Chemical found in 'widely used sweetener' damages human DNA, new study says

[Leroy N. Soetoro]

https://katu.com/news/nation-world/chemical-found-in-widely-used-sweetner-
damages-human-dna-new-study-says-genotoxic-north-carolina-state-
university-sucralose-splenda-susan-shiffman-diet-health-artificial-sugar#

WASHINGTON (TND) — According to a new study, a chemical that forms when
humans digest a certain type of "widely used" sweetener is "genotoxic,"
meaning it damages DNA.

That chemical is also said to be found in the sweetener itself in trace
amounts and researchers claim "the finding raises questions about how the
sweetener may contribute to health problems."

North Carolina State University shared the findings of its new study in a
news release. It names "sucralose," said to be the most widely used
artificial sweetener in the United States, as the "issue."


Previous work from the new study's research team "established that several
fat-soluble compounds are produced in the gut after sucralose ingestion,"
according to NC State's news release, adding that "one of these compounds
is sucralose-6-acetate."

The new work now "establishes that sucralose-6-acetate is genotoxic"
according to Susan Schiffman, corresponding author of the study and an
adjunct professor in the joint department of biomedical engineering at
North Carolina State University and the University of North Carolina at
Chapel Hill, who is quoted in the release.

We also found that trace amounts of sucralose-6-acetate can be found in
off-the-shelf sucralose, even before it is consumed and metabolized,"
Schiffman added.

To put this in context, the European Food Safety Authority has a threshold
of toxicological concern for all genotoxic substances of 0.15 micrograms
per person per day,” Schiffman explains. “Our work suggests that the trace
amounts of sucralose-6-acetate in a single, daily sucralose-sweetened
drink exceed that threshold. And that’s not even accounting for the amount
of sucralose-6-acetate produced as metabolites after people consume
sucralose."

According to NC State, researchers in the study conducted a series of
experiments where they exposed human blood cells to sucralose-6-acetate
and monitored for "markers of genotoxicity."

Schiffman says that "in short," the research team "found that sucralose-6-
acetate is genotoxic, and that it effectively broke up DNA in cells that
were exposed to the chemical."

Chemical Found in Common Sweetener Damages DNA
A new study finds a chemical formed when we digest a widely used sweetener
breaks up DNA. The finding raises questions about how the sweetener may
contribute to health problems.

NC State News

Human gut tissues were also exposed to sucralose-6-acetate as part of the
study, according to the news release.

Other studies have found that sucralose can adversely affect gut health,
so we wanted to see what might be happening there,” Schiffman says. “When
we exposed sucralose and sucralose-6-acetate to gut epithelial tissues –
the tissue that lines your gut wall – we found that both chemicals cause
‘leaky gut.’

Basically, they make the wall of the gut more permeable. The chemicals
damage the ‘tight junctions,’ or interfaces, where cells in the gut wall
connect to each other," Schiffman explains. “A leaky gut is problematic,
because it means that things that would normally be flushed out of the
body in feces are instead leaking out of the gut and being absorbed into
the bloodstream.”

The "genetic activity" of the gut cells exposed to sucralose-6-acetate was
also examined during the study and Schiffman says that those cells "had
increased activity in genes related to oxidative stress, inflammation and
carcinogenicity."

This work raises a host of concerns about the potential health effects
associated with sucralose and its metabolites," Schiffman says. "It’s time
to revisit the safety and regulatory status of sucralose, because the
evidence is mounting that it carries significant risks. If nothing else, I
encourage people to avoid products containing sucralose. It’s something
you should not be eating."

The World Health Organization (WHO) recently released a new set of
guidelines at the beginning of May urging people to not use non-sugar
sweeteners (NSS) "to control body weight or reduce the risk of
noncommunicable diseases (NCDs)."

Sucralose is named as a common NSS by the WHO in its release of the new
guidelines.

The Food and Drug Administration (FDA) approved sucralose for use in 15
food categories in 1998 and then, one year later, approved the artificial
sweetener as a general-purpose sweetener.

According to Healthline.com, "Splenda" is the "most common sucralose-based
product." The makers of Splenda, British food supplier Tate & Lyle PLC,
say on their website that "Splenda Sucralose a reliable partner in a huge
range of products."

The sugar-like taste makes it ideal for manufacturers, looking to create
low calorie products that appeal to consumers," Tate & Lyle PLC says in
its "Introduction to Sucralose" section. "Tate & Lyle is the sole
manufacturer of SPLENDA Sucralose, a zero-calorie sweetener invented over
40 years ago. Part of our unique food and beverage solutions portfolio
SPLENDA Sucralose offers sugar-like sweetness, stability and versatility."



SPLENDA® Sucralose
SPLENDA® Sucralose is a high-potency, zero-calorie sweetener

Tate & Lyle

NC State's study directly names the brand in its news release, saying
sucralose is "a widely used artificial sweetener sold under the trade name
Splenda."

Sucralose has been sold under other brand names as well, such as Cukren,
Zerocal, Nevella, Canderel Yellow and SucraPlus according to The
Washington Post.

The National Desk has reached out to Tate & Lyle PLC seeking comment but
has yet to hear back. If a comment is received it will be added to this
article.


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