The word senso [ˈsɛn.so] is Italian for "sense," "feeling," or "lust." The title refers to the delight Livia experiences while reflecting on her affair with a handsome lieutenant, in spite of her political convictions.
Chefs Riccardo Bacciottini and Alfano Giuseppe propose a sensory journey through traditional Italian and Tuscan cuisine, recalling the ancients with this land's skill and creative flavors. Among our gastronomic proposals, you will find a selection of carefully selected meats from all over Europe.
Understanding the molecular mechanisms of nociception has recently grown impressively. Nociception is mediated by mechanical, chemical, or microbial stimuli that evoke unpleasant feelings, alerting the host of the risk of tissue damage. Such diverse arrays of noxious stimuli trigger various escape reactions, usually altering immune homeostasis. Notably, nociceptors can recognize cytokines or pathogens via sensory molecules or innate immune receptors, participating in immune responses. Accumulating evidence suggests that activated nociceptors produce various humoral factors that affect the immune system and act like endocrine/paracrine signals. Thus, understanding the interplay between the nociceptive and immune systems may open new avenues for the development of an interdisciplinary research field, hereinafter referred to as 'senso-immunology'. This review will discuss the physiological relevance of the senso-immune system in the host defense context, focusing on how senso-immune research might yield novel treatments to cure pain and inflammation.
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