SMC, EMCI, LMCI only avail. at bl? LONI - weird 'Visit Descriptions'?

[Peter H]

Dear Experts,

I've recently started working with the ADNI-1, -GO, -2 datasets and come across some questions I couldn't find an exact answer to yet neither in the documents, nor here on the forums:

-  Is it correct that SMC, LMCI and EMCI diagnoses are only available at screening/baseline - at any other further visits patients only get either CN, MCI or AD diags?

- If clinicians only assign SMC, LMCI and EMCI at baseline, why is it that these diagnoses show up at later visits in the statistics (e.g.: at 'ADNI1/GO Month 12' and '24', or 'ADNIGO Month 3 MRI', or 'ADNI2 Year 3 Visit' just to name a few)? 

[I found this data on the LONI website > ADNI > Participant Distribution: Visit > Research Group ticked - https://ida.loni.usc.edu/home/projectPage.jsp?project=ADNI&page=HOME&subPage=OVERVIEW_PR]

- Regarding the table on the same page, under the graphs (see attached picture) - I can see some columns named: 'ADNI1/GO Month 6, 12, etc.' and 'ADNIGO Month 54-78'. As far as I know there's only a 1 year overlap in ADNI-GO and -2, but not within ADNI-1 and -GO. What do those columns really mean? Also do 'ADNIGO Month 54-78' columns represent the ADNI-1 follow-up patients?

Thank you very much for your help!

Kind regards,

Peter

[Danielle J Harvey]

Hi Peter,

 

SMC, LMCI and EMCI were categories used at recruitment. However, clinically, SMC are considered cognitively normal, while EMCI and LMCI both fall into the MCI category. Diagnosis at later visits just used the CN, MCI, AD categories. For the LONI visualization page that you mention, I suspect that the diagnoses are just the screening diagnoses (that is what is linked to the images), so it summarizes of those with a particular diagnosis at screening, which visits do they have…

 

ADNI-1, GO, and 2 had specific visitation schedules within the 1^st couple of years, but then visits were annual after that. For example, in ADNI-1, all groups had visits at sc, bl, m06, m12, and m24, MCI also had m18 and m36 and CN also had m36. In ADNI-2, a m03 image was acquired in addition to m06. The later visits refer to roll-over participants who have continued on from an earlier phase of ADNI.

 

I hope this helps!

Danielle

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[Peter H]

Hi Danielle,

thank you very much, it definetely helped a lot!

I only have one more follow-up question regarding the LONI database (can be seen on the previously attached screenshot).

As far as I know ADNI1 only lasted for 6+ years / 72+ months (~2004-2010), and ADNIGO for 2 years / 24 months (2009-2011), however in the 'Visit Description" column I can see entries named 'ADNI1/GO Month 30 -> 48' and 'ADNIGO Month 54 -> 78' - and I don't really know how to interpret these. Could you please provide some insight on this?

Thank you very much for your help!

Peter

[Naomi Saito]

Hi Peter,

Some ADNI1 subjects continue for ADNIGO (and ADNI2, and 3).

ADNIGO  Month 54 ->78  are most likely ADNI1 subjects who continue into ADNIGO, and their follow-up time is month 54 ~78 from their ADNI1 baseline. 

Naomi

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From: adni...@googlegroups.com <adni...@googlegroups.com> on behalf of Peter H <herba...@gmail.com>
Sent: Monday, August 16, 2021 2:06 AM

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Subject: Re: [adni-data] SMC, EMCI, LMCI only avail. at bl? LONI - weird 'Visit Descriptions'?

 

To view this discussion on the web visit https://groups.google.com/d/msgid/adni-data/7261f7d4-bf7d-4350-829d-b26b07ff4200n%40googlegroups.com.

[Peter H]

Hi Naomi,

so in this case 'ADNI1/GO Month 6-24' represent ADNI-1 and -GO patients, and 'ADNI1/GO Month 30-48' + 'ADNIGO Month 54-78' means ADNI-1 follow-up patients?

Thank you in advance!

Peter

[Danielle J Harvey]

If you are trying to identify in which phase a participant enrolled, you can use the RID (<2000 means ADNI-1, 2000s means ADNI-GO, 4000s and 5000s are ADNI-2 and 6000s are ADNI-3). RID is the same as the last 4 digits of the PTID with the scans (XXX_S_XXXX). If you are seeing a visit beyond m36, that likely refers to visits that occurred in a later phase of ADNI, because the individual continued on in the study.

 

It does seem as though what you state below is true but you can check with the PTID (or RID)…

To view this discussion on the web visit https://groups.google.com/d/msgid/adni-data/a51211b4-bf14-45d3-b09a-1236121e857en%40googlegroups.com.

[Peter H]

Hi Danielle,

thank you for your help, I didn't know this about PTIDs!

Peter