Diagnosis in DX and DX_bl in ADNIMERGE.csv

[Espen Riskedal]

Hi,

As I understand ADNIMERGE.csv the column DX_bl is Diagnosis at baseline, and DX is the diagnosis given at the EXAMDATE for that RID.

Can someone explain why the DX_bl categories are: AD CN EMCI LMCI SMC,

but the DX categories are: CN Dementia MCI? 

Most importantly I am trying to verify that the Dementia in DX means dementia due to AD, and not a more general term for dementia?

[Naomi Saito]

Hello,

These 5 categories were used in ADNI2 baseline.

http://adni.loni.usc.edu/wp-content/themes/freshnews-dev-v2/documents/clinical/ADNI-2_Protocol.pdf

Please see page 18~.  It has inclusion/exclusion criteria for these 5 categories.

ADNI3 and follow-ups use 3 categories. 

To identify Dementia due to AD, I had used a variable called DXAPP (if dementia due to AD?) in DXSUM_PDXADNIALL.csv data.

The variable DXODES (if dementia due to other etiology, select best diagnosis) may be also helpful.

Please check DATADIC and DXSUM data. 

Naomi Saito

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To: Alzheimer's Disease Neuroimaging Initiative (ADNI) Data <adni...@googlegroups.com>
Subject: [adni-data] Diagnosis in DX and DX_bl in ADNIMERGE.csv

 

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[Espen Riskedal]

Thank you Naomi, that is very helpful!

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regards,

Espen Riskedal,

CTO Age Labs

+47 414 36 739

[Espen Riskedal]

I have a two follow-up question.

1) There seems to be two similar columns in DXSUM_PDXCONV_ADNIALL.csv, one called DXAPP and another called DXDDUE

• DXAPP - If Dementia due to Alzheimer's Disease, indicate likelihood - 1=Probable; 2=Possible
• DXDDUE - Suspected cause of dementia - 1=Dementia due to Alzheimer's Disease; 2=Dementia due to other etiology

Can someone explain how these were set, by whom, and how they can be used together?

2) I notice many who are AD in DX_bl, and then later set to Dementia in DX, but where DXAPP is never set.

Can DX_bl AD cases who were later were set to Dementia in DX be assumed to always be AD?

Note: You said DXSUM_PDXADNIALL.csv - but I assume you mean DXSUM_PDXCONV_ADNIALL.csv

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[Naomi Saito]

Hi,

I have been treating AD and Dementia group as same.  I understand that AD group does not imply having AD diagnosis, so they started calling this group Dementia group. 

I checked crosstab of DXAPP and DXDDUE, and DXAPP is missing when DXDDUE = 2, so it makes sense to me. 

All new ADNI1 subjects who had DXCURREN = 3 at baseline have DXAPP values. 

All new ADNI2 subjects who had DXCHANGE = 3 at baseline have DXDDUE (DXAPP is missing when DXDDUE=2). 

All new ADNi3 subjects who had DIAGNOSIS = 3 at baseline have DXDDUE = 1, and N=4 is missing DXAPP.

I understand that diagnosis summary was filled by site clinician.  (ADNI3 procedure manual page 10 describes about clinician)

http://adni.loni.usc.edu/wp-content/uploads/2012/10/ADNI3-Procedures-Manual_v3.0_20170627.pdf

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From: adni...@googlegroups.com <adni...@googlegroups.com> on behalf of Espen Riskedal <es...@agelabs.com>

Sent: Monday, May 10, 2021 8:16 AM
To: adni...@googlegroups.com <adni...@googlegroups.com>
Subject: Re: [adni-data] Diagnosis in DX and DX_bl in ADNIMERGE.csv

 

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[Mike Donohue]

 

The change in labels is related to the evolution of the field since the start of ADNI when "AD" implied "AD Dementia". But now the concept of Alzheimer's Disease encompasses pre-symptomatic through dementia. Now it is common for AD to indicate Alzheimer's type pathology with or without the clinical symptoms of dementia.

Mike

[Espen Riskedal]

Thank you Naomi and Mike for the clarifications, much appreciated.