Most Hospitalized Monkeypox Patients in the U.S. Were H.I.V.-Positive

[Leroy N. Soetoro]

https://www.nytimes.com/2022/10/26/health/monkeypox-hiv.html

<https://static01.nyt.com/images/2022/10/26/science/26monkeypox-
01/26monkeypox-01-jumbo.jpg?quality=75&auto=webp>

A scan showing monkeypox particles (red) found within an infected cell,
cultured in the laboratory at the National Institute of Allergy and
Infectious Diseases.Credit...National Institute of Allergy and Infectious
Diseases, via Associated Press

Nearly all Americans hospitalized for monkeypox infection had weakened
immune systems, most often because of H.I.V. infection, the Centers for
Disease Control and Prevention reported on Wednesday.

Of 57 hospitalized patients described in the report, 82 percent had H.I.V.
More than two-thirds of the patients were Black and nearly one-quarter
were homeless, reflecting racial and economic inequities seen in the
outbreak overall.

The finding suggests that although most cases of monkeypox are mild,
doctors should test patients with suspected cases for H.I.V. as well, and
be prepared to offer prompt treatment for both infections.

“Monkeypox and H.I.V. have collided with tragic effects,” Dr. Jonathan
Mermin, the C.D.C.’s lead scientist on monkeypox, said in a statement.

Most of the patients in the study were given tecovirimat, or Tpoxx, but
treatment for some patients was delayed by as long as four weeks after
they first sought care.

As of Tuesday, more than 28,000 cases of monkeypox had been reported in
the United States, and nearly 76,000 cases worldwide. A vast majority are
still among men who have sex with men, according to the C.D.C.

The number of new monkeypox infections has declined steadily since
September. But the number of high-risk people opting for vaccination has
also dropped. Only 7 percent of the vaccine doses administered so far have
gone to recipients who are Black.

People living with H.I.V. or with other conditions that weaken the immune
system fared poorly in previous outbreaks of monkeypox in African
countries.

In the new report, C.D.C. scientists analyzed case reports from 57
patients older than 18 who were hospitalized for monkeypox between Aug. 10
and Oct. 10. Roughly 95 percent of the patients were male.

All of them had skin rashes, and most also had severe lesions in the
mouth, urethra, rectum or vagina. About one in five experienced symptoms
in their lungs and eyes, and in four patients the brain and spinal cord
were affected.

Four of the 47 patients with H.I.V. were taking drugs to suppress the
virus before they were diagnosed with monkeypox. About one in three had a
CD4 count — a proxy for the immune system’s strength — of less than 50,
indicating severe immunosuppression.

Two of the patients, one of whom had H.I.V., were being treated for
cancer; three were solid organ transplant recipients; and three were
pregnant. All of these conditions are linked to a weakened immune system.

One third of the patients were admitted to intensive care units. Of the 12
recorded deaths, five were a result of complications from monkeypox
infection, six are under investigation and one was determined to be
unrelated.


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"LOCKDOWN", left-wing COVID fearmongering. 95% of COVID infections
recover with no after effects.

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Under Barack Obama's leadership, the United States of America became the
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President Trump boosted the economy, reduced illegal invasions, appointed
dozens of judges and three SCOTUS justices.