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Phlebotomy and Iron In Hormone Dysregulation

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Jan 8, 2022, 9:59:25 PM1/8/22
“Effect of phlebotomy versus oral contraceptives containing cyproterone acetate on the clinical and biochemical parameters in women with polycystic ovary syndrome: a randomized controlled trial.”

"Background: Reduction of the body iron stores can improve hyperandrogenemia and insulin resistance. This study aimed to compare clinical and para-clinical responses to the treatment of phlebotomy using oral contraceptive pills (OCs) containing cyproterone acetate in women with PCOS."

"Both treatment modalities had similar beneficial effects on insulin resistance and on androgenic profiles"

Resistance to the Insulin and Elevated Level of Androgen: A Major Cause of Polycystic Ovary Syndrome
Front Endocrinol (Lausanne)
. 2021 Oct 20;12:741764. doi: 10.3389/fendo.2021.741764. eCollection 2021.
Haigang Ding 1 2, Juan Zhang 1 2, Feng Zhang 1 2, Songou Zhang 3, Xiaozhen Chen 3, Wenqing Liang 4, Qiong Xie 5
PMID: 34745009 PMCID: PMC8564180 DOI: 10.3389/fendo.2021.741764
PCOS has a wide range of negative impacts on women's health and is one of the most frequent reproductive systemic endocrine disorders. PCOS has complex characteristics and symptom heterogeneity due to the several pathways that are involved in the infection and the absence of a comm14on cause. A recent study has shown that the main etiology and endocrine aspects of PCOS are the increased level of androgen, which is also known as "hyperandrogenemia (HA)" and secondly the "insulin resistance (IR)". The major underlying cause of the polycystic ovary is these two IR and HA, by initiating the disease and its severity or duration. As a consequence, study on Pathogenesis is crucial to understand the effect of "HA" and "IR" on the pathophysiology of numerous symptoms linked to PCOS. A deep understanding of the pattern of the growth in PCOS for HA and IR can help ameliorate the condition, along with adjustments in nutrition and life, as well as the discovery of new medicinal products. However, further research is required to clarify the mutual role of IR and HA on PCOS development.

Keywords: androgen; endocrine disorder; hyper-androgenemia; insulin resistance; polycystic ovary syndrome (PCOS).

Copyright © 2021 Ding, Zhang, Zhang, Zhang, Chen, Liang and Xie.


Hyperandrogenemia and insulin resistance: The chief culprit of polycystic ovary syndrome
Juan Wang 1, Daichao Wu 1, Hui Guo 1, Meixiang Li 2
Life Sci
. 2019 Nov 1;236:116940. doi: 10.1016/j.lfs.2019.116940. Epub 2019 Oct 8.
PMID: 31604107 DOI: 10.1016/j.lfs.2019.116940
Polycystic ovary syndrome (PCOS) is one of the most common systemic reproductive endocrine diseases, which has a variety of effects on a woman's health. Because of the involvement of multiple pathways and the lack of common clues, PCOS demonstrates multifactorial properties and heterogeneity of symptoms. Recent studies have demonstrated that the core etiology and primary endocrine characteristics of PCOS are hyperandrogenemia (HA) and insulin resistance (IR). HA and IR are the main causes of PCOS and they can interplay each other in the occurrence and development of PCOS. Just because of this, the study about the effects of HA and IR on pathophysiology of various related symptoms of PCOS is very important to understand the pathogenesis of PCOS. This paper reviews the main symptoms of PCOS, including neuroendocrine disorders, reproductive processes, dyslipidemia, obesity, hypertension, nonalcoholic fatty liver disease (NAFLD), and sleep disordered breathing, which seriously affect the physical and mental health of PCOS women. The increasing knowledge of the development pattern of HA and IR in PCOS suggests that changes in diet and lifestyle, and the discovery of potential therapeutic agents may improve PCOS. However, further studies are needed to clarify the mutual influence and relation of HA and IR in development of PCOS. This review provides an overview of the current knowledge about the effects of HA and IR on PCOS.

Keywords: Advanced glycosylation end products; Endocrine disrupting chemicals; Hyperandrogenemia; Insulin resistance; PCOS.

Copyright © 2019 Elsevier Inc. All rights reserved.

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