Queen Victoria and Hemophilia
RCLOVELY
Everyone is aware that the Tzarvitch Alexi had hemophilia that came from his
Great Grandmother, Queen Victoria. Marline Dahling, since you are the resident
Victoria expert, what other of her decendents had it?
RC
Marlene A Koenig
Frank -- Sigisimund of Prussia was not a hemophiliac
nor was Prince Maurice of Battenberg (he served in the British armed
forces and died in battle )
Irene Hesse had three sons - Waldemar-Sigismund and Henry -
the eldest and the youngest were hemophiliacs.
Beatrix of Hohenlohe is not carrying anything - she's dead.
Of Alice's children -only Alix and Irene were carriers -
Victoria was not a carrier, thus none of her descendants would carry
or have the disease.
(It would have shown up in her children). Most likely, the disease
has died out - Neither Maria Cristina or Beatriz of Spain
had hemophiliac sons - and none of their daughters were apparently carriers --
Princess ALice of Albany was not a Countess of Teck.
She was HRH Princess Alice, Countess of Athlone from 1917 -
from her marriage until 1917 she was HRH Princess Alexander of Teck.
Nor was Jaime, Duke of Segovia a hemophiliac, Frank - he was a deaf-mute
due to a childhood disease -
of Beatriz's three surviving sons (she also had a stillbirth)
make that 4 surviving sons: Alfonso, Jaime, Juan, Gonzalo -
the eldest and the youngest were hemophiliacs.
So, let's try again - for your records
Alice was a carrier
of her two sons, the youngest Friedrich Wilhelm (Frittie) was
a hemophiliac. Two daughters, Irene and Alix were carriers.
Irene had three sons: the eldest and the youngest were hemophiliacs
Alix's only son was a hemophiliac.
Leopold - his daughter Alice was a carrier - her eldest son Rupert
was a hemophiliac. Baby Maurice might also have been. Daughter May
did not carry the disease
Beatrice. Three sons -but only one was a hemophilic, Lord Leopold
Mountbatten and Ena was a carrier -- Ena had four sons - the eldest and
the youngest were diseased -- neither daughter appears to have been
a carrier.
Got it
--
and author of Queen Victoria's Descendants,
published by Rosvall Royal Books
Publisher of Royal Book News, the only newsletter for and about
Royal Books
Frank H. Johansen
RCLOVELY wrote:
Descendants of Queen Victoria that was hemophiliacs or carried the gene:
1. Princess Alice of the UK, Grand Duchess of Hesse by Rhine. Carrier.
1.1. Princess Irene of Hesse by Rhine, Princess of Prussia. Carrier.
1.1.1. Prince Waldemar of Prussia. Hemophiliac
1.1.2. Prince Sigismund of Prussia. Hemophiliac
1.1.2.1. Prince Alfred of Prussia. Hemophiliac
1.2. Princess Alix of Hesse by Rhine, Empress Alexandra of Russia. Carrier.
1.2.1. Grand Duke Alexej, Tseczarevich of Russia. Hemophiliac
2. Duke Leopold of Albany, hemophiliac
2.1. Princess Alice of Albany, Countess of Teck. Carrier.
2.1.1. Rupert Teck, Viscount Trematon, hemophiliac
3. Princess Beatrice, Princess of Battenberg. Carrier.
3.1. Prince Maurice of Battenberg, hemophiliac
3.2. Prince Leopold of Battenberg, hemophiliac
3.3. Princess Victoria Eugenia of Battenberg, Queen of Spain. Carrier.
3.3.1. Infant Alfonso Spain, Prince of Asturias, later Count of Covadonga
3.3.2. Infant Jaime of Spain, Duke of Segovia
Possible carriers are (all matrilinneal descendants of Queen Victoria):
Beatrix Prinzessin zu Hohenlohe-Langenburg
Margarita Prinzessin von Baden
Princess Katharina of Yugoslavia
Victoria Maria de Silva
Christine Prinzessin von Hessen
Princess Tatiana of Yugoslavia
Sonja Thune-Larsen
Olga Thune-Larsen
Helen Sophie Harman, née van Eyck
Sascha Harman
Pascale Harman
Dorothea Prinzessin zu Windisch-Grätz, née Prinzessin von Hessen
Marina Jakabffy, née Prinzessin zu Windisch-Grätz
Reka Jakabffy
Sophia Jakabffy
Clarissa de Waele, née Prinzessin zu Windsich-Grätz
Clarissa Prinzessin von Hessen
Johanna von Hessen
Friederikke Cyr, née Prinzessin von Hannover
Julia Emma Cyr
Countess Sandra Lequio di Assaba, née Torlonia
Countess Desideria Touron, née dei Conti Lequio di Assaba
Olimpia Weiller, née Torlonia
Beatrice Correia do Lago, née Weiller
Helena Corriea do Lago
Princess Sibilla of Luxembourg, née Weiller
Cosima Weiller
Domitilla Weiller
Vittoria dei Conti Marone Cinzano (de Marone Cinzano y Borbón)
Vittoria Alvarez de Toledo y Marone Cinzano
Ana Codorniu y Alvarez de Toledo
Carla Codorniu y Alvarez de Toledo
Giovanna dei Conti Marone Cinzano
Cristina Ruiz de Arana
Isabael Ruiz de Arana
Inez Ruiz de Arana
Anna Sandra dei Conti Marone Cinzano
Astrid Stavro di Santarosa
Yara Cristina Stavro di Santarosa
Regards
Frank H. Johansen
frank.j...@hm.telia.no
RCLOVELY
>Descendants of Queen Victoria that was hemophiliacs or carried the gene:
Thanks Frank, it is most interesting to note that only two of Victorias
daughters carried the gene and only one son had it. Isn't it unusual for a
father to pass it on ot a daughter, as in the case of Duke Leopold and his
daughter Princess Alice?
RC
Craig K. Gowens (Commissioner of the SWC)
rclo...@aol.com (RCLOVELY) wrote:
>
> >Descendants of Queen Victoria that was hemophiliacs or carried the gene:
>
> Thanks Frank, it is most interesting to note that only two of Victorias
> daughters carried the gene and only one son had it.
Victoria had five daugthers. Two were carriers. It would have been more
unusual for only one or for four to be carriers and very unusual for all to
be normal or all to be carriers. With five daugthers, the probability of
two being carriers is 10/32 or 31.25%. That along with three carriers is the
highest probability for the six different combinations. As for only one of
her four sons having the disease, the chances of that are 4/16 or 25%,
which appears somewhat usual. On its face, it would appear that there is a
50% that two would have the disease and two would be normal, however the
real probability of two being hemophiliac is 37.5%. There is also a 25%
chance that three would have been hemophiliac. The probability of all being
hemophiliac or for none being hemophiliac was 1/16 or 6.25%
> Isn't it unusual for a
> father to pass it on ot a daughter, as in the case of Duke Leopold and his
> daughter Princess Alice?
What do you mean by passed on? Being a carrier or the disease itelf?
If the father is hemophiliac, all daughters are carriers. If the father is
hemophiliac and the mother is a carrier, all daughters will be carriers and
there is a 50% chance that a daughter will be hemophiliac. If the father is
hemophiliac and the mother is hemophiliac, all children will be hemophiliac.
Craig K. Gowens
Frank H. Johansen
RCLOVELY wrote:
> >Descendants of Queen Victoria that was hemophiliacs or carried the gene:
>
> Thanks Frank, it is most interesting to note that only two of Victorias
> daughters carried the gene and only one son had it. Isn't it unusual for a
> father to pass it on ot a daughter, as in the case of Duke Leopold and his
> daughter Princess Alice?
No, IF the hemophiliacs live long enough to have children, the daughters (not
the sons) are as likely to be carriers, as the children of a female carrier.
But a hemophiliac cannot pass on his decease to his son, unless his spouse is a
carrier too. That's because the gene's are on the X-chromosome. Therefore,
Prince Alfred of Prussia could not have been a hemophiliac, as I said
yesterday.
Please set you standard font to "Fixed with" to read the chart properly
Xx -- xy
Vic Alb
__|____________________________________
| | |
Xx -- xy Xy -- xx Xx -- xy
Al Lud Leo Hel Bea Hen
__|_____________ __| __|________
| | | | | |
Xx -- xy Xx -- xy Xx -- xy Xy Xy Xx -- xy
Ir Hein Alx Nic Al Alx Mau Leo Ena Alf
__|___ ___| __| ____________|
| | | | | |
Xy Xy -- xx Xy Xy Xy Xy
Wld Sig Alx Rup Alf Jai
|
|
xy
Alfred
The X-gene is the carrier gene
xx = normal female
xy = normal male
Xx = carrier female
Xy = hemophiliac male
Regards,
Frank H. Johansen
RCLOVELY
>IF the hemophiliacs live long enough to have children, the daughters (not the
sons) are as likely to be carriers, as the children of a female carrier.
Thank you gentlemen, this has been most interesting. Now, another silly
question, Frank posted a lits of Victorias decendents who are possible cariers,
but are any of her male decendents living today hemophiliacs?
RC
JackH35785
Just a note to tell all of you what a fascinating discussion this is! I have
always been very interested in this subject.
The British monarchy's plan to "annex" all the European monarchies by
"procreation" turned into a horror story of incredible proportions.
Little did Queen Vic realize she would contribute to the distruction of the
European monarchies!
Jack
RCLOVELY
>The British monarchy's plan to "annex" all the European monarchies by
"procreation" turned into a horror story of incredible proportions.
On the other hand, Victoria had nine children. They had to marry someone. Who
better than people they and their parents kenw, and had the same lifestyle.
RC
Marlene A Koenig
RC -- it is not unusual for only one or two members of the family
to have the disease or carry it --
A hemophiliac can pass the gene to a daughter who becomes a carrier,
but cannot pass the gene to a son. This is why Leopold's daughtter
daughter was a carrier, but his son, Charles Edward, was free of
the disease
Marlene A Koenig
RC -- Frank's list was largely inaccurate - the only possible
chance would be with the descendants of Beatriz and Maria Cristina of
Spain -- Frank listed men and women who descend from non carriers --
no male descendant of Queen Victoria living today as hemophilia --
has hemophilia
William Addams Reitwiesner
"Frank H. Johansen" <frank.j...@hm.telia.no> wrote:
>
>
>RCLOVELY wrote:
>
>> Everyone is aware that the Tzarvitch Alexi had hemophilia that came from his
>> Great Grandmother, Queen Victoria. Marline Dahling, since you are the resident
>> Victoria expert, what other of her decendents had it?
>>
>> RC
>
>Descendants of Queen Victoria that was hemophiliacs or carried the gene:
>
>1. Princess Alice of the UK, Grand Duchess of Hesse by Rhine. Carrier.
>1.1. Princess Irene of Hesse by Rhine, Princess of Prussia. Carrier.
>1.1.1. Prince Waldemar of Prussia. Hemophiliac
>1.1.2. Prince Sigismund of Prussia. Hemophiliac
>1.1.2.1. Prince Alfred of Prussia. Hemophiliac
Incorrect. Neither Sigismund nor Alfred were hemophiliacs. Sigismund's
younger brother Heinrich, however, was a hemophiliac.
>1.2. Princess Alix of Hesse by Rhine, Empress Alexandra of Russia. Carrier.
>1.2.1. Grand Duke Alexej, Tseczarevich of Russia. Hemophiliac
Also 1.3. Frederick of Hesse (1870-1873), the first hemophiliac descendant
of Queen Victoria to die.
>2. Duke Leopold of Albany, hemophiliac
>2.1. Princess Alice of Albany, Countess of Teck. Carrier.
>2.1.1. Rupert Teck, Viscount Trematon, hemophiliac
>3. Princess Beatrice, Princess of Battenberg. Carrier.
>3.1. Prince Maurice of Battenberg, hemophiliac
>3.2. Prince Leopold of Battenberg, hemophiliac
>3.3. Princess Victoria Eugenia of Battenberg, Queen of Spain. Carrier.
>3.3.1. Infant Alfonso Spain, Prince of Asturias, later Count of Covadonga
>3.3.2. Infant Jaime of Spain, Duke of Segovia
Alfonso was a hemophiliac, but Jaime was not. Their younger brother
Gonzalo was.
William Addams Reitwiesner
wr...@erols.com
"Friendless, adj. Having no favors to bestow. Destitute of fortune.
Addicted to utterance of truth and common sense."
-- Ambrose Bierce, *The Devil's Dictionary*
William Addams Reitwiesner
NOSPAMc...@uts.cc.utexas.edu.REMOVEFORMAIL (Craig K. Gowens
(Commissioner of the SWC)) wrote:
>rclo...@aol.com (RCLOVELY) wrote:
>>
>> >Descendants of Queen Victoria that was hemophiliacs or carried the gene:
>>
>> Thanks Frank, it is most interesting to note that only two of Victorias
>> daughters carried the gene and only one son had it.
>
>Victoria had five daugthers. Two were carriers. It would have been more
>unusual for only one or for four to be carriers and very unusual for all to
>be normal or all to be carriers. With five daugthers, the probability of
>two being carriers is 10/32 or 31.25%. That along with three carriers is the
>highest probability for the six different combinations. As for only one of
>her four sons having the disease, the chances of that are 4/16 or 25%,
>which appears somewhat usual. On its face, it would appear that there is a
>50% that two would have the disease and two would be normal, however the
>real probability of two being hemophiliac is 37.5%. There is also a 25%
>chance that three would have been hemophiliac. The probability of all being
>hemophiliac or for none being hemophiliac was 1/16 or 6.25%
>
>> Isn't it unusual for a
>> father to pass it on ot a daughter, as in the case of Duke Leopold and his
>> daughter Princess Alice?
>
>What do you mean by passed on? Being a carrier or the disease itelf?
>If the father is hemophiliac, all daughters are carriers. If the father is
>hemophiliac and the mother is a carrier, all daughters will be carriers and
>there is a 50% chance that a daughter will be hemophiliac. If the father is
>hemophiliac and the mother is hemophiliac, all children will be hemophiliac.
All of this is assuming that the hemophilia suffered by Victoria's
descendants was a type which is inherited as a sex-linked recessive. The
classic hemophilias are Hemophilia A (factor VIII) and Hemophilia B (factor
IX), which have identical symptoms and are inherited as sex-linked
recessives. The symptoms reported among Victoria's hemophiliac descendants
match these hemophilias, as does the inheritance pattern, but if any
immunoassay has been performed on any of these descendants, the results
have not been published.
The reason I bring this up is that I have a friend with severe factor XI
hemophilia. The symptoms are very different from those of Victoria's
descendants, and factor XI hemophilia is inherited as an autosomal
recessive.
JackH35785
In an adjacent post someone asks how Queen Vic was to get afflicted with
hemophillia but it has'nt been answered. Anyone for a try at this ?
Also, did Albert have a problem that would have been a factor in this ?
Jack
Marlene A Koenig
I already answered this -- spontaneous mutation at
V's conception or inherited from her mother's side. If you go
back several generations from Victoria through her mother - as well
as other maternal collateral lines - you will see a number of
sons who died as children or young men. Victoria's aunt,
Sophie, had two sons who died young
see Charlotte zeepvat's new bio on prince Leopold for more
information
William Addams Reitwiesner
jackh...@aol.com (JackH35785) wrote:
>In an adjacent post someone asks how Queen Vic was to get afflicted with
>hemophillia but it has'nt been answered. Anyone for a try at this ?
There have been a lot of guesses, but nothing definite.
>Also, did Albert have a problem that would have been a factor in this ?
His mother bled to death, but that was a uterine hemorrhage.
Inge Cubitt
In article <199806282315...@ladder03.news.aol.com>,
jackh...@aol.com (JackH35785) wrote:
> In an adjacent post someone asks how Queen Vic was to get afflicted with
> hemophillia but it has'nt been answered. Anyone for a try at this ?
Women do not suffer from haemophilia, but they can be carriers and pass it on
to their sons.
Inge
Frank H. Johansen
Inge Cubitt wrote:
Women can be hemophiliacs if their father was a hemoph. and their mother was a
carrier. Then we get this chart:
Xy --- Xx
____|________
| | | |
XX Xx Xy xy
XX = female hemophiliac
Xx = female carrier
Xy = male hemophiliac
xy = "normal" male
A female hemophiliac is of obvious reasons not very likely to live through the
early years of her puberty...
Regards,
Frank H. Johansen
RCLOVELY
>> In an adjacent post someone asks how Queen Vic was to get afflicted with
hemophillia but it has'nt been answered.
According to the University of Hull, Geneticsts say the mutation started with
Edward Augustus, Duke of Kent who was an elderly father of Queen Victoria.
RC
Pamela Gray
Oh. Did she have more than one?
Pamela
Marlene A Koenig
The University of Hull database is wrong - the gene would not start wth
her father, but with her mother's family or at V's conception -
but there are a number of maternal lines from Victoria where many of the
sons died young. See Charlotte Zeepvat'snew bio Prince Leopld
with the family tree
RCLOVELY
>Oh. Did she have more than one?
Just quoting from Hull. That is how it is written there.
RC
RCLOVELY
> the gene would not start wth her father, but with her mother's family
Marlene, that does make a lot more sense.
RC
William Addams Reitwiesner
"Frank H. Johansen" <frank.j...@hm.telia.no> wrote:
>
>
>Inge Cubitt wrote:
>
>> In article <199806282315...@ladder03.news.aol.com>,
>> jackh...@aol.com (JackH35785) wrote:
>>
>> > In an adjacent post someone asks how Queen Vic was to get afflicted with
>> > hemophillia but it has'nt been answered. Anyone for a try at this ?
>>
>> Women do not suffer from haemophilia, but they can be carriers and pass it on
>> to their sons.
>
>Women can be hemophiliacs if their father was a hemoph. and their mother was a
>carrier. Then we get this chart:
>
>Xy --- Xx
>____|________
>| | | |
>XX Xx Xy xy
>
>XX = female hemophiliac
>Xx = female carrier
>Xy = male hemophiliac
>xy = "normal" male
>
>A female hemophiliac is of obvious reasons not very likely to live through the
>early years of her puberty...
Why? Menstrual fluid, though it resembles blood in many ways, is not blood
at all, it's emulsified (i.e., liquified) endometrium. It doesn't clot
because it has no clotting factors (what are called clots are actually
incompletely emulsified chunks of endometrium). So, yes, adult female
hemophiliacs can and do survive. Pregnancy and childbirth may be risky,
but not ordinary menses.
In fact, the presence of blood in menstrual fluid is usually a symptom of
cervical cancer.
Marlene A Koenig
Frank - please see Charlotte Zeepvat's book on Leopold which discusses
this further - Charlotte goes back to Fernande, Ctss of Stolberg
who married Georg AUgust of Erbach-Schoenberg -
Eldest daughter Christine married Heinrich XII Reuss
a son Heinrich lived for a year
2nd daughter Karoline married Heinrich XXIV Reuss Ebersdorf
Third daughter Auguste married Friedrich Count of Glech
also ygst son Kasimir died young (1736-1760)
Christine Reuss's eldest son ived for a year.
Karoline Reuss' eldest chson Heinrich XLVI (1755=57) died
from an infection of the teeth
another son Heinrich LI died of convulsive fit (similar to Leopold)
Karoline's eldest daughter Auguste married Franz Coburg
Auguste's youngest son Maximilian died at age 1
Auguste's daughter Sophie Mensdorff had six sons - Alfred
and Leo died young
Auguste's daugter Antoinette married Alexander Wurttemberg -
2 sons, paul and Friedrich died young
Go back to Fernande's family - daughter Auguste married Glech
8 children - including twin daughters dead in infancy -
4 of the six sons died young
Karoline Reuss' daughter Luise married another Reuss -
one son of three sons died young
The Heinrich who died of a convulsive fit married - 1 son 2
daughters - yr daughter Adelheid married a Reuss --
three sons of Adelheid died young.
Henriette of Reuss (sister of Heinrich LI) married Leiningen
one son Friedrich Karl died young --
other possibilities through V's 1/2 sister, Feodora (grandson
Victor of Saxe Meiningen
and Feodora's daughter Adelheid had two sons die young
Marlene A Koenig
Yes, women can suffer from hemopholia if the father is a hemophiliac and
the mother a carrier --
Frank H. Johansen
Marlene A Koenig wrote:
> The University of Hull database is wrong - the gene would not start wth
> her father, but with her mother's family or at V's conception -
> but there are a number of maternal lines from Victoria where many of the
> sons died young. See Charlotte Zeepvat'snew bio Prince Leopld
> with the family tree
I've done some checking on this subject, and when following Victorias
matrilinneal ancestors only 4 generations back, I come up with several boys
dieing at a very early age. These are:
- Her uncle, Duke Franz Maximillian Ludwig of S-C-Saalfeld (1792-1793)
- Her maternal cousins, Dukes Karl Alexander (1800-1802) and Friedrich
Wilhelm Ferdinand (1810-1815) of Württemberg
- Her great uncles, Counts Heinrich XLVI (1755-1757) and LVII (1767-1770)
Reuss of Ebersdorf
- Her mothers maternal cousins, Count Heinrich LIX Reuss of Köstritz
(1783-1784) and Prince Friedrich Karl Heinrich of Leiningen (1793-1800)
- Her great-great uncles Christian Adolf (1725-1726) and Friedrich
(1733-1733) of Erbach-Schönberg
Many of these could have been hemophiliacs, but I don't know if they were.
Does anyone know what their *allegded* causes of death was?
Frank H. Johansen
frank.j...@hm.telia.no
Bee...@my-dejanews.com
In article <OBowg85...@nih2naaa.prod2.compuserve.com>,
Marlene A Koenig <74642...@CompuServe.COM> wrote:
>
> The University of Hull database is wrong - the gene would not start wth
> her father, but with her mother's family or at V's conception -
> but there are a number of maternal lines from Victoria where many of the
> sons died young. See Charlotte Zeepvat'snew bio Prince Leopld
> with the family tree
Marlene and Group,
I met and interviewed Charlotte during my visit to Kent last week. We talked
about her great book...and she does put forward a very interesting case in
her book. Yet...there are many unanswered questions...it is one thing to
identify all the boys who died young...which Charlotte effectively did...and
it is a thoroughly different issue claiming that they all "died most likely
of hemophilia." Obviously...we will never know the exact cause of death for
all of these royal princelings...but Charlotte's book does break ground on
this very interesting topic. Her insight into the topic is that the gene
most "likely" came into the Saxe-Coburg-Gotha family through Augusta of
Reuss-Ebersdorff, Queen Victoria's grandmother...Charlotte says she rtelied
greatly on previously ignored sources...such as Augusta's memoirs. My
interview with Charlotte will appear in Issue VI of the European Royal
History Journal.
She is a nice lady...and thoroughly knowledgeable on royal topics. She
signed a copy of her book for me...and we spent the entire day together at
Royalty Digest book shopping...even took time to meet us at the train station
and drive us to Ticehurst...an enjoyable day...and all those books!
Eurohistory.com (art...@eurohistory.com) will be the first bookstore with
available copies of her book...they are already on their way from the US
distributor.
The genealogical charts that Charlotte built for the book...although she was
not happy with the way in which these were printed...are fantastic...I'm
almost done reading the book...and have enjoyed it immensely.
Arturo Beeche
Webmaster and Bookseller at http://www.eurohistory.com
Publisher of The European Royal History Journal
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FMSNURSE
Craig with all due respects your statistics are incorrect. Each daughter has a
50-50 percent chance of inheriting the gene--being a carrier, as she gets one X
chromosome from her mother. Equally each son has a 50-50 chance of being
affected, as he gets one X from his mother. However, if a male has hemophilia,
as Prince Leopold did, all his daughters must be carriers because they inherit
his only X which carries the gene.
JackH35785
My thanks to you all ! ! ! This is a fabulous discussion ! ! !
Jack
Craig K. Gowens (Commissioner of the SWC)
Which one may I ask? For the most common type of hemophilia, the
probabilities are correct.
> Each daughter has a
> 50-50 percent chance of inheriting the gene--being a carrier,
Under which condition? The only case where a single daughter has a 50-50
chance of being a carrier is if the mother is a carrier and the father
is normal. RCLOVELY's question was in regards to a father passing it on
to a daughter. Thus we must assume she refers to the father being hemophiliac
himself. Whenever a couple produces the daughter, eack parent contributes
one X chromosome. The father only has one X chromosom to donated, the one
with the gene for hemophilia, thus all daughters will be carriers. Your
statement that each daughter has a 50-50 chance of being a carrier in not
correct. Each child has a 50-50 chance if the mother is normal and the father
is hemophiliac.
> as she gets one X
> chromosome from her mother. Equally each son has a 50-50 chance of being
> affected, as he gets one X from his mother.
I covered most of the senarios in my post. There are 6 different senarios.
mother normal, father normal: all children normal unless by mutation
mother carrier, father normal: each daughter has 50% chance of being a carrier
each son ha 50% chance of being hemophiliac
mother hemophiliac, father normal: all daughters are carriers
all sons hemophiliac
mother normal, father hemophiliac: all daughters are carriers
all sons are normal
mother carrier, father hemophiliac: each daughter has 50% chance of being
hemophiliac
if not hemophiliac, the daughter is a
carrier
each son has a 50% chance of being
hemophiliac
mother hemophiliac, father hemophiliac: all children are hemophiliac
>However, if a male has hemophilia,
> as Prince Leopold did, all his daughters must be carriers because they inherit
> his only X which carries the gene.
correct, which leads me to ask where is the error you speak of.
Craig K. Gowens
Craig K. Gowens (Commissioner of the SWC)
wr...@erols.com (William Addams Reitwiesner) wrote:
>
> All of this is assuming that the hemophilia suffered by Victoria's
> descendants was a type which is inherited as a sex-linked recessive. The
> classic hemophilias are Hemophilia A (factor VIII) and Hemophilia B (factor
> IX), which have identical symptoms and are inherited as sex-linked
> recessives. The symptoms reported among Victoria's hemophiliac descendants
> match these hemophilias, as does the inheritance pattern, but if any
> immunoassay has been performed on any of these descendants, the results
> have not been published.
True. I was basing it on the fact that it appears to be of this form and
these are the more common types of hemophilia.
Craig K. Gowens
Sam Dotson
It has been postulated that the defective gene that Queen Victoria
passed along to her descendants may have arisen as a spontaneous
mutation at her conception because of the lack of a history of
hemophilia in her family prior to this time. I would be very hesitant to
accept any of these childhood deaths as an indication of hemophilia,
since the infant mortality rate at the time was very high, primarily due
to lack of antibiotics to treat the common infectious diseases (consider
the Hessian deaths in 1878, for example). One need not look at the
matrilinear realtions of Queen Victoria to see this kind of death rate
among children. Look at a genealogy of any other family of this era and
you will find a very similiar childhood mortality.
Sam Dotson
Marlene A Koenig
Sam = neither I nor Charlotte are saying that these young boys died
from hemophilia = but there is a large number of young males in her maternal
ancestry who died - and not an equal proportion of females
Sam Dotson
Marlene A Koenig wrote:
>
> Sam = neither I nor Charlotte are saying that these young boys died
> from hemophilia = but there is a large number of young males in her maternal
> ancestry who died - and not an equal proportion of females
> --
Despite what you may read, females are the stronger sex - because they
are balanced by having two X chromosomes. Males, unbalanced with an X
and a Y chromosome are the weaker sex, medically speaking. That is why
there are more in utero and perinatal male deaths than female deaths and
why there is a slightly greater than 50% population of females relative
to males. This concerns the entire population, independent of any
specific causes of mortality like hemophilia or infections. This must
also be kept in mind when evaluating a situation like this - the less
than equal female mortality you mention in Queen Victoria's matrilinear
relatives.
Fred Cherry
OH, HEMOphilia. At first I thought the subject was HOMOphilia.
There is a certain princess who posts to this newsgroup who is afflicted
with homophilia.
jo...@world.std.com (Fred Cherry)
Grand Duke of Yugoslobia
Duke of Vulgaria
Grand Muff-Diver of Jerusalem
Elector of Homophobia
& Baron of Gray Matter