You can find two kinds of answers. In this example, a user
manages to find a utility that won't run, because the utility
checked carefully for desktop OSes and didn't find one.
http://vip.asus.com/forum/view.aspx?board_id=1&model=E35M1-I&id=20120520103703235&page=1&SLanguage=en-us
Whereas here, a user installed on a mixture of hardware and
didn't have a problem. Apparently, WHS 2011 is similar
to Windows 7 in terms of drivers.
http://social.microsoft.com/Forums/en-US/whshardware/thread/fc477586-42e9-4030-a29e-7b454b0053ba
"I have installed it on everything from an Atom Based Mini server
to a Dual Xeon based server, the only issue I had was when i tried
to run it on a Mac as a virtual machine, didn't like that and after
a few tries gave up on it."
That suggests it's better than some older home server setups.
Some of the previous desktop server OSes were a PITA when
it came to drivers.
Now, this thread on some RAIDs isn't very encouraging.
http://social.microsoft.com/Forums/en-US/whshardware/thread/293f7827-a714-4ce3-88e7-384a52708bb5
So it might all depend on whether you used just the chipset
hardware, or "got all fancy" with RAID cards. And this
being the case, maybe Microsoft really should have provided
an HCL for it (hardware compatibility list). I couldn't
find one.
There just isn't enough traffic here, to get some good hints.
http://social.microsoft.com/Forums/en-US/whshardware/threads
Paul