"Before KI became so readily available (in the late 1980s), some studies were done on the efficacy of topical application of tincture of iodine and/or povidone-iodine solution (Betadine) to the skin as a means of providing a loading of stable iodine to saturate the thyroid and prevent or reduce the potential uptake of the radioiodine. There is an established scientific basis for the success of that method for protection of the thyroid
gland. As the method relies solely on the topical application of first-aid treatments typically found in most homes and having no particular shelf-life problems, it may provide the public with an alternative to worrying about when and where to get and take
KI in an actual emergency. Preliminary human studies have shown that 4 mL of 2 percent tincture of iodine applied to a single forearm produced an average serum Iodine level of 138 pg mm....
-3
(13.8 µg dL
-
1
) at 2 hours post-application. Previous studies have indicated that serum levels greater
than 100 pg mm
-3
(10 µg dL
-1
) provides nearly 100 percent blockage of radioiodine
uptake by the thyroid gland. In the absence of KI tablets or solution for ingestion, for
thyroid protection from airborne radioiodine uptake, topical application of 8 mL
(equivalent to 120 drops, or 1.5 teaspoons, or ½ tablespoon, or ¼ ounce) of 2 percent
tincture of Iodine or Betadine (Povidone-Iodine solution) to the skin of the abdomen over Feasibility Study for Potassium Iodide (KI) Distribution in New York City
9
an area of approximately 4” by 8” would produce serum Iodine levels greater than 200
pg mm
-3
(20 µg dL
-1
) persisting over 26 hours with an effectiveness comparable to oral
KI in blocking uptake of radioiodine. CAUTION: TOPICAL application only. Ingestion
of tincture of iodine or Betadine can cause poisoning. (There is anecdotal information
regarding such occurrences in Eastern Europe when another Russian Reactor was
believed to be having an accident.) A significant public information and education effort
must accompany any such recommendation to the public.
[14,15]