is the "hair manufacturing plant." The papilla is fed
by the blood-stream which carries nourishment to produce new hair. Male hormones or androgens
regulate hair growth. Pubic and axillary (armpit) hair are particularly androgen-sensitive and grow
at lower androgen levels than hair on the chest or legs. In boys, most pubic hair is grown by age
15, followed by the development of armpit hair two to three years later. In girls, too, an increase in
androgens at puberty triggers growth of pubic and armpit hair. Scalp hair, not directly androgen-
responsive, is influenced by local amounts of a testosterone derivative, dihydrotestosterone.
Hair follicles initially form in utero. No new follicles are created after birth, and none are lost in
adult life. The first hair to be produced by the fetal hair follicles is Lanugo hair, which is fine, soft,
and unpigmented. This is usually shed in about the eighth month of gestation.
The first postnatal hair is vellus hair, which is fine, soft, usually unpigmented, and seldom more
than 2 cm long. Vellus hair remains on the so-called hairless regions of the body, such as the
forehead and balding scalp.
At puberty, the vellus hair in some areas is replaced by terminal hair, which is longer, coarser, and
pigmented. Growth starts in the pubic region; then the eyelashes and eyebrows become thicker.
Axillary hair and male facial hair appear about two years after growth of pubic hair begins. Body
hair continues to develop long after puberty, stimulated by male hormones that paradoxically, also
cause terminal hair to be replaced by vellus hair when balding begins.
Scalp hair fibers grow from 100,000 to 350,000 follicles which are reported to occupy the human
scalp; however, not all the follicles are productive.[1] In each producing follicle, the duration of the
hair's life cycle is influenced by age, pathology and a wide variety of physiological factors.[1,2] The
life cycle is divided into the anagen (active), catagen (transitional) and telogen (resting) phases.
The anagen phase is the period of active hair growth where protein synthesis and keratinization
are continuously occurring. In normal subjects, this phase lasts for up to five years, although
longer durations have been documented.
The cessation of the anagen phase is characterized by a transitory phase known as catagen. This
phase lasts for two to three weeks.
Following the catagen phase, the hair enters the telogen or "resting" phase. In normal subjects,
telogen hair is retained within the scalp for up to 12 weeks before the emerging new hair dislodges
it from its follicle.
During the anagen phase, protein s thesis is the main distinction of the hair bulb. In the telogen
phase, the dermal papilla undergoes renewal. It is at this time that structural characteristics can be
modified. The new hair should be identical to its predecessor, but with advancing age, and in
some pathological states, a strict copy is not maintained. In these circumstances, the hair may
become finer and shorter, modifying the esthetic profile. Since these effects occur over several hair
cycles, years may elapse before the affected individual recognizes the difference.
Like skin cells, hair grows and is shed regularly. Shedding anywhere from 50 to 100 hairs per
day is considered normal. The average rate of growth is about 1/2 inch a month. It is now known
that hair grows fastest in the summer, slowest in the winter, speeds up under heat and friction, but
slows down when exposed to cold. Hair grows the best between the ages of 15 to 30. But, hair
growth begins to wind down sometime between the ages of 40 and 50. Progressive hair loss
begins naturally in both sex about age 50, accelerating in the 70s. About 40 percent of Caucasian
men lose hair to some extent by age 35.
What cause hair loss? can we do something about it? we will discuss these matters upcoming
chapters.
Hair Loss, Men and Women
Androgenic alopecia
By far the most common form of hair loss is determined by our genes and hormones: Also known
as androgen-dependent, androgenic, or genetic hair loss. It is the largest single type of
recognizable alopecia to affect both men and women. It is estimated that around 30% of
Caucasian females are affected before menopause. Other commonly used names for genetic hair
loss include common baldness, diffuse hair loss, male or female pattern baldness.
1. Male Pattern Baldness (MPB)
Signs and Symptoms
* Receding hairline
* Moderate to extensive loss of hair, especially on the crown
2. Female pattern Baldness (FPB)
Signs and Symptoms
* General thinning of hair all over the head
* Moderate loss of hair on the crown or at hairline
MPB is the hair loss most frequently encountered. It usually starts with the hair at the temples,
which gradually recedes to form an "M" shape. You also may find your hair is finer and does not
grow as long as it once did. The hair on the crown of your head begins to thin out and eventually at
the top points of the "M" meet the thinned spot on your crown. Over time, you are left with a horse-
shoe pattern of hair around the sides of your head. Any remaining hair in the balding areas usually
manifests some miniaturization - it is thinner and grows at a below-normal rate, changing from
long, thick, coarse, pigmented hair into fine, unpigmented sprouts.
Female pattern baldness usually begins about age 30, becomes noticeable around age 40, and
may be even more noticeable after menopause. Female hair loss is usually an overall thinning--
two hairs where five used to be--rather than a bald area on top of the head, though women may
have a receding hairline, too. It's thought that about 20 million American women have such hair
loss. As in males, hair follicles simply shut down, with hormones playing some role in the process.
The mechanism of balding
The rate of hair shedding in androgenic alopecia is speeded up by three forces: advancing age, an
inherited tendency to bald early, and an over-abundance of the male hormone dihydrotestosterone
(DHT) within the hair follicle. DHT is a highly active form of testosterone, which influences many
aspects of manly behavior, from sex drive to aggression. The conversion from testosterone to DHT
is driven by an enzyme called 5-alpha reductase, which is produced in the prostate, various
adrenal glands, and the scalp. Over time, the action of DHT causes the hair follicle to degrade and
shortens the anagen phase. Thought the follicle is technically still alive and connected to a good
blood supply--it can successfully nurture a transplanted follicle which is immune to the effects of
DHT--it will grow smaller and smaller (figure 3). Some follicles will gradually die, but most will
simply shrink to the size they were when you were born which produce weaker hairs. With a
steadily shorter anagen growing cycle, more hairs are shed, the hairs becoming thinner and
thinner until they are too fine to survive daily wear and tear. Balding hair gradually changes from
long, thick, coarse, pigmented hair into fine, unpigmented vellus sprouts.
However, the sebaceous gland attached to it remains the same size. As the hair shafts become
smaller, the gland continues to pump out about the same amount of oil. So as your hair thins, you
will notice that your hair becomes flatter and oilier.
Other physiological factors might cause hair loss. Recently, a group of Japanese researcher
reported a correlation between excessive sebum in the scalp and hair loss. Excessive sebum often
accompanying thinning hair is attributed to an enlargement of the sebaceous gland. They believed
excessive sebum causes an high level of 5-alpha reductase and pore clogging, thus malnutrition
of the hair root.
Although this condition could be hereditary, they believe diet is a more prominent cause. The
researchers note that Japanese hair was thick and healthy, with a small gland and little scalp oil,
until the occidental habit of consuming animal fat crept into their diet after World War II. This
change has led to a significant height increase in the Japanese population, but it has also resulted
in more Japanese men losing hair. To some extent, their observation makes sense since
problems with greasy hair have often been noted as much as six months to a year prior to when
thinning hair becomes noticeable, but this might be just one of the symptons, not underlying
cause, more research is needed. Most doctors agree that If you have a oily scalp with thinning
hair, frequent shampooing is advised. shampooing can reduce surface sebum, which contains
high levels of testosterone and DHT that may reenter the skin and affect the hair follicle.
Treatment for Male Pattern Baldness
Balding men and women seem to go to almost any lengths to regrow thinning hair. Until now,
inherited balding in either sex has not responded well to any anti-balding stimulants, applications,
injections, or other treatments. Specific foods or vitamins don't regrow hair -- although good
nutrition is essential for healthy hair.
Antiandrogen Therapy
In the United Kingdom, the most commonly used anti-androgen for women is CPA (cyproterone
acetate) in combination with ethinyl-estradiol. In the United States, where CPA is not available, the
aldosterone antagonist spironolactone has been given in dosages from 75 to 100 mg per day with
some benefit. However, higher doses (150 to 200 mg per day) appear necessary to produce a
significant increase in cosmetically useful hair, as occurs with CPA therapy.
Anti-androgen treatment must be continued for at least 12 months. Often two years is required
before a subjective improvement is observed.
Complete reversal of the hair loss can never be achieved unless treatment is instigated within two
years of its onset. This is probably due to the atrophy of the miniaturized hair follicles with time.
The degree of benefit observed is dependent upon the subject's age and the duration of alopecia;
however, most patients are satisfied with the thought that no further hair loss will occur. Some
improvement in hair quality should be expected in all cases, although withdrawal of therapy
results in further progression of the alopecia.
Nonhormonal aspects are critical to ensure an optimal therapeutic response is achieved. And, the
need to maintain vitamin and serum ferritin levels above values previously thought adequate has
recently been demonstrated.
The side effects of oral CPA therapy in combination with ethinyl-estradiol are well documented and
are similar to those associated with other oral contraceptive regimens. Spironolactone disrupts the
menstrual cycle and increases menstrual bleeding in some patients; but, in general, it is well
tolerated.
To understand how these hormonal remedies work, you need to know a little science. DHT is one
of several male hormones, called androgens, that compete for a berth on the hair follicle's receptor
sites. In principle, if you could keep the receptor busy metabolizing other hormones, like
progesterone, DHT would never have a chance to move in and start shrinking the follicle. The
researched based on this concept have made little progress over the past decade. The biggest
hurdle: to limit the effects of the androgen blocker to the scalp only. If DHT is blocked at other sites
around the body, a male will lose his sex drive and develop a vocal delivery that resembles a
teenage girl's. Blocking the activities of DHT in female who have hair loss is, of course, less
problematic. Spironolactone or Aldactone does just that, and very effectively.
Rogaine
By far the most publicized medical treatment available for male pattern baldness is minoxidil
(Rogaine). The idea of using minoxidil topically to grow hair was serendipitous. This drug was
originally developed to treat high blood pressure and had the unanticipated side effect of
stimulating hair growth, sometimes in unwanted areas. This observation led to the testing of
topical minoxidil on balding areas of the scalp. Since its introduction in 1988, Upjohn, the
manufacturer, sells about $150 million worth of the drug each year, even though its ability to grow
back hair is, at best, modest.
A large-scale clinical trial involved over 2,300 participants with male pattern baldness
was carried out by having 1,547 patients apply 1 ml of 2% or 3% minoxidil and 779 patients apply
1 ml of placebo ( no active ingradients, only alcohol and propylene glycol) twice a day to the
balding area. Actual counts of vellus hairs, indeterminate hairs, and terminal hairs in an one-inch
patch were made before and after treatment. At 4 months, 5% to 8% of patients had moderate to
marked hair growth on the balding vertex of the scalp. This figure is statistically no different from
the number of men who regrow hair in response to a plcaebo. another 15% to 20% of patients had
some growth of vellus hair on the balding area. At 12 months, 39% of patients had moderate to
marked hair growth, while 11% of those using placebo reported an increase in hair growth. This
result shows that you to used minoxidil for more than 4 months in order to decide whether this
treatment works for you.
Who is the best candidate for this drug? research showed that you have to be:
1) young man (20 to 30 years old), who only recently (within 5 years) had begun to bald
2) not completely bald, and
3) not bald at the temples
This drug works best on small areas of vertex baldness (smaller than 1 square inch).
There is no evidence that topical minoxidil could regenerate hair on the receding temple area.
Topical minoxidil was as effective at a concentration of 2% as at 3%. A 1% formulation was less
effective.
Successful treatment, however, does require a lifetime commitment. The topical solution must be
applied to the balding area twice a day, every day. Decreasing the dosage to once a day results in
some hair loss, and discontinuing application causes regression to pretreatment baldness within
3 to 6 weeks. The cost? Anywhere between $600 to $1,000 a year, depending on the size of the
area to be treated.
Why minoxidil works remain a mystery. It is know to be a powerful vasodilator, but other drugs the
dilate blood vessels do not promote hair growth. It is postulated that it delays or prevents some
follicles' entry into the next anagen phase for long periods of time and stimulate these follicles back
into active production. But this theory remains to be vindicated.
The disadvantages of minoxidil are: 1) lifetime commitment; 2) high cost : It is not covered by
health insurance schemes as it's considered a cosmetic; 3)Its side effects; including itching and
prickling, headaches (in 40 per cent), dizzy spells and, in some, heartbeat irregularities. Although
apparently safe when rubbed into the scalp - since little is absorbed into the bloodstream - it is a
vasodilator and not recommended for anyone with heart trouble. Its safety in men over age 49 and
its long-term safety remain unknown. Some scientists believe that minoxidil is more effective in
preventing hair loss than in promoting regrowth, but no controlled trials are available.
At the time of writing this book, the only away you can obtain rogaine is through a doctor's
prescription. That could be changed soon. Upjohn is confident it will obtain FDA approval to take
the drug over the counter.
Meanwhile, researchers are working on ways to make minoxidil work better and are also exploring
other avenues.
Increasing the concentration of minoxidil from its prescribed 2 percent concentration to 5 percent
in some cases has produced a 10 percent increase in hair growth. Enhancing the drug with
Retin-A also has improved hair growth in some experiments. You can't find these solutions in U.S.
pharmacies (they are available in Europe), but some dermatologists over here can have
pharmacists prepare these mixtures.
Check around.
Other proposed nonsurgical baldness remedies
One anti-androgenic drug now being tried as a baldness remedy is oral finasteride. It inhibits the
5-alpha reductase (enzyme) that transforms testosterone into the dihydrotestosterone (DHT) form
responsible for hair loss. Blocking the action of DHT seems to stimulate growth of stronger, thicker
and more pigmented hair. In one multicentre study, 200 males aged 18 to 35 with distinct
baldness had a one-inch circle of scalp shaved and periodically examined for hair growth. The
report states that "men taking 5 mg per day of oral finasteride had significantly increased hair
growth. Side effects - such as impotence, loss of libido and reduced sperm counts - were not
widespread, and often decreased with time, affecting about three per cent of the sample." Ideal
candidates for finasteride treatment are men who have already
fathered all the children they wish, as its use for baldness might be lifelong and it could harm any
fetus conceived (while taking it). Further studies are needed to assess the drug's efficacy, dosage
and long-term safety. Another dihydrotestosterone-inhibitor now being tested is a derivative of
hyaluronic acid, the chemical at the tip of sperm that aids penetration of the egg's membrane.
Massaged into the scalp, this substance apparently blocks the androgenic action that causes hair
loss, but more research is needed.
Medical researchers in Asia believe that hair loss is caused mainly by insufficient blood supply to
the scalp. The other possibility is excessive sebum in the scalp which causes pore clogging and
malnutrition in the hair root( "sebaceous Gland Hypothesis", proposed by Dr. Yoshikata Inaba of
The Inaba Aesthetic Surgery in Tokyo). The so-called 101 hair regrowth lotion is formulated to
attack the problems. 101 became famous after it had won several international awards, among
them, "gold medal" from 14th International Inventors Exposition in New York (June 4, 1991).
According to Dr. Zhuang-Guang Zhao, the inventor, 101 promotes blood circulation by removing
blood stasis in the scalp and dilating the blood capillaries, it also remove sebum in the scalp.
Unlike other treatments, it has no side effects, the active compounds in this lotion are isolated
from plants, According to Newsweek and New York Times reports (references at page 48), there
is no questioning its popularity with the 3 million bald folks in Japan. Masashi Sada, a popular
Japanese singer, said recently on the radio
that the product worked wonders on his head. Millions of men and women in Asia reportedly have
used 101 and 90 percent are said to have found it effective in hair regrowth and a significant
reduction of hair loss. According to a spokesperson for the 101 products the improved formula
called Fabao 101D will be introduced to USA this year. But will 101D work on American heads?
(Interested reader can obtain a copy of brochure
by writting to: Pan State Health Products, Division of Hair Care, 155-21 Cherry Ave, Flushing, NY
11355, or e-mail: PanSt...@AOL.COM)
Other types of Hair Loss and treatments
Alopecia Areata
Sudden hair loss most commonly is due to alopecia areata, a condition that occurs in 2% of the
population and affects all races and bothsexes equally. Alopecia areata starts abruptly with one or
more circular patches of hair loss, up to 3 inches across, that may overlap, these bald patches
normally occur on the scalp but occasionally elsewhere on the body, such as the beard or the
eyebrows. The bald areas are smooth and painless.
Alopecia areata is thought to be an autoimmune disease and strongly associated with vitiligo and
diabetes. Patients with Down syndrome are especially prone to the disease.
In 90% of the cases, the hair grows back within 6 to 24 months. The outcome is worse if the
episode occurs early in life or if you lose all scalp hair in a single episode.
To diagnose alopecia areata, your doctor will perform a complete medical history and examination.
The treatment of alopecia areata depends on the extent of the disease. Monthly injections of
intralesional steroids are a common form of treatment, which usually hasten resolution to 4 to 6
months. New topical forms of treatment include dinitrochlorobenzene (which is a topical sensitizer)
anthralin 0.2% (anthra-Derm, Lasan, the only irritant subsistence), or psoralen plus ultraviolet light
A (PUVA). These treatment act by inducing an allergic contact dermatitis that, in healing,
promotes hair growth by a mechanism that is not fully understood. Resolution usually occurs in 8
to 12 weeks.
Topical minoxidil may be effective in alopecia areata, especially when used in the 5%
concentrations that are currently available only on a study protocol basis. The lower concentrations
(2%, Rogaine) are primarily effective in patchy alopecia areata.
Telogen Effluvium
Telogen effluvium is a form of abrupt, rapid, diffuse hair loss. This condition affects the entire
scalp, but the crown and bitemporal areas may appear to be mainly involved if there is associated
androgenic alopecia.
In telogen effluvium, there is an abrupt end to the anagen phase, so that the hair follicle phases
into catagen, then telogen. It is rarely severe and does not usually lead to baldness. But if the
condition is chronic and many generations of hair are lost, it may eventually lead to permanent hair
loss.
The common causes of telogen effluvium include
1) stress, especially after severe infection, fever, childbirth or surgery;
2) Severe psychogenic distress;
3) nutritional deficiencies;
4) various medications
The hair loss seen after childbirth is the protype of telogen effluvium. Three months after giving
birth, women often complain of hair loss that can be extensive. This is a result of parturition, when
physical stress causes anagen hairs to switch abruptly into the telogen phase. Telogen hairs are
retained for an average of 3 months before being shed.
Since this type of hair loss is temporary, the only therapy from your doctor is probably
reassurance.
New Treatments Now Under Study That Promise Hair Growth
Here is another story quite like that of Rogaine. ProCyte, based in Kirkland, Wash., discovered
the hair-growing effects of peptide copper in 1990 when it was testing the compound as a wound-
healing agent on laboratory mice, whose fur had been shaven. "The mouse wounds weren't
healing, but the hair was growing," (continued in part 2)
Eric Sieferman
<peter@.interramp.com> wrote:
>
>HOW TO STOP HAIR LOSS and REGROW HAIR (condensed)**
>1995 Infonet communication Inc. (inquiry: in...@infonet.com)
>by Mary Sheen, MD
>
>Part 1 Introduction
>Hair plays a significant role in our life.
Apparently, you've never met Jay Buhner.
Jimbone
>>Part 1 Introduction
>>Hair plays a significant role in our life.
>
>
>
Or Matt Williams.
Live like your gonna die tomorrow.
Work like your gonna live forever.
***** I can be annoyed at: *****
jim...@emf.net or jsie...@maxis.com
Ski
peter@.interramp.com says...
>
>
Hi,
My name is Frank Koniszewski, and I am a technical support representative for
InterRamp, an Internet access provider.
Please do not flame peter@.interramp.com as he is not the true sender of the
message.
If you look at the message ID,
Message-ID: <NEWTNews.14933.8...@interramp.com>
You can see that it was posted by usd3...@interramp.com
We are looking into this matter and appropriate action will be taken.
Frank
InterRamp Support
>
>
