Hi Nalani,
I haven’t worked with the GWAS data from ADNI, but there is information on diagnosis on the Study Data page. The Diagnostic Summary table, for example, contains the diagnosis at each visit for each individual (RID). You can refer to the ADNI data dictionary (also available on the Study Data page) for the coding of the DXCURREN variable.
I just downloaded some of the .csv files (rather than the PLINK) for the ADNI-1 GWAS data. It looks like Sample ID is in the format XXX_S_YYYY (the numbers in YYYY correspond to the RID).
Not sure if this is helpful or not…
Danielle
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Hi Nalani,
Great! ADNIMERGE also has the diagnosis information in it (DX_bl is the screening diagnosis while DX is the diagnosis at different visits).
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Hi Nalani,
Just some background for you: In ADNI-1 (RID<2000), we only had 3 diagnostic groups (NL, MCI, AD), but based on our definition for MCI, they were really deemed to be “later” in MCI (based on a variety of data, this group was much closer to the AD group than the NL group) – we called them LMCI. So, in ADNI-GO (2000<RID<4000), we newly enrolled folks earlier in the course of MCI (EMCI). In ADNI-2 (4000<RID<6000), we had NL, MCI, and AD, but MCI included both EMCI and LMCI folks. We also added SMC (subjective memory complaint/concern) – these folks are NL, but have a concern about their memory.
According to the Clinical Core, the diagnoses are really NL, MCI, and AD, so from their perspective, knowing whether a participant with MCI is EMCI or LMCI or progresses from EMCI to LMCI isn’t all that meaningful, since they are all MCI. That’s why the information in the Diagnostic Summary and ADNIMERGE (for the diagnosis at each visit) only includes the 3 categories.
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Yes, SMC falls into NL and CN and NL are the same.
Danielle
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