About Matching rs-fMRI with T1 MRI Scans in ADNI

[Rishab Dhiman]

Hello everyone,

I am working with ADNI resting-state fMRI data and had a question regarding how researchers typically match rs-fMRI scans with T1-weighted anatomical MRI scans for preprocessing.

In ADNI, for a single subject and visit, there are often multiple T1-related scans available, such as:

• MPRAGE

• MPRAGE SENSE

• MPRAGE REPE

• MT1

• N3m

• Scaled / Mask variants

For fMRI preprocessing (e.g., using fMRIPrep/SPM/FSL), I understand that a corresponding T1 anatomical scan is needed for registration and normalization. However, I am unsure:

1. Which T1 variant is generally preferred in ADNI studies?

   • Raw MPRAGE?

   • MT1/N3 corrected images?

   • MPRAGE SENSE?

   • Other?

2. What is the recommended strategy for matching rs-fMRI scans with T1 scans across a large cohort (~1100 subjects)?

   • Match by VISCODE?

   • Acquisition date?

   • Closest age?

   • Same visit/session?

3. Is there any standard or published workflow commonly followed by ADNI researchers for this pairing process?

I would really appreciate any guidance, best practices, or references from people who have worked with ADNI rs-fMRI data before.

Thank you!

Regards, 

Rishab Dhiman

Research Scholar

Department of Biostatistics 

National Institute of Mental Health and Neuroscience (NIMHANS),

Bengaluru- 560029

Email- Rishabk...@gmail.com