Question about Amyloid (Aβ) Status in ADNI Data

[Shahzad ALi]

Dear ADNI team,

I’m currently working with ADNI data and would like to determine the amyloid (Aβ) positive/negative status of participants. Could you please advise which files or variables I should refer to in order to obtain/ compute this information?

Thank you very much for your guidance and support.

Best,

Ali

[Danielle J Harvey]

Hi Ali,

 

In the amyloid PET data table from UC Berkeley, there is a variable for amyloid positive/negative. There are also CSF amyloid and plasma amyloid data tables available (in the Biospecimens section), but those, I believe just have the measured levels, so no designation of positive vs negative.

 

Danielle

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[Shahzad ALi]

Dear Danielle,

Thank you very much for the clarification. That helps a lot!

I just wanted to confirm: in the UC Berkeley Amyloid PET 6mm Res analysis file, what is the difference between the AMYLOID_STATUS and AMYLOID_STATUS_COMPOSITE_REF variables (since there are some differences across a few subjects)?
Also, given that the plasma Aβ42/40 cutoff data include only a limited number of subjects, would you recommend relying mainly on the PET-based amyloid status for analyses?

Thanks again for your help!

Best,

Ali

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[Danielle J Harvey]

Hi Ali,

 

I would recommend referring to the methods document for the UCBerkeley amyloid PET (should be in the same location as the data file) – you will see that the cerebellum is the recommended reference region for cross-sectional analyses, while the composite reference region is preferred for longitudinal analyses. The two status variables are based on the corresponding SUVR (for cross-sectional using cerebellum or for longitudinal using composite reference region).

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