June lecture: Alex Mogilner
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Leo Zeitler
May 28, 2025, 3:37:27 AM5/28/25
to AdaBioSys lectures
Save the date! We're super excited to announce Alex Mogilner's June lecture:
Collective cell chirality
June 19, 5pm CET
Abstract:
Individual and collective cell polarity has fascinated biologists and modelers for a long time. Recently, a more subtle type of symmetry breaking started to attract attention of experimentalists and theorists alike - emergence of chirality in single cells and in cell groups. I will describe a study of collective cell chirality on adhesive islands. From the initial microscopy data, two potential models emerged: in one, cells elongate and slowly rotate, and neighboring cells align with each other. When the collective rotation is stopped by the island boundaries, chirality emerges. In an alternative model, cells become chiral due to stress fibers turning inside the cells on
the boundary, and then the polarity pattern propagates inward into the cellular groups. Simulations of these two models generates many predictions, and I will show how we discriminated between the models by comparing the data to these predictions.
Further information
Alex Mogilner is professor of mathematics and biology at NYU with focus on computational biology, cell biophysics, and mathematical biology: https://cims.nyu.edu/~mogilner/.
Please share and spread the word, the more the merrier!
If you've any other question or request, post in the group or contact us at
leo [dot] zeitler [at] pasteur [dot] fr
gautham [dot] ganesh [at] cbs [dot] cnrs [dot] fr
Individual and collective cell polarity has fascinated biologists and modelers for a long time. Recently, a more subtle type of symmetry breaking started to attract attention of experimentalists and theorists alike - emergence of chirality in single cells and in cell groups. I will describe a study of collective cell chirality on adhesive islands. From the initial microscopy data, two potential models emerged: in one, cells elongate and slowly rotate, and neighboring cells align with each other. When the collective rotation is stopped by the island boundaries, chirality emerges. In an alternative model, cells become chiral due to stress fibers turning inside the cells on
the boundary, and then the polarity pattern propagates inward into the cellular groups. Simulations of these two models generates many predictions, and I will show how we discriminated between the models by comparing the data to these predictions.
Further information
Alex Mogilner is professor of mathematics and biology at NYU with focus on computational biology, cell biophysics, and mathematical biology: https://cims.nyu.edu/~mogilner/.
Please share and spread the word, the more the merrier!
If you've any other question or request, post in the group or contact us at
leo [dot] zeitler [at] pasteur [dot] fr
gautham [dot] ganesh [at] cbs [dot] cnrs [dot] fr
Leo Zeitler
Jun 18, 2025, 7:10:24 AM6/18/25
to AdaBioSys lectures
REMINDER: Our June lecture by Alex Mogilner on Collective Cell Chirality is TOMORROW (June 19) at 5pm CEST.
Spread the word and tune in, the more the merrier! If you have any questions, you can contact us anytime.
Leo Zeitler
Jun 19, 2025, 3:11:42 AM6/19/25
to AdaBioSys lectures
Tune in for our June lecture by Alex Mogilner on Collective Cell Chirality TODAY at 5pm CEST.
Abstract below!
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