Comparison of Oxidative Stress in Pregnancies with and without First Trimester Iron Supplement: A Randomized Double Blind Controlled Trial.
Korkmaz V, Ozkaya E, Seven BY, Duzguner S, Karsli MF, Tuncay K.
J Matern Fetal Neonatal Med. 2013 Nov 8.
Dr. Sami Ulus Maternity and Women's Health Training and Research Hospital, Ankara, TURKEY.
Abstract
Abstract Objective:
Iron supplementation was found to be a cause of oxidative stress.
The aim of this study was to compare oxidative stress in pregnancies with and without iron supplementation in the first trimester pregnancies.
Methods:
One hundred and eight women in the first trimester of normal pregnancies were randomly assigned to three groups.
Patients were grouped as following: group 1 received placebo (n=36), group 2 received folate supplementation (n=36) and group 3 was directed to administer the medication of the iron supplementation (n=36).
Oxidative stress was assesed at 14 th weeks of gestation by the utilization of serum γ- glutamyl transferase level.
Pregnancies were followed until delivery.
Relationship between the oxidative stress and pregnancy outcome was assessed among groups.
Results:
Mean age was similar among groups, mean gravidity and parity were significantly lower in group with Fe supplementation (p < 0.05).
Maternal weight and weight gain during pregnancy were also significantly lower in Group 3 (p < 0.05).
Mean serum albumin levels were similar among groups while serum γ- glutamyl transferase (GGT) levels were significantly higher in Group 3.
There were 10 cases of oligohydramnios in Group 3, 2 cases in Group 2 and no cases in Group 1 (p < 0.001).
Conclusion:
Iron supplementation during first trimester pregnancy was found to be associated with an increased oxidative stress.
PMID:24199687
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