Re: six DNA repair mechanisms identified

[Jan Panteltje]

On a sunny day (Sun, 26 Mar 2023 12:11:30 -0400) it happened Joe Gwinn
<joeg...@comcast.net> wrote in <4fr02iteffsv24gil...@4ax.com>:

>On Sun, 26 Mar 2023 15:28:43 GMT, Jan Panteltje <al...@comet.invalid>
>wrote:
>
>>On a sunny day (Sun, 26 Mar 2023 10:56:26 -0400) it happened Joe Gwinn
>><joeg...@comcast.net> wrote in <q9m02iddomabr3oi4...@4ax.com>:
>>
>>>On Sun, 26 Mar 2023 06:22:39 GMT, Jan Panteltje <al...@comet.invalid>
>>>wrote:
>>>
>>>>On a sunny day (Sat, 25 Mar 2023 14:42:05 -0400) it happened Joe Gwinn
>>>><joeg...@comcast.net> wrote in <hpfu1i1dff2qo7vo7...@4ax.com>:
>>>>
>>>>>On Mon, 20 Mar 2023 15:23:32 GMT, Jan Panteltje <al...@comet.invalid>
>>>>>wrote:
>>>>>
>>>>>>On a sunny day (Mon, 20 Mar 2023 11:01:33 -0400) it happened Joe Gwinn
>>>>>><joeg...@comcast.net> wrote in <crsg1i910k39g1uk3...@4ax.com>:
>>>>>>
>>>>>>>On Mon, 20 Mar 2023 05:40:41 GMT, Jan Panteltje <al...@comet.invalid>
>>>>>>>wrote:
>>>>>>>
>>>>>>>>
>>>>>>>>Researchers highlight nucleolar DNA damage response in fight against cancer
>>>>>>>>< https://www.sciencedaily.com/releases/2023/03/230316113153.htm >
>>>>>>>>Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways.
>>>>>>>>A new review highlights six mechanisms by which cells repair DNA damage.
>>>>>>>>By attacking these mechanisms, future applied researchers will be able to trip up cancer's reproduction and growth.
>>>>>>>
>>>>>>>
>>>>>>>I'm not sure what's new there.
>>>>>>>
>>>>>>>A good place to look for the historical background is Doxorubicin,
>>>>>>>specifically its mechanism of action and uses in cancer treatment.
>>>>>>>This drug is also known as the Red Devil, and for good reason.
>>>>>>>
>>>>>>>.< https://en.wikipedia.org/wiki/Doxorubicin >
>>>>>>>
>>>>>>>.<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116111/#:~:text=There%20are%20two%20proposed%20mechanisms,1)%20%5B9%5D.>
>>>>>>>
>>>>>>>Joe Gwinn
>>>>>>
>>>>>>See the paragph in the link I gave starting with:
>>>>>>"
>>>>>>While the first four mechanisms take place inside the nucleolus,
>>>>>>which is in a room cordoned off within the watery cell,
>>>>>>the last two mechanisms use a new cellular process which won the 2023 Breakthrough Prize in Life Sciences.
>>>>>>... -----
>>>>>>"What's new is that APE1 acts like a GPS or a first responder,"
>>>>>>Yan said. "It says there's a problem here, we need a police car, a medic, and others to come and be concentrated here."
>>>>>>
>>>>>>
>>>>>>
>>>>>>In the process, called liquid-liquid phase transition,
>>>>>>proteins pop up their own liquid 'tents' to do their work instead of staying inside a room."
>>>>>>
>>>>>>
>>>>>>
>>>>>>Its very intersting how many DNA repair mechanisms exist!
>>>>>
>>>>>Yes, at all levels. Basically, the larger the animal, the better the
>>>>>DNA repair mechanisms must be. And if the animal is to live very
>>>>>long, those mechanisms must be better still.
>>>>>
>>>>>A lot of the immune system is designed to detect and eliminate cancers
>>>>>as well.
>>>>>
>>>>>Lots of things damage DNA, with ionizing radiation (like UV light) and
>>>>>radioactive isotopes, fungal toxins, and viruses being leading causes.
>>>>>The list is long.
>>>>>
>>>>>Joe Gwinn
>>>>
>>>>Yes, and depleted Uranium:
>>>>< https://www.rt.com/news/573597-nato-inhumane-balkans/ >
>>>
>>>Umm. Exactly backwards. Depleted uranium is what's left after the
>>>bomb stuff has been removed.
>>>
>>>It's used for anti-tank projectiles because it will physically bull
>>>through a lot of steel armor-plate when fired at meteor-strike speed.
>>>
>>>Basically, it is the modern version of a cross-bow bolt.
>>>
>>>.< https://en.wikipedia.org/wiki/Kinetic_energy_penetrator >
>>
>>Yes, read again what I wrote.
>>And US used depleted Uranium ammo in Iraq too, an other war crime.
>>Depleted Uranium was also used as couter-weight in the Boeing 747 cargo plane that flew into the flat
>>next to where I once used to live in Amsterdam (left 4 years before that, did see it coming):
>> < https://www.wise-uranium.org/dhap997.html#:~:text=About%20400%20kg%20of%20uranium,dangerous%20to%20the%20public%20health. >
>>
>>US army is well aware of it:
>> publichealth.va.gov/exposures/depleted_uranium/
>>
>
>It's a weapon, used in war. The alternative is farmland littered with
>tons of unexploded ordinance, which Ukraine already has in spades.

Agent orange in Vietnam
US used tons of that sort of cluster ammo you mentioned in several other countries.
US , when its Afganistan market for its Military Industrial Complex closed,
needed an other big war so it could keep selling their crap weapons.
So Ukrain with its dummy leader was a nice alternative to Afghanistan.
Soon US will be no more, nuclear underwater drones are set to attack it all around.
Nukes to Belarus? How about some in Cuba next to that US torture base in Qantanamo?
This is all going out of control, a few low IQ leaders in the US .. miscalculating is guaranteed.
US get the fuck out of Europe with your war machine!!! Or I will ask the intergalactic...
Well, let US self-destruct, so be it!
IQ of the AI it is controlled by now ?
Justice Junta .. matter of time.
I think 2024 but seems US wants express delivery!

You can't always get what you want, but you may find, sometimes, you get what you need!
Rolling STones...

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