Patent on Gray Hair Treatment
KevinRog
United States Patent 5,017,368
Sugiyama , et al. May 21, 1991
Composition for application to hair or scalp
Abstract
A composition for application to hair or scalp comprises (A) at least one
compound selected from the group consisting of (i) forskolin and derivatives
thereof and (ii) peptides having a basic skeletal structure represented by the
following general formula (I): -P-Glu-His-Q-Arg-Trp-Gly-Lys- (I) (wherein P
represents an L-norleucine or L-methionine residue; Q represents a D- or
L-phenylalamine residue; and Glu, His, Arg, Trp, Gly and Lys are L-glutamic
acid, L-histidine, L-arginine, L-tryptophan, glycine and L-lysine residues
respectively); or the component A and (B) at least one compound selected from
the group consisting of aliphatic acids, alcohols and derivatives thereof
having an odd number of carbon atoms. The composition for hair or scalp
exhibits excellent effect of preventing graying of the hair and restoring
grayed hair to its natural color upon externally applied to the scalp and is
highly safe as regards to the possibility of causing skin damage. Therefore,
the composition can be widely used in various forms capable of being externally
applied to the scalp.
[[Kev]]
See my hair loss treatments site at:
http://members.aol.com/kevinrog/
For drugs, topicals, vitamins, studies, and patents
dejav
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BCgrad94
andrea...@my-deja.com
is this the gene therapy treatment researched by AntiCancer Inc. or
something else?
Thank you
Andreas
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Kev
<<Hello Kevin,
is this the gene therapy treatment researched by AntiCancer Inc. or
something else?
Thank you
Andreas>>
Its something else... Here is another patent on the use of cAMP for reversing
gray hair. This one is more interesting if you ask me. This is only the first
part of the patent. You can search for the whole thing on
http://www.uspto.gov/patft/index.html. There may be some studies on cAMP
helping to grow hair too.
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United States Patent 5,439,676
Kurusu , et al. August 8, 1995
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cAMP derivatives and use thereof for preventing or restoring grayed hair to its
natural color
Abstract
Methods and compositions containing cAMP salts in combination with inert
carriers for preventing or restoring grayed hair to its natural color.
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Parent Case Text
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This application is a continuation of application Ser. No. 07/631,478, filed
Dec. 21, 1990, now abandoned.
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Claims
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1. A method for preventing graying of hair and restoring grayed hair to its
natural color by applying to a human scalp an effective amount of a composition
consisting essentially of a salt of formula I or II set forth below and an
inert carrier wherein the concentration of said salt ranges from about 0.001 to
5% by weight, based on the total weight of the composition: ##STR24## wherein
R.sub.1 and R.sub.2 each represent a hydrogen atom or an acyl group having 1 to
12 carbon atoms, X represents a hydrogen atom, an O-containing group, an
S-containing group, an alkylamino group having 1 to 12 carbon atoms or a
halogen atom, and R.sub.3.sup.+ represents an ammonium cation derived from
2-amino-2-methyl-1,3-propanediol, 2-amino-alkanol having 3 to 6 carbon atoms,
monoalkylamine having 1 to 3 carbon atoms, lysine or histidine.
2. The method of claim 1, wherein said composition for hair comprises:
(a) a compound according to claim 1
(b) a nonionic surfactant having an HLB in the range of 3 to 19 or a
polyoxyethylene alkyl ester phosphate anionic surfactant, and
(c) an inert carrier.
3. The method of claim 2, wherein said nonionic surfactant is a polyoxyethylene
ether of a higher alcohol having 8 to 24 carbon atoms and which has an average
addition molar number of ethylene oxides of 2 to 40.
4. The method of claim 2, wherein said polyoxyethylene alkyl ester phosphate
anionic surfactant is a sodium phosphate salt of a polyoxyethylene derivative
of a higher alcohol having 12 to 18 carbon atoms and which has an average
addition molar number of ethylene oxides of 1 to 20.
5. The method of claim 2, wherein the concentration of said nonionic surfactant
or polyoxyethylene alkyl ester phosphate anionic surfactant is about 0.1 to 20%
by weight, based on the total weight of the composition.
6. The method of claim 2, wherein the weight ratio of component (a) to
component (b) is 1/2000 to 50/1.
7. The method of claim 2, which the composition further contains an oil and/or
a humectant.
8. The method of claim 1, wherein said effective amount when applied daily to
the human scalp is an amount of said composition which provides for about 1 to
100 mg per cm.sup.2 area of the human scalp.
9. The method of claim 1, wherein said composition is in the form of a hair
tonic alcoholic preparation which comprises 0.01 to 2% by weight of component
(a), 0.3 to 10% by weight of component (b), 10 to 98% by weight of a lower
alcohol, 0 to 3% by weight of a pharmaceutical component, 0 to 15% by weight of
a humectant, 1 to 85% by weight of purified water, based on the total weight of
the composition.
10. The method of claim 1, wherein said composition is in the form of a hair
cream which comprises 0.01 to 2% by weight of component (a), 0.3 to 10% by
weight of component (b), 20 to 80% by weight of an oil, 0 to 15% by weight of a
humectant, 15 to 80% by weight of purified water, based on the total weight of
the composition.
11. The method of claim 1, wherein said composition is in the form of a milky
lotion which comprises 0.01 to 2% by weight of component (a), 0.3 to 10% by
weight of component (b), 5 to 30% by weight of an oil, 0 to 15% by weight of a
humectant, 50 to 95% by weight of purified water, based on the total weight of
the composition.
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Description
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BACKGROUND OF THE INVENTION
The present invention relates to a composition for hair which, upon application
to the scalp, activates melanocytes of the radix pili and promotes synthesis of
melanin, thereby preventing graying of hair and restoring grayed hair to its
natural color. Graying of hair is a universal aging phenomenon. While hair dyes
have been commonly used to dye grayed hair from the viewpoint of beauty, the
use of such dyes is troublesome and sometimes causes side-effects such as rash
of the scalp. Therefore, many users find hair dyes to be an unsatisfactory
solution of the graying of the hair. Under such circumstances, it has been
desired to develop a pharmaceutical preparation or a cosmetic composition for
application to hair capable of essentially preventing graying of hair and
restoring grayed hair to its natural color. There have been some-proposals
heretofore such as those described in Japanese Patent Unexamined Publication
(hereinafter referred to as "J.P. KOKAI") Nos. 60-174705, 61-165310, 62-45527,
62-63509 and 62-63510 in compliance with such a demand. However, the proposed
techniques suffer from various disadvantages such as low effectiveness, low
stability of the active components and insufficient safety. Thus no practically
satisfactory composition can be obtained at present. The inventors previously
completed an invention based on a finding that the above-described problems can
be effectively solved by incorporating a specified nucleic acid compound or a
derivative thereof which is contained in a very small amount in the tissues and
cells in the living organisms and which has various regulating functions and
physiological effects into a cosmetic base (J.P. KOKAI Nos. 63-183518 and
64-25712). However, the effects of such a compound are yet unsatisfactory,
since the absorbability thereof through the scalp is insufficient. Summary of
the Invention Accordingly, a primary object of the present invention is to
provide a practically useful composition for hair which, upon application to
the scalp, can exhibit remarkable effects of preventing graying of hair and
restoring grayed hair to its natural color, since it has an effect of improving
the absorbability of the effective component through the scalp. Another object
of the present invention is to provide a method for preventing graying of hair
and restoring grayed hair to its natural color. These and other objects of the
present invention will be apparent from the following description and Examples.
The present invention has been completed on the basis of a finding that the
absorbability of the effective component through the scalp can be improved by
incorporating adenosine 3',5'-cyclic phosphoric acid (hereinafter referred to
as "cAMP") derivative which is a specific nucleic acid compound in the form of
a specific salt thereof into a cosmetic base and that the absorbability thereof
through the scalp can be further improved by incorporating a specific nonionic
or anionic surfactant thereinto and, therefore, the foregoing objects of the
present invention can be effectively achieved. The present invention provides a
composition for hair comprising a salt of the following formula [I] or [II] and
an inert carrier; ##STR1## wherein R.sub.1 and R.sub.2 each represent a
hydrogen atom or an acyl group having 1 to 12 carbon atoms, X represents a
hydrogen atom, an O-containing group, a S-containing group, an alkylamino group
having 1 to 12 carbon atoms or a halogen atom, and R.sup.+.sub.3 represents an
ammonium cation derived from 2-amino-2-methyl-1,3-propanediol,
2-amino-1-alkanol having 3 to 6 carbon atoms, monoalkylamine having 1 to 3
carbon atoms, lysine or histidine. The present invention also provides a
composition for hair, comprising [A] the salt represented by formulas [I] or
[II], [B] a nonionic surfactant having an HLB in the range of 3 to 19 or
phosphoric ester-type anionic surfactant and [C] an inert carrier.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
In the above formulae, [I] and [II]; R.sub.1 and R.sub.2 each represent a
hydrogen atom or an acyl group having 1 to 12 carbon atoms, preferably 1 to 6
carbon atoms, X represents a hydrogen atom, a halogen atom such as bromine,
iodine, chlorine or fluorine, an O-containing group such as a hydroxyl group,
an -o-alkyl group having 1 to 12, preferably 1 to 6 carbon atoms, -o-phenyl
group or a phenylalkyleneoxy group in which the alkylene group has 1 to 6
carbon atoms, preferably 1 to 4 carbon atoms, an S-containing group such as a
mercapto group, an alkylthio group or hydroxyalkylthio group having 1 to 12
carbon atoms, preferably 1 to 4 carbon atoms, a phenylthio group, a halogenated
phenylthio group such as chlorinated or brominated phenylthio group, a
hydroxyphenylthio group, an alkylphenylthio group in which the alkyl group has
1 to 6 carbon atoms, preferably 1 to 4 carbon atoms, an alkoxyphenylthio group
wherein the alkoxyl group has 1 to 6 carbon atoms or an aromatic thio group
such as a phenylalkylenethio group wherein the alkylene group has 1 to 6,
preferably 1 to 4 carbon atoms, e.g. benzylthio group or phenethylthio group,
or an alkylamino group having 1 to 12 carbon atoms, preferably 1 to 4 carbon
atoms. The acyl group and alkyl group may be either saturated or unsaturated
and straight chain or branched one. It may have a substituent such as a halogen
atom, an amino group, a nitro group, a carboxyl group or a hydroxyl group and
it may have an aromatic ring. The acyl group may be derived from a dibasic
acid. R.sub.3.sup.+ represents an ammonium cation derived from
2-amino-2-methyl-1,3-propanediol, 2-amino-1-alkanol having 3 to 6 carbon atoms,
preferably 2-amino-2-methyl-1-propanol, 2-amino-1-propanol, 2-amino-1-hexanol,
monoalkylamine having 1 to 3 carbon atoms, preferably methylamine, lysine or
histidine. The compound of the general formula [I] or [II] is a compound shown
in Table 1 or a mixture of two or more of these compounds. In Table 1, AMP and
AMPD represent an ammonium cation derived from 2-amino-2-methyl-1-propanol and
2-amino-2-methyl-1,3-propanediol, respectively.
[[Kev]]
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